{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:18:00Z","timestamp":1774880280259,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81872457"],"award-info":[{"award-number":["81872457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81972846"],"award-info":[{"award-number":["81972846"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To use cone-beam computed tomography (CBCT) imaging to determine the impacts of patient characteristics on the magnitude of geometric setup errors and obtain patient-specific planning target volume (PTV) margins from the correlated patient characteristics in whole breast irradiation (WBI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Between January 2019 and December 2019, a total of 97 patients who underwent breast-conserving surgery, followed by intensity-modulated radiation therapy in WBI, were scanned with pre-treatment CBCT for the first three treatment fractions and weekly for the subsequent fractions. Setup errors in the left\u2013right (LR), superior\u2013inferior (SI) and anterior\u2013posterior (AP) directions were recorded and analyzed with patient characteristics\u2014including age, tumor location, body mass index (BMI), chest circumference (CC) and breast volume (BV)\u2014to examine the predictors for setup errors and obtain specific PTV margins.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 679 CBCT images from 97 patients were acquired for analysis. The mean setup errors for the whole group were 2.32\u2009\u00b1\u20091.21\u00a0mm, 3.71\u2009\u00b1\u20092.21\u00a0mm and 2.75\u2009\u00b1\u20091.56\u00a0mm in the LR, SI and AP directions, respectively. Patients\u2019 BMI, CC and BV were moderately associated with setup errors, especially in the SI directions (R\u2009=\u20090.40, 0.43 and 0.22, respectively). Setup errors in the SI directions for patients with BMI\u2009&gt;\u200923.8\u00a0kg\/m<jats:sup>2<\/jats:sup>, CC\u2009&gt;\u200989\u00a0cm and BV\u2009&gt;\u2009657 cm<jats:sup>3<\/jats:sup> were 4.56\u2009\u00b1\u20092.59\u00a0mm, 4.77\u2009\u00b1\u20092.42\u00a0mm and 4.30\u2009\u00b1\u20092.43\u00a0mm, respectively, which were significantly greater than those of patients with BMI\u2009\u2264\u200923.8\u00a0kg\/m<jats:sup>2<\/jats:sup>, CC\u2009\u2264\u200989\u00a0cm and BV\u2009\u2264\u2009657 cm<jats:sup>3<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Correspondingly, the calculated PTV margins in patients with BMI\u2009&gt;\u200923.8\u00a0kg\/m<jats:sup>2<\/jats:sup>, CC\u2009&gt;\u200989\u00a0cm and BV\u2009&gt;\u2009657 cm<jats:sup>3<\/jats:sup> were 4.25\/7.95\/4.93\u00a0mm, 4.37\/7.66\/5.24\u00a0mm and 4.22\/7.54\/5.29\u00a0mm in the LR\/SI\/AP directions, respectively, compared with 3.64\/4.64\/5.09\u00a0mm, 3.31\/4.50\/4.82\u00a0mm and 3.29\/5.74\/4.73\u00a0mm for BMI\u2009\u2264\u200923.8\u00a0kg\/m<jats:sup>2<\/jats:sup>, CC\u2009\u2264\u200989\u00a0cm and BV\u2009\u2264\u2009657 cm<jats:sup>3<\/jats:sup>, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The magnitude of geometric setup errors was moderately correlated with BMI, CC and BV. It was recommended to set patient-specific PTV margins according to patient characteristics in the absence of daily image-guided treatment setup.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13014-021-01863-w","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T05:33:08Z","timestamp":1628832788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Does the protocol-required uniform margin around the CTV adequately account for setup inaccuracies in whole breast irradiation?"],"prefix":"10.1186","volume":"16","author":[{"given":"Jurui","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"issue":"22","key":"1863_CR1","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1056\/NEJM199306033282202","volume":"328","author":"U Veronesi","year":"1993","unstructured":"Veronesi U, Luini A, Del Vecchio M, Greco M, Galimberti V, Merson M, et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med. 1993;328(22):1587\u201391.","journal-title":"N Engl J Med"},{"issue":"16","key":"1863_CR2","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1056\/NEJMoa022152","volume":"347","author":"B Fisher","year":"2002","unstructured":"Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233\u201341.","journal-title":"N Engl J Med"},{"issue":"2","key":"1863_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.critrevonc.2014.04.005","volume":"92","author":"O Kaidar-Person","year":"2014","unstructured":"Kaidar-Person O, Kuten A, Belkacemi Y, Arome O. Primary systemic therapy and whole breast irradiation for locally advanced breast cancer: a systematic review. Crit Rev Oncol Hematol. 2014;92(2):143\u201352.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"1863_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.radonc.2008.10.010","volume":"90","author":"P Jain","year":"2009","unstructured":"Jain P, Marchant T, Green M, Watkins G, Davies J, McCarthy C, et al. Inter-fraction motion and dosimetric consequences during breast intensity-modulated radiotherapy (IMRT). Radiother Oncol. 2009;90(1):93\u20138.","journal-title":"Radiother Oncol"},{"issue":"3","key":"1863_CR5","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.ijrobp.2007.06.060","volume":"69","author":"WA Beckham","year":"2007","unstructured":"Beckham WA, Popescu CC, Patenaude VV, Wai ES, Olivotto IA. Is multibeam IMRT better than standard treatment for patients with left-sided breast cancer? Int J Radiat Oncol Biol Phys. 2007;69(3):918\u201324.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"1863_CR6","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.ijrobp.2010.07.032","volume":"79","author":"A van Mourik","year":"2011","unstructured":"van Mourik A, van Kranen S, den Hollander S, Sonke JJ, van Herk M, van Vliet-Vroegindeweij C. Effects of setup errors and shape changes on breast radiotherapy. Int J Radiat Oncol Biol Phys. 2011;79(5):1557\u201364.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1863_CR7","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ijrobp.2007.01.048","volume":"68","author":"EA White","year":"2007","unstructured":"White EA, Cho J, Vallis KA, Sharpe MB, Lee G, Blackburn H, et al. Cone beam computed tomography guidance for setup of patients receiving accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys. 2007;68(2):547\u201354.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1863_CR8","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.ijrobp.2007.07.2344","volume":"70","author":"T Fatunase","year":"2008","unstructured":"Fatunase T, Wang Z, Yoo S, Hubbs JL, Prosnitz RG, Yin FF, et al. Assessment of the residual error in soft tissue setup in patients undergoing partial breast irradiation: results of a prospective study using cone-beam computed tomography. Int J Radiat Oncol Biol Phys. 2008;70(4):1025\u201334.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1863_CR9","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ijrobp.2016.07.008","volume":"96","author":"S Du","year":"2016","unstructured":"Du S, Lockamy V, Zhou L, Xue C, LeBlanc J, Glenn S, et al. Stereotactic body radiation therapy delivery in a genetically engineered mouse model of lung cancer. Int J Radiat Oncol Biol Phys. 2016;96(3):529\u201337.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1863_CR10","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ijrobp.2007.08.062","volume":"70","author":"MW Kan","year":"2008","unstructured":"Kan MW, Leung LH, Wong W, Lam N. Radiation dose from cone beam computed tomography for image-guided radiation therapy. Int J Radiat Oncol Biol Phys. 2008;70(1):272\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1863_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.radonc.2009.07.013","volume":"93","author":"SM Goddu","year":"2009","unstructured":"Goddu SM, Yaddanapudi S, Pechenaya OL, Chaudhari SR, Klein EE, Khullar D, et al. Dosimetric consequences of uncorrected setup errors in helical tomotherapy treatments of breast-cancer patients. Radiother Oncol. 2009;93(1):64\u201370.","journal-title":"Radiother Oncol"},{"key":"1863_CR12","unstructured":"NCT01872975. A randomized phase III clinical trial evaluating post-mastectomy chestwall and regional nodal XRT and post-lumpectomy regional nodal XRT in patients with positive axillary nodes before neoadjuvant chemotherapy who convert to pathologically negative axillary nodes after neoadjuvant chemotherapy. Available from https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01872975. Accessed 31 Aug 2020."},{"key":"1863_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejmp.2019.07.021","volume":"65","author":"J Seppala","year":"2019","unstructured":"Seppala J, Vuolukka K, Viren T, Heikkila J, Honkanen JTJ, Pandey A, et al. Breast deformation during the course of radiotherapy: the need for an additional outer margin. Phys Med. 2019;65:1\u20135.","journal-title":"Phys Med"},{"issue":"4","key":"1863_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s00066-016-0943-6","volume":"192","author":"T Mulliez","year":"2016","unstructured":"Mulliez T, Gulyban A, Vercauteren T, van Greveling A, Speleers B, De Neve W, et al. Setup accuracy for prone and supine whole breast irradiation. Strahlenther Onkol. 2016;192(4):254\u20139.","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"1863_CR15","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.radonc.2017.04.023","volume":"124","author":"K Hirata","year":"2017","unstructured":"Hirata K, Yoshimura M, Mukumoto N, Nakamura M, Inoue M, Sasaki M, et al. Three-dimensional intrafractional internal target motions in accelerated partial breast irradiation using three-dimensional conformal external beam radiotherapy. Radiother Oncol. 2017;124(1):118\u201323.","journal-title":"Radiother Oncol"},{"issue":"1","key":"1863_CR16","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s13014-018-1200-1","volume":"13","author":"J Lee","year":"2018","unstructured":"Lee J, Liu SH, Lin JB, Wu MH, Wu CJ, Tai HC, et al. Image-guided study of inter-fraction and intra-fraction set-up variability and margins in reverse semi-decubitus breast radiotherapy. Radiat Oncol. 2018;13(1):254.","journal-title":"Radiat Oncol"},{"issue":"1","key":"1863_CR17","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13014-017-0889-6","volume":"12","author":"X Zhen","year":"2017","unstructured":"Zhen X, Zhao B, Wang Z, Timmerman R, Spangler A, Kim N, et al. Comprehensive target geometric errors and margin assessment in stereotactic partial breast irradiation. Radiat Oncol. 2017;12(1):151.","journal-title":"Radiat Oncol"},{"issue":"1019","key":"1863_CR18","doi-asserted-by":"publisher","first-page":"e1051","DOI":"10.1259\/bjr\/28845176","volume":"85","author":"EM Donovan","year":"2012","unstructured":"Donovan EM, Castellano I, Eagle S, Harris E. Clinical implementation of kilovoltage cone beam CT for the verification of sequential and integrated photon boost treatments for breast cancer patients. Br J Radiol. 2012;85(1019):e1051-1057.","journal-title":"Br J Radiol"},{"issue":"3","key":"1863_CR19","doi-asserted-by":"publisher","first-page":"e187","DOI":"10.1016\/j.ijrobp.2010.12.027","volume":"81","author":"R Topolnjak","year":"2011","unstructured":"Topolnjak R, de Ruiter P, Remeijer P, van Vliet-Vroegindeweij C, Rasch C, Sonke JJ. Image-guided radiotherapy for breast cancer patients: surgical clips as surrogate for breast excision cavity. Int J Radiat Oncol Biol Phys. 2011;81(3):e187-195.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1863_CR20","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/S0360-3016(00)00518-6","volume":"47","author":"M van Herk","year":"2000","unstructured":"van Herk M, Remeijer P, Rasch C, Lebesque JV. The probability of correct target dosage: dose-population histograms for deriving treatment margins in radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47(4):1121\u201335.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"1863_CR21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1600-0846.2009.00363.x","volume":"15","author":"LC Gerhardt","year":"2009","unstructured":"Gerhardt LC, Lenz A, Spencer ND, Munzer T, Derler S. Skin-textile friction and skin elasticity in young and aged persons. Skin Res Technol. 2009;15(3):288\u201398.","journal-title":"Skin Res Technol"},{"issue":"4","key":"1863_CR22","doi-asserted-by":"publisher","first-page":"e647","DOI":"10.1016\/j.ijrobp.2011.08.024","volume":"82","author":"R Topolnjak","year":"2012","unstructured":"Topolnjak R, Borst GR, Nijkamp J, Sonke JJ. Image-guided radiotherapy for left-sided breast cancer patients: geometrical uncertainty of the heart. Int J Radiat Oncol Biol Phys. 2012;82(4):e647-655.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1863_CR23","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.ijrobp.2011.07.026","volume":"83","author":"LL Lin","year":"2012","unstructured":"Lin LL, Hertan L, Rengan R, Teo BK. Effect of body mass index on magnitude of setup errors in patients treated with adjuvant radiotherapy for endometrial cancer with daily image guidance. Int J Radiat Oncol Biol Phys. 2012;83(2):670\u20135.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1863_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ijrobp.2008.07.049","volume":"75","author":"JR Wong","year":"2009","unstructured":"Wong JR, Gao Z, Merrick S, Wilson P, Uematsu M, Woo K, et al. Potential for higher treatment failure in obese patients: correlation of elevated body mass index and increased daily prostate deviations from the radiation beam isocenters in an analysis of 1,465 computed tomographic images. Int J Radiat Oncol Biol Phys. 2009;75(1):49\u201355.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"1863_CR25","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.ijrobp.2003.07.005","volume":"58","author":"RC Frazier","year":"2004","unstructured":"Frazier RC, Vicini FA, Sharpe MB, Yan D, Fayad J, Baglan KL, et al. Impact of breathing motion on whole breast radiotherapy: a dosimetric analysis using active breathing control. Int J Radiat Oncol Biol Phys. 2004;58(4):1041\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1863_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13014-021-01777-7","volume":"16","author":"Y Ono","year":"2021","unstructured":"Ono Y, Yoshimura M, Ono T, Fujimoto T, Miyabe Y, Matsuo Y, et al. Appropriate margin for planning target volume for breast radiotherapy during deep inspiration breath-hold by variance component analysis. Radiat Oncol. 2021;16(1):1\u20138.","journal-title":"Radiat Oncol"},{"issue":"2","key":"1863_CR27","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.radonc.2010.05.014","volume":"96","author":"AM Kirby","year":"2010","unstructured":"Kirby AM, Evans PM, Donovan EM, Convery HM, Haviland JS, Yarnold JR. Prone versus supine positioning for whole and partial-breast radiotherapy: a comparison of non-target tissue dosimetry. Radiother Oncol. 2010;96(2):178\u201384.","journal-title":"Radiother Oncol"},{"issue":"5","key":"1863_CR28","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1016\/j.ijrobp.2010.10.070","volume":"82","author":"L Veldeman","year":"2012","unstructured":"Veldeman L, De Gersem W, Speleers B, Truyens B, Van Greveling A, Van den Broecke R, et al. Alternated prone and supine whole-breast irradiation using IMRT: setup precision, respiratory movement and treatment time. Int J Radiat Oncol Biol Phys. 2012;82(5):2055\u201364.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10026","key":"1863_CR29","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/S0140-6736(16)30054-X","volume":"387","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2016","unstructured":"NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387(10026):1377\u201396.","journal-title":"Lancet"},{"issue":"3","key":"1863_CR30","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1158\/1055-9965.EPI-07-2554","volume":"17","author":"A Stuedal","year":"2008","unstructured":"Stuedal A, Ma H, Bernstein L, Pike MC, Ursin G. Does breast size modify the association between mammographic density and breast cancer risk? Cancer Epidemiol Biomark Prev. 2008;17(3):621\u20137.","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"1","key":"1863_CR31","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/s41598-018-19437-4","volume":"8","author":"LY Lim","year":"2018","unstructured":"Lim LY, Ho PJ, Liu J, Chay WY, Tan MH, Hartman M, et al. Determinants of breast size in Asian women. Sci Rep. 2018;8(1):1201.","journal-title":"Sci Rep"},{"issue":"6","key":"1863_CR32","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/acm2.12599","volume":"20","author":"SH Hattel","year":"2019","unstructured":"Hattel SH, Andersen PA, Wahlstedt IH, Damkjaer S, Saini A, Thomsen JB. Evaluation of setup and intrafraction motion for surface guided whole-breast cancer radiotherapy. J Appl Clin Med Phys. 2019;20(6):39\u201344.","journal-title":"J Appl Clin Med Phys"},{"issue":"2","key":"1863_CR33","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ijrobp.2004.10.022","volume":"62","author":"RP Smith","year":"2005","unstructured":"Smith RP, Bloch P, Harris EE, McDonough J, Sarkar A, Kassaee A, et al. Analysis of interfraction and intrafraction variation during tangential breast irradiation with an electronic portal imaging device. Int J Radiat Oncol Biol Phys. 2005;62(2):373\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"1863_CR34","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ijrobp.2006.05.038","volume":"66","author":"EK Hansen","year":"2006","unstructured":"Hansen EK, Larson DA, Aubin M, Chen J, Descovich M, Gillis AM, et al. Image-guided radiotherapy using megavoltage cone-beam computed tomography for treatment of paraspinous tumors in the presence of orthopedic hardware. Int J Radiat Oncol Biol Phys. 2006;66(2):323\u20136.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1863_CR35","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ijrobp.2010.06.014","volume":"80","author":"HC Cheng","year":"2011","unstructured":"Cheng HC, Wu VW, Liu ES, Kwong DL. Evaluation of radiation dose and image quality for the varian cone beam computed tomography system. Int J Radiat Oncol Biol Phys. 2011;80(1):291\u2013300.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"1863_CR36","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1118\/1.2751074","volume":"34","author":"LC Ezzell","year":"2007","unstructured":"Ezzell LC, Hansen EK, Quivey JM, Xia P. Detection of treatment setup errors between two CT scans for patients with head and neck cancer. Med Phys. 2007;34(8):3233\u201342.","journal-title":"Med Phys"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-021-01863-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13014-021-01863-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-021-01863-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T05:43:13Z","timestamp":1628833393000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/s13014-021-01863-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1863"],"URL":"https:\/\/doi.org\/10.1186\/s13014-021-01863-w","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"15 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Review Board of Fudan University Shanghai Cancer Center.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors and participators consent to publicate the data in the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"143"}}