{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:20:05Z","timestamp":1791566405086,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13014-016-0625-7","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:33:41Z","timestamp":1458606821000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Total body irradiation with volumetric modulated arc therapy: Dosimetric data and first clinical experience"],"prefix":"10.1186","volume":"11","author":[{"given":"Andreas","family":"Springer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-830X","authenticated-orcid":false,"given":"Josef","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Track","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswitha","family":"Huppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedwig","family":"Kasparu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Weltermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Aschauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas L.","family":"Petzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Putz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Altenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Wiesauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Geinitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,22]]},"reference":[{"issue":"5","key":"625_CR1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0360-3016(82)90083-9","volume":"8","author":"ED Thomas","year":"1982","unstructured":"Thomas ED, Clift RA, Hersman J, et al. Marrow transplantation for acute nonlymphoblastic leukemic in first remission using fractionated or single-dose irradiation. Int J Radiat Oncol Biol Phys. 1982;8(5):817\u201321.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"625_CR2","first-page":"151","volume":"1","author":"HJ Deeg","year":"1986","unstructured":"Deeg HJ, Sullivan KM, Buckner CD, et al. Marrow transplantation for acute nonlymphoblastic leukaemia in first remission: toxicity and long-term follow-up of patients conditioned with single dose or fractionated total body irradiation. Bone Marrow Transplant. 1986;1(2):151\u20137.","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"625_CR3","first-page":"361","volume":"75","author":"D Baume","year":"1988","unstructured":"Baume D, Cosset JM, Pico JL, et al. Comparison between single-dose and hyperfractionated total-body irradiation for the conditioning of allogenic grafts of the bone marrow. A retrospective study of 54 patients with malignant hematologic diseases. Bull Cancer. 1988;75(4):361\u201372.","journal-title":"Bull Cancer"},{"issue":"2","key":"625_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0167-8140(89)90129-1","volume":"15","author":"JM Cosset","year":"1989","unstructured":"Cosset JM, Baume D, Pico JL, et al. Single dose versus hyperfractionated total body irradiation before allogeneic bone marrow transplantation: a non-randomized comparative study of 54 patients at the Institut Gustave-Roussy. Radiother Oncol. 1989;15(2):151\u201360.","journal-title":"Radiother Oncol"},{"issue":"2","key":"625_CR5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF03038482","volume":"174","author":"Y Belkac\u00e9mi","year":"1998","unstructured":"Belkac\u00e9mi Y, P\u00e8ne F, Touboul E, et al. Total-body irradiation before bone marrow transplantation for acute leukaemia in first or second complete remission. Results and prognostic factors in 326 consecutive patients. Strahlenther Onkol. 1998;174(2):92\u2013104.","journal-title":"Strahlenther Onkol"},{"issue":"6","key":"625_CR6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/07357909809115780","volume":"16","author":"B Shank","year":"1998","unstructured":"Shank B. Total body irradiation for marrow or stem-cell transplantation. Cancer Invest. 1998;16(6):397\u2013404.","journal-title":"Cancer Invest"},{"key":"625_CR7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/sj.bmt.1702230","volume":"25","author":"RM Sobecks","year":"2000","unstructured":"Sobecks RM, Daugherty CK, Hallahan DE, et al. A dose escalation study of total body irradiation followed by high-dose etoposide and allogeneic blood stem cell transplantation for the treatment of advanced hematologic malignancies. Bone Marrow Transplant. 2000;25:807\u201313.","journal-title":"Bone Marrow Transplant"},{"issue":"4","key":"625_CR8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/leu.2013.259","volume":"28","author":"A Ruggeri","year":"2014","unstructured":"Ruggeri A, Sanz G, Bittencourt H, et al. Comparison of outcomes after single or double cord blood transplantation in adults with acute leukaemia using different types of myeloablative conditioning regimen, a retrospective study on behalf of Eurocord and the Acute Leukaemia Working Party of EBMT. Leukaemia. 2014;28(4):779\u201386. doi: 10.1038\/leu.2013.259 . Epub 2013 Sep 5.","journal-title":"Leukaemia"},{"issue":"5","key":"625_CR9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00066-014-0607-3","volume":"190","author":"S Marnitz","year":"2014","unstructured":"Marnitz S, Zich A, Martus P, et al. Long-term results of total body irradiation in adults with acute lymphoblastic leukaemia. Strahlenther Onkol. 2014;190(5):453\u20138.","journal-title":"Strahlenther Onkol"},{"key":"625_CR10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0360-3016(80)90235-7","volume":"6","author":"FM Khan","year":"1980","unstructured":"Khan FM, Williamson JF, Sewchand W, et al. Basic data for dosage calculation and compensation. Int J Radiat Oncol Biol Phys. 1980;6:745\u201351.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"625_CR11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0360-3016(89)90446-X","volume":"17","author":"CA Lawton","year":"1989","unstructured":"Lawton CA, Barber-Derus S, Murray KJ, Casper JT, Ash RC, Gillin MT, Wilson JF. Technical modifications in hyperfractionated total body irradiation for T-lymphocyte deplete bone marrow transplant. Int J Radiat Oncol Biol Phys. 1989;17(2):319\u201322.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"625_CR12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1118\/1.595677","volume":"12","author":"U Quast","year":"1985","unstructured":"Quast U. Physical treatment planning of total-body irradiation: patient translation and beam-zone method. Med Phys. 1985;12:567\u201374.","journal-title":"Med Phys"},{"issue":"1","key":"625_CR13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1118\/1.3668055","volume":"39","author":"M Surucu","year":"2012","unstructured":"Surucu M, Yeginer M, Kavak G, Fan J, Radosvich JA, Aydogan B. Verification of dose distribution for volumetric modulated Arc therapy total marrow irradiation (VMAT-TMI) in human-like phantom. Med Phys. 2012;39(1):281\u20138.","journal-title":"Med Phys"},{"issue":"6","key":"625_CR14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.rpor.2012.07.013","volume":"17","author":"A Kawa-Iwanicka","year":"2012","unstructured":"Kawa-Iwanicka A, Lobodziec W, Dybek M, et al. Dose distribution homogeneity in two TBI techniques\u2014Analysis of 208 irradiated patients conducted in Stanislaw Leszczynski Memorial Hospital, Katowice. Rep Pract Oncol Radiother. 2012;17(6):367\u201375.","journal-title":"Rep Pract Oncol Radiother"},{"issue":"4","key":"625_CR15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jmir.2015.09.007","volume":"46","author":"M Peters","year":"2015","unstructured":"Peters M, Taylor B, Turner W. An evidence-based review of total body irradiation. J Med Imaging Radiat Sci. 2015;46(4):442\u20139.","journal-title":"J Med Imaging Radiat Sci"},{"key":"625_CR16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0167-8140(87)80197-4","volume":"9","author":"U Quast","year":"1987","unstructured":"Quast U. Total body irradiation \u2013 review of treatment techniques in Europe. Radiother Oncol. 1987;9:91\u2013106.","journal-title":"Radiother Oncol"},{"key":"625_CR17","first-page":"237","volume":"163","author":"M Molls","year":"1987","unstructured":"Molls M, Bamberg M, Beelen DW, Mahmoud H-K, Quast U, Sch\u00e4fer U. Different TBI procedures in Essen: results and clinical considerations on the risk of leukemic relapse and interstitial pneumonitis. Strahlenther Onkol. 1987;163:237\u201340.","journal-title":"Strahlenther Onkol"},{"key":"625_CR18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.radonc.2013.12.009","volume":"110","author":"A Jahnke","year":"2014","unstructured":"Jahnke A, Jahnke L, Molina-Duran F, et al. Arc therapy for total body irradiation - A robust novel treatment technique for standard treatment rooms. Radiother Oncol. 2014;110:553\u20137.","journal-title":"Radiother Oncol"},{"key":"625_CR19","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1118\/1.2044428","volume":"32","author":"SK Hui","year":"2005","unstructured":"Hui SK, Kapatoes J, Fowler J, et al. Feasibility study of helical tomotherapy for total body or total marrow irradiation. Med Phys. 2005;32:3214\u201324.","journal-title":"Med Phys"},{"key":"625_CR20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbmt.2005.10.026","volume":"12","author":"JYC Wong","year":"2006","unstructured":"Wong JYC, Liu A, Schultheiss T, et al. Targeted total marrow irradiation using three-dimensional image-guided tomographic intensity-modulated radiation therapy: An alternative to standard total body irradiation. Biol Blood Marrow Transplant. 2006;12:306\u201315.","journal-title":"Biol Blood Marrow Transplant"},{"key":"625_CR21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.radonc.2011.06.005","volume":"102","author":"C Han","year":"2012","unstructured":"Han C, Schultheisss TE, Wong JY. Dosimetric study of volumetric modulated arc therapy fields for total marrow irradiation. Radiother Oncol. 2012;102:315\u201320.","journal-title":"Radiother Oncol"},{"key":"625_CR22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1748-717X-8-92","volume":"8","author":"A Gruen","year":"2013","unstructured":"Gruen A, Ebell W, Wlodarczyk W, et al. Total Body Irradiation (TBI) using Helical Tomotherapy in children and young adults undergoing stem cell transplantation. Radiat Oncol. 2013;8:92.","journal-title":"Radiat Oncol"},{"key":"625_CR23","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1120\/jacmp.v13i1.3653","volume":"13","author":"P Mancosu","year":"2012","unstructured":"Mancosu P, Navarria P, Castagna L, et al. Anatomy driven optimization strategy for total marrow irradiation with a volumetric modulated arc therapy technique. J Appl Clin Med Phys. 2012;13:3653.","journal-title":"J Appl Clin Med Phys"},{"key":"625_CR24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1182\/blood.V71.1.123.123","volume":"71","author":"D Hoelzer","year":"1988","unstructured":"Hoelzer D, Thiel E, Loffler H, et al. Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukaemia in adults. Blood. 1988;71:123\u201331.","journal-title":"Blood"},{"key":"625_CR25","unstructured":"Dieckmann K, Wolff U, personal communication. Department of Radiotherapy and Radiobiology, Division of Medical Radiation Physics, Austria; Medical University Vienna: 2011."},{"key":"625_CR26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijrobp.2014.01.036","volume":"89","author":"JH Kim","year":"2014","unstructured":"Kim JH, Stein A, Tsai N, et al. Extramedullary Relapse Following Total Marrow and Lymphoid Irradiation in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation. Int J Radiation Oncol Biol Phys. 2014;89:75\u201381.","journal-title":"Int J Radiation Oncol Biol Phys"},{"key":"625_CR27","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.ijrobp.2010.11.028","volume":"80","author":"A Fogliata","year":"2011","unstructured":"Fogliata A, Cozzi L, Clivio A, et al. Preclinical assessment of volumetric modulated arc therapy for total marrow irradiation. Int J Radiat Oncol Biol Phys. 2011;80:628\u201336.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"625_CR28","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ijrobp.2010.11.035","volume":"81","author":"B Aydogan","year":"2011","unstructured":"Aydogan B, Yeginer M, Kavak GO, Fan J, Radosevich JA, Gwe-Ya K. Total marrow irradiation with RapidArc volumetric arc therapy. Int J Radiat Oncol Biol Phys. 2011;81:592\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"625_CR29","first-page":"194","volume":"183","author":"H Lingitz","year":"2007","unstructured":"Lingitz H. Analysis of acute and late complications after total body irradiation of 160 consecutive patients. Strahlenther Onkol. 2007;183:194\u20135.","journal-title":"Strahlenther Onkol"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-016-0625-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T14:36:32Z","timestamp":1600353392000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ro-journal.com\/content\/11\/1\/46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,22]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["625"],"URL":"https:\/\/doi.org\/10.1186\/s13014-016-0625-7","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,22]]},"article-number":"46"}}