{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:38:43Z","timestamp":1768873123367,"version":"3.49.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Zahedan University of Medical Sciences, Zahedan, Iran.","award":["6210"],"award-info":[{"award-number":["6210"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head Face Med"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13005-017-0148-y","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T06:19:50Z","timestamp":1498544390000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population"],"prefix":"10.1186","volume":"13","author":[{"given":"Zahra","family":"Heidari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Moudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamidreza","family":"Mahmoudzadeh-Sagheb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnoosh","family":"Moudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"148_CR1","first-page":"3","volume":"7","author":"TE Dyke Van","year":"2005","unstructured":"Van Dyke TE, Dave S. Risk factors for periodontitis. J Int Acad Periodontol. 2005;7:3\u20137.","journal-title":"J Int Acad Periodontol"},{"key":"148_CR2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0757.2011.00397.x","volume":"61","author":"A Dentino","year":"2013","unstructured":"Dentino A, Lee S, Mailhot J, Hefti AF. Principles of periodontology. Periodontol. 2013;61:16\u201353.","journal-title":"Periodontol"},{"issue":"11","key":"148_CR3","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","volume":"71","author":"BS Michalowicz","year":"2000","unstructured":"Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, et al. Evidence of a substantial genetic basis for risk of adult periodontitis. Periodontol. 2000;71(11):1699\u2013707.","journal-title":"Periodontol"},{"issue":"2","key":"148_CR4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/1735-3327.178199","volume":"13","author":"Z Heidari","year":"2016","unstructured":"Heidari Z, Mahmoudzadeh-Sagheb H, Hashemi M, Ansarimoghaddam S, Sheibak N. Estimation of volume density of interdental papilla components in patients with chronic periodontitis and interleukin-6 (\u2212174G\/C) gene polymorphisms. Dent Res J. 2016;13(2):139\u201344.","journal-title":"Dent Res J"},{"issue":"11","key":"148_CR5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-051X.2010.01682.x","volume":"38","author":"DF Kinane","year":"2011","unstructured":"Kinane DF, Preshaw PM, Loos BG. Host-response: understanding the cellular and molecular mechanisms of host-microbial interactions\u2014consensus of the seventh European workshop of periodontology. J Clin Periodontol. 2011;38(11):44\u20138.","journal-title":"J Clin Periodontol"},{"key":"148_CR6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ni873","volume":"4","author":"P Sheppard","year":"2003","unstructured":"Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol. 2003;4:63\u20138.","journal-title":"Nat Immunol"},{"key":"148_CR7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/03946320040170S217","volume":"17","author":"D Kempuraj","year":"2004","unstructured":"Kempuraj D, Donelan J, Frydas S, Iezzi T, Conti F, Boucher W. Interleukin-28 and 29 (IL-28 and IL-29): new cytokines with anti-viral activities. Int J Immunopathol Pharmacol. 2004;17:103\u20136.","journal-title":"Int J Immunopathol Pharmacol"},{"key":"148_CR8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","volume":"4","author":"SV Kotenko","year":"2003","unstructured":"Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK. IFN-ls mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003;4:69\u201377.","journal-title":"Nat Immunol"},{"key":"148_CR9","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1365-2184.2008.00558.x","volume":"41","author":"WA Li","year":"2008","unstructured":"Li WA, Lewis-Antes A, Huang J, Balan M. Regulation of apoptosis by type III interferons. Cell Prolif. 2008;41:960\u201379.","journal-title":"Cell Prolif"},{"key":"148_CR10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/gene.2008.87","volume":"10","author":"C Dellgren","year":"2009","unstructured":"Dellgren C, Gad HH, Hamming OJ, Melchjorsen J. Human interferon-lambda 3 is a potent member of the type III interferon family. Genes Immun. 2009;10:125\u201331.","journal-title":"Genes Immun"},{"issue":"1","key":"148_CR11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/0022034516664509","volume":"96","author":"AE Sanders","year":"2017","unstructured":"Sanders AE, Sofer T, Wong Q, Kerr KF, Agler C, Shaffer JR, et al. Chronic Periodontitis genome-wide association study in the Hispanic community health study\/study of Latinos. J Dent Res. 2017;96(1):64\u201372.","journal-title":"J Dent Res"},{"key":"148_CR12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2741\/e802","volume":"9","author":"CB Lopes","year":"2017","unstructured":"Lopes CB, Barroso RFF, Burbano RMR, Garcia PA, Pinto P, Santos N, et al. Effect of ancestry on interleukin-10 haplotypes in chronic periodontitis. Frontiers Biosci (Elite Ed). 2017;9:276\u201385.","journal-title":"Frontiers Biosci (Elite Ed)"},{"key":"148_CR13","first-page":"9612421","volume":"2016","author":"J Zhu","year":"2016","unstructured":"Zhu J, Guo B, Fu M, Guo W, Yuan Y, Yuan H, et al. Interleukin-6-174G\/C polymorphism contributes to Periodontitis susceptibility: an updated meta-analysis of 21 case-control studies. Dis Markers. 2016;2016:9612421.","journal-title":"Dis Markers"},{"key":"148_CR14","doi-asserted-by":"crossref","unstructured":"Yang ZJ, Tang XP, Lai QG, Ci JB, Yuan KF. Interleukin-8-251A\/T polymorphism and periodontitis susceptibility: a meta-analysis. Genet Mol Res. 2016;15(4):gmr15047379.","DOI":"10.4238\/gmr15047379"},{"issue":"1","key":"148_CR15","first-page":"51","volume":"14","author":"V Lavu","year":"2017","unstructured":"Lavu V, Venkatesan V, Venugopal P, Lakkakula BV, Paul SF, Peria K, et al. Clinical relevance of cytokines Gene polymorphisms and protein levels in gingival cervical fluid from chronic Periodontitis patients. Iran J Immunol. 2017;14(1):51\u20138.","journal-title":"Iran J Immunol"},{"issue":"1","key":"148_CR16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.14712\/23362936.2017.4","volume":"118","author":"N Sheibak","year":"2017","unstructured":"Sheibak N, Heidari Z, Mahmoudzadeh-Sagheb H. Quantitative parameters of Interdental Gingiva in chronic Periodontitis patients with IFN-gamma Gene polymorphism. Prag Med Rep. 2017;118(1):37\u201348.","journal-title":"Prag Med Rep"},{"issue":"3","key":"148_CR17","doi-asserted-by":"crossref","first-page":"e34266","DOI":"10.5812\/hepatmon.34266","volume":"16","author":"Z Heidari","year":"2016","unstructured":"Heidari Z, Moudi B, Mahmoudzadeh-Sagheb H, Hashemi M. The correlation between interferon lambda 3 Gene polymorphisms and susceptibility to hepatitis B virus infection. Hepat Mon. 2016;16(3):e34266.","journal-title":"Hepat Mon"},{"issue":"4","key":"148_CR18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cytogfr.2010.04.002","volume":"21","author":"K Witte","year":"2010","unstructured":"Witte K, Witte E, Sabat R, Wolk K. IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties. Cytokine Growth Factor Rev. 2010;21(4):237\u201351.","journal-title":"Cytokine Growth Factor Rev"},{"key":"148_CR19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","volume":"461","author":"D Ge","year":"2009","unstructured":"Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461:399\u2013401.","journal-title":"Nature"},{"key":"148_CR20","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng.447","volume":"41","author":"V Suppiah","year":"2009","unstructured":"Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet. 2009;41:1100\u20134.","journal-title":"Nat Genet"},{"issue":"3","key":"148_CR21","doi-asserted-by":"crossref","first-page":"10682","DOI":"10.4238\/2015.September.9.8","volume":"14","author":"L Xiao","year":"2015","unstructured":"Xiao L, Gao LB, Wei Q. Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese. Genet Mol Res. 2015;14(3):10682\u201391.","journal-title":"Genet Mol Res"},{"key":"148_CR22","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/jac\/dks015","volume":"67","author":"M Cheng","year":"2012","unstructured":"Cheng M, Si Y, Yang Y, Liu X. Recombinant human interleukin 28B: anti-HCV potency, receptor usage and restricted cell-type responsiveness. J Antimicrob Chemother. 2012;67:1080\u20137.","journal-title":"J Antimicrob Chemother"},{"key":"148_CR23","first-page":"525","volume":"5","author":"R Osaki","year":"2012","unstructured":"Osaki R, Nishimura T, Shioya M, Takeuchi T. Interleukin-28B genotypes determine response to pegylatedinterferon plus ribavirin therapy in patients with hepatitis C virus infection. Mol Med Rep. 2012;5:525\u20138.","journal-title":"Mol Med Rep"},{"issue":"8","key":"148_CR24","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1478-3231.2011.02507.x","volume":"31","author":"W Li","year":"2011","unstructured":"Li W, Jiang Y, Jin Q, Shi X, Jin J, Gao Y, et al. Expression and gene polymorphisms of interleukin 28B and hepatitis B virus infection in a Chinese Han population. Liver Int. 2011;31(8):1118\u201326.","journal-title":"Liver Int"},{"key":"148_CR25","first-page":"2","volume":"1","author":"Z Heidari","year":"2014","unstructured":"Heidari Z. The association between Proinflammatory Gene polymorphisms and level of gingival tissue degradation in chronic Periodontitis. Gene Cell Tissue. 2014;1:2.","journal-title":"Gene Cell Tissue"},{"key":"148_CR26","doi-asserted-by":"publisher","unstructured":"Heidari Z, Mahmoudzadeh-Sagheb H, Hashemi M, Ansarimoghaddam S, Moudi B, Sheibak N. Association between IFN-\u03b3 +874 A\/T and IFN-\u03b3R1 (\u2212611A\/G, +189T\/G and +95C\/T) gene polymorphisms and chronic periodontitis in a sample of Iranian population. Int J Dent. 2015; doi: 10.1155\/2015\/375359 .","DOI":"10.1155\/2015\/375359"},{"issue":"1","key":"148_CR27","doi-asserted-by":"crossref","first-page":"e18315","DOI":"10.17795\/gct-18315","volume":"1","author":"Z Heidari","year":"2014","unstructured":"Heidari Z, Mahmoudzadeh-Sagheb H, Hashemi M, Rigi Ladez MA. Stereological analysis of interdental gingiva in chronic periodontitis patients with tumor necrosis factor alpha (\u2212308G\/a) gene polymorphisms. Gene Cell Tissue. 2014;1(1):e18315.","journal-title":"Gene Cell Tissue"},{"issue":"2","key":"148_CR28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.gene.2012.12.108","volume":"518","author":"Z Heidari","year":"2013","unstructured":"Heidari Z, Mahmoudzadeh-Sagheb H, Rigi-Ladiz MA, Taheri M, Moazenni-Roodi A, Hashemi M. Association of TGF-\u03b21\u2212 509 C\/T, 29 C\/T and 788 C\/T gene polymorphisms with chronic periodontitis: a case\u2013control study. Gene. 2013;518(2):330\u20134.","journal-title":"Gene"},{"issue":"3","key":"148_CR29","doi-asserted-by":"crossref","first-page":"e31698","DOI":"10.17795\/gct-31698","volume":"2","author":"Z Heidari","year":"2015","unstructured":"Heidari Z, Mahmoudzadeh-Sagheb H, Sheibak N. Association between TGF-BETA1 (\u2212509) C\/T gene polymorphism and tissue degradation level in chronic peridontitis: a stereological study. Gene Cell Tissue. 2015;2(3):e31698.","journal-title":"Gene Cell Tissue"},{"issue":"2","key":"148_CR30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1902\/jop.2013.130087","volume":"85","author":"Z Heidari","year":"2014","unstructured":"Heidari Z, Mahmoudzadeh-Sagheb HR, Hashemi M, Rigi-Ladiz MA. Quantitative analysis of Interdental Gingiva in patients with chronic Periodontitis and transforming growth factor-\u03b21 29C\/T Gene polymorphisms. J Periodontol. 2014;85(2):281\u20139.","journal-title":"J Periodontol"},{"key":"148_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999;4:1\u20136.","journal-title":"Ann Periodontol."},{"key":"148_CR32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.0906-6713.2002.003421.x","volume":"34","author":"GC Armitage","year":"2004","unstructured":"Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol. 2004;34:9\u201321.","journal-title":"Periodontol"},{"issue":"2","key":"148_CR33","first-page":"10","volume":"16","author":"S Solhjoo","year":"2014","unstructured":"Solhjoo S, Mahmoudzadeh-Sagheb H, Heidari Z, Hashemi M, Rigi Ladez MA. Association between TNF-\u03b1 (\u2212 308 G \u2192 a) Gene polymorphism and chronic Periodontitis. Zahedan J Res Med Sci. 2014;16(2):10\u20134.","journal-title":"Zahedan J Res Med Sci"},{"key":"148_CR34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/15257770.2011.643846","volume":"3","author":"M Hashemi","year":"2012","unstructured":"Hashemi M, Moazeni-roodi A, Bahari A, Taheri M. A tetra-primer amplification refractory mutation system\u2013polymerase chain reaction for the detection of rs 8099917 il28b genotype. Nucleosides Nucleotides Nucleic Acids. 2012;3:55\u201360.","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"148_CR35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ni0103-8","volume":"4","author":"J Vilcek","year":"2003","unstructured":"Vilcek J. Novel interferons. Nat Immunol. 2003;4:8\u20139.","journal-title":"Nat Immunol"},{"key":"148_CR36","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-5347(01)69139-0","volume":"167","author":"LJ Miller","year":"2002","unstructured":"Miller LJ, Fischer KA, Goralnick SJ, Litt M. Interleukin-10 levels in seminal plasma: implications for chronic prostatitis-chronic pelvic pain syndrome. J Urol. 2002;167:753\u20136.","journal-title":"J Urol"},{"key":"148_CR37","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1128\/JVI.79.6.3851-3854.2005","volume":"79","author":"MD Robek","year":"2005","unstructured":"Robek MD, Boyd BS, Chisari FV. Lambda interferon inhibits hepatitis B and C virus replication. J Virol. 2005;79:3851.","journal-title":"J Virol"},{"issue":"7265","key":"148_CR38","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nature08463","volume":"461","author":"DL Thomas","year":"2009","unstructured":"Thomas DL, Thio CL, Martinetal MP. Geneticvariation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461(7265):798\u2013801.","journal-title":"Nature"},{"key":"148_CR39","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","volume":"41","author":"Y Tanaka","year":"2009","unstructured":"Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet. 2009;41:1105\u20139.","journal-title":"Nat Genet"},{"key":"148_CR40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1556\/CEMED.4.2010.2.2","volume":"5","author":"A P\u00e1r","year":"2001","unstructured":"P\u00e1r A, Kisfali P, Melegh B, Tornai I, Lengyel G, Nemes Z, et al. Cytokine (IL-10, IL-28B and LT-A) Gene polymorphisms in chronic hepatitis C virus infection. Clin Exp Med J. 2001;5:9\u201319.","journal-title":"Clin Exp Med J"},{"key":"148_CR41","doi-asserted-by":"crossref","unstructured":"Par A, Kisfali P, Melegh B, Miseta A, Tornai I, Papp M, et al. Genetic polymorphisms in IL-10R, IL-28B and LTA genes in HCV Infection. Do they have protective role and predict sustained virological response? J Hepatol. 2010;52:\u2013457.","DOI":"10.1016\/S0168-8278(10)61183-X"},{"key":"148_CR42","doi-asserted-by":"publisher","unstructured":"Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, Hashemi M. Association between IL-10 gene promoter polymorphisms (\u2212592 A\/C, \u2212819 T\/C, \u22121082 A\/G) and susceptibility to HBV infection in an Iranian population. Hepat Mon. 2016;16(2):DOI: 10.5812\/hepatmon.32427 .","DOI":"10.5812\/hepatmon.32427"},{"key":"148_CR43","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/infdis\/jir113","volume":"203","author":"P Barreiro","year":"2011","unstructured":"Barreiro P, Pineda JA, Rall\u00f3n N, Naggie S. Influence of interleukin-28B single-nucleotide polymorphisms on progression to liver cirrhosis in human immunodeficiency virus-hepatitis C virus-coinfected patients receiving antiretroviral therapy. J Infect Dis. 2011;203:1629\u201336.","journal-title":"J Infect Dis"},{"key":"148_CR44","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1053\/j.gastro.2009.12.056","volume":"138","author":"A Rauch","year":"2010","unstructured":"Rauch A, Kutalik Z, Descombes P, Cai T, Di Iulio J, Mueller T, et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterolog. 2010;138:1338\u201345.","journal-title":"Gastroenterolog"},{"issue":"1-2","key":"148_CR45","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.virol.2013.06.025","volume":"444","author":"M Derbala","year":"2013","unstructured":"Derbala M, Rizk NM, Al-Kaabi S, John A, Sharma M, El-dweik N, et al. The predictive value of IL28B rs 12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients. Virology. 2013;444(1-2):292\u2013300.","journal-title":"Virology"},{"key":"148_CR46","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/hep.25749","volume":"57","author":"P Lampertico","year":"2012","unstructured":"Lampertico P, Vigan\u00f2 M, Cheroni C, Facchetti F. IL28B polymorphisms predict interferon-related HBs-Ag seroclearance in genotype D HBeAg-negative patients with chronic hepatitis B. Hepatology. 2012;57:890\u20136.","journal-title":"Hepatology"},{"issue":"12","key":"148_CR47","doi-asserted-by":"crossref","first-page":"e1004556","DOI":"10.1371\/journal.ppat.1004556","volume":"10","author":"A Egli","year":"2014","unstructured":"Egli A, Santer DM, O\u2019Shea D, Barakat K, Syedbasha M, Vollmer M, et al. IL-28B is a key regulator of B- and T-cell vaccine responses against influenza. PLoS Pathog. 2014;10(12):e1004556.","journal-title":"PLoS Pathog"},{"key":"148_CR48","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/TP.0b013e318242be0b","volume":"93","author":"D Eurich","year":"2012","unstructured":"Eurich D, Boas-Knoop S, Bahra M, Neuhaus R. Role of IL28B polymorphism in the development of hepatitis C virus-induced hepatocellular carcinoma, graft fibrosis, and posttransplant antiviral therapy. Transplantation. 2012;93:644\u20139.","journal-title":"Transplantation"},{"issue":"3","key":"148_CR49","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.clinre.2012.09.012","volume":"37","author":"NM Rizk","year":"2013","unstructured":"Rizk NM, Derbala MF. Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4. Clin Res Hepatol Gastroenterol. 2013;37(3):262\u20138.","journal-title":"Clin Res Hepatol Gastroenterol"}],"container-title":["Head &amp; Face Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13005-017-0148-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T01:45:23Z","timestamp":1569548723000},"score":1,"resource":{"primary":{"URL":"http:\/\/head-face-med.biomedcentral.com\/articles\/10.1186\/s13005-017-0148-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["148"],"URL":"https:\/\/doi.org\/10.1186\/s13005-017-0148-y","relation":{},"ISSN":["1746-160X"],"issn-type":[{"value":"1746-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,27]]},"article-number":"16"}}