{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:12:48Z","timestamp":1740143568342,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head Face Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to compare new bone formation, resorbed bone matrix, and fibrous enclosed residual bone substitute material in laterally augmented alveolar bone defects using allogeneic, pre-treated and cleaned human bone blocks (tested in dogs, therefore considered to be xenogeneic), and pre-treated and cleaned bovine cancellous bone blocks, both with and without a collagen membrane in order to evaluate their augmentative potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty-two critical size horizontal defects were prepared in the mandible of 4 adult foxhound dogs (8 per dog, 4 on each side). After 3 months of healing, the defects were laterally augmented in a split-mouth-design with either human (HXB) or bovine solvent-preserved bone blocks (BXB). Afterwards, defects were randomly covered with a bovine collagenous membrane (HXB\u2009+\u2009M, BXB\u2009+\u2009M). After a healing interval of 6 months, percentages of new bone formation, resorbed bone matrix, and fibrous enclosed residual bone substitute material were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed little new bone formation of up to 3.7\u2009% in human bone blocks (HXB 3.7\u2009% \u00b1 10.2, HXB\u2009+\u2009M 0.3\u2009%\u00b1 0.4, BXB, 0.1\u2009% \u00b1 0.8, BXB\u2009+\u2009M 2.6\u2009% \u00b1 3.2,<jats:italic>p<\/jats:italic>\u2009=\u2009&gt;\u20090.05). Percentages of fibrous encapsulation were higher in human bone blocks than in bovine bone blocks (HXB 71.2\u2009% \u00b1 8.6, HXB\u2009+\u2009M 73.71\u2009% \u00b1 10.6, BXB, 60.5\u2009% \u00b1 27.4, BXB\u2009+\u2009M 52.5\u2009% \u00b1 28.4,<jats:italic>p<\/jats:italic>\u2009=\u2009&gt;\u20090.05). Resorption rates differed from 44.8\u2009% in bovine bone blocks covered with a membrane to 17.4\u2009% in human bone blocks (HXB 17.4\u2009% \u00b1 7.4, HXB\u2009+\u2009M 25.9\u2009% \u00b1 10.7, BXB, 38.4\u2009% \u00b1 27.2, BXB\u2009+\u2009M 44.8\u2009% \u00b1 29.6,<jats:italic>p<\/jats:italic>\u2009=\u2009&gt;\u20090.05). The use of additional membranes did not significantly affect results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within its limitations, results of this study suggest that solvent-preserved xenogenic human and bovine bone blocks are not suitable for lateral bone augmentation in dogs. Furthermore, defect coverage with a membrane does not positively affect the outcome.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13005-021-00275-1","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T06:02:41Z","timestamp":1624946561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The use of solvent-preserved human and bovine cancellous bone blocks for lateral defect augmentation - an experimental controlled study in vivo"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-0693","authenticated-orcid":false,"given":"Lara","family":"Schorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Fienitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Berndsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert R.","family":"K\u00fcbler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rothamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"275_CR1","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1111\/j.1600-051X.2009.01482.x","volume":"36","author":"F Van der Weijden","year":"2009","unstructured":"Van der Weijden F, Dell\u2019Acqua F, Slot DE. 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This study has been approved by the state office for nature, environment and consumer protection of North-Rhine Westphalia, Germany (LANUV NRW AZ: 50.05-230-7\/06).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"LS declares that she has no conflict of interest, TF declares that he has no conflict of interest, KB declares that she has no conflict of interest, NK declares that he has no conflict of interest, HH declares that he has no conflict of interest, DR declares that he has no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21"}}