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This study compared 5\u2009\u00d7\u20095\u00a0Gy in 1\u00a0week to 10\u2009\u00d7\u20093\u00a0Gy in 2\u00a0weeks in a prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients receiving 5\u2009\u00d7\u20095\u00a0Gy in a phase II trial were matched 1:2 to 213 patients receiving 10\u2009\u00d7\u20093\u00a0Gy in two previous prospective studies for tumor type, ambulatory status, time developing motor deficits, interval between tumor diagnosis and MSCC and visceral metastases. These factors were consistent in all three patients (triple) used for each 1:2 matching. Groups were compared for local progression-free survival (LPFS), motor function, ambulatory status, and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After matching, 32 triples remained for analyses (N\u2009=\u200996 in total). Six-month LPFS-rates were 94% after 5\u2009\u00d7\u20095\u00a0Gy and 87% after 10\u2009\u00d7\u20093\u00a0Gy (<jats:italic>p<\/jats:italic>\u2009=\u20090.36), 6-month OS-rates 43% and 35% (<jats:italic>p<\/jats:italic>\u2009=\u20090.74). Improvement of motor function was achieved in 59% and 34% of patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.028); overall response rates (improvement or no further progression of motor deficits) were 94% and 89% (<jats:italic>p<\/jats:italic>\u2009=\u20090.71). Post-treatment ambulatory rates were 81% after 5\u2009\u00d7\u20095\u00a0Gy and 85% after 10\u2009\u00d7\u20093\u00a0Gy (<jats:italic>p<\/jats:italic>\u2009=\u20090.61). Of non-ambulatory patients, 50% (6\/12) and 46% (11\/24) regained the ability to walk (<jats:italic>p<\/jats:italic>\u2009=\u20091.00).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>5\u2009\u00d7\u20095\u00a0Gy in 1\u00a0week appeared similarly effective as 10\u2009\u00d7\u20093\u00a0Gy in 2\u00a0weeks. These results may not be applicable to long-term survivors and should be confirmed in a randomized trial directly comparing 5\u2009\u00d7\u20095\u00a0Gy and 10\u2009\u00d7\u20093\u00a0Gy.<\/jats:p><jats:p><jats:italic>Trial registration<\/jats:italic>clinicaltrials.gov NCT03070431. 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This article has been updated to correct this error.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the local ethics committee (University of L\u00fcbeck, ref. 16-163). It was conducted in accordance with principles of the Declaration of Helsinki and Good Clinical Practice.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests related to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7"}}