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In order to be able to irradiate from different angles, usually expensive, complex and large gantries are used. Instead rotating the beam via a gantry, the patient itself might be rotated. Here we present tolerance and compliance of volunteers for a fully-enclosed patient rotation system in a clinical magnetic resonance (MR)-scanner for potential use in MR-guided radiotherapy, conducted within a prospective evaluation study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A patient rotation system was used to simulate and perform magnetic resonance imaging (MRI)-examinations with 50 volunteers without an oncological question. For 20 participants, the MR-examination within the bore was simulated by introducing realistic MRI noise, whereas 30 participants received an examination with image acquisition. Initially, body parameters and claustrophobia were assessed. The subjects were then rotated to different angles for simulation (0\u00b0, 45\u00b0, 90\u00b0, 180\u00b0) and imaging (0\u00b0, 70\u00b0, 90\u00b0, 110\u00b0). At each angle, anxiety and motion sickness were assessed using a 6-item State-Trait-Anxiety-Inventory (STAI-6) and a modified Motion Sickness Assessment Questionnaire (MSAQ). In addition, general areas of discomfort were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 50 subjects, three (6%) subjects terminated the study prematurely. One subject dropped out during simulation due to nausea while rotating to 45\u00b0. During imaging, further two subjects dropped out due to shoulder pain from positioning at 90\u00b0 and 110\u00b0, respectively. The average result for claustrophobia (0\u2009=\u2009no claustrophobia to 4\u2009=\u2009extreme claustrophobia) was none to light claustrophobia (average score: simulation 0.64\u2009\u00b1\u20090.33, imaging 0.51\u2009\u00b1\u20090.39). The mean anxiety scores (0%\u2009=\u2009no anxiety to 100%\u2009=\u2009maximal anxiety) were 11.04% (simulation) and 15.82% (imaging). Mean motion sickness scores (0%\u2009=\u2009no motion sickness to 100%\u2009=\u2009maximal motion sickness) of 3.5% (simulation) and 6.76% (imaging) were obtained across all participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study proves the feasibility of horizontal rotation in a fully-enclosed rotation system within an MR-scanner. Anxiety scores were low and motion sickness was only a minor influence. Both anxiety and motion sickness showed no angular dependency. Further optimizations with regard to immobilization in the rotation device may increase subject comfort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13014-024-02461-2","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T22:01:47Z","timestamp":1717797707000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy: a prospective study"],"prefix":"10.1186","volume":"19","author":[{"given":"Cedric","family":"Beyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina Maria","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Dorsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Echner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Dinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Welzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Seidensaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"H\u00f6rner-Rieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"J\u00e4kel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kl\u00fcter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"issue":"1114","key":"2461_CR1","doi-asserted-by":"publisher","first-page":"20200183","DOI":"10.1259\/bjr.20200183","volume":"93","author":"L Schaub","year":"2020","unstructured":"Schaub L, Harrabi SB, Debus J. 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The study has received approval by the Ethics Committee of the Medical Faculty Heidelberg (study number S-903\/2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The author declares that volunteers gave written consent that personal images could be processed and published in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JHR reports research grants from IntraOP Medical (COSMOPOLITAN trial) and Varian Medical Systems (AIM-C1 trial) as well as speaker fees from ViewRay Inc., Pfizer Inc. and Sanofi Aventis and travel reimbursement from VARIAN Medical Systems outside the submitted work. JD received grants from View Ray Inc., CRI\u2014The Clinical Research Institute GmbH, Accuray Incorporated, Accuray International S\u00e0rl, RaySearch Laboratories AB, Vision RT limited, Astellas Pharma GmbH, Astra Zeneca GmbH, Solution Akademie GmbH, Ergomed PLC Surrey Research Park, Merck Serono GmbH, Siemens Healthcare GmbH, Quintiles GmbH, Pharmaceutical Research Associates GmbH, Boehringer Ingelheim Pharma GmbH Co, PTW-Freiburg Pychlau GmbH, Nanobiotix A.A. and IntraOP Medical outside the submitted work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"71"}}