{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:45:17Z","timestamp":1783568717425,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"he Practical Research for Innovative Cancer Control Program from Japan Agency for Medical Research and development"},{"name":"Cancer Research and Development Fund of NCC","award":["#23-A-46"],"award-info":[{"award-number":["#23-A-46"]}]},{"name":"JSPS KAKENHI","award":["JP26461873"],"award-info":[{"award-number":["JP26461873"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13014-017-0763-6","type":"journal-article","created":{"date-parts":[[2017,1,14]],"date-time":"2017-01-14T12:31:32Z","timestamp":1484397092000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Relationship between the uptake of 18F-borono-L-phenylalanine and L-[methyl-11C] methionine in head and neck tumors and normal organs"],"prefix":"10.1186","volume":"12","author":[{"given":"Yoshiaki","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Itami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuro","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,14]]},"reference":[{"key":"763_CR1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1748-717X-7-146","volume":"7","author":"RF Barth","year":"2012","unstructured":"Barth RF, Vicente MG, Harling OK, Kiger 3rd WS, Riley KJ, Binns PJ, et al. Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer. Radiat Oncol. 2012;7:146.","journal-title":"Radiat Oncol"},{"key":"763_CR2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ejmp.2013.01.006","volume":"29","author":"MS Herrera","year":"2013","unstructured":"Herrera MS, Gonzalez SJ, Minsky DM, Kreiner AJ. Evaluation of performance of an accelerator-based BNCT facility for the treatment of different tumor targets. Phys Med. 2013;29:436\u201346.","journal-title":"Phys Med"},{"key":"763_CR3","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/j.ijrobp.2010.09.057","volume":"82","author":"L Kankaanranta","year":"2012","unstructured":"Kankaanranta L, Seppala T, Koivunoro H, Saarilahti K, Atula T, Collan J, et al. Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer: final analysis of a phase I\/II trial. Int J Radiat Oncol Biol Phys. 2012;82:e67\u201375.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"763_CR4","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/j.apradiso.2009.03.020","volume":"67","author":"PR Menendez","year":"2009","unstructured":"Menendez PR, Roth BM, Pereira MD, Casal MR, Gonzalez SJ, Feld DB, et al. BNCT for skin melanoma in extremities: updated Argentine clinical results. Appl Radiat Isot. 2009;67:S50\u20133.","journal-title":"Appl Radiat Isot"},{"key":"763_CR5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.radonc.2006.04.015","volume":"88","author":"R Henriksson","year":"2008","unstructured":"Henriksson R, Capala J, Michanek A, Lindahl SA, Salford LG, Franzen L, et al. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA). Radiother Oncol. 2008;88:183\u201391.","journal-title":"Radiother Oncol"},{"key":"763_CR6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.radonc.2014.11.001","volume":"113","author":"H Tani","year":"2014","unstructured":"Tani H, Kurihara H, Hiroi K, Honda N, Yoshimoto M, Kono Y, et al. Correlation of (18)F-BPA and (18)F-FDG uptake in head and neck cancers. Radiother Oncol. 2014;113:193\u20137.","journal-title":"Radiother Oncol"},{"key":"763_CR7","first-page":"325","volume":"39","author":"Y Imahori","year":"1998","unstructured":"Imahori Y, Ueda S, Ohmori Y, Kusuki T, Ono K, Fujii R, et al. Fluorine-18-labeled fluoroboronophenylalanine PET in patients with glioma. J Nucl Med. 1998;39:325\u201333.","journal-title":"J Nucl Med"},{"key":"763_CR8","first-page":"1833","volume":"4","author":"Y Imahori","year":"1998","unstructured":"Imahori Y, Ueda S, Ohmori Y, Sakae K, Kusuki T, Kobayashi T, et al. Positron emission tomography-based boron neutron capture therapy using boronophenylalanine for high-grade gliomas: part II. Clin Cancer Res. 1998;4:1833\u201341.","journal-title":"Clin Cancer Res"},{"key":"763_CR9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.nucmedbio.2013.02.010","volume":"40","author":"M Yoshimoto","year":"2013","unstructured":"Yoshimoto M, Kurihara H, Honda N, Kawai K, Ohe K, Fujii H, et al. Predominant contribution of L-type amino acid transporter to 4-borono-2-18\u00a0F-fluoro-phenylalanine uptake in human glioblastoma cells. Nucl Med Biol. 2013;40:625\u20139.","journal-title":"Nucl Med Biol"},{"key":"763_CR10","first-page":"1037","volume":"28","author":"B L\u00e5ngstr\u00f6m","year":"1987","unstructured":"L\u00e5ngstr\u00f6m B, Antoni G, Gullberg P, Halldin C, Malmborg P, N\u00e5gren K, et al. Synthesis of L-and D-[methyl-11C] methionine. J Nucl Med. 1987;28:1037\u201340.","journal-title":"J Nucl Med"},{"key":"763_CR11","first-page":"225","volume":"28","author":"M Bergstr\u00f6m","year":"1987","unstructured":"Bergstr\u00f6m M, Lundqvist H, Ericson K, Lilja A, Johnstr\u00f6m P, L\u00e5ngstr\u00f6m B, et al. Comparison of the accumulation kinetics of L-(methyl-11C)-methionine and D-(methyl-11C)-methionine in brain tumors studied with positron emission tomography. Acta Radiol. 1987;28:225\u20139.","journal-title":"Acta Radiol"},{"key":"763_CR12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/BF02988499","volume":"15","author":"K Kubota","year":"2001","unstructured":"Kubota K. From tumor biology to clinical PET: a review of positron emission tomography (PET) in oncology. Ann Nucl Med. 2001;15:471\u201386.","journal-title":"Ann Nucl Med"},{"key":"763_CR13","first-page":"691","volume":"33","author":"S Leskinen-Kallio","year":"1992","unstructured":"Leskinen-Kallio S, Nagren K, Lehikoinen P, Ruotsalainen U, Teras M, Joensuu H. Carbon-11-methionine and PET is an effective method to image head and neck cancer. J Nucl Med. 1992;33:691\u20135.","journal-title":"J Nucl Med"},{"key":"763_CR14","first-page":"1393","volume":"39","author":"P Lindholm","year":"1998","unstructured":"Lindholm P, Leskinen S, Lapela M. Carbon-11-methionine uptake in squamous cell head and neck cancer. J Nucl Med. 1998;39:1393\u20137.","journal-title":"J Nucl Med"},{"key":"763_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2191-219X-3-27","volume":"3","author":"K Isohashi","year":"2013","unstructured":"Isohashi K, Shimosegawa E, Kato H, Kanai Y, Naka S, Fujino K, et al. Optimization of [11 C] methionine PET study: appropriate scan timing and effect of plasma amino acid concentrations on the SUV. EJNMMI Res. 2013;3:1.","journal-title":"EJNMMI Res"},{"key":"763_CR16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11060-008-9621-6","volume":"89","author":"M Miyashita","year":"2008","unstructured":"Miyashita M, Miyatake S-I, Imahori Y, Yokoyama K, Kawabata S, Kajimoto Y, et al. Evaluation of fluoride-labeled boronophenylalanine-PET imaging for the study of radiation effects in patients with glioblastomas. J Neurooncol. 2008;89:239\u201346.","journal-title":"J Neurooncol"},{"key":"763_CR17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/BF02988503","volume":"15","author":"Y Nakasone","year":"2001","unstructured":"Nakasone Y, Inoue T, Oriuchi N, Takeuchi K, Negishi A, Endo K, et al. The role of whole-body FDG-PET in preoperative assessment of tumor staging in oral cancers. Ann Nucl Med. 2001;15:505\u201312.","journal-title":"Ann Nucl Med"},{"key":"763_CR18","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2214\/AJR.14.12497","volume":"203","author":"KC Alluri","year":"2014","unstructured":"Alluri KC, Tahari AK, Wahl RL, Koch W, Chung CH, Subramaniam RM. Prognostic value of FDG PET metabolic tumor volume in human papillomavirus-positive stage III and IV oropharyngeal squamous cell carcinoma. AJR Am J Roentgenol. 2014;203:897\u2013903.","journal-title":"AJR Am J Roentgenol"},{"key":"763_CR19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00259-012-2295-5","volume":"40","author":"AW Glaudemans","year":"2013","unstructured":"Glaudemans AW, Enting RH, Heesters MA, Dierckx RA, van Rheenen RW, Walenkamp AM, et al. Value of 11C-methionine PET in imaging brain tumours and metastases. Eur J Nucl Med Mol Imaging. 2013;40:615\u201335.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"763_CR20","doi-asserted-by":"crossref","first-page":"R458","DOI":"10.1152\/ajpregu.1992.263.3.R458","volume":"263","author":"BR Stevens","year":"1992","unstructured":"Stevens BR. Vertebrate intestine apical membrane mechanisms of organic nutrient transport. Am J Physiol Regul Integr Comp Physiol. 1992;263:R458\u201363.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"763_CR21","doi-asserted-by":"crossref","unstructured":"Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1in cancer: partners in crime? Semin Cancer Biol. 2005;15:254\u201366.","DOI":"10.1016\/j.semcancer.2005.04.005"},{"key":"763_CR22","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2967\/jnumed.107.043620","volume":"48","author":"C Haase","year":"2007","unstructured":"Haase C, Bergmann R, Fuechtner F, Hoepping A, Pietzsch J. L-type amino acid transporters LAT1 and LAT4 in cancer: uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo. J Nucl Med. 2007;48:2063\u201371.","journal-title":"J Nucl Med"},{"key":"763_CR23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0005-2736(01)00384-4","volume":"1514","author":"O Yanagida","year":"2001","unstructured":"Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, et al. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophysica Acta. 2001;1514:291\u2013302.","journal-title":"Biochim Biophysica Acta"},{"key":"763_CR24","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.2967\/jnumed.107.043240","volume":"48","author":"DJ Coope","year":"2007","unstructured":"Coope DJ, \u010c\u00ed\u017eek J, Eggers C, Vollmar S, Heiss W-D, Herholz K. Evaluation of primary brain tumors using 11C-methionine PET with reference to a normal methionine uptake map. J Nucl Med. 2007;48:1971\u201380.","journal-title":"J Nucl Med"},{"key":"763_CR25","first-page":"432","volume":"42","author":"PL Jager","year":"2001","unstructured":"Jager PL, Vaalburg W, Pruim J, De Vries EG, Langen K-J, Piers DA. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med. 2001;42:432\u201345.","journal-title":"J Nucl Med"},{"key":"763_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-13-482","volume":"13","author":"K Kaira","year":"2013","unstructured":"Kaira K, Sunose Y, Ohshima Y, Ishioka NS, Arakawa K, Ogawa T, et al. Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer. BMC Cancer. 2013;13:1.","journal-title":"BMC Cancer"},{"key":"763_CR27","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.mam.2012.12.006","volume":"34","author":"S Bodoy","year":"2013","unstructured":"Bodoy S, Fotiadis D, Stoeger C, Kanai Y, Palac\u00edn M. The small SLC43 family: facilitator system l amino acid transporters and the orphan EEG1. Mol Aspects Med. 2013;34:638\u201345.","journal-title":"Mol Aspects Med"},{"key":"763_CR28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mam.2012.10.007","volume":"34","author":"D Fotiadis","year":"2013","unstructured":"Fotiadis D, Kanai Y, Palac\u00edn M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013;34:139\u201358.","journal-title":"Mol Aspects Med"},{"key":"763_CR29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.mam.2012.07.012","volume":"34","author":"HB Schi\u00f6th","year":"2013","unstructured":"Schi\u00f6th HB, Roshanbin S, H\u00e4gglund MG, Fredriksson R. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med. 2013;34:571\u201385.","journal-title":"Mol Aspects Med"},{"key":"763_CR30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.mam.2012.07.002","volume":"34","author":"AB Pramod","year":"2013","unstructured":"Pramod AB, Foster J, Carvelli L, Henry LK. SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013;34:197\u2013219.","journal-title":"Mol Aspects Med"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-017-0763-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T15:19:36Z","timestamp":1568733576000},"score":1,"resource":{"primary":{"URL":"http:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/s13014-017-0763-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,14]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["763"],"URL":"https:\/\/doi.org\/10.1186\/s13014-017-0763-6","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,14]]},"article-number":"17"}}