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The variations of volumes as well as the dosimetric impact from treatment planning to delivery (intra-application) were evaluated. The dose volume histogram parameters including volume, D90 of high-risk clinical target volume (HRCTV) and D2cc of organs at risk (OARs) were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The relative differences (mean\u2009\u00b1\u20091SD) of the volume and D90 HRCTV across the two scans were \u2212\u20092.0\u2009\u00b1\u20093.3% and \u2212\u20091.2\u2009\u00b1\u20094.5%, respectively. The variations of D2cc for bladder, rectum, sigmoid and small intestine are \u2212\u20090.6\u2009\u00b1\u200917.1%, 9.3\u2009\u00b1\u200914.6%, 7.2%\u2009\u00b1\u200920.5% and 1.5\u2009\u00b1\u200912.6%, respectively. Most of them are statistically nonsignificant except the D2cc for rectum, which showed a significant increase (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). Using 5% and 10% uncertainty of physical dose for HRCTV at a 6\u00a0Gy\u2009\u00d7\u20095 high-dose-rate schedule, the possibility of total equivalent doses in 2\u00a0Gy fractions (EQD2) lower than 85\u00a0Gy is close to 0% and 3%, respectively. Performing similar simulation at 15% and 20% uncertainty of a 4\u00a0Gy physical dose for OARs, the possibility of total EQD2 dose exceeding 75\u00a0Gy is about 70%. Less than 1% of the total EQD2 of OARs would exceed 80\u00a0Gy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Average intra-fractional dosimetric variation of HRCTV was small in an interval of less than 1\u00a0h, and the possibility of total EQD2 exceeding 85\u00a0Gy is higher than 97%. The intra-fractional dosimetric variations of OARs might result in an overdose for OARs in a single fraction or the whole treatment. It is necessary to detect unfavorable anatomical changes by re-imaging and take interventions to minimize applied doses and reduce the risk of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13014-021-01870-x","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T05:03:05Z","timestamp":1628053385000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intra-fractional dosimetric analysis of image-guided intracavitary brachytherapy of cervical cancer"],"prefix":"10.1186","volume":"16","author":[{"given":"Junfang","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"issue":"6","key":"1870_CR1","doi-asserted-by":"publisher","first-page":"660","DOI":"10.6004\/jnccn.2020.0027","volume":"18","author":"NR Abu-Rustum","year":"2020","unstructured":"Abu-Rustum NR, Yashar CM, Bean S, Bradley K, Campos SM, Chon HS, Chu C, Cohn D, Crispens MA, Damast S, et al. 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