{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:02:45Z","timestamp":1791406965680,"version":"4.3.3"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head Face Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13005-017-0146-0","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T11:17:09Z","timestamp":1496834229000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Vertical bone regeneration using rhBMP-2 and VEGF"],"prefix":"10.1186","volume":"13","author":[{"given":"Lara","family":"Schorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-9255","authenticated-orcid":false,"given":"Christoph","family":"Sproll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Ommerborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Naujoks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert R.","family":"K\u00fcbler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Depprich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"146_CR1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1902\/jop.1999.70.2.139","volume":"70","author":"DL Cochran","year":"1999","unstructured":"Cochran DL, Schenk R, Buser D, Wozney JM, Jones AA. Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. J Periodontol. 1999;70:139\u201350.","journal-title":"J Periodontol"},{"key":"146_CR2","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1902\/jop.2006.050337","volume":"77","author":"AA Jones","year":"2006","unstructured":"Jones AA, Buser D, Schenk R, Wozney J, Cochran DL. The effect of rhBMP-2 around endosseous implants with and without membranes in the canine model. J Periodontol. 2006;77:1184\u201393.","journal-title":"J Periodontol"},{"key":"146_CR3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ijom.2012.03.016","volume":"41","author":"M Clementini","year":"2012","unstructured":"Clementini M, Morlupi A, Canullo L, Agrestini C, Barlattani A. Success rate of dental implants inserted in horizontal and vertical guided bone regenerated areas: a systematic review. Int J Oral Maxillofac Surg. 2012;41:847\u201352.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"146_CR4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jobcr.2015.03.001","volume":"5","author":"D Daga","year":"2015","unstructured":"Daga D, Mehrotra D, Mohammad S, Singh G, Natu SM. Tentpole technique for bone regeneration in vertically deficient alveolar ridges: a review. J Oral Biol Craniofac Res. 2015;5:92\u20137.","journal-title":"J Oral Biol Craniofac Res"},{"key":"146_CR5","first-page":"524","volume":"16","author":"TJ Sigurdsson","year":"1996","unstructured":"Sigurdsson TJ, Nygaard L, Tatakis DN, Fu E, Turek TJ, Jin L, et al. Periodontal repair in dogs: evaluation of rhBMP-2 carriers. Int J Periodontics Restorative Dent. 1996;16:524\u201337.","journal-title":"Int J Periodontics Restorative Dent."},{"key":"146_CR6","first-page":"167","volume":"2","author":"M Esposito","year":"2009","unstructured":"Esposito M, Grusovin MG, Felice P, Karatzopoulos G, Worthington HV, Coulthard P. The efficacy of horizontal and vertical bone augmentation procedures for dental implants - a Cochrane systematic review. Eur J Oral Implantol. 2009;2:167\u201384.","journal-title":"Eur J Oral Implantol."},{"key":"146_CR7","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.ijom.2015.05.019","volume":"44","author":"A Restoy-Lozano","year":"2015","unstructured":"Restoy-Lozano A, Dominguez-Mompell JL, Infante-Cossio P, Lara-Chao J, Espin-Galvez F, Lopez-Pizarro V. Reconstruction of mandibular vertical defects for dental implants with autogenous bone block grafts using a tunnel approach: clinical study of 50 cases. Int J Oral Maxillofac Surg. 2015;44:1416\u201322.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"146_CR8","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/j.oooo.2011.09.031","volume":"114","author":"IE Zakhary","year":"2012","unstructured":"Zakhary IE, El-Mekkawi HA, Elsalanty ME. Alveolar ridge augmentation for implant fixation: status review. Oral Surg Oral med Oral Pathol Oral Radiol. 2012;114:S179\u201389.","journal-title":"Oral Surg Oral med Oral Pathol Oral Radiol"},{"key":"146_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/jop.2016.150342","volume":"87","author":"CF Octavi","year":"2016","unstructured":"Octavi CF, Genis BB, Rui F, Jung RE, Cosme GE, Eduard VC. Interventions for dental implant placement in atrophic edentulous mandibles: vertical bone augmentation and alternative treatments. A meta-analysis of randomized clinical trials. J Periodontol. 2016;87:1\u201323.","journal-title":"J Periodontol"},{"key":"146_CR10","first-page":"83","volume":"7","author":"S Nosouhian","year":"2015","unstructured":"Nosouhian S, Rismanchian M, Sabzian R, Shadmehr E, Badrian H, Davoudi A. A mini-review on the effect of mini-implants on contemporary orthodontic science. J Int Oral Health. 2015;7:83\u20137.","journal-title":"J Int Oral Health"},{"key":"146_CR11","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1089\/ten.tec.2010.0020","volume":"16","author":"KH Schuckert","year":"2010","unstructured":"Schuckert KH, Jopp S, Osadnik M. Modern bone regeneration instead of bone transplantation: a combination of recombinant human bone morphogenetic protein-2 and platelet-rich plasma for the vertical augmentation of the maxillary bone-a single case report. Tissue Eng Part C Methods. 2010;16:1335\u201346.","journal-title":"Tissue Eng Part C Methods"},{"key":"146_CR12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-540-77755-7_13","volume-title":"Fundamentals of tissue engineering and regenerative medicine","author":"J Handschel","year":"2009","unstructured":"Handschel J, Meyer U, Wiesmann HP. Embryonic stem cell use. In: Meyer U, Meyer T, Handschel J, Wiesmann HP, editors. Fundamentals of tissue engineering and regenerative medicine. Heidelberg: Springer-Verlag; 2009. p. 159\u201366."},{"key":"146_CR13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/1678-775720150357","volume":"24","author":"JA Keestra","year":"2016","unstructured":"Keestra JA, Barry O, Jong L, Wahl G. Long-term effects of vertical bone augmentation: a systematic review. J Appl Oral Sci. 2016;24:3\u201317.","journal-title":"J Appl Oral Sci"},{"key":"146_CR14","first-page":"297","volume":"4","author":"KE Kahnberg","year":"1989","unstructured":"Kahnberg KE, Nystrom E, Bartholdsson L. Combined use of bone grafts and Branemark fixtures in the treatment of severely resorbed maxillae. Int J Oral Maxillofac Implants. 1989;4:297\u2013304.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"146_CR15","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1053\/joms.2002.33856","volume":"60","author":"RE Marx","year":"2002","unstructured":"Marx RE, Shellenberger T, Wimsatt J, Correa P. Severely resorbed mandible: predictable reconstruction with soft tissue matrix expansion (tent pole) grafts. J Oral Maxillofac Surg. 2002;60:878\u201388. discussion 888-879","journal-title":"J Oral Maxillofac Surg"},{"key":"146_CR16","first-page":"1144","volume":"24","author":"K Wannfors","year":"2009","unstructured":"Wannfors K, Johansson C, Donath K. Augmentation of the mandible via a \"tent-pole\" procedure and implant treatment in a patient with type III osteogenesis imperfecta: clinical and histologic considerations. Int J Oral Maxillofac Implants. 2009;24:1144\u20138.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"146_CR17","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.jcms.2016.07.028","volume":"44","author":"M Troeltzsch","year":"2016","unstructured":"Troeltzsch M, Troeltzsch M, Kauffmann P, Gruber R, Brockmeyer P, Moser N, et al. Clinical efficacy of grafting materials in alveolar ridge augmentation: a systematic review. J Craniomaxillofac Surg. 2016;44:1618\u201329.","journal-title":"J Craniomaxillofac Surg."},{"key":"146_CR18","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.joms.2015.07.004","volume":"73","author":"RA Fahmy","year":"2015","unstructured":"Fahmy RA, Mahmoud N, Soliman S, Nouh SR, Cunningham L, El-Ghannam A. Acceleration of alveolar ridge augmentation using a low dose of recombinant human bone morphogenetic protein-2 loaded on a Resorbable bioactive ceramic. J Oral Maxillofac Surg. 2015;73:2257\u201372.","journal-title":"J Oral Maxillofac Surg"},{"key":"146_CR19","first-page":"267","volume":"2","author":"P Felice","year":"2009","unstructured":"Felice P, Checchi V, Pistilli R, Scarano A, Pellegrino G, Esposito M. Bone augmentation versus 5-mm dental implants in posterior atrophic jaws. Four-month post-loading results from a randomised controlled clinical trial. Eur J Oral Implantol. 2009;2:267\u201381.","journal-title":"Eur J Oral Implantol."},{"key":"146_CR20","first-page":"183","volume":"1","author":"P Felice","year":"2008","unstructured":"Felice P, Marchetti C, Piattelli A, Pellegrino G, Checchi V, Worthington H, et al. Vertical ridge augmentation of the atrophic posterior mandible with interpositional block grafts: bone from the iliac crest versus bovine anorganic bone. Eur J Oral Implantol. 2008;1:183\u201398.","journal-title":"Eur J Oral Implantol."},{"issue":"Suppl 1","key":"146_CR21","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1111\/j.1708-8208.2009.00212.x","volume":"11","author":"P Felice","year":"2009","unstructured":"Felice P, Pistilli R, Lizio G, Pellegrino G, Nisii A, Marchetti C. Inlay versus onlay iliac bone grafting in atrophic posterior mandible: a prospective controlled clinical trial for the comparison of two techniques. Clin Implant Dent Relat res. 2009;11(Suppl 1):e69\u201382.","journal-title":"Clin Implant Dent Relat res"},{"key":"146_CR22","first-page":"293","volume":"2","author":"P Felice","year":"2009","unstructured":"Felice P, Scarano A, Pistilli R, Checchi L, Piattelli M, Pellegrino G, et al. A comparison of two techniques to augment maxillary sinuses using the lateral window approach: rigid synthetic resorbable barriers versus anorganic bovine bone. Five-month post-loading clinical and histological results of a pilot randomised controlled clinical trial. Eur J Oral Implantol. 2009;2:293\u2013306.","journal-title":"Eur J Oral Implantol"},{"issue":"Suppl 1","key":"146_CR23","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1111\/cid.12191","volume":"17","author":"M Chiapasco","year":"2015","unstructured":"Chiapasco M, Di Martino G, Anello T, Zaniboni M, Romeo E. Fresh frozen versus autogenous iliac bone for the rehabilitation of the extremely atrophic maxilla with onlay grafts and endosseous implants: preliminary results of a prospective comparative study. Clin Implant Dent Relat res. 2015;17(Suppl 1):e251\u201366.","journal-title":"Clin Implant Dent Relat res"},{"key":"146_CR24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1902\/jop.1998.69.4.414","volume":"69","author":"W Becker","year":"1998","unstructured":"Becker W, Clokie C, Sennerby L, Urist MR, Becker BE. Histologic findings after implantation and evaluation of different grafting materials and titanium micro screws into extraction sockets: case reports. J Periodontol. 1998;69:414\u201321.","journal-title":"J Periodontol"},{"key":"146_CR25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1034\/j.1600-0501.1994.050205.x","volume":"5","author":"NP Lang","year":"1994","unstructured":"Lang NP, Hammerle CH, Bragger U, Lehmann B, Nyman SR. Guided tissue regeneration in jawbone defects prior to implant placement. Clin Oral Implants res. 1994;5:92\u20137.","journal-title":"Clin Oral Implants res"},{"key":"146_CR26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-051X.2008.01271.x","volume":"35","author":"I Rocchietta","year":"2008","unstructured":"Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol. 2008;35:203\u201315.","journal-title":"J Clin Periodontol"},{"key":"146_CR27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1034\/j.1600-0501.1990.010104.x","volume":"1","author":"D Buser","year":"1990","unstructured":"Buser D, Bragger U, Lang NP, Nyman S. Regeneration and enlargement of jaw bone using guided tissue regeneration. Clin Oral Implants res. 1990;1:22\u201332.","journal-title":"Clin Oral Implants res"},{"key":"146_CR28","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0278-2391(10)80108-9","volume":"51","author":"K Gotfredsen","year":"1993","unstructured":"Gotfredsen K, Nimb L, Buser D, Hjorting-Hansen E. Evaluation of guided bone generation around implants placed into fresh extraction sockets: an experimental study in dogs. J Oral Maxillofac Surg. 1993;51:879\u201384. discussion 885-876","journal-title":"J Oral Maxillofac Surg"},{"key":"146_CR29","doi-asserted-by":"crossref","unstructured":"Penarrocha MA, Vina JA, Maestre L, Penarrocha-Oltra D. Bilateral vertical ridge augmentation with block grafts and guided bone regeneration in the posterior mandible: a case report. J Oral Implantol. 2012;38 Spec No:533-537.","DOI":"10.1563\/AAID-JOI-D-10-00075"},{"key":"146_CR30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1061-3315(18)30059-3","volume":"7","author":"M Chin","year":"1999","unstructured":"Chin M. Distraction osteogenesis for dental implants. Atlas Oral Maxillofac Surg Clin North Am. 1999;7:41\u201363.","journal-title":"Atlas Oral Maxillofac Surg Clin North Am"},{"key":"146_CR31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1054\/ijom.2001.0134","volume":"30","author":"A Rachmiel","year":"2001","unstructured":"Rachmiel A, Srouji S, Peled M. Alveolar ridge augmentation by distraction osteogenesis. Int J Oral Maxillofac Surg. 2001;30:510\u20137.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"146_CR32","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ijom.2007.05.002","volume":"36","author":"EB Wolvius","year":"2007","unstructured":"Wolvius EB, Scholtemeijer M, Weijland M, Hop WC, van der Wal KG. Complications and relapse in alveolar distraction osteogenesis in partially dentulous patients. Int J Oral Maxillofac Surg. 2007;36:700\u20135.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"146_CR33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S1010-5182(99)80032-8","volume":"27","author":"A Gaggl","year":"1999","unstructured":"Gaggl A, Schultes G, Karcher H. Distraction implants: a new operative technique for alveolar ridge augmentation. J Craniomaxillofac Surg. 1999;27:214\u201321.","journal-title":"J Craniomaxillofac Surg"},{"key":"146_CR34","first-page":"1239842","volume":"2016","author":"F Asa'ad","year":"2016","unstructured":"Asa'ad F, Pagni G, Pilipchuk SP, Gianni AB, Giannobile WV, Rasperini G. 3D-printed scaffolds and biomaterials: review of alveolar bone augmentation and periodontal regeneration applications. Int J Dent. 2016;2016:1239842.","journal-title":"Int J Dent"},{"key":"146_CR35","doi-asserted-by":"publisher","unstructured":"Roccuzzo M, Savoini M, Dalmasso P, Ramieri G. Long-term outcomes of implants placed after vertical alveolar ridge augmentation in partially edentulous patients: a 10-year prospective clinical study. Clin Oral Implants Res. 2016; doi: 10.1111\/clr.12941 .","DOI":"10.1111\/clr.12941"},{"key":"146_CR36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1615\/CritRevBiomedEng.v40.i5.10","volume":"40","author":"AR Amini","year":"2012","unstructured":"Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit rev Biomed Eng. 2012;40:363\u2013408.","journal-title":"Crit rev Biomed Eng"},{"key":"146_CR37","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s00776-003-0702-2","volume":"8","author":"BA Roelen","year":"2003","unstructured":"Roelen BA, Dijke P. Controlling mesenchymal stem cell differentiation by TGFBeta family members. J Orthop Sci. 2003;8:740\u20138.","journal-title":"J Orthop Sci"},{"key":"146_CR38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-3-540-77755-7_11","volume-title":"Fundamentals of tissue engineering and regenerative engineering","author":"RA Depprich","year":"2009","unstructured":"Depprich RA. Biomolecule use in tissue engineering. In: Meyer U, Meyer T, Handschel J, Wiesmann HP, editors. Fundamentals of tissue engineering and regenerative engineering. Heildelberg: Springer-Verlag; 2009. p. 121\u201336."},{"key":"146_CR39","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3390\/jfb6030833","volume":"6","author":"A Jamjoom","year":"2015","unstructured":"Jamjoom A, Cohen RE. Grafts for ridge preservation. J Funct Biomater. 2015;6:833\u201348.","journal-title":"J Funct Biomater"},{"key":"146_CR40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/ID.0000000000000035","volume":"23","author":"SC Wallace","year":"2014","unstructured":"Wallace SC, Pikos MA, Prasad H. De novo bone regeneration in human extraction sites using recombinant human bone morphogenetic protein-2\/ACS: a clinical, histomorphometric, densitometric, and 3-dimensional cone-beam computerized tomographic scan evaluation. Implant Dent. 2014;23:132\u20137.","journal-title":"Implant Dent"},{"key":"146_CR41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1601-6343.2009.01461.x","volume":"12","author":"UM Wikesjo","year":"2009","unstructured":"Wikesjo UM, Qahash M, Huang YH, Xiropaidis A, Polimeni G, Susin C. Bone morphogenetic proteins for periodontal and alveolar indications; biological observations - clinical implications. Orthod Craniofac Res. 2009;12:263\u201370.","journal-title":"Orthod Craniofac Res"},{"key":"146_CR42","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1600-0501.2006.01324.x","volume":"18","author":"SA Jovanovic","year":"2007","unstructured":"Jovanovic SA, Hunt DR, Bernard GW, Spiekermann H, Wozney JM, Wikesjo UM. Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clin Oral Implants res. 2007;18:224\u201330.","journal-title":"Clin Oral Implants res"},{"key":"146_CR43","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1016\/j.joms.2015.04.009","volume":"73","author":"J Glowacki","year":"2015","unstructured":"Glowacki J. Demineralized bone and BMPs: basic science and clinical utility. J Oral Maxillofac Surg. 2015;73:S126\u201331.","journal-title":"J Oral Maxillofac Surg"},{"key":"146_CR44","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.3390\/ijms12031744","volume":"12","author":"J Jiang","year":"2011","unstructured":"Jiang J, Fan CY, Zeng BF. Experimental construction of BMP2 and VEGF Gene modified tissue engineering bone in vitro. Int J Mol Sci. 2011;12:1744\u201355.","journal-title":"Int J Mol Sci"},{"key":"146_CR45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1096\/fasebj.13.1.9","volume":"13","author":"G Neufeld","year":"1999","unstructured":"Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. Faseb J. 1999;13:9\u201322.","journal-title":"Faseb J"},{"key":"146_CR46","doi-asserted-by":"crossref","unstructured":"Kleinheinz J, Wiesmann HP, Stratmann U, Joos U. Beeinflussung der Angiogenese und Osteogenese unter dem Einfluss von vascular endothelial growth factor (VEGF). Mund-Kiefer GesichtsCHir. 2002;6:175\u201382.","DOI":"10.1007\/s10006-002-0368-5"},{"key":"146_CR47","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/mt.2009.315","volume":"18","author":"S Kumar","year":"2010","unstructured":"Kumar S, Wan C, Ramaswamy G, Clemens TL, Ponnazhagan S. Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect. Mol Ther. 2010;18:1026\u201334.","journal-title":"Mol Ther"},{"key":"146_CR48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.matbio.2016.02.005","volume":"52-54","author":"X Duan","year":"2016","unstructured":"Duan X, Bradbury SR, Olsen BR, Berendsen AD. VEGF stimulates intramembranous bone formation during craniofacial skeletal development. Matrix Biol. 2016;52-54:127\u201340.","journal-title":"Matrix Biol"},{"key":"146_CR49","first-page":"325","volume":"38","author":"D Katanec","year":"2014","unstructured":"Katanec D, Granic M, Majstorovic M, Trampus Z, Panduric DG. Use of recombinant human bone morphogenetic protein (rhBMP2) in bilateral alveolar ridge augmentation: case report. Coll Antropol. 2014;38:325\u201330.","journal-title":"Coll Antropol"},{"key":"146_CR50","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bjoms.2014.08.009","volume":"52","author":"M Stimmelmayr","year":"2014","unstructured":"Stimmelmayr M, Beuer F, Schlee M, Edelhoff D, Guth JF. Vertical ridge augmentation using the modified shell technique--a case series. Br J Oral Maxillofac Surg. 2014;52:945\u201350.","journal-title":"Br J Oral Maxillofac Surg"},{"key":"146_CR51","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1600-0501.2011.02341.x","volume":"24","author":"Z Du","year":"2013","unstructured":"Du Z, Chen J, Yan F, Doan N, Ivanovski S, Xiao Y. Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin. Clin Oral Implants Res. 2013;24:422\u20137.","journal-title":"Clin Oral Implants Res"},{"key":"146_CR52","first-page":"211","volume":"18","author":"K Matin","year":"2003","unstructured":"Matin K, Senpuku H, Hanada N, Ozawa H, Ejiri S. Bone regeneration by recombinant human bone morphogenetic protein-2 around immediate implants: a pilot study in rats. Int J Oral Maxillofac Implants. 2003;18:211\u20137.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"146_CR53","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0968-0004(03)00193-2","volume":"28","author":"MJ Cross","year":"2003","unstructured":"Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L. VEGF-receptor signal transduction. Trends Biochem Sci. 2003;28:488\u201394.","journal-title":"Trends Biochem Sci"},{"key":"146_CR54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10529-012-1084-3","volume":"35","author":"Y Bai","year":"2013","unstructured":"Bai Y, Li P, Yin G, Huang Z, Liao X, Chen X, et al. BMP-2, VEGF and bFGF synergistically promote the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. Biotechnol Lett. 2013;35:301\u20138.","journal-title":"Biotechnol Lett."},{"key":"146_CR55","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3892\/etm.2013.1464","volume":"7","author":"Z Lin","year":"2014","unstructured":"Lin Z, Wang JS, Lin L, Zhang J, Liu Y, Shuai M, et al. Effects of BMP2 and VEGF165 on the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. Exp Ther Med. 2014;7:625\u20139.","journal-title":"Exp Ther Med."},{"key":"146_CR56","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10006-009-0185-1","volume":"14","author":"H Schliephake","year":"2010","unstructured":"Schliephake H. Application of bone growth factors--the potential of different carrier systems. Oral Maxillofac Surg. 2010;14:17\u201322.","journal-title":"Oral Maxillofac Surg"},{"key":"146_CR57","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/clr.12503","volume":"27","author":"JP Carrel","year":"2016","unstructured":"Carrel JP, Wiskott A, Moussa M, Rieder P, Scherrer S, Durual S. A 3D printed TCP\/HA structure as a new osteoconductive scaffold for vertical bone augmentation. Clin Oral Implants Res. 2016;27:55\u201362.","journal-title":"Clin Oral Implants Res"},{"key":"146_CR58","first-page":"371","volume":"20","author":"M Kahle","year":"2010","unstructured":"Kahle M, Wiesmann HP, Berr K, Depprich RA, Kubler NR, Naujoks C, et al. Embryonic stem cells induce ectopic bone formation in rats. Biomed Mater Eng. 2010;20:371\u201380.","journal-title":"Biomed Mater Eng."},{"key":"146_CR59","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ten.tea.2009.0131","volume":"16","author":"F Langenbach","year":"2012","unstructured":"Langenbach F, Naujoks C, Kersten-Thiele PV, Berr K, Depprich RA, Kubler NR, et al. Osteogenic differentiation influences stem cell migration out of scaffold-free microspheres. Tissue Eng Part A. 2012;16:759\u201366.","journal-title":"Tissue Eng Part A."},{"key":"146_CR60","volume-title":"Biocoating of implants with mediator molecules: surface enhancement of metals by treatment with Chromosulfuric acid-Biologisierung von Implantaten mit Biomolek\u00fclen: Oberfl\u00e4chenveredelung von Metallen durch Behandlung mit Chromschwefels\u00e4ure","author":"H Jennissen","year":"1999","unstructured":"Jennissen H, Zumbrink T, Chatzinikolaidou M, Steppuhn J. Biocoating of implants with mediator molecules: surface enhancement of metals by treatment with Chromosulfuric acid-Biologisierung von Implantaten mit Biomolek\u00fclen: Oberfl\u00e4chenveredelung von Metallen durch Behandlung mit Chromschwefels\u00e4ure. Weinheim: Wiley-VCH Verlag GmbH; 1999."},{"key":"146_CR61","first-page":"377","volume":"17","author":"AB Novaes Jr","year":"2002","unstructured":"Novaes AB Jr, Souza SL, de Oliveira PT, Souza AM. Histomorphometric analysis of the bone-implant contact obtained with 4 different implant surface treatments placed side by side in the dog mandible. Int J Oral Maxillofac Implants. 2002;17:377\u201383.","journal-title":"Int J Oral Maxillofac Implants"},{"key":"146_CR62","doi-asserted-by":"crossref","unstructured":"Rammelt S, Schulze E, Bernhardt R, Hanisch U, Scharnweber D, Worch H, et al. Coating of titanium implants with type-I collagen. J Orthop Res. 2004;22:1025\u201334.","DOI":"10.1016\/j.orthres.2004.02.011"},{"key":"146_CR63","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0167-7799(01)01665-1","volume":"19","author":"RH Li","year":"2001","unstructured":"Li RH, Wozney JM. Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol. 2001;19:255\u201365.","journal-title":"Trends Biotechnol"},{"key":"146_CR64","first-page":"129","volume":"24","author":"B Giesenhagen","year":"2008","unstructured":"Giesenhagen B. Die einzeitige vertikale Augmentation mit ringf\u00f6rmigen Knochentransplantaten. Z Zahn\u00e4rztl Impl. 2008;24:129\u201332.","journal-title":"Z Zahn\u00e4rztl Impl"},{"key":"146_CR65","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.ijom.2012.04.005","volume":"41","author":"JB Huh","year":"2012","unstructured":"Huh JB, Kim SE, Kim HE, Kang SS, Choi KH, Jeong CM, et al. Effects of anodized implants coated with Escherichia Coli-derived rhBMP-2 in beagle dogs. Int J Oral Maxillofac Surg. 2012;41:1577\u201384.","journal-title":"Int J Oral Maxillofac Surg."},{"key":"146_CR66","first-page":"31","volume":"24","author":"D Weng","year":"2009","unstructured":"Weng D, Poehling S, Pippig S, Bell M, Richter EJ, Zuhr O, et al. The effects of recombinant human growth\/differentiation factor-5 (rhGDF-5) on bone regeneration around titanium dental implants in barrier membrane-protected defects: a pilot study in the mandible of beagle dogs. Int J Oral Maxillofac Implants. 2009;24:31\u20137.","journal-title":"Int J Oral Maxillofac Implants."},{"key":"146_CR67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-213X-5-1","volume":"5","author":"NI Zur Nieden","year":"2005","unstructured":"Zur Nieden NI, Kempka G, Rancourt DE, HJ AHR. Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages. BMC Dev Biol. 2005;5:1.","journal-title":"BMC Dev Biol"},{"key":"146_CR68","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bone.2012.02.017","volume":"51","author":"H Matsubara","year":"2012","unstructured":"Matsubara H, Hogan DE, Morgan EF, Mortlock DP, Einhorn TA, Gerstenfeld LC. Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis. Bone. 2012;51:168\u201380.","journal-title":"Bone"},{"key":"146_CR69","doi-asserted-by":"crossref","first-page":"E829","DOI":"10.1097\/BRS.0000000000001408","volume":"41","author":"M Refaat","year":"2016","unstructured":"Refaat M, Klineberg EO, Fong MC, Garcia TC, Leach JK, Haudenschild DR. Binding to COMP reduces the BMP2 dose for spinal fusion in a rat model. Spine (Phila Pa 1976). 2016;41:E829\u201336.","journal-title":"Spine (Phila Pa 1976)"},{"key":"146_CR70","doi-asserted-by":"crossref","unstructured":"Peng H, Usas A, Olshanski A, Ho AM, Gearhart B, Cooper GM, et al. VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. J Bone Miner Res. 2005;20:2017\u201327.","DOI":"10.1359\/JBMR.050708"}],"container-title":["Head & Face Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13005-017-0146-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T14:35:16Z","timestamp":1569422116000},"score":1,"resource":{"primary":{"URL":"http:\/\/head-face-med.biomedcentral.com\/articles\/10.1186\/s13005-017-0146-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["146"],"URL":"https:\/\/doi.org\/10.1186\/s13005-017-0146-0","relation":{},"ISSN":["1746-160X"],"issn-type":[{"value":"1746-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,7]]},"article-number":"11"}}