{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:02:30Z","timestamp":1779894150205,"version":"3.53.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH-2018-C-010"],"award-info":[{"award-number":["FEMH-2018-C-010"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 102-2314-B-418-001; MOST 102-2314-B-418-002"],"award-info":[{"award-number":["MOST 102-2314-B-418-001; MOST 102-2314-B-418-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13014-019-1302-4","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T15:03:03Z","timestamp":1559228583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prophylactic NS-21 maintains the skin moisture but does not reduce the severity of radiation dermatitis in patients with head and neck cancer: a randomized control trial"],"prefix":"10.1186","volume":"14","author":[{"given":"Hsiu-Ling","family":"Chou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Wei","family":"Shueng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Xiong","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-Yu","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chia","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Fang","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-4695","authenticated-orcid":false,"given":"Chen-Hsi","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"1302_CR1","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/hed.20279","volume":"27","author":"J Bernier","year":"2005","unstructured":"Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27:843\u201350.","journal-title":"Head Neck"},{"key":"1302_CR2","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1056\/NEJMoa032646","volume":"350","author":"JS Cooper","year":"2004","unstructured":"Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937\u201344.","journal-title":"N Engl J Med"},{"key":"1302_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/14737140.2018.1446832","volume":"18","author":"R Mazzola","year":"2018","unstructured":"Mazzola R, Fiorentino A, Ricchetti F, Gregucci F, Corradini S, Alongi F. An update on radiation therapy in head and neck cancers. Expert Rev Anticancer Ther. 2018;18:359\u201364.","journal-title":"Expert Rev Anticancer Ther"},{"issue":"3","key":"1302_CR4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/medicines4030044","volume":"4","author":"Suresh Rao","year":"2017","unstructured":"Rao S, Hegde SK, Baliga-Rao MP, Palatty PL, George T, Baliga MS. An aloe Vera-based cosmeceutical cream delays and mitigates ionizing radiation-induced dermatitis in head and neck Cancer patients undergoing curative radiotherapy: a clinical study. Medicines (Basel). 2017;4(3):44.","journal-title":"Medicines"},{"key":"1302_CR5","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1148\/radiology.143.3.7079509","volume":"143","author":"ME Potera","year":"1982","unstructured":"Potera ME, Lookingbill DP, Stryker JA. Prophylaxis of radiation dermatitis with a topical cortisone cream. Radiology. 1982;143:775\u20137.","journal-title":"Radiology."},{"key":"1302_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0360-3016(01)01576-0","volume":"51","author":"E Szumacher","year":"2001","unstructured":"Szumacher E, Wighton A, Franssen E, Chow E, Tsao M, Ackerman I, et al. Phase II study assessing the effectiveness of Biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy. Int J Radiat Oncol Biol Phys. 2001;51:81\u20136.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1302_CR7","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1200\/JCO.2005.04.9148","volume":"24","author":"EA Elliott","year":"2006","unstructured":"Elliott EA, Wright JR, Swann RS, Nguyen-Tan F, Takita C, Bucci MK, et al. Phase III trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of radiation therapy oncology group trial 99-13. J Clin Oncol. 2006;24:2092\u20137.","journal-title":"J Clin Oncol"},{"key":"1302_CR8","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.ijrobp.2011.09.021","volume":"83","author":"C Pinnix","year":"2012","unstructured":"Pinnix C, Perkins GH, Strom EA, Tereffe W, Woodward W, Oh JL, et al. Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial. Int J Radiat Oncol Biol Phys. 2012;83:1089\u201394.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1302_CR9","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1200\/JCO.2004.07.063","volume":"22","author":"P Pommier","year":"2004","unstructured":"Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol. 2004;22:1447\u201353.","journal-title":"J Clin Oncol"},{"key":"1302_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2017.07.002","volume":"184","author":"H Butt","year":"2017","unstructured":"Butt H, Mehmood A, Ali M, Tasneem S, Anjum MS, Tarar MN, et al. Protective role of vitamin E preconditioning of human dermal fibroblasts against thermal stress in vitro. Life Sci. 2017;184:1\u20139.","journal-title":"Life Sci"},{"key":"1302_CR11","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.fsi.2013.05.014","volume":"35","author":"DA Przybylska-Diaz","year":"2013","unstructured":"Przybylska-Diaz DA, Schmidt JG, Vera-Jimenez NI, Steinhagen D, Nielsen ME. Beta-glucan enriched bath directly stimulates the wound healing process in common carp (Cyprinus carpio L). Fish Shellfish Immunol. 2013;35:998\u20131006.","journal-title":"Fish Shellfish Immunol"},{"key":"1302_CR12","first-page":"217","volume":"59","author":"C Puglia","year":"2008","unstructured":"Puglia C, Bonina F. In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols. J Cosmet Sci. 2008;59:217\u201324.","journal-title":"J Cosmet Sci"},{"key":"1302_CR13","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/ptr.3363","volume":"25","author":"B Shivananda Nayak","year":"2011","unstructured":"Shivananda Nayak B, Dan Ramdath D, Marshall JR, Isitor G, Xue S, Shi J. Wound-healing properties of the oils of Vitis vinifera and Vaccinium macrocarpon. Phytother Res. 2011;25:1201\u20138.","journal-title":"Phytother Res"},{"key":"1302_CR14","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/S0891-5849(02)00999-1","volume":"33","author":"S Khanna","year":"2002","unstructured":"Khanna S, Venojarvi M, Roy S, Sharma N, Trikha P, Bagchi D, et al. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med. 2002;33:1089\u201396.","journal-title":"Free Radic Biol Med"},{"key":"1302_CR15","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00403-011-1145-9","volume":"303","author":"S Kaur","year":"2011","unstructured":"Kaur S, Lyte P, Garay M, Liebel F, Sun Y, Liu JC, et al. Galvanic zinc-copper microparticles produce electrical stimulation that reduces the inflammatory and immune responses in skin. Arch Dermatol Res. 2011;303:551\u201362.","journal-title":"Arch Dermatol Res"},{"key":"1302_CR16","volume":"3","author":"ABCN Jull","year":"2015","unstructured":"Jull ABCN, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;3:CD005083.","journal-title":"Cochrane Database Syst Rev"},{"key":"1302_CR17","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.ijrobp.2015.02.028","volume":"92","author":"DC Rollmann","year":"2015","unstructured":"Rollmann DC, Novotny PJ, Petersen IA, Garces YI, Bauer HJ, Yan ES, et al. Double-blind, placebo-controlled pilot study of processed ultra emu oil versus placebo in the prevention of radiation dermatitis. Int J Radiat Oncol Biol Phys. 2015;92:650\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1302_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.12968\/jowc.2008.17.3.28670","volume":"17","author":"BS Nayak","year":"2008","unstructured":"Nayak BS, Raju SS, Chalapathi Rao AV. Wound healing activity of Persea americana (avocado) fruit: a preclinical study on rats. J Wound Care. 2008;17:123\u20136.","journal-title":"J Wound Care"},{"key":"1302_CR19","volume":"2013","author":"AP de Oliveira","year":"2013","unstructured":"de Oliveira AP, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, et al. Effect of semisolid formulation of persea Americana mill (avocado) oil on wound healing in rats. Evid Based Complement Alternat Med. 2013;2013:472382.","journal-title":"Evid Based Complement Alternat Med"},{"key":"1302_CR20","doi-asserted-by":"publisher","first-page":"426","DOI":"10.2174\/1567201813666160513132321","volume":"14","author":"M Nasr","year":"2017","unstructured":"Nasr M, Abdel-Hamid S, Moftah NH, Fadel M, Alyoussef AA. Jojoba oil soft colloidal Nanocarrier of a synthetic retinoid: preparation, characterization and clinical efficacy in psoriatic patients. Curr Drug Deliv. 2017;14:426\u201332.","journal-title":"Curr Drug Deliv"},{"issue":"1","key":"1302_CR21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/ijms19010070","volume":"19","author":"Tzu-Kai Lin","year":"2017","unstructured":"Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci. 2018;19(1):70.","journal-title":"International Journal of Molecular Sciences"},{"key":"1302_CR22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/ptr.2400","volume":"22","author":"C Chrubasik","year":"2008","unstructured":"Chrubasik C, Roufogalis BD, Muller-Ladner U, Chrubasik S. A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res. 2008;22:725\u201333.","journal-title":"Phytother Res"},{"key":"1302_CR23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s12094-010-0465-0","volume":"12","author":"J Pardo Masferrer","year":"2010","unstructured":"Pardo Masferrer J, Murcia Mejia M, Vidal Fernandez M, Alvarado Astudillo A, Hernandez Armenteros ML, Macias Hernandez V, et al. Prophylaxis with a cream containing urea reduces the incidence and severity of radio-induced dermatitis. Clin Transl Oncol. 2010;12:43\u20138.","journal-title":"Clin Transl Oncol"},{"key":"1302_CR24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1471-2407-11-37","volume":"11","author":"CH Hsieh","year":"2011","unstructured":"Hsieh CH, Kuo YS, Liao LJ, Hu KY, Lin SC, Wu LJ, et al. Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. BMC Cancer. 2011;11:37.","journal-title":"BMC Cancer"},{"key":"1302_CR25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12885-016-2165-9","volume":"16","author":"CH Hsieh","year":"2016","unstructured":"Hsieh CH, Shueng PW, Wang LY, Huang YC, Liao LJ, Lo WC, et al. Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer. BMC Cancer. 2016;16:139.","journal-title":"BMC Cancer"},{"key":"1302_CR26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/hed.21177","volume":"32","author":"YJ Lee","year":"2010","unstructured":"Lee YJ, Lee CG, Cho BC, Kim GE, Choi HJ, Choi EC, et al. Weekly 5-fluorouracil plus cisplatin for concurrent chemoradiotherapy in patients with locally advanced head and neck cancer. Head Neck. 2010;32:235\u201343.","journal-title":"Head Neck."},{"key":"1302_CR27","first-page":"40","volume":"97","author":"A Korinko","year":"1997","unstructured":"Korinko A, Yurick A. Maintaining skin integrity during radiation therapy. Am J Nurs. 1997;97:40\u20134.","journal-title":"Am J Nurs"},{"key":"1302_CR28","first-page":"81","volume":"15","author":"LL Chang","year":"2015","unstructured":"Chang LL, Chou HL, Chiu WT, Hsieh CF, Lee CY, Hong MY, et al. Clinical practice guideline on radiation dermatitis in Cancer patients. The Journal of Oncology Nursing. 2015;15:81\u20139.","journal-title":"The Journal of Oncology Nursing"},{"key":"1302_CR29","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.soncn.2011.02.009","volume":"27","author":"M McQuestion","year":"2011","unstructured":"McQuestion M. Evidence-based skin care management in radiation therapy: clinical update. Semin Oncol Nurs. 2011;27:e1\u201317.","journal-title":"Semin Oncol Nurs"},{"key":"1302_CR30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0167-8140(02)00060-9","volume":"63","author":"JW Denham","year":"2002","unstructured":"Denham JW, Hauer-Jensen M. The radiotherapeutic injury--a complex 'wound. Radiother Oncol. 2002;63:129\u201345.","journal-title":"Radiother Oncol"},{"key":"1302_CR31","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.clindermatol.2011.08.007","volume":"30","author":"A Baroni","year":"2012","unstructured":"Baroni A, Buommino E, De Gregorio V, Ruocco E, Ruocco V, Wolf R. Structure and function of the epidermis related to barrier properties. Clin Dermatol. 2012;30:257\u201362.","journal-title":"Clin Dermatol"},{"issue":"Suppl 1","key":"1302_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1396-0296.2004.04S1005.x","volume":"17","author":"AV Rawlings","year":"2004","unstructured":"Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol Ther. 2004;17(Suppl 1):43\u20138.","journal-title":"Dermatol Ther"},{"key":"1302_CR33","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s00520-016-3521-7","volume":"25","author":"EB Ferreira","year":"2017","unstructured":"Ferreira EB, Vasques CI, Gadia R, Chan RJ, Guerra EN, Mezzomo LA, et al. Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review. Support Care Cancer. 2017;25:1001\u201311.","journal-title":"Support Care Cancer"},{"key":"1302_CR34","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1471-2407-14-53","volume":"14","author":"RJ Chan","year":"2014","unstructured":"Chan RJ, Webster J, Chung B, Marquart L, Ahmed M, Garantziotis S. Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials. BMC Cancer. 2014;14:53.","journal-title":"BMC Cancer"},{"key":"1302_CR35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000339613","volume":"49","author":"JM Reinke","year":"2012","unstructured":"Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res. 2012;49:35\u201343.","journal-title":"Eur Surg Res"},{"key":"1302_CR36","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1600-0846.2011.00578.x","volume":"18","author":"A Patzelt","year":"2012","unstructured":"Patzelt A, Lademann J, Richter H, Darvin ME, Schanzer S, Thiede G, et al. In vivo investigations on the penetration of various oils and their influence on the skin barrier. Skin Res Technol. 2012;18:364\u20139.","journal-title":"Skin Res Technol"},{"key":"1302_CR37","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000338076","volume":"19","author":"L Meier","year":"2012","unstructured":"Meier L, Stange R, Michalsen A, Uehleke B. Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study. Forsch Komplementmed. 2012;19:75\u20139.","journal-title":"Forsch Komplementmed"},{"key":"1302_CR38","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.jep.2010.12.042","volume":"134","author":"E Ranzato","year":"2011","unstructured":"Ranzato E, Martinotti S, Burlando B. Wound healing properties of jojoba liquid wax: an in vitro study. J Ethnopharmacol. 2011;134:443\u20139.","journal-title":"J Ethnopharmacol"},{"key":"1302_CR39","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0360-3016(96)00320-3","volume":"36","author":"MS Williams","year":"1996","unstructured":"Williams MS, Burk M, Loprinzi CL, Hill M, Schomberg PJ, Nearhood K, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys. 1996;36:345\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1302_CR40","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s11604-012-0073-8","volume":"30","author":"H Yamazaki","year":"2012","unstructured":"Yamazaki H, Yoshida K, Kobayashi K, Tsubokura T, Kodani N, Aibe N, et al. Assessment of radiation dermatitis using objective analysis for patients with breast cancer treated with breast-conserving therapy: influence of body weight. Jpn J Radiol. 2012;30:486\u201391.","journal-title":"Jpn J Radiol"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-019-1302-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13014-019-1302-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-019-1302-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T21:55:09Z","timestamp":1721339709000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/s13014-019-1302-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,30]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1302"],"URL":"https:\/\/doi.org\/10.1186\/s13014-019-1302-4","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,30]]},"assertion":[{"value":"18 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The study was approved by the Institutional Review Board of our hospital (FEMH-IRB, 104048-F).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent to publish has been obtained from the applicable persons and is available upon request.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests. All authors have disclosed that there are no financial relationships relevant to this publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"90"}}