{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:24:17Z","timestamp":1772166257104,"version":"3.50.1"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Rhinocerebral mucormycosis is a rare and severe form of opportunistic fungal infection that can develop rapidly and cause significant mortality, particularly among diabetic patients suffering from ketoacidosis. Diagnosing rhinocerebral mucormycosis during the early stages of infection is challenging.<\/jats:p>\n <\/jats:sec>\n \n Case presentation<\/jats:title>\n We describe a case of rhinocerebral mucormycosis secondary to severe acute pancreatitis in a patient suffering from diabetic ketoacidosis. In this case, the condition was not diagnosed during the optimal treatment window. we therefore provide a thorough overview of related clinical findings and histopathological characteristics, and we discuss potential differential diagnoses.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In summary, we described a case of rhinocerebral mucormycosis secondary to severe acute pancreatitis in a patient suffering from diabetic ketoacidosis, with the optimal treatment window for this condition having been missed. This report suggests that a definitive mucormycosis diagnosis can be made based upon tissue biopsy that reveals the presence of characteristic hyphae. Early diagnosis and treatment are essential in order to improve patient prognosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s13000-021-01094-3","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T11:07:41Z","timestamp":1619003261000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rhinocerebral mucormycosis secondary to severe acute pancreatitis and diabetic ketoacidosis: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Jinjing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"1094_CR1","first-page":"8974619","volume":"2019","author":"FZ Zaher","year":"2019","unstructured":"Zaher FZ, et al. Diabetic ketoacidosis revealing a severe hypertriglyceridemia and acute pancreatitis in type 1 diabetes mellitus. Case Rep Endocrinol. 2019;2019:8974619.","journal-title":"Case Rep Endocrinol"},{"issue":"3","key":"1094_CR2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3346\/jkms.2000.15.3.351","volume":"15","author":"IW Suh","year":"2000","unstructured":"Suh IW, et al. Hepatic and small bowel mucormycosis after chemotherapy in a patient with acute lymphocytic leukemia. J Korean Med Sci. 2000;15(3):351\u20134.","journal-title":"J Korean Med Sci"},{"issue":"1","key":"1094_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4314\/ejhs.v27i1.11","volume":"27","author":"R Sahota","year":"2017","unstructured":"Sahota R, et al. Rhinocerebral Mucormycosis: report of a rare case. Ethiop J Health Sci. 2017;27(1):85\u201390.","journal-title":"Ethiop J Health Sci"},{"key":"1094_CR4","doi-asserted-by":"publisher","unstructured":"Galletti B, Gazia F, Galletti C, Perani F, Ciodaro F, Freni F, et al. Rhinocerebral mucormycosis with dissemination to pontine area in a diabetic patient: Treatment and management. Clin Case Rep. 2019;7(7):1382\u20137. https:\/\/doi.org\/10.1002\/ccr3.2255 PMID: 31360493; PMCID: PMC6637368.","DOI":"10.1002\/ccr3.2255"},{"issue":"1","key":"1094_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/mmy\/myx017","volume":"56","author":"DE Corzo-Leon","year":"2018","unstructured":"Corzo-Leon DE, et al. Diabetes mellitus as the major risk factor for mucormycosis in Mexico: epidemiology, diagnosis, and outcomes of reported cases. Med Mycol. 2018;56(1):29\u201343.","journal-title":"Med Mycol"},{"issue":"11","key":"1094_CR6","first-page":"e1841","volume":"9","author":"P Bavikar","year":"2017","unstructured":"Bavikar P, Mehta V. Rhino-orbital-cerebral Mucormycosis: a fatal complication of uncontrolled diabetes mellitus. Cureus. 2017;9(11):e1841.","journal-title":"Cureus"}],"container-title":["Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-021-01094-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13000-021-01094-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13000-021-01094-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T11:07:44Z","timestamp":1619003264000},"score":1,"resource":{"primary":{"URL":"https:\/\/diagnosticpathology.biomedcentral.com\/articles\/10.1186\/s13000-021-01094-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1094"],"URL":"https:\/\/doi.org\/10.1186\/s13000-021-01094-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-141428\/v1","asserted-by":"object"}]},"ISSN":["1746-1596"],"issn-type":[{"value":"1746-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"28 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was approved by the Ethics Committee of the Affiliated Hospital of Zunyi Medical University. Written informed consent was obtained from the patient for publication of this clinical case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the family of the patient for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"34"}}