{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:16:20Z","timestamp":1790820980803,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head Face Med"],"DOI":"10.1186\/s13005-025-00568-9","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:18:45Z","timestamp":1766053125000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The diagnostic significance and value of vestibular function testing combined with MRI in Meniere\u2019s disease"],"prefix":"10.1186","volume":"21","author":[{"given":"Yao","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"568_CR1","first-page":"1317","volume":"31","author":"CS Hallpike","year":"1938","unstructured":"Hallpike CS, Cairns H. Observations on the pathology of m\u00e9ni\u00e8re\u2019s syndrome: (section of otology). Proc R Soc Med. 1938;31:1317\u201336.","journal-title":"Proc R Soc Med"},{"issue":"2S","key":"568_CR2","first-page":"S1","volume":"162","author":"GJ Basura","year":"2020","unstructured":"Basura GJ, Adams ME, Monfared A, Schwartz SR, Antonelli PJ, Burkard R, et al. Clinical practice guideline: M\u00e9ni\u00e8re\u2019s disease. Otolaryngol Head Neck Surg. 2020;162(2S):S1-55.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"568_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116972","author":"M Mohseni-Dargah","year":"2023","unstructured":"Mohseni-Dargah M, Falahati Z, Pastras C, Khajeh K, Mukherjee P, Razmjou A, et al. Meniere\u2019s disease: pathogenesis, treatments, and emerging approaches for an idiopathic bioenvironmental disorder. Environ Res. 2023. https:\/\/doi.org\/10.1016\/j.envres.2023.116972.","journal-title":"Environ Res"},{"key":"568_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3233\/VES-1990-1101","volume":"1","author":"MM Paparella","year":"1990","unstructured":"Paparella MM, Kimberley BP. Pathogenesis of meni\u00e8re\u2019s disease. J Vestib Res. 1990;1:3\u20137.","journal-title":"J Vestib Res"},{"key":"568_CR5","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/jamaoto.2021.4282","volume":"148","author":"HG Rizk","year":"2022","unstructured":"Rizk HG, Mehta NK, Qureshi U, Yuen E, Zhang K, Nkrumah Y, et al. Pathogenesis and etiology of m\u00e9ni\u00e8re disease: a scoping review of a century of evidence. JAMA Otolaryngol Head Neck Surg. 2022;148:360\u20138.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"568_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2019.107872","author":"A Gallego-Martinez","year":"2020","unstructured":"Gallego-Martinez A, Lopez-Escamez JA. Genetic architecture of Meniere\u2019s disease. Hear Res. 2020. https:\/\/doi.org\/10.1016\/j.heares.2019.107872.","journal-title":"Hear Res"},{"key":"568_CR7","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1007\/s00415-022-11532-x","volume":"270","author":"J-Y Chen","year":"2023","unstructured":"Chen J-Y, Guo Z-Q, Wang J, Liu D, Tian E, Guo J, et al. Vestibular migraine or meniere\u2019s disease: a diagnostic dilemma. J Neurol. 2023;270:1955\u201368.","journal-title":"J Neurol"},{"key":"568_CR8","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1001\/jamaoto.2022.0331","volume":"148","author":"SY Kim","year":"2022","unstructured":"Kim SY, Lee CH, Yoo DM, Kwon MJ, Kim JH, Kim J-H, et al. Association between Meniere disease and migraine. JAMA Otolaryngol Head Neck Surg. 2022;148:457\u201364.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"568_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00749","volume":"9","author":"T Murofushi","year":"2018","unstructured":"Murofushi T, Tsubota M, Kitao K, Yoshimura E. Simultaneous presentation of definite vestibular migraine and definite m\u00e9ni\u00e8re\u2019s disease: overlapping syndrome of two diseases. Front Neurol. 2018;9:749.","journal-title":"Front Neurol"},{"key":"568_CR10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1177\/0194599819889343","volume":"162","author":"GJ Basura","year":"2020","unstructured":"Basura GJ, Adams ME, Monfared A, Schwartz SR, Antonelli PJ, Burkard R, et al. Clinical practice guideline: M\u00e9ni\u00e8re\u2019s disease. Otolaryngol Head Neck Surg. 2020;162:S1-55.","journal-title":"Otolaryngol Head Neck Surg"},{"key":"568_CR11","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s00405-024-09029-6","volume":"282","author":"M Bachelet","year":"2025","unstructured":"Bachelet M, Mathilde P, Abdalah EB, Boyer L, Saroul N, B\u00e9caud J, et al. 3T-3D FLAIR MRI in meni\u00e8re\u2019s disease: associated profiles with clinical symptoms and electroacoustic characteristics. Eur Arch Otorhinolaryngol. 2025;282:1237\u201346.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"568_CR12","unstructured":"Editorial Board of the Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Audiology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. [China expert consensus on clinical practice of vestibular evoked myogenic potentials testing(2024)]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024;59:306\u201314."},{"key":"568_CR13","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00234-019-02155-7","volume":"61","author":"A Bernaerts","year":"2019","unstructured":"Bernaerts A, Vanspauwen R, Blaivie C, van Dinther J, Zarowski A, Wuyts FL, et al. The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meni\u00e8re\u2019s disease on MRI. Neuroradiology. 2019;61:421\u20139.","journal-title":"Neuroradiology"},{"key":"568_CR14","doi-asserted-by":"crossref","unstructured":"Nakashima T, Naganawa S, Pyykko I, Gibson WPR, Sone M, Nakata S et al. Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol. 2009;560:5\u20138.","DOI":"10.1080\/00016480902729827"},{"key":"568_CR15","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1007\/s00415-021-10699-z","volume":"269","author":"AS Young","year":"2022","unstructured":"Young AS, Nham B, Bradshaw AP, Calic Z, Pogson JM, Gibson WP, et al. Clinical, oculographic and vestibular test characteristics of M\u00e9ni\u00e8re\u2019s disease. J Neurol. 2022;269:1927\u201344.","journal-title":"J Neurol"},{"key":"568_CR16","doi-asserted-by":"crossref","unstructured":"Leticia da RH, Marcelo AM da RF, Artur ZS, Amanda CP, Samuel A de FT, Luiz L, et al. Correlation between vestibular response to caloric stimulation and cochlear function in m\u00e9ni\u00e8re\u2019s disease. Braz J Otorhinolaryngol. 2005;91:101513.","DOI":"10.1016\/j.bjorl.2024.101513"},{"key":"568_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-024-00455-9","volume":"20","author":"X Liu","year":"2024","unstructured":"Liu X, Wang D, Hsieh Y-L, Shi S, Wang W. The relationship between endolymphatic hydrops features and hearing loss in bilateral Meniere\u2019s disease. Head Face Med. 2024;20:50.Liu X, Wang D, Hsieh Y-L, Shi S, Wang W. The relationship between endolymphatic hydrops features and hearing loss in bilateral Meniere\u2019s disease. Head Face Med. 2024;20:50.\u89e3\u9501\u4f1a\u5458\u67e5\u770b\u8bd1\u6587","journal-title":"Head Face Med"},{"key":"568_CR18","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1097\/AUD.0000000000000584","volume":"40","author":"R Quatre","year":"2019","unstructured":"Quatre R, Atty\u00e9 A, Karkas A, Job A, Dumas G, Schmerber S. Relationship between audio-vestibular functional tests and inner ear MRI in meniere\u2019s disease. Ear Hear. 2019;40:168\u201376.","journal-title":"Ear Hear"},{"key":"568_CR19","doi-asserted-by":"publisher","first-page":"E444","DOI":"10.1002\/lary.28362","volume":"130","author":"L Kahn","year":"2020","unstructured":"Kahn L, Hautefort C, Guichard J-P, Toupet M, Jourdaine C, Vitaux H, et al. Relationship between video head impulse test, ocular and cervical vestibular evoked myogenic potentials, and compartmental magnetic resonance imaging classification in Meni\u00e8re\u2019s disease. Laryngoscope. 2020;130:E444-52.","journal-title":"Laryngoscope"},{"key":"568_CR20","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.anl.2023.03.006","volume":"50","author":"H Fujita","year":"2023","unstructured":"Fujita H, Ueda K, Kageyama H, Shiozaki T, Inui H, Kitahara T. Relationship between stress levels and endolymphatic space volume in Meniere\u2019s disease. Auris Nasus Larynx. 2023;50:866\u201373.","journal-title":"Auris Nasus Larynx"},{"key":"568_CR21","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1080\/14992027.2019.1627008","volume":"58","author":"FS Obeidat","year":"2019","unstructured":"Obeidat FS, Lewis Bell S. Comparing the sensitivity and specificity of cervical vestibular-evoked myogenic potentials and electrocochleography in the diagnosis of M\u00e9ni\u00e8re\u2019s disease. Int J Audiol. 2019;58:738\u201346.","journal-title":"Int J Audiol"},{"key":"568_CR22","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.bjorl.2019.02.002","volume":"86","author":"TA Grigol","year":"2020","unstructured":"Grigol TA, de AES, Lopes K, de Ganan\u00e7a C FF. Cervical vestibular evoked myogenic potentials and video head impulse test in m\u00e9ni\u00e8re disease. Braz J Otorhinolaryngol. 2020;86:534\u201344.","journal-title":"Braz J Otorhinolaryngol"},{"key":"568_CR23","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1111\/coa.13847","volume":"46","author":"Q Sun","year":"2021","unstructured":"Sun Q, Jiang G, Xiong G, Sun W, Wen W, Wei F. Quantification of endolymphatic hydrops and its correlation with Meniere\u2019s disease clinical features. Clin Otolaryngol. 2021;46:1354\u201361.","journal-title":"Clin Otolaryngol"},{"key":"568_CR24","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00405-019-05735-8","volume":"277","author":"S Limviriyakul","year":"2020","unstructured":"Limviriyakul S, Luangsawang C, Suvansit K, Prakairungthong S, Thongyai K, Atipas S. Video head impulse test and caloric test in definite m\u00e9ni\u00e8re\u2019s disease. Eur Arch Otorhinolaryngol. 2020;277:679\u201386.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"568_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103557","volume":"43","author":"W Deng","year":"2022","unstructured":"Deng W, Lin X, Su Y, Cai Y, Zhong J, Ou Y. Comparison between 3D-FLAIR and 3D-real IR MRI sequences with visual classification method in the imaging of endolymphatic hydrops in Meniere\u2019s disease. Am J Otolaryngol. 2022;43:103557.","journal-title":"Am J Otolaryngol"},{"key":"568_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.anl.2021.03.027","volume":"49","author":"A Jasi\u0144ska","year":"2022","unstructured":"Jasi\u0144ska A, Lachowska M, Wnuk E, Piercha\u0142a K, Rowi\u0144ski O, Niemczyk K. Correlation between magnetic resonance imaging classification of endolymphatic hydrops and clinical manifestations and audiovestibular test results in patients with definite m\u00e9ni\u00e8re\u2019s disease. Auris Nasus Larynx. 2022;49:34\u201345.","journal-title":"Auris Nasus Larynx"},{"key":"568_CR27","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/00129492-200604000-00011","volume":"27","author":"JW House","year":"2006","unstructured":"House JW, Doherty JK, Fisher LM, Derebery MJ, Berliner KI. Meniere\u2019s disease: prevalence of contralateral ear involvement. Otol Neurotol. 2006;27:355\u201361.","journal-title":"Otol Neurotol"},{"key":"568_CR28","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1007\/s00405-022-07412-9","volume":"279","author":"C Guajardo-Vergara","year":"2022","unstructured":"Guajardo-Vergara C, Su\u00e1rez-Vega V, Dominguez P, Manrique-Huarte R, Arbizu L, P\u00e9rez-Fern\u00e1ndez N. Endolymphatic hydrops in the unaffected ear of patients with unilateral M\u00e9ni\u00e8re\u2019s disease. Eur Arch Otorhinolaryngol. 2022;279:5591\u2013600.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"568_CR29","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.anl.2015.12.006","volume":"43","author":"T Murofushi","year":"2016","unstructured":"Murofushi T. Clinical application of vestibular evoked myogenic potential (VEMP). Auris Nasus Larynx. 2016;43:367\u201376.","journal-title":"Auris Nasus Larynx"}],"container-title":["Head &amp; Face Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13005-025-00568-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13005-025-00568-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13005-025-00568-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:18:47Z","timestamp":1766053127000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13005-025-00568-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["568"],"URL":"https:\/\/doi.org\/10.1186\/s13005-025-00568-9","relation":{},"ISSN":["1746-160X"],"issn-type":[{"value":"1746-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"5 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethical committee of Gansu Provincial People\u2019s Hospital approved this study (2025\u2009\u2212\u2009517). All patients signed informed consent forms prior to participating in the clinical study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"I confirm that I have obtained consent from all participants for the publication of the content of this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"89"}}