{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:26:57Z","timestamp":1793064417096,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adaptive radiation therapy (ART) allows real-time treatment plan adjustment based on daily anatomical changes but involves a time-consuming workflow. Surface-guided radiation therapy (SGRT) provides precise patient positioning and intra-fractional motion management. This study retrospectively analyses intra-fractional patient motion using SGRT during long-duration radiotherapy (RT) like ART for prostate cancer and further assesses the relation for internal target position measured by cone-beam CT (CBCT) and surface position measured by SGRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty ultra-hypo-fractionated prostate cancer patients (137 fractions) treated with ART on Ethos (version 1.0, Varian Medical Systems, Siemens Healthineers, Palo Alto, CA, USA) using a ring-mounted SGRT system (AlignRT inBore, Vision RT Ltd., UK) were retrospectively analyzed. The mean and standard deviation values of surface positions across three translational axes of up to 60\u00a0min of treatment were analyzed. Further, the translational shifts from the second daily CBCT before irradiation and surface position data were compared to evaluate the agreement between internal and surface position. Correlations between CBCT shifts and SGRT data were assessed with the Wilcoxon paired samples test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The maximum mean (\u00b1\u2009SD) surface motion was \u2212\u20092.21\u2009\u00b1\u20091.27\u00a0mm (vertical, at 45\u00a0min), 0.22\u2009\u00b1\u20091.55\u00a0mm (longitudinal, at 35\u00a0min), and 0.16\u2009\u00b1\u20090.77\u00a0mm (lateral, at 20\u00a0min). After the second CBCT shift, the mean (\u00b1\u2009SD) surface position deviations were \u2212\u20090.63\u2009\u00b1\u20091.43\u00a0mm (vertical), -0.24\u2009\u00b1\u20091.63\u00a0mm (longitudinal), and 0.05\u2009\u00b1\u20090.87\u00a0mm (lateral) with ranges of 8.30\u00a0mm, 10.02\u00a0mm, and 6.08\u00a0mm on the vertical, longitudinal, and lateral axes, respectively. Significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) were found between CBCT and SGRT on the vertical and longitudinal axes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGRT revealed a consistent vertical shift over the whole course of long-duration RT and not only for the first minutes of the treatment. Further, SGRT exclusively is not an adequate inter-fractional positioning tool for prostate cancer patients, however additional SGRT-based intra-fractional monitoring can add a value for long duration RT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13014-025-02638-3","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:45:34Z","timestamp":1744890334000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of intra-fractional surface motion during adaptive radiation therapy and relation of internal vs. external position for prostate cancer"],"prefix":"10.1186","volume":"20","author":[{"given":"Fernanda","family":"Macedo-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kalisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Simeonova-Chergou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Boda-Heggemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Dreher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Stieler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"2638_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1088\/0031-9155\/42\/1\/008","volume":"42","author":"D Yan","year":"1997","unstructured":"Yan D, Vicini F, Wong J, Martinez A. 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F.S. reports travel expenses and honoraria from Elekta AB and Vision RT, Inc. J. F. reports travel expenses and honoraria from Vision RT, Inc.A.S-C reports no competing interests. J. B-H reports AstraZeneca speaker fees and EBAMed SA consulting fees and travel expenses.C.D. reports Varian research grant and travel expenses, AstraZeneca speaker fees and travel expenses, and DGVS speaker fees and travel expenses. F.A.G. reports travel expenses, stocks and honoraria from TME Pharma AG related to this work; research grants and travel expenses from ELEKTA AB; grants, research grants, travel expenses and honoraria from Carl Zeiss Meditec AG; grants, research grants, travel expenses and honoraria from OncoMANGETx, Inc.; travel expenses and research grants from Varian Medical Systems, Inc.; travel expenses and\/or honoraria from Bristol- Myers Squibb, Cureteq AG, Roche Pharma AG, MSD Sharp and Dohme GmbH, Siemens Healthineers AG, Varian Medical Systems, and AstraZeneca GmbH; non-financial support from Oncare GmbH and Opasca GmbH and patent US10857388B2 together with Carl Zeiss Meditec AG and patent EP4119191A1.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"57"}}