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Our aim is to evaluate the impact of SRS doses and other patient and disease characteristics on vestibular function in patients with VS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data on VS patients treated with single-fraction SRS to 12\u00a0Gy were retrospectively reviewed. No dose constraints were given to the vestibule during optimization in treatment planning. Patient and tumor characteristics, pre- and post-SRS vestibular examination results and patient-reported dizziness were assessed from patient records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty-three patients were analyzed. Median follow-up was 32\u00a0months (range, 6\u201379). The median minimum, mean and maximum vestibular doses were 2.6\u2009\u00b1\u20091.6\u00a0Gy, 6.7\u2009\u00b1\u20092.8\u00a0Gy, and 11\u2009\u00b1\u20093.6\u00a0Gy, respectively. On univariate analysis, Koos grade (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04; OR: 3.45; 95% CI 1.01\u201311.81), tumor volume (median 6.1\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ; range, 0.8\u201338;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01; OR: 4.85; 95% CI 1.43\u201316.49), presence of pre-SRS dizziness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02; OR: 3.98; 95% CI 1.19\u201313.24) and minimum vestibular dose (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033; OR: 1.55; 95% CI 1.03\u20132.32) showed a significant association with patient-reported dizziness. On multivariate analysis, minimum vestibular dose remained significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02; OR: 1.75; 95% CI 1.05\u20132.89). Patients with improved caloric function had received significantly lower mean (1.5\u2009\u00b1\u20090.7\u00a0Gy,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and maximum doses (4\u2009\u00b1\u20091.5\u00a0Gy,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) to the vestibule.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results reveal that 5\u00a0Gy and above minimum vestibular doses significantly worsened dizziness. Additionally, mean and maximum doses received by the vestibule were significantly lower in patients who had improved caloric function. Further investigations are needed to determine dose-volume parameters and their effects on vestibular toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13014-021-01793-7","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T08:02:56Z","timestamp":1616745776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vestibular dose correlates with dizziness after radiosurgery for the treatment of vestibular schwannoma"],"prefix":"10.1186","volume":"16","author":[{"given":"Ekin","family":"Ermi\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Anschuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Leiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Poel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Raabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Manser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Aebersold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Caversaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Mantokoudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Abu-Isa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"1793_CR1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.ijrobp.2007.01.001","volume":"68","author":"R Chopra","year":"2007","unstructured":"Chopra R, Kondziolka D, Niranjan A, Lunsford LD, Flickinger JC. 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