{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:51:14Z","timestamp":1769388674763,"version":"3.49.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Diagn Pathol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuroendocrine carcinoma arising from the urachus is extremely rare. We describe a case of a 33-year-old gentleman who presented with hematuria and diagnosed to have a composite adenocarcinoma and small cell neuroendocrine carcinoma arising from the urachus. The patient also had widespread metastasis at the time of presentation, therefore, he was referred for chemotherapy. However, the disease showed progression despite treatment. Recognition of neuroendocrine carcinoma component in urachal tumors, although rare, is very essential as this histologic type carries poor prognosis with aggressive clinical outcome.<\/jats:p>","DOI":"10.1186\/s13000-024-01490-5","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:06:48Z","timestamp":1718352408000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Urachal mixed adenocarcinoma and small cell neuroendocrine carcinoma with widespread metastasis and resistance to chemotherapy: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Sarah","family":"Obiedat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Murshed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Szabados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Al Rumaihi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issam","family":"Al Bozom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"issue":"2","key":"1490_CR1","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.juro.2014.09.004","volume":"193","author":"JM Gleason","year":"2015","unstructured":"Gleason JM, Bowlin PR, Bagli DJ, et al. A comprehensive review of pediatric urachal anomalies and predictive analysis for adult urachal adenocarcinoma. J Urol. 2015;193(2):632\u20136. https:\/\/doi.org\/10.1016\/j.juro.2014.09.004.","journal-title":"J Urol"},{"issue":"4 SUPPLEMENT","key":"1490_CR2","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.juro.2007.03.194","volume":"178","author":"RA Ashley","year":"2007","unstructured":"Ashley RA, Inman BA, Routh JC, Rohlinger AL, Husmann DA, Kramer SA. Urachal anomalies: a longitudinal study of Urachal remnants in children and adults. J Urol. 2007;178(4 SUPPLEMENT):1615\u20138. https:\/\/doi.org\/10.1016\/j.juro.2007.03.194.","journal-title":"J Urol"},{"issue":"6","key":"1490_CR3","doi-asserted-by":"publisher","first-page":"100711","DOI":"10.1016\/j.currproblcancer.2021.100711","volume":"45","author":"I Moreira","year":"2021","unstructured":"Moreira I, Coelho S, Rodrigues \u00c2, Patr\u00e3o AS, Maur\u00edcio MJ. Urachal carcinoma: a case of a rare neoplasm. 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Informed consent from the patient has been waived by the institutional review board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent from the patient has been waived by the institutional review board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"81"}}