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There is no consensus on a standard therapeutic modality for SCCE. In this study, we aimed to characterize the outcomes of primary SCCE patients treated by radiation therapy as part of treatment and investigate prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the data of 42 SCCE patients who were treated by RT as part of treatment at the Sun Yat-sen University Cancer Center from 2001 to 2014. The Kaplan-Meier and log-rank method were used to analyze survival. Cox\u2019s hazard regression model was applied to determine prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 42 enrolled patients, 25 had limited disease (LD) and 17 with extensive disease (ED). The overall response rate (CR\u2009+\u2009PR) was 60.0% (21\/35). The median overall survival time (OS) for whole and LD group were 12.9 and 36.8\u2009months. The 1-, 3- and 5-year OS rates of the whole cohort were 64.9, 31.3, and 13.9%, respectively. OS was significantly longer in patients with ECOG performance score (ECOG PS) &lt;\u20092 (<jats:italic>p\u00a0=<\/jats:italic>\u00a00.001), lesion length\u2009\u2264\u20095\u2009cm (<jats:italic>p<\/jats:italic>\u00a0<jats:italic>=<\/jats:italic>\u00a00.001), and LD (<jats:italic>p<\/jats:italic>\u2009=\u20090.049). In the patients with LD, multivariate analysis indicated that combined with chemotherapy (<jats:italic>P<\/jats:italic>\u2009=\u20090.046) and higher radiation dose (<jats:italic>P<\/jats:italic>\u2009=\u20090.027) predicted better prognosis in OS. The overall rate of grade 3\u20134 toxicities in the whole cohort was 37.5%. In total, 65% (17\/26) patients with recurrent disease died with the metastasis with or without the primary recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RT was one of the effective and safe treatments for locoregional control of SCCE. Lower ECOG PS score, shorter lesion length, treated with chemotherapy, and a higher dose of RT were identified as favorable independent prognostic factors.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13014-019-1415-9","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T16:03:17Z","timestamp":1574352197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Radiotherapy for small cell carcinoma of the esophagus: outcomes and prognostic factors from a retrospective study"],"prefix":"10.1186","volume":"14","author":[{"given":"Baoqing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-0125","authenticated-orcid":false,"given":"Yujia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"issue":"4","key":"1415_CR1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/path.1700640420","volume":"64","author":"F McKeown","year":"1952","unstructured":"McKeown F. 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