{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:46:25Z","timestamp":1792813585936,"version":"4.5.0"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aim<\/jats:title>\n                <jats:p>Advances in therapy have resulted in improved cure rates and an increasing number of long-term\u00a0Hodgkin's lymphoma\u00a0(HL) survivors. However, radiotherapy (RT)-related late effects are still a significant issue, particularly for younger patients with mediastinal disease (secondary cancers, heart diseases). In many Centers, technological evolution has substantially changed RT planning and delivery. This consensus document aims to analyze the current knowledge of Intensity-Modulated Radiation Therapy (IMRT) and Image-Guided Radiation Therapy (IGRT) for mediastinal\u00a0HL and formulate practical recommendations based on scientific evidence and expert opinions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A dedicated working group was set up within the Fondazione Italiana Linfomi (FIL) Radiotherapy Committee in May 2018. After a first meeting, the group adopted a dedicated platform to share retrieved articles and other material. Two group coordinators redacted a first document draft, that was further discussed and finalized in two subsequent meetings. Topics of interest were: 1) Published data comparing 3D-conformal radiotherapy (3D-CRT) and IMRT 2) dose objectives for the organs at risk 3) IGRT protocols and motion management.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Data review showed that IMRT might allow for an essential reduction in the high-dose regions for all different thoracic OAR. As very few studies included specific dose constraints for lungs and breasts, the low-dose component for these OAR resulted slightly higher with IMRT vs. 3D-CRT, depending on the technique used. We propose a set of dose objectives for the heart, breasts, lungs, and thyroid. The use of IGRT is advised for margin reduction without specific indications, such as the use of breath-holding techniques. An individual approach, including comparative planning and considering different risk factors for late morbidity, is recommended for each patient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>As\u00a0HL therapy continues to evolve, with an emphasis on treatment reduction, radiation oncologists should use at best all the available tools to minimize the dose to organs at risk and optimize treatment plans. This document provides indications on the use of IMRT\/IGRT based on expert consensus, providing a basis for clinical implementation and future development.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13014-020-01504-8","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T05:40:42Z","timestamp":1583991642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Fondazione Italiana Linfomi (FIL) expert consensus on the use of intensity-modulated and image-guided radiotherapy for Hodgkin\u2019s lymphoma involving the mediastinum"],"prefix":"10.1186","volume":"15","author":[{"name":"on behalf of the Fondazione Italiana Linfomi (FIL) Radiotherapy Committee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Riccardo","family":"Filippi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Meregalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"DI Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Levis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Ciammella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Buglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Emanuele","family":"Guerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaliana","family":"De Sanctis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Vagge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Ricardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Simontacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"issue":"suppl 4","key":"1504_CR1","doi-asserted-by":"publisher","first-page":"vi19","DOI":"10.1093\/annonc\/mdy080","volume":"29","author":"DA Eichenauer","year":"2018","unstructured":"Eichenauer DA, Aleman BMP, Andr\u00e9 M, Federico M, Hutchings M, Illidge T, ESMO Guidelines Working Group. Hodgkin lymphoma: ESMO clinical practice guidelines for diagnosis, treatment, and follow-up. Ann Oncol. 2018;29(suppl 4):vi19\u201329.","journal-title":"Ann Oncol"},{"issue":"5","key":"1504_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s11912-017-0592-7","volume":"19","author":"AR Filippi","year":"2017","unstructured":"Filippi AR, Levis M, Parikh R, Hoppe B. Optimal therapy for early-stage Hodgkin's lymphoma: risk adapting, response adapting, and role of radiotherapy. Curr Oncol Rep. 2017;19(5):34.","journal-title":"Curr Oncol Rep"},{"key":"1504_CR3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0360-3016(03)00073-7","volume":"56","author":"EJ Hall","year":"2003","unstructured":"Hall EJ, Wuu CS. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys. 2003;56:83\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR4","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.ijrobp.2014.06.069","volume":"90","author":"MV Maraldo","year":"2014","unstructured":"Maraldo MV, Specht L. A decade of comparative dose planning studies for early-stage Hodgkin lymphoma: what can we learn? Int J Radiat Oncol Biol Phys. 2014;90:1126\u201335.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR5","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ijrobp.2012.09.001","volume":"86","author":"A Berrington de Gonzalez","year":"2013","unstructured":"Berrington de Gonzalez A, Gilbert E, Curtis R, et al. Second solid cancers after radiation therapy: a systematic review of the epidemiologic studies of the radiation dose-response relationship. Int J Radiat Oncol Biol Phys. 2013;86:224\u201333.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijrobp.2017.09.039","volume":"100","author":"AR Filippi","year":"2018","unstructured":"Filippi AR, Vanoni V, Meduri B, et al. Intensity modulated radiation therapy and second cancer risk in adults. Int J Radiat Oncol Biol Phys. 2018;100:17\u201320.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR7","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1093\/annonc\/mdt156","volume":"24","author":"MV Maraldo","year":"2013","unstructured":"Maraldo MV, Brodin NP, Aznar MC, et al. Estimated risk of cardiovascular disease and second cancers with modern highly conformal radiotherapy for early stage mediastinal Hodgkin lymphoma. Ann Oncol. 2013;24:2113\u20138.","journal-title":"Ann Oncol"},{"key":"1504_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ijrobp.2015.02.030","volume":"92","author":"AR Filippi","year":"2015","unstructured":"Filippi AR, Ragona R, Piva C, et al. Optimized volumetric modulated arc therapy versus 3D-CRT for early stage mediastinal Hodgkin lymphoma without axillary involvement: a comparison of second cancers and heart disease risk. Int J Radiat Oncol Biol Phys. 2015;92:161\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1504_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1200\/JCO.2015.63.4444","volume":"34","author":"FA van Nimwegen","year":"2016","unstructured":"van Nimwegen FA, Schaapveld M, Cutter DJ, et al. Radiation dose-response relationship for risk of coronary heart disease in survivors of Hodgkin lymphoma. J Clin Oncol. 2016;34(3):235\u201343.","journal-title":"J Clin Oncol"},{"key":"1504_CR10","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.radonc.2015.07.043","volume":"117","author":"A Moignier","year":"2015","unstructured":"Moignier A, Broggio D, Derreumaux S, et al. Coronary stenosis risk analysis following Hodgkin lymphoma radiotherapy: a study based on patient specific artery segments dose calculation. Radiother Oncol. 2015;117:467\u201372.","journal-title":"Radiother Oncol"},{"issue":"4","key":"1504_CR11","doi-asserted-by":"publisher","first-page":"djv008","DOI":"10.1093\/jnci\/djv008","volume":"107","author":"DJ Cutter","year":"2015","unstructured":"Cutter DJ, Schaapveld M, Darby SC, et al. Risk for valvular heart disease after treatment for Hodgkin lymphoma. J Natl Cancer Inst. 2015;107(4):djv008.","journal-title":"J Natl Cancer Inst"},{"key":"1504_CR12","doi-asserted-by":"publisher","first-page":"245","DOI":"10.6004\/jnccn.2018.0013","volume":"16","author":"R Hoppe","year":"2018","unstructured":"Hoppe R, Advani RH, Ai WZ, et al. NCCN guidelines insights: Hodgkin lymphoma, version 1.2018. J Natl Compr Can Net. 2018;16:245\u201354.","journal-title":"J Natl Compr Can Net"},{"issue":"3","key":"1504_CR13","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.radonc.2006.05.015","volume":"79","author":"T Girinsky","year":"2006","unstructured":"Girinsky T, van der Maazen R, Specht L, et al. Involved-node radiotherapy (INRT) in patients with early Hodgkin lymphoma: concepts and guidelines. Radiother Oncol. 2006;79(3):270\u20137.","journal-title":"Radiother Oncol"},{"issue":"4","key":"1504_CR14","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.ijrobp.2013.05.005","volume":"89","author":"L Specht","year":"2014","unstructured":"Specht L, Yahalom J, Illidge T, et al. Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the International Lymphoma Radiation Oncology Group (ILROG). Int J Radiat Oncol Biol Phys. 2014;89(4):854\u201362.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1504_CR15","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ijrobp.2014.01.041","volume":"89","author":"AR Filippi","year":"2014","unstructured":"Filippi AR, Ciammella P, Piva C, et al. Involved-site image-guided intensity-modulated radiotherapy vs. 3D conformal radiotherapy in supra-diaphragmatic early-stage Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys. 2014;89(2):370\u20135.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR16","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.1200\/JCO.2007.15.1001","volume":"26","author":"BA Campbell","year":"2008","unstructured":"Campbell BA, Voss N, Pickles T, et al. Involved-nodal radiation therapy as a component of combination therapy for limited-stage Hodgkin\u2019s lymphoma: a question of field size. J Clin Oncol. 2008;26:5170\u20134.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1504_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ijrobp.2010.09.007","volume":"80","author":"A Paumier","year":"2011","unstructured":"Paumier A, Ghalibafian M, Beaudre A, et al. Involved-node radio- therapy and modern radiation treatment techniques in patients with Hodgkin lymphoma. Int J Radiat Oncol Biol Phys. 2011;80(1):199\u2013205.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1504_CR18","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.ijrobp.2012.08.041","volume":"85","author":"MV Maraldo","year":"2013","unstructured":"Maraldo MV, Aznar MC, Vogelius IR, et al. Involved node radiation therapy: an effective alternative in early-stage Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys. 2013;85(4):1057\u201365.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1504_CR19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ijrobp.2004.08.048","volume":"62","author":"KA Goodman","year":"2005","unstructured":"Goodman KA, Toner S, Hunt M, Wu EJ, Yahalom J. Intensity-modulated radiotherapy fol lymphoma involving the mediastinum. Int J Radiat Oncol Biol Phys. 2005;62(1):198\u2013206.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1504_CR20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ijrobp.2005.06.004","volume":"64","author":"T Girinsky","year":"2006","unstructured":"Girinsky T, Pichenot C, Beaudre A, Ghalibafian M, Lefkopoulos D. Is intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin's disease, and is there a role for beam orientation optimization and dose constraints assigned to virtual volumes? Int J Radiat Oncol Biol Phys. 2006;64(1):218\u201326.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1504_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.radonc.2006.10.015","volume":"82","author":"C Nieder","year":"2007","unstructured":"Nieder C, Schill S, Kneschaurek P, Molls M. Comparison of three different mediastinal radiotherapy techniques in female patients: impact on heart sparing and dose to the breasts. Radiother Oncol. 2007;82(3):301\u20137.","journal-title":"Radiother Oncol"},{"issue":"4","key":"1504_CR22","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.ijrobp.2008.12.048","volume":"75","author":"BS Chera","year":"2009","unstructured":"Chera BS, Rodriguez C, Morris CG, Louis D, Yeung D, Li Z, Mendenhall NP. Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin's lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy. Int J Radiat Oncol Biol Phys. 2009;75(4):1173\u201380.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1748-717X-5-33","volume":"5","author":"L Cella","year":"2010","unstructured":"Cella L, Liuzzi R, Magliulo M, Conson M, Camera L, Salvatore M, Pacelli R. Radiotherapy of large target volumes in Hodgkin's lymphoma: normal tissue sparing capability of forward IMRT versus conventional techniques. Radiat Oncol. 2010;5:33.","journal-title":"Radiat Oncol"},{"issue":"2","key":"1504_CR24","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.ijrobp.2010.05.035","volume":"81","author":"DC Weber","year":"2011","unstructured":"Weber DC, Johanson S, Peguret N, et al. Predicted risk of radiation-induced cancers after involved field and involved node radiotherapy with or without intensity modulation for early-stage hodgkin lymphoma in female patients. Int J Radiat Oncol Biol Phys. 2011 Oct 1;81(2):490\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1504_CR25","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.ijrobp.2011.12.034","volume":"84","author":"BS Hoppe","year":"2012","unstructured":"Hoppe BS, Flampouri S, Su Z, Latif N, Dang NH, Lynch J, Joyce M, Sandler E, Li Z, Mendenhall NP. Effective dose reduction to cardiac structures using protons compared with 3DCRT and IMRT in mediastinal Hodgkin lymphoma. Int J Radiat Oncol Biol Phys. 2012;84(2):449\u201355.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1504_CR26","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ijrobp.2011.05.054","volume":"83","author":"J Koeck","year":"2012","unstructured":"Koeck J, Abo-Madyan Y, Lohr F, Stieler F, Kriz J, Wenz F, Eich HT. Radiotherapy for early mediastinal Hodgkin lymphoma according to the German Hodgkin study group (GHSG): the roles of intensity-modulated radiotherapy and involved-node radiotherapy. Int J Radiat Oncol Biol Phys. 2012;83(1):268\u201376.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR27","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1093\/annonc\/mdr439","volume":"23","author":"BA Campbell","year":"2012","unstructured":"Campbell BA, Hornby C, Cunninghame J, et al. Minimising critical organ irradiation in limited stage Hodgkin lymphoma: a dosimetric study of the benefit of involved node radiotherapy. Ann Oncol. 2012;23:1259\u201366.","journal-title":"Ann Oncol"},{"key":"1504_CR28","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1748-717X-7-129","volume":"7","author":"V De Sanctis","year":"2012","unstructured":"De Sanctis V, Bolzan C, D'Arienzo M, et al. Intensity modulated radiotherapy in early stage Hodgkin lymphoma patients: is it better than three dimensional conformal radiotherapy? Radiat Oncol. 2012;7:129.","journal-title":"Radiat Oncol"},{"key":"1504_CR29","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/1748-717X-7-186","volume":"7","author":"C Fiandra","year":"2012","unstructured":"Fiandra C, Filippi AR, Catuzzo P, et al. Different IMRT solutions vs. 3D-conformal radiotherapy in early stage Hodgkin's lymphoma: dosimetric comparison and clinical considerations. Radiat Oncol. 2012;7:186.","journal-title":"Radiat Oncol"},{"issue":"6","key":"1504_CR30","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1120\/jacmp.v13i6.3769","volume":"13","author":"X Chen","year":"2012","unstructured":"Chen X, Jin D, Wang S, Li M, Huang P, Dai J. Noncoplanar intensity-modulated radiation therapy for young female patients with mediastinal lymphoma. J Appl Clin Med Phys. 2012;13(6):3769.","journal-title":"J Appl Clin Med Phys"},{"key":"1504_CR31","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1748-717X-8-22","volume":"8","author":"L Cella","year":"2013","unstructured":"Cella L, Conson M, Pressello MC, et al. Hodgkin's lymphoma emerging radiation treatment techniques: trade-offs between late radio-induced toxicities and secondary malignant neoplasms. Radiat Oncol. 2013;8:22.","journal-title":"Radiat Oncol"},{"key":"1504_CR32","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/1748-717X-8-112","volume":"8","author":"D Antoni","year":"2013","unstructured":"Antoni D, Natarajan-Ame S, Meyer P, et al. Contribution of three-dimensional conformal intensity-modulated radiation therapy for women affected by bulky stage II supradiaphragmatic Hodgkin disease. Radiat Oncol. 2013;8:112.","journal-title":"Radiat Oncol"},{"key":"1504_CR33","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1748-717X-9-94","volume":"9","author":"KR Voong","year":"2014","unstructured":"Voong KR, McSpadden K, Pinnix CC, Shihadeh F, Reed V, Aristophanous M, Dabaja BS. Dosimetric advantages of a \"butterfly\" technique for intensity-modulated radiation therapy for young female patients with mediastinal Hodgkin's lymphoma. Radiat Oncol. 2014;9:94.","journal-title":"Radiat Oncol"},{"issue":"1","key":"1504_CR34","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ijrobp.2015.01.013","volume":"92","author":"MC Aznar","year":"2015","unstructured":"Aznar MC, Maraldo MV, Schut DA, et al. Minimizing late effects for patients with Mediastinal Hodgkin lymphoma: deep inspiration breath-hold, IMRT, or both? Int J Radiat Oncol Biol Phys. 2015;92(1):169\u201374.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"1504_CR35","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00066-015-0839-x","volume":"191","author":"J Kriz","year":"2015","unstructured":"Kriz J, Spickermann M, Lehrich P, et al. Breath-hold technique in conventional APPA or intensity-modulated radiotherapy for Hodgkin's lymphoma: comparison of ILROG IS-RT and the GHSG IF-RT. Strahlenther Onkol. 2015;191(9):717\u201325.","journal-title":"Strahlenther Onkol"},{"issue":"1059","key":"1504_CR36","doi-asserted-by":"publisher","first-page":"20150409","DOI":"10.1259\/bjr.20150409","volume":"89","author":"N Besson","year":"2016","unstructured":"Besson N, Pernin V, Zefkili S, Kirova YM. Evolution of radiation techniques in the treatment of mediastinal lymphoma: from 3D conformal radiotherapy (3DCRT) to intensity-modulated RT (IMRT) using helical tomotherapy (HT): a single-Centre experience and review of the literature. Br J Radiol. 2016;89(1059):20150409.","journal-title":"Br J Radiol"},{"issue":"2","key":"1504_CR37","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.canrad.2015.11.002","volume":"20","author":"S Horn","year":"2016","unstructured":"Horn S, Fournier-Bidoz N, Pernin V, et al. Comparison of passive-beam proton therapy, helical tomotherapy and 3D conformal radiation therapy in Hodgkin\u2019s lymphoma female patients receiving involved-field or involved site radiation therapy. Cancer Radiother. 2016 Apr;20(2):98\u2013103.","journal-title":"Cancer Radiother"},{"issue":"3","key":"1504_CR38","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jnci.2016.04.007","volume":"28","author":"C Higby","year":"2016","unstructured":"Higby C, Khafaga Y, Al-Shabanah M, Mousa A, Ilyas M, Nazer G, Khalil EM. Volumetric-modulated arc therapy (VMAT) versus 3D-conformal radiation therapy in supra-diaphragmatic Hodgkin's lymphoma with mediastinal involvement: a dosimetric comparison. J Egypt Natl Canc Inst. 2016;28(3):163\u20138.","journal-title":"J Egypt Natl Canc Inst"},{"key":"1504_CR39","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3109\/0284186X.2013.850739","volume":"53","author":"L Cella","year":"2014","unstructured":"Cella L, Liuzzi R, D\u2019Avino V, et al. Pulmonary damage in Hodgkin\u2019s lymphoma patients treated with sequential chemo-radiotherapy: predictors of radiation-induced lung injury. Acta Oncol. 2014;53:613\u20139.","journal-title":"Acta Oncol"},{"issue":"1","key":"1504_CR40","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijrobp.2006.03.063","volume":"66","author":"ES Koh","year":"2006","unstructured":"Koh ES, Sun A, Tran TH, et al. Clinical dose-volume histogram analysis in predicting radiation pneumonitis in Hodgkin\u2019s lymphoma. Int J Rad Oncol Biol Phys. 2006;66(1):223\u20138.","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"1504_CR41","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1002\/cncr.23081","volume":"110","author":"DC Hodgson","year":"2007","unstructured":"Hodgson DC, Koh ES, Tran TH, et al. Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma. Cancer. 2007;110:2576\u201386.","journal-title":"Cancer"},{"issue":"5","key":"1504_CR42","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.ijrobp.2009.05.012","volume":"75","author":"DC Weber","year":"2009","unstructured":"Weber DC, Peguret N, Dipasquale G, Cozzi L. Involved-node and involved-field volumetric modulated arc vs. fixed beam intensity-modulated radiotherapy for female patients with early-stage supra-diaphragmatic Hodgkin lymphoma: a comparative planning study. Int J Radiat Oncol Biol Phys. 2009;75(5):1578\u201386.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR43","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.radonc.2019.05.009","volume":"138","author":"M Levis","year":"2019","unstructured":"Levis M, Filippi AR, Fiandra C, et al. Inclusion of heart substructures in the optimization process of volumetric modulated arc therapy techniques may reduce the risk of heart disease in Hodgkin's lymphoma patients. Radiother Oncol. 2019;138:52\u20138.","journal-title":"Radiother Oncol"},{"key":"1504_CR44","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.ijrobp.2011.09.020","volume":"83","author":"MV Maraldo","year":"2012","unstructured":"Maraldo MV, Brodin NP, Vogelius IR, et al. Risk of developing cardiovascular disease after involved-node radiotherapy versus mantle field for Hodgkin lymphoma. Int J Radiat Oncol Biol Phys. 2012;83:1232\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR45","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1001\/archinte.1943.00210120009002","volume":"72","author":"JEL Leach","year":"1943","unstructured":"Leach JEL. Effect of roentgen therapy on the heart: clinical study. Arch Intern Med. 1943;72:715\u201345.","journal-title":"Arch Intern Med"},{"key":"1504_CR46","first-page":"790","volume":"124","author":"G Seguy","year":"1897","unstructured":"Seguy G, Quenisset F. Action des rayons X sur le Coeur. Comptes rendus hebdomadaires des s\u00e9ances de l\u2019Acad\u00e9mie des sciences. 1897;124:790.","journal-title":"Comptes rendus hebdomadaires des s\u00e9ances de l\u2019Acad\u00e9mie des sciences"},{"key":"1504_CR47","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1001\/jama.1966.03100040122039","volume":"195","author":"MR Dollinger","year":"1966","unstructured":"Dollinger MR, Lavine DM, Foye LV Jr. Myocardial infarction due to post-irradiation fibrosis of the coronary arteries. Case of successfully treated Hodgkin\u2019s disease with lower esophageal involvement. JAMA. 1966;195:316\u20139.","journal-title":"JAMA"},{"key":"1504_CR48","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/1097-0142(19830815)52:4<637::AID-CNCR2820520411>3.0.CO;2-X","volume":"52","author":"J Yahalom","year":"1983","unstructured":"Yahalom J, Hasin Y, Fuks Z. Acute myocardial infarction with normal coronary arteriogram after mantle field radiation therapy for Hodgkin\u2019s disease. Cancer. 1983;52:637\u201341.","journal-title":"Cancer"},{"key":"1504_CR49","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1001\/jama.1993.03510160067031","volume":"270","author":"SL Hancock","year":"1993","unstructured":"Hancock SL, Tucker MA, Hoppe RT. Factors affecting late mortality from heart disease after treatment of Hodgkin\u2019s disease. JAMA. 1993;270:1949\u201355.","journal-title":"JAMA"},{"key":"1504_CR50","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1200\/JCO.1993.11.7.1208","volume":"11","author":"SL Hancock","year":"1993","unstructured":"Hancock SL, Donaldson SS, Hoppe RT. Cardiac disease following treatment of Hodgkin\u2019s disease in children and adolescents. J Clin Oncol. 1993;11:1208\u201315.","journal-title":"J Clin Oncol"},{"key":"1504_CR51","doi-asserted-by":"publisher","first-page":"b4606","DOI":"10.1136\/bmj.b4606","volume":"339","author":"DA Mulrooney","year":"2009","unstructured":"Mulrooney DA, Yeazel MW, Kawashima T, et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the childhood Cancer survivor study cohort. BMJ. 2009;339:b4606.","journal-title":"BMJ"},{"key":"1504_CR52","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1200\/JCO.2008.20.2267","volume":"28","author":"M Tukenova","year":"2010","unstructured":"Tukenova M, Guibout C, Oberlin O, et al. Role of cancer treatment in long term overall and cardiovascular mortality after childhood cancer. J Clin Oncol. 2010;28:1308\u201315.","journal-title":"J Clin Oncol"},{"key":"1504_CR53","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa1209825","volume":"368","author":"SC Darby","year":"2013","unstructured":"Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368:987\u201398.","journal-title":"N Engl J Med"},{"issue":"5","key":"1504_CR54","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1182\/blood-2006-07-034405","volume":"109","author":"BPM Aleman","year":"2007","unstructured":"Aleman BPM, van den Belt-Dusebout AW, De Bruin ML, et al. Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood. 2007;109(5):1878\u201386.","journal-title":"Blood"},{"issue":"23","key":"1504_CR55","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1016\/j.jacc.2013.01.090","volume":"61","author":"C Jaworski","year":"2013","unstructured":"Jaworski C, Mariani JA, Wheeler G, et al. Cardiac complications of thoracic irradiation. JACC. 2013;61(23):2319\u201328.","journal-title":"JACC"},{"key":"1504_CR56","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1056\/NEJMoa1111961","volume":"366","author":"RM Meyer","year":"2012","unstructured":"Meyer RM, Gospodarowicz MK, Connors JM, et al. ABVD alone versus radiation-based therapy in limited-stage Hodgkin\u2019s lymphoma. N Engl J Med. 2012;366:399\u2013408.","journal-title":"N Engl J Med"},{"issue":"12","key":"1504_CR57","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1200\/JCO.2013.51.9298","volume":"32","author":"JM Raemaekers","year":"2014","unstructured":"Raemaekers JM, Andr\u00e9 MP, Federico M, et al. Omitting radiotherapy in early positron emission tomography-negative stage I\/II Hodgkin lymphoma is associated with an increased risk of early relapse: clinical results of the preplanned interim analysis of the randomized EORTC\/LYSA\/FIL H10 trial. J Clin Oncol. 2014;32(12):1188\u201394.","journal-title":"J Clin Oncol"},{"issue":"17","key":"1504_CR58","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1056\/NEJMoa1408648","volume":"372","author":"J Radford","year":"2015","unstructured":"Radford J, Illidge T, Counsell N, et al. Results of a trial of PET-directed therapy for early-stage Hodgkin\u2019s lymphoma. N Engl J Med. 2015;372(17):1598\u2013607.","journal-title":"N Engl J Med"},{"issue":"31","key":"1504_CR59","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1200\/JCO.19.00964","volume":"37","author":"M Fuchs","year":"2019","unstructured":"Fuchs M, Goergen H, Kobe C, et al. Positron emission tomography-guided treatment in early-stage favorable Hodgkin lymphoma: final results of the international, randomized phase III HD16 trial by the German Hodgkin study group. J Clin Oncol. 2019;37(31):2835\u201345.","journal-title":"J Clin Oncol"},{"issue":"3","key":"1504_CR60","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1200\/JCO.2015.64.6588","volume":"34","author":"MV Maraldo","year":"2016","unstructured":"Maraldo MV, Ng AK. Minimizing cardiac risks with contemporary radiation therapy for Hodgkin lymphoma. J Clin Oncol. 2016;34(3):208\u201310.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1504_CR61","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ijrobp.2009.10.058","volume":"79","author":"M Feng","year":"2011","unstructured":"Feng M, Moran JM, Koelling T, et al. Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer. Int J Radiat Oncol Biol Phys. 2011;79(1):10\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR62","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.radonc.2017.01.008","volume":"122","author":"F Duane","year":"2017","unstructured":"Duane F, Aznar MC, Bartlett F, et al. A cardiac atlas for contouring. Radiother Oncol. 2017;122:416\u201322.","journal-title":"Radiother Oncol"},{"key":"1504_CR63","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.radonc.2018.04.014","volume":"127","author":"M Levis","year":"2018","unstructured":"Levis M, De Luca V, Fiandra C. Plan optimization for mediastinal radiotherapy: estimation of coronary arteries motion with ECG-gated cardiac imaging and creation of compensatory expansion margins. Radiother Oncol. 2018;127:481\u20136.","journal-title":"Radiother Oncol"},{"key":"1504_CR64","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.radonc.2016.08.006","volume":"121","author":"T Kataria","year":"2016","unstructured":"Kataria T, Bisht SS, Gupta D, et al. Quantification of coronary artery motion and internal risk volume from ECG gated radiotherapy planning scans. Radiother Oncol. 2016;121:59\u201363.","journal-title":"Radiother Oncol"},{"key":"1504_CR65","unstructured":"Hoppe BS, Bates JE, Mendenhall NP, et al. The meaningless meaning of mean heart dose in mediastinal lymphoma in the modern radiotherapy era. Pract Radiat Oncol. 2019; (in press)."},{"key":"1504_CR66","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.ijrobp.2017.03.026","volume":"98","author":"E Hahn","year":"2017","unstructured":"Hahn E, Jiang H, Ng A, et al. Late cardiac toxicity after mediastinal radiation therapy for Hodgkin lymphoma: contributions of coronary artery and whole heart dose-volume variables to risk prediction. Int J Radiat Oncol Biol Phys. 2017;98:1116\u201323.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1504_CR67","doi-asserted-by":"publisher","first-page":"S88","DOI":"10.1016\/j.ijrobp.2018.06.230","volume":"102","author":"M Levis","year":"2018","unstructured":"Levis M, De Luca V, Bartoncini S, et al. A prospective, observational study evaluating early subclinical Cardiotoxicity with global longitudinal strain imaging in lymphoma patients treated with chemotherapy +\/\u2212 Mediastinal radiotherapy: the CARDIOCARE project. Int J Radiat Oncol Biol Phys. 2018;102(3):S88.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"16","key":"1504_CR68","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1182\/blood-2016-09-740332","volume":"129","author":"FA van Nimwegen","year":"2018","unstructured":"van Nimwegen FA, Ntentas G, Darby SC, et al. Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines. Blood. 2018;129(16):2257\u201365.","journal-title":"Blood"},{"key":"1504_CR69","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1200\/JCO.2000.18.3.487","volume":"18","author":"FE Van Leeuwen","year":"2000","unstructured":"Van Leeuwen FE, Klokman WJ, Veer MB, et al. Long-term risk of second malignancy in survivors of Hodgkin\u2019s disease treated during adolescence or young adulthood. J Clin Oncol. 2000;18:487\u201397.","journal-title":"J Clin Oncol"},{"key":"1504_CR70","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1182\/blood-2002-02-0634","volume":"100","author":"AK Ng","year":"2002","unstructured":"Ng AK, Bernardo MV, Weller E, et al. Second malignancy after Hodgkin\u2019s disease treated with radiation therapy with or without chemotherapy: long term risks and risk factors. Blood. 2002;100:1989\u201396.","journal-title":"Blood"},{"key":"1504_CR71","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1200\/JCO.2002.09.038","volume":"20","author":"GM Dores","year":"2002","unstructured":"Dores GM, Metayer C, Curtis RE, et al. Second malignant neoplasms among long-term survivors of Hodgkin\u2019s disease: a population-based evaluation over 25 years. J Clin Oncol. 2002;20:3484\u201394.","journal-title":"J Clin Oncol"},{"key":"1504_CR72","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1093\/jnci\/dji290","volume":"97","author":"LB Travis","year":"2005","unstructured":"Travis LB, Hill D, Dores GM, et al. Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma. J Natl Cancer Inst. 2005;97:1428\u201337.","journal-title":"J Natl Cancer Inst"},{"issue":"22","key":"1504_CR73","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1200\/JCO.2011.38.8835","volume":"30","author":"AJ Swerdlow","year":"2012","unstructured":"Swerdlow AJ, Cooke R, Bates A, et al. Breast cancer risk after supradiaphragmatic radiotherapy for Hodgkin's lymphoma in England and Wales: a National Cohort Study. J Clin Oncol. 2012;30(22):2745\u201352.","journal-title":"J Clin Oncol"},{"issue":"2","key":"1504_CR74","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10555-016-9616-2","volume":"35","author":"C Chargari","year":"2016","unstructured":"Chargari C, Goodman K. Diallo et al. risk of second cancers in the era of modern radiation therapy: does the risk benefit analysis overcome theoretical models? Cancer Metastasis Rev. 2016;35(2):277\u201388.","journal-title":"Cancer Metastasis Rev"},{"key":"1504_CR75","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejmp.2017.03.011","volume":"42","author":"Uwe Schneider","year":"2017","unstructured":"Schneider U, Walsh L. Risk of second cancers: bridging epidemiology and modeling. Phys Med. 2017. https:\/\/doi.org\/10.1016\/j.ejmp.2017.03.011.","journal-title":"Physica Medica"},{"issue":"1","key":"1504_CR76","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1200\/JCO.2005.06.225","volume":"23","author":"C Guibout","year":"2005","unstructured":"Guibout C, Adjadj E, Rubino C, et al. Malignant breast tumors after radiotherapy for a first cancer during childhood. J Clin Oncol. 2005;23(1):197\u2013204.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1504_CR77","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ijrobp.2011.05.078","volume":"83","author":"AM Fox","year":"2012","unstructured":"Fox AM, Dosoretz AP, Mauch PM, et al. Predictive factors for radiation pneumonitis in Hodgkin lymphoma patients receiving combined-modality therapy. Int J Radiat Oncol Biol Phys. 2012;83(1):277\u201383.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1504_CR78","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ijrobp.2015.02.010","volume":"92","author":"CC Pinnix","year":"2015","unstructured":"Pinnix CC, Smith GL, Milgrom S, et al. Predictors of radiation pneumonitis in patients receiving intensity modulated radiation therapy for Hodgkin and non-Hodgkin lymphoma. Int J Rad Oncol Biol Phys. 2015;92(1):175\u201382.","journal-title":"Int J Rad Oncol Biol Phys"},{"issue":"9","key":"1504_CR79","first-page":"3227","volume":"85","author":"C Sklar","year":"2000","unstructured":"Sklar C, Whitton J, Mertens A, et al. Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the childhood Cancer survivor study. J Clin Endocrinol Metab. 2000;85(9):3227\u201332.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1504_CR80","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/1097-0142(19840215)53:4<878::AID-CNCR2820530411>3.0.CO;2-J","volume":"53","author":"LS Constine","year":"1984","unstructured":"Constine LS, Donaldson SS, McDougall IR, Cox RS, Link MP, Kaplan HS. Thyroid dysfunction after radiotherapy in children with Hodgkin's disease. Cancer. 1984;53(4):878\u201383.","journal-title":"Cancer"},{"issue":"9","key":"1504_CR81","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1056\/NEJM199108293250902","volume":"325","author":"SL Hancock","year":"1991","unstructured":"Hancock SL, Cox RS, McDougall IR. Thyroid diseases after treatment of Hodgkin's disease. N Engl J Med. 1991;325(9):599\u2013605.","journal-title":"N Engl J Med"},{"issue":"5","key":"1504_CR82","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.ijrobp.2010.09.054","volume":"82","author":"L Cella","year":"2012","unstructured":"Cella L, Conson M, Caterino M, et al. Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys. 2012;82(5):1802\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1504_CR83","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.ijrobp.2018.03.003","volume":"101","author":"CC Pinnix","year":"2018","unstructured":"Pinnix CC, Cella L, Andraos TY, et al. Predictors of hypothyroidism in Hodgkin lymphoma survivors after intensity modulated versus 3-dimensional radiation therapy. Int J Radiat Oncol Biol Phys. 2018;101(3):530\u201340.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1504_CR84","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/j.ijrobp.2011.05.015","volume":"82","author":"A Paumier","year":"2012","unstructured":"Paumier A, Ghalibafian M, Gilmore J, et al. Dosimetric benefits of intensity-modulated radiotherapy combined with the deep inspiration breath hold technique in patients with mediastinal Hodgkin\u2019s lymphoma. Int J Radiat Oncol Biol Phys. 2012;82(4):1522\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1504_CR85","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.prro.2013.07.015","volume":"4","author":"AM Charpentier","year":"2014","unstructured":"Charpentier AM, Conrad T, Sykes J, et al. Active breathing control for patients receiving mediastinal radiation therapy for lymphoma: impact on normal tissue dose. Practical Radiation Oncology. 2014;4:174.","journal-title":"Practical Radiation Oncology"},{"key":"1504_CR86","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3109\/0284186X.2014.932435","volume":"54","author":"PM Petersen","year":"2015","unstructured":"Petersen PM, Aznar MC, Berthelsen AK, et al. Prospective phase II trial of image-guided radiotherapy in Hodgkin lymphoma: benefit of deep inspiration breath-hold. Acta Oncol. 2015;54:60\u20136.","journal-title":"Acta Oncol"},{"issue":"1","key":"1504_CR87","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ijrobp.2007.08.062","volume":"70","author":"MW Kan","year":"2008","unstructured":"Kan MW, Leung LH, Wong W, Lam N. Radiation dose from cone beam computed tomography for image-guided radiation therapy. Int J Rad Oncol Biol Phys. 2008;70(1):272\u20139.","journal-title":"Int J Rad Oncol Biol Phys"},{"issue":"6","key":"1504_CR88","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1118\/1.2198169","volume":"33","author":"MK Islam","year":"2006","unstructured":"Islam MK, Purdie TG, Norrlinger BD, Alasti H, Moseley DJ, Sharpe MB, Siewerdsen JH, Jaffray DA. Patient dose from kilovoltage cone beam computed tomography imaging in radiation therapy. Med Phys. 2006;33(6):1573\u201382.","journal-title":"Med Phys"},{"issue":"5","key":"1504_CR89","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1118\/1.2722470","volume":"34","author":"O Morin","year":"2007","unstructured":"Morin O, Gillis A, Descovich M, Chen J, Aubin M, Aubry JF, Chen H, Gottschalk AR, Xia P, Pouliot J. Patient dose considerations for routine megavoltage cone-beam CT imaging. Med Phys. 2007;34(5):1819\u201327.","journal-title":"Med Phys"},{"issue":"16","key":"1504_CR90","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1182\/blood-2018-03-837633","volume":"132","author":"BS Dabaja","year":"2018","unstructured":"Dabaja BS, Hoppe BS, Plastaras JP, et al. Proton therapy for adults with mediastinal lymphomas: the international lymphoma radiation oncology group guidelines. Blood. 2018;132(16):1635\u201346.","journal-title":"Blood"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-020-01504-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13014-020-01504-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-020-01504-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:55:34Z","timestamp":1615510534000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/s13014-020-01504-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,12]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1504"],"URL":"https:\/\/doi.org\/10.1186\/s13014-020-01504-8","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,12]]},"assertion":[{"value":"28 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"62"}}