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In other organs, a subgroup of undifferentiated carcinoma related to SWI\/SNF complex\u2013deficiency have been described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 30-year-old woman presented with rising inflammatory markers (C-reactive protein (CRP)). Ultrasound examination revealed a large tumor of the liver. A computed tomography scan was performed and was primarily interpreted as a tumor-forming liver abscess, possibly caused by gallbladder perforation. Subsequent liver segment resection was performed. Microscopic examination showed an undifferentiated carcinoma with rhabdoid morphology and prominent inflammatory infiltrate in the gallbladder base. With SWI\/SNF immunohistochemistry, intact expression of SMARCB1, SMARCA4, ARID1A, but loss of SMARCA2 and PBRM1 was detected. Next-generation-sequencing detected\n                      <jats:italic>KRAS<\/jats:italic>\n                      ,\n                      <jats:italic>PBRM1<\/jats:italic>\n                      and\n                      <jats:italic>ARID1B<\/jats:italic>\n                      mutations, a deleterious splice-site mutation in the\n                      <jats:italic>POLE<\/jats:italic>\n                      -gene and a mutation in the\n                      <jats:italic>TP53<\/jats:italic>\n                      -gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We were able to demonstrate loss of SMARCA2 expression and mutations characteristic of an SWI\/SNF-deficient carcinoma in a tumor derived from the gallbladder. This is the first reported case of an undifferentiated carcinoma with rhabdoid features in the gallbladder carrying a\n                      <jats:italic>POLE<\/jats:italic>\n                      mutation and SWI\/SNF-deficiency of\n                      <jats:italic>PBRM1<\/jats:italic>\n                      and\n                      <jats:italic>SMARCA2<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13000-021-01112-4","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T04:02:49Z","timestamp":1623470569000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["SWI\/SNF-deficient undifferentiated\/rhabdoid carcinoma of the gallbladder carrying a POLE mutation in a 30-year-old woman: a case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Tiemo S.","family":"Gerber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Habekost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Stenzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schirmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate K.","family":"Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"issue":"1","key":"1112_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/jhbp.3","volume":"21","author":"HJ Park","year":"2014","unstructured":"Park HJ, Jang KT, Choi DW, Heo JS, Choi SH. 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