{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:28:50Z","timestamp":1740144530866,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Distant Metastases from Head and Neck Squamous cell carcinomas are uncommon (9\u201311%) and they are usually found in the lung and less frequently in the liver, kidney and adrenals.<\/jats:p>\n<jats:p>Central nervous system (CNS) metastases are extremely rare (2\u20138%), and they are described mainly in patients who already have extracranial metastases. So there\u2019s scarcity of data about their optimal management .<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods and results<\/jats:title>\n<jats:p>A patient presented CNS metastases after having been successfully treated with induction chemotherapy and definitive radiotherapy for a pyriform sinus carcinoma. The patient\u2019s work up, treatment and outcome are described.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>CNS metastases from Head and Neck carcinomas are exceptionally rare. Nevertheless, clinicians should be alert of neurological symptoms in these patients, in order to set up a timely assessment and treatment. Secondarily, given the rarity of this condition, additional research on this topic is warranted in order to improve therapeutic strategies and outcomes of such patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13014-020-1472-0","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T16:02:38Z","timestamp":1579536158000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Squamous cell carcinoma (SCC) of the Pyriform sinus with multiple metachronous brain metastases, a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-1109","authenticated-orcid":false,"given":"Agostino","family":"Cristaudo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Stefanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ursino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durim","family":"Delishaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Baldaccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Gonnelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Paiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"1472_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ctro.2017.07.002","volume":"6","author":"ZAR Gouw","year":"2017","unstructured":"Gouw ZAR, Jasperse B, Sonke JJ, et al. 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