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Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and multiple organ failure. The disease is associated with a hypercatabolic state that entails excessive protein loss. This review commentary sheds the light on hypoproteinemia in symptomatic\/hospitalized COVID-19 with a special emphasis on its pathophysiology, screening, as well as its contribution to disease severity and adverse effects.<\/jats:p>","DOI":"10.1186\/s13000-021-01092-5","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T13:14:14Z","timestamp":1618319654000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action"],"prefix":"10.1186","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-8282","authenticated-orcid":false,"given":"Amira Mohammed","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kunugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"1092_CR1","doi-asserted-by":"publisher","unstructured":"Ali AM, Kunugi H. 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Evaluation of Nutrition Risk and Its Association With Mortality Risk in Severely and Critically Ill COVID-19 Patients. J Parenteral Enteral Nutr. 2020; n\/a(n\/a).","DOI":"10.1002\/jpen.1953"},{"issue":"2","key":"1092_CR8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3164\/jcbn.20-91","volume":"67","author":"C Wei","year":"2020","unstructured":"Wei C, Liu Y, Li Y, Zhang Y, Zhong M, Meng X. Evaluation of the nutritional status in patients with COVID-19. J Clin Biochem Nutr. 2020;67(2):116\u201321. https:\/\/doi.org\/10.3164\/jcbn.20-91.","journal-title":"J Clin Biochem Nutr"},{"issue":"3","key":"1092_CR9","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.cmet.2020.07.007","volume":"32","author":"AC Codo","year":"2020","unstructured":"Codo AC, Davanzo GG, Monteiro LB, de Souza GF, Muraro SP, Virgilio-da-Silva JV, et al. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1\u03b1\/Glycolysis-Dependent Axis. 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