{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:12:13Z","timestamp":1777525933468,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13014-018-1161-4","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T08:58:36Z","timestamp":1540889916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bone density and pain response following intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for vertebral metastases - secondary results of a randomized trial"],"prefix":"10.1186","volume":"13","author":[{"given":"Tanja","family":"Sprave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"F\u00f6rster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingmar","family":"Schlampp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Hees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman","family":"Bostel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami Ateyah","family":"El Shafie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Welzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils Henrik","family":"Nicolay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-973X","authenticated-orcid":false,"given":"Harald","family":"Rief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"issue":"1","key":"1161_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00007632-199001000-00001","volume":"15","author":"DA Wong","year":"1990","unstructured":"Wong DA, Fornasier VL, MacNab I. Spinal metastases: the obvious, the occult, and the impostors. Spine. 1990;15(1):1\u20134.","journal-title":"Spine"},{"key":"1161_CR2","first-page":"CD004721","volume":"2","author":"WM Sze","year":"2004","unstructured":"Sze WM, Shelley M, Held I, Mason M. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of the randomised trials. Cochrane Database Syst Rev. 2004;2:CD004721.","journal-title":"Cochrane Database Syst Rev"},{"key":"1161_CR3","first-page":"Cd001793","volume":"2","author":"HJ McQuay","year":"2000","unstructured":"McQuay HJ, Collins SL, Carroll D, Moore RA. Radiotherapy for the palliation of painful bone metastases. Cochrane Database Syst Rev. 2000;2:Cd001793.","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"1161_CR4","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13063-017-1847-1","volume":"18","author":"E Meyerhof","year":"2017","unstructured":"Meyerhof E, Sprave T, Welte SE, Nicolay NH, Forster R, Bostel T, Bruckner T, Schlampp I, Debus J, Rief H. Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial. Trials. 2017;18(1):98.","journal-title":"Trials"},{"issue":"3","key":"1161_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0167-8140(02)00170-6","volume":"64","author":"E Chow","year":"2002","unstructured":"Chow E, Wu JS, Hoskin P, Coia LR, Bentzen SM, Blitzer PH. International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol. 2002;64(3):275\u201380.","journal-title":"Radiother Oncol"},{"issue":"3 Suppl","key":"1161_CR6","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.ijrobp.2009.07.1754","volume":"76","author":"LB Marks","year":"2010","unstructured":"Marks LB, Yorke ED, Jackson A, Ten Haken RK, Constine LS, Eisbruch A, Bentzen SM, Nam J, Deasy JO. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys. 2010;76(3 Suppl):S10\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"1161_CR7","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s00066-018-1333-z","volume":"194","author":"Tanja Sprave","year":"2018","unstructured":"Sprave T, Verma V, Forster R, Schlampp I, Bruckner T, Bostel T, Welte SE, Tonndorf-Martini E, El Shafie R, Nicolay NH, et al. Radiation-induced acute toxicities after image-guided intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for patients with spinal metastases (IRON-1 trial) : First results of a randomized controlled trial. Strahlentherapie und Onkologie. 2018. \n                    https:\/\/doi.org\/10.1007\/s00066-018-1333-z\n                    \n                   Epub ahead of print.","journal-title":"Strahlentherapie und Onkologie"},{"issue":"1","key":"1161_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13063-018-2452-7","volume":"19","author":"T Sprave","year":"2018","unstructured":"Sprave T, Welte SE, Bruckner T, Forster R, Bostel T, Schlampp I, Nicolay NH, Debus J, Rief H. Intensity-modulated radiotherapy with integrated-boost in patients with bone metastasis of the spine: study protocol for a randomized controlled trial. Trials. 2018;19(1):59.","journal-title":"Trials"},{"issue":"1","key":"1161_CR9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.adro.2016.11.001","volume":"2","author":"F Eggermont","year":"2017","unstructured":"Eggermont F, Derikx LC, Verdonschot N, Hannink G, Kaatee R, Tanck E, van der Linden YM. Limited short-term effect of palliative radiation therapy on quantitative computed tomography-derived bone mineral density in femora with metastases. Advances in radiation oncology. 2017;2(1):53\u201361.","journal-title":"Advances in radiation oncology"},{"issue":"5","key":"1161_CR10","first-page":"380","volume":"165","author":"K Rieden","year":"1989","unstructured":"Rieden K, Adolph J, Lellig U, Zum Winkel K. The radiotherapeutic effect on bone metastases in relation to the frequency of metastases, sites of metastases and histology of the primary tumor. Strahlentherapie und Onkologie. 1989;165(5):380\u20135.","journal-title":"Strahlentherapie und Onkologie"},{"issue":"6","key":"1161_CR11","first-page":"332","volume":"172","author":"I Wachenfeld","year":"1996","unstructured":"Wachenfeld I, Sanner G, Bottcher HD, Kollath J. The remineralization of the vertebral metastases of breast carcinoma after radiotherapy. Strahlentherapie und Onkologie. 1996;172(6):332\u201341.","journal-title":"Strahlentherapie und Onkologie"},{"issue":"10","key":"1161_CR12","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s000660050061","volume":"175","author":"S Koswig","year":"1999","unstructured":"Koswig S, Budach V. Remineralization and pain relief in bone metastases after after different radiotherapy fractions (10 times 3 Gy vs. 1 time 8 Gy). A prospective study. Strahlenther Onkol. 1999;175(10):500\u20138.","journal-title":"Strahlenther Onkol"},{"key":"1161_CR13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1471-2407-14-67","volume":"14","author":"H Rief","year":"2014","unstructured":"Rief H, Omlor G, Akbar M, Welzel T, Bruckner T, Rieken S, Haefner MF, Schlampp I, Gioules A, Habermehl D, et al. Feasibility of isometric spinal muscle training in patients with bone metastases under radiation therapy - first results of a randomized pilot trial. BMC Cancer. 2014;14:67.","journal-title":"BMC Cancer"},{"issue":"10","key":"1161_CR14","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1080\/0284186X.2017.1332426","volume":"56","author":"P Strang","year":"2017","unstructured":"Strang P, Bergqvist J. Does palliative chemotherapy provide a palliative effect on symptoms in late palliative stages? An interview study with oncologists. Acta oncologica. 2017;56(10):1258\u201364.","journal-title":"Acta oncologica"},{"issue":"2","key":"1161_CR15","first-page":"28","volume":"4","author":"T Daimon","year":"2016","unstructured":"Daimon T, Kosaka T, Oya M. A metastatic castration resistant prostate cancer patient with multiple bone metastases has durable biochemical and radiological response to docetaxel chemotherapy. American journal of clinical and experimental urology. 2016;4(2):28\u201331.","journal-title":"American journal of clinical and experimental urology"},{"issue":"4","key":"1161_CR16","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3892\/ol.2016.5003","volume":"12","author":"C Nieder","year":"2016","unstructured":"Nieder C, Haukland E, Mannsaker B, Norum J. Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer. Oncol Lett. 2016;12(4):2930\u20135.","journal-title":"Oncol Lett"},{"issue":"2","key":"1161_CR17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jbo.2014.05.001","volume":"3","author":"K Steinauer","year":"2014","unstructured":"Steinauer K, Huang DJ, Eppenberger-Castori S, Amann E, Guth U. Bone metastases in breast cancer: frequency, metastatic pattern and non-systemic locoregional therapy. Journal of bone oncology. 2014;3(2):54\u201360.","journal-title":"Journal of bone oncology"},{"issue":"2","key":"1161_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.radonc.2016.03.001","volume":"119","author":"KH Groenen","year":"2016","unstructured":"Groenen KH, Pouw MH, Hannink G, Hosman AJ, van der Linden YM, Verdonschot N, Tanck E. The effect of radiotherapy, and radiotherapy combined with bisphosphonates or RANK ligand inhibitors on bone quality in bone metastases. A systematic review. Radiother Oncol. 2016;119(2):194\u2013201.","journal-title":"Radiother Oncol"},{"issue":"1","key":"1161_CR19","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1080\/15384047.2017.1394545","volume":"19","author":"HW Leung","year":"2018","unstructured":"Leung HW, Wang SY, Jin-Jhih H, Chan AL. Abscopal effect of radiation on bone metastases of breast cancer: a case report. Cancer Biol. Ther. 2018;19(1):20\u20134.","journal-title":"Cancer Biol. Ther"},{"issue":"1","key":"1161_CR20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/imr.12573","volume":"280","author":"N Brix","year":"2017","unstructured":"Brix N, Tiefenthaller A, Anders H, Belka C, Lauber K. Abscopal, immunological effects of radiotherapy: narrowing the gap between clinical and preclinical experiences. Immunol Rev. 2017;280(1):249\u201379.","journal-title":"Immunol Rev"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-018-1161-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13014-018-1161-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-018-1161-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T16:58:03Z","timestamp":1572454683000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/s13014-018-1161-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,30]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1161"],"URL":"https:\/\/doi.org\/10.1186\/s13014-018-1161-4","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,30]]},"assertion":[{"value":"13 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Independent Ethics Committee of Heidelberg University (Nr. S-238\/2016).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"212"}}