{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T03:01:37Z","timestamp":1774148497434,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Dedifferentiated liposarcoma, one of the most deadly types of soft tissue sarcoma, is an aggressive and high-grade form of liposarcoma. Liposarcoma occurs most commonly in the retroperitoneum, extremities and trunk, but less frequently in the female genital tract. The vagina is a very rare site of origin. Herein we report the first case of dedifferentiated Liposarcoma deriving from vagina and discuss its clinical course.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 38-year-old female patient presented to our institution with a painless vaginal mass. Abdominal computed tomography showed a 17.6\u2009cm\u00d7\u200910.4\u2009cm solid mass originating from the right lateral wall of her vagina. Then she underwent complete surgical resection of the tumor mass, and postoperative pathological result confirmed the diagnosis of dedifferentiated liposarcoma deriving from vagina. Six courses of combination chemotherapy with pirarubicin plus ifosfamide were performed after surgery. The patient remains with no evidence of disease recurrence with 13\u2009months of follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Liposarcoma is very rare in female genital tract, and more rare for dedifferentiated liposarcoma in gynecologic field. Little is known about the clinical characteristics, pathological diagnosis, prognosis and optimal management strategy of vaginal dedifferentiated liposarcoma. Complete surgical resection followed by systemic chemotherapy is suggested to be standard treatment for dedifferentiated liposarcoma. Combination chemotherapy with pirarubicin and ifosfamide may be effective for treating vaginal dedifferentiated liposarcoma.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13000-020-01062-3","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T09:10:20Z","timestamp":1610183420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Primary dedifferentiated Liposarcoma of vagina: a first case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Chuan","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-5273","authenticated-orcid":false,"given":"Yangmei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"1062_CR1","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1259\/bjr\/29206613","volume":"76","author":"AR Azar","year":"2003","unstructured":"Azar AR, Weynand B, Daumerie C, Coche E. Metastatic liposarcoma of the thyroid gland. Br J Radiol. 2003;76:750\u20132.","journal-title":"Br J Radiol"},{"key":"1062_CR2","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/00000478-197912000-00004","volume":"3","author":"HL Evans","year":"1979","unstructured":"Evans HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol. 1979;3:507\u201323.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1062_CR3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/PAP.0000000000000284","volume":"28","author":"JH Choi","year":"2021","unstructured":"Choi JH, RO JY. The 2020 WHO classification of tumors of soft tissue: selected changes and new entities. Adv Anat Pathol. 2021;28(1):44\u201358.","journal-title":"Adv Anat Pathol"},{"issue":"2","key":"1062_CR4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1053\/j.semdp.2019.02.006","volume":"36","author":"K Thway","year":"2019","unstructured":"Thway K. Well-differentiated liposarcoma and dedifferentiated liposarcoma: an updated review. Semin Diagn Pathol. 2019;36(2):112\u201321.","journal-title":"Semin Diagn Pathol"},{"issue":"2","key":"1062_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11864-020-0705-7","volume":"21","author":"Z Gahvari","year":"2020","unstructured":"Gahvari Z, Parkes A. Dedifferentiated Liposarcoma: systemic therapy options. Curr Treat Options in Oncol. 2020;21(2):15.","journal-title":"Curr Treat Options in Oncol"},{"key":"1062_CR6","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.gore.2018.10.008","volume":"26","author":"K Kiuchi","year":"2018","unstructured":"Kiuchi K, Hasegawa K, Ochiai S, et al. Liposarcoma of the uterine corpus: a case report and literature review. Gynecol Oncol Rep. 2018;26:78\u201381.","journal-title":"Gynecol Oncol Rep"},{"issue":"4 Pt 2","key":"1062_CR7","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1447-0756.2008.00913.x","volume":"34","author":"H Oishi","year":"2008","unstructured":"Oishi H, Moriyama S, Kotera K, Miura K, Masuzaki H. First case of liposarcoma arising from the fallopian tube: case report and review of the literature. J Obstet Gynaecol Res. 2008;34(4 Pt 2):713\u20136.","journal-title":"J Obstet Gynaecol Res"},{"issue":"2","key":"1062_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.4329\/wjr.v4.i2.58","volume":"4","author":"CY Chu","year":"2012","unstructured":"Chu CY, Tang YK, Chan TS, Wan YH, Fung KH. Diagnostic challenge of lipomatous uterine tumors in three patients. World J Radiol. 2012;4(2):58\u201362.","journal-title":"World J Radiol"},{"issue":"2","key":"1062_CR9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1200\/JCO.2017.74.9598","volume":"36","author":"ATJ Lee","year":"2018","unstructured":"Lee ATJ, Thway K, Huang PH, Jones RL. Clinical and molecular spectrum of liposarcoma. J Clin Oncol. 2018;36(2):151\u20139.","journal-title":"J Clin Oncol"},{"key":"1062_CR10","first-page":"258","volume":"18","author":"L Laurino","year":"2001","unstructured":"Laurino L, Furlanetto A, Orvieto E, Dei Tos AP. Well-differentiated liposarcoma (atypical lipomatous tumors). Semin Diagn Pathol. 2001;18:258\u201362.","journal-title":"Semin Diagn Pathol"},{"issue":"1","key":"1062_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00432-018-2777-3","volume":"145","author":"J Gootee","year":"2019","unstructured":"Gootee J, Aurit S, Curtin C, Silberstein P. Primary anatomical site, adjuvant therapy, and other prognostic variables for dedifferentiated liposarcoma. J Cancer Res Clin Oncol. 2019;145(1):181\u201392.","journal-title":"J Cancer Res Clin Oncol"},{"key":"1062_CR12","first-page":"37","volume-title":"WHO classification of Tumours of soft tissue and bone","author":"AP Dei Tos","year":"2013","unstructured":"Dei Tos AP. Dedifferentiated liposarcoma. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of Tumours of soft tissue and bone. fourth ed. Lyon, France: IARC; 2013. p. 37\u20138.","edition":"fourth ed."},{"key":"1062_CR13","first-page":"363","volume-title":"Biopsy interpretation of soft tissue tumors","author":"C Fisher","year":"2010","unstructured":"Fisher C. Liposarcoma. In: Fisher C, Montgomery E, Thway K, editors. Biopsy interpretation of soft tissue tumors. Philadelphia, PA: Wolters Kluwer; 2010. p. 363\u201380."},{"key":"1062_CR14","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1097\/01.pas.0000170343.09562.39","volume":"29","author":"MB Binh","year":"2005","unstructured":"Binh MB, Sastre-Garau X, Guillou L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005;29:1340\u20137.","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"1062_CR15","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.soc.2016.05.007","volume":"25","author":"AM Crago","year":"2016","unstructured":"Crago AM, Dickson MA. Liposarcoma: multimodality management and future targeted therapies. Surg Oncol Clin N Am. 2016;25(4):761\u201373.","journal-title":"Surg Oncol Clin N Am"},{"issue":"2","key":"1062_CR16","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jamcollsurg.2013.10.009","volume":"218","author":"EZ Keung","year":"2014","unstructured":"Keung EZ, Hornick JL, Bertagnolli MM, Baldini EH, Raut CP. Predictors of outcomes in patients with primary retroperitoneal dedifferentiated liposarcoma undergoing surgery. J Am Coll Surg. 2014;218(2):206\u201317.","journal-title":"J Am Coll Surg"},{"issue":"4","key":"1062_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/CCO.0b013e32834796e6","volume":"23","author":"AM Crago","year":"2011","unstructured":"Crago AM, Singer S. Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma. Curr Opin Oncol. 2011;23(4):373\u20138.","journal-title":"Curr Opin Oncol"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-020-01062-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13000-020-01062-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-020-01062-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T21:03:31Z","timestamp":1610226211000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/s13000-020-01062-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,9]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1062"],"URL":"https:\/\/doi.org\/10.1186\/s13000-020-01062-3","relation":{},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,9]]},"assertion":[{"value":"2 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval and patient consent were acquired and recorded in the patient medical record with witness signature. All ethical approval and consent procedures were approved by the Medical Ethical Committee of West China Second University Hospital, Sichuan University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest\/competing interests in publishing the present manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3"}}