{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T06:46:23Z","timestamp":1775371583162,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-182A-011-MY2"],"award-info":[{"award-number":["111-2314-B-182A-011-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3N0461"],"award-info":[{"award-number":["CMRPG3N0461"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2314-B-182-054-MY3"],"award-info":[{"award-number":["112-2314-B-182-054-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chang Gung University, Taiwan","award":["UMRPD1N0061"],"award-info":[{"award-number":["UMRPD1N0061"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Oncol"],"DOI":"10.1186\/s13014-025-02673-0","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:32:30Z","timestamp":1749216750000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic profiles of early biological responses to predict the treatment efficacy of proton therapy in liver cancer assessed with in vivo kinetic [18F]-FDG PET\/MRI"],"prefix":"10.1186","volume":"20","author":[{"given":"Yi-Hsiu","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Chun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujie","family":"Jhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chang","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gigin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Fang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Hsin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"issue":"2","key":"2673_CR1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3350\/cmh.2022.0421","volume":"29","author":"TH Su","year":"2023","unstructured":"Su TH, Wu CH, Liu TH, Ho CM, Liu CJ. Clinical practice guidelines and real-life practice in hepatocellular carcinoma: A Taiwan perspective. Clin Mol Hepatol. 2023;29(2):230\u201341.","journal-title":"Clin Mol Hepatol"},{"issue":"3","key":"2673_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"2673_CR3","unstructured":"PDQ Adult Treatment Editorial Board. Primary Liver Cancer Treatment (PDQ\u00ae): Health Professional Version. 2023."},{"issue":"2","key":"2673_CR4","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/pro6.1149","volume":"6","author":"R Mohan","year":"2022","unstructured":"Mohan R. A review of proton Therapy - Current status and future directions. Precis Radiat Oncol. 2022;6(2):164\u201376.","journal-title":"Precis Radiat Oncol"},{"issue":"8","key":"2673_CR5","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1080\/02841860500341157","volume":"44","author":"J Lundkvist","year":"2005","unstructured":"Lundkvist J, Ekman M, Ericsson SR, Jonsson B, Glimelius B. Proton therapy of cancer: potential clinical advantages and cost-effectiveness. Acta Oncol. 2005;44(8):850\u201361.","journal-title":"Acta Oncol"},{"issue":"1","key":"2673_CR6","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s13014-017-0931-8","volume":"12","author":"M Cubillos-Mesias","year":"2017","unstructured":"Cubillos-Mesias M, Baumann M, Troost EGC, Lohaus F, Lock S, Richter C, et al. Impact of robust treatment planning on single- and multi-field optimized plans for proton beam therapy of unilateral head and neck target volumes. Radiat Oncol. 2017;12(1):190.","journal-title":"Radiat Oncol"},{"key":"2673_CR7","doi-asserted-by":"crossref","unstructured":"Kobeissi JM, Hilal L, Simone CB 2nd, Lin H, Crane CH, Hajj C. Proton therapy in the management of hepatocellular carcinoma. Cancers (Basel). 2022;14(12).","DOI":"10.3390\/cancers14122900"},{"issue":"7826","key":"2673_CR8","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1038\/d41586-020-02677-8","volume":"585","author":"AB Keener","year":"2020","unstructured":"Keener AB. Making radiation oncology more personal. Nature. 2020;585(7826):S10\u20132.","journal-title":"Nature"},{"issue":"5","key":"2673_CR9","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/j.ijrobp.2016.03.051","volume":"95","author":"FH Chen","year":"2016","unstructured":"Chen FH, Wang CC, Liu HL, Fu SY, Yu CF, Chang C, et al. Decline of tumor vascular function as assessed by dynamic Contrast-Enhanced magnetic resonance imaging is associated with poor responses to radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys. 2016;95(5):1495\u2013503.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"2673_CR10","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1007\/s00259-019-04318-3","volume":"46","author":"YH Chung","year":"2019","unstructured":"Chung YH, Yu CF, Chiu SC, Chiu H, Hsu ST, Wu CR, et al. Diffusion-weighted MRI and (18)F-FDG PET correlation with immunity in early radiotherapy response in BNL hepatocellular carcinoma mouse model: timeline validation. Eur J Nucl Med Mol Imaging. 2019;46(8):1733\u201344.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"7","key":"2673_CR11","doi-asserted-by":"publisher","first-page":"914","DOI":"10.3109\/0284186X.2010.498831","volume":"49","author":"K Roe","year":"2010","unstructured":"Roe K, Aleksandersen TB, Kristian A, Nilsen LB, Seierstad T, Qu H, et al. Preclinical dynamic 18F-FDG PET - tumor characterization and radiotherapy response assessment by kinetic compartment analysis. Acta Oncol. 2010;49(7):914\u201321.","journal-title":"Acta Oncol"},{"key":"2673_CR12","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1200\/EDBK_201441","volume":"38","author":"M Nishino","year":"2018","unstructured":"Nishino M. Tumor response assessment for precision Cancer therapy: response evaluation criteria in solid tumors and beyond. Am Soc Clin Oncol Educ Book. 2018;38:1019\u201329.","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"2673_CR13","doi-asserted-by":"crossref","unstructured":"Ganesan R, Yoon SJ, Suk KT. Microbiome and metabolomics in liver cancer: scientific technology. Int J Mol Sci. 2022;24(1).","DOI":"10.3390\/ijms24010537"},{"issue":"Suppl 1","key":"2673_CR14","doi-asserted-by":"publisher","first-page":"S122","DOI":"10.2967\/jnumed.108.057307","volume":"50","author":"RL Wahl","year":"2009","unstructured":"Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med. 2009;50(Suppl 1):S122\u201350.","journal-title":"J Nucl Med"},{"key":"2673_CR15","first-page":"181","volume":"2","author":"I Pinilla","year":"2008","unstructured":"Pinilla I, Rodr\u00edguez-Vigil B, G\u00f3mez-Le\u00f3n N. Integrated FDG PET\/CT: utility and applications in clinical oncology. Clin Med Oncol. 2008;2:181\u201398.","journal-title":"Clin Med Oncol"},{"issue":"1","key":"2673_CR16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00259-020-04843-6","volume":"48","author":"A Dimitrakopoulou-Strauss","year":"2021","unstructured":"Dimitrakopoulou-Strauss A, Pan L, Sachpekidis C. Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future perspectives. Eur J Nucl Med Mol Imaging. 2021;48(1):21\u201339.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2673_CR17","doi-asserted-by":"crossref","unstructured":"Sommariva S, Caviglia G, Sambuceti G, Piana M. Mathematical models for FDG kinetics in cancer: A review. Metabolites. 2021;11(8).","DOI":"10.3390\/metabo11080519"},{"issue":"2","key":"2673_CR18","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s12253-019-00641-0","volume":"26","author":"K Kajary","year":"2020","unstructured":"Kajary K, Lengyel Z, Tokes AM, Kulka J, Dank M, Tokes T. Dynamic FDG-PET\/CT in the initial staging of primary breast cancer: clinicopathological correlations. Pathol Oncol Res. 2020;26(2):997\u20131006.","journal-title":"Pathol Oncol Res"},{"issue":"13","key":"2673_CR19","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3748\/wjg.v16.i13.1567","volume":"16","author":"PG Kele","year":"2010","unstructured":"Kele PG, van der Jagt EJ. Diffusion weighted imaging in the liver. World J Gastroenterol. 2010;16(13):1567\u201376.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2673_CR20","doi-asserted-by":"publisher","first-page":"14157","DOI":"10.1038\/s41598-019-50503-7","volume":"9","author":"CH Lo","year":"2019","unstructured":"Lo CH, Huang WY, Hsiang CW, Lee MS, Lin CS, Yang JF, et al. Prognostic significance of apparent diffusion coefficient in hepatocellular carcinoma patients treated with stereotactic ablative radiotherapy. Sci Rep. 2019;9(1):14157.","journal-title":"Sci Rep"},{"issue":"9","key":"2673_CR21","doi-asserted-by":"publisher","first-page":"5955","DOI":"10.1007\/s00330-023-09788-6","volume":"33","author":"A Surov","year":"2023","unstructured":"Surov A, Eger KI, Potratz J, Gottschling S, Wienke A, Jechorek D. Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors. Eur Radiol. 2023;33(9):5955\u201364.","journal-title":"Eur Radiol"},{"issue":"1","key":"2673_CR22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.14338\/IJPT-18-00011.1","volume":"5","author":"H Paganetti","year":"2018","unstructured":"Paganetti H. Proton relative biological Effectiveness \u2013 Uncertainties and opportunities. Int J Part Therapy. 2018;5(1):2\u201314.","journal-title":"Int J Part Therapy"},{"issue":"6","key":"2673_CR23","first-page":"538","volume":"23","author":"RA Brooks","year":"1982","unstructured":"Brooks RA. Alternative formula for glucose utilization using labeled Deoxyglucose. J Nucl Med. 1982;23(6):538\u20139.","journal-title":"J Nucl Med"},{"key":"2673_CR24","doi-asserted-by":"crossref","unstructured":"Chung YH, Hung TH, Yu CF, Tsai CK, Weng CC, Jhang F et al. Glycolytic plasticity of metastatic lung Cancer captured by noninvasive (18)F-FDG PET\/CT and serum (1)H-NMR analysis: an orthotopic murine model study. Metabolites. 2023;13(1).","DOI":"10.3390\/metabo13010110"},{"issue":"5","key":"2673_CR25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.21315\/mjms2017.24.5.11","volume":"24","author":"WN Arifin","year":"2017","unstructured":"Arifin WN, Zahiruddin WM. Sample size calculation in animal studies using resource equation approach. Malays J Med Sci. 2017;24(5):101\u20135.","journal-title":"Malays J Med Sci"},{"key":"2673_CR26","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/B0-12-443710-9\/00308-2","volume-title":"Encyclopedia of biological chemistry","author":"E Van Schaftingen","year":"2004","unstructured":"Van Schaftingen E. Hexokinases\/Glucokinases. In: Lennarz WJ, Lane MD, editors. Encyclopedia of biological chemistry. New York: Elsevier; 2004. pp. 372\u20137."},{"issue":"1","key":"2673_CR27","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12885-020-6617-x","volume":"20","author":"FP Fliedner","year":"2020","unstructured":"Fliedner FP, Engel TB, El-Ali HH, Hansen AE, Kjaer A. Diffusion weighted magnetic resonance imaging (DW-MRI) as a non-invasive, tissue cellularity marker to monitor cancer treatment response. BMC Cancer. 2020;20(1):134.","journal-title":"BMC Cancer"},{"issue":"4","key":"2673_CR28","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1002\/jmri.24042","volume":"38","author":"AD Cohen","year":"2013","unstructured":"Cohen AD, LaViolette PS, Prah M, Connelly J, Malkin MG, Rand SD, et al. Effects of perfusion on diffusion changes in human brain tumors. J Magn Reson Imaging. 2013;38(4):868\u201375.","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"2673_CR29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13014-020-01605-4","volume":"15","author":"JY Cheng","year":"2020","unstructured":"Cheng JY, Liu CM, Wang YM, Hsu HC, Huang EY, Huang TT, et al. Proton versus photon radiotherapy for primary hepatocellular carcinoma: a propensity-matched analysis. Radiat Oncol. 2020;15(1):159.","journal-title":"Radiat Oncol"},{"key":"2673_CR30","doi-asserted-by":"crossref","unstructured":"Sanford NN, Pursley J, Noe B, Yeap BY, Goyal L, Clark JW, et al. Protons versus photons for unresectable hepatocellular carcinoma. Liver Decompensation and Overall Survival; 2019.","DOI":"10.1016\/j.ijrobp.2019.01.076"},{"issue":"2","key":"2673_CR31","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.ijrobp.2009.02.030","volume":"76","author":"S Sugahara","year":"2010","unstructured":"Sugahara S, Oshiro Y, Nakayama H, Fukuda K, Mizumoto M, Abei M, et al. Proton beam therapy for large hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2010;76(2):460\u20136.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2673_CR32","doi-asserted-by":"crossref","unstructured":"Chen MF, Chen PT, Hsieh CC, Wang CC. Effect of proton therapy on tumor cell killing and immune microenvironment for hepatocellular carcinoma. Cells. 2023;12(2).","DOI":"10.3390\/cells12020332"},{"issue":"2","key":"2673_CR33","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jhep.2019.04.007","volume":"71","author":"DP Chen","year":"2019","unstructured":"Chen DP, Ning WR, Jiang ZZ, Peng ZP, Zhu LY, Zhuang SM, et al. Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma. J Hepatol. 2019;71(2):333\u201343.","journal-title":"J Hepatol"},{"issue":"5","key":"2673_CR34","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1007\/s11307-021-01602-3","volume":"23","author":"D Brasse","year":"2021","unstructured":"Brasse D, Burckel H, Marchand P, Rousseau M, Ouadi A, Vanstalle M, et al. Comparison of the [(18)F]-FDG and [(18)F]-FLT PET tracers in the evaluation of the preclinical proton therapy response in hepatocellular carcinoma. Mol Imaging Biol. 2021;23(5):724\u201332.","journal-title":"Mol Imaging Biol"},{"issue":"2","key":"2673_CR35","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00259-018-4153-6","volume":"46","author":"A Rahmim","year":"2019","unstructured":"Rahmim A, Lodge MA, Karakatsanis NA, Panin VY, Zhou Y, McMillan A, et al. Dynamic whole-body PET imaging: principles, potentials and applications. Eur J Nucl Med Mol Imaging. 2019;46(2):501\u201318.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"11","key":"2673_CR36","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1007\/s00259-020-04755-5","volume":"47","author":"C Wimberley","year":"2020","unstructured":"Wimberley C, Nguyen DL, Truillet C, Peyronneau MA, Gulhan Z, Tonietto M, et al. Longitudinal mouse-PET imaging: a reliable method for estimating binding parameters without a reference region or blood sampling. Eur J Nucl Med Mol Imaging. 2020;47(11):2589\u2013601.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"2673_CR37","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12880-021-00623-2","volume":"21","author":"J Wang","year":"2021","unstructured":"Wang J, Shao Y, Liu B, Wang X, Geist BK, Li X, et al. Dynamic (18)F-FDG PET imaging of liver lesions: evaluation of a two-tissue compartment model with dual blood input function. BMC Med Imaging. 2021;21(1):90.","journal-title":"BMC Med Imaging"},{"issue":"1","key":"2673_CR38","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40658-024-00619-1","volume":"11","author":"T Wang","year":"2024","unstructured":"Wang T, Deng Y, Wang S, He J, Wang S. Kinetic (18)F-FDG PET\/CT imaging of hepatocellular carcinoma: a dual input four-compartment model. EJNMMI Phys. 2024;11(1):20.","journal-title":"EJNMMI Phys"},{"key":"2673_CR39","doi-asserted-by":"crossref","unstructured":"Nuyts S, Bollen H, Ng SP, Corry J, Eisbruch A, Mendenhall WM et al. Proton therapy for squamous cell carcinoma of the head and neck: early clinical experience and current challenges. Cancers (Basel). 2022;14(11).","DOI":"10.3390\/cancers14112587"},{"issue":"1107","key":"2673_CR40","doi-asserted-by":"publisher","first-page":"20190601","DOI":"10.1259\/bjr.20190601","volume":"93","author":"H Thomas","year":"2020","unstructured":"Thomas H, Timmermann B. Paediatric proton therapy. Br J Radiol. 2020;93(1107):20190601.","journal-title":"Br J Radiol"},{"issue":"3","key":"2673_CR41","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.jcmgh.2020.10.010","volume":"11","author":"K Sasaki","year":"2021","unstructured":"Sasaki K, Nishina S, Yamauchi A, Fukuda K, Hara Y, Yamamura M, et al. Nanoparticle-Mediated delivery of 2-Deoxy-D-Glucose induces antitumor immunity and cytotoxicity in liver tumors in mice. Cell Mol Gastroenterol Hepatol. 2021;11(3):739\u201362.","journal-title":"Cell Mol Gastroenterol Hepatol"}],"container-title":["Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-025-02673-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13014-025-02673-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13014-025-02673-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:32:35Z","timestamp":1749216755000},"score":1,"resource":{"primary":{"URL":"https:\/\/ro-journal.biomedcentral.com\/articles\/10.1186\/s13014-025-02673-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2673"],"URL":"https:\/\/doi.org\/10.1186\/s13014-025-02673-0","relation":{},"ISSN":["1748-717X"],"issn-type":[{"value":"1748-717X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,6]]},"assertion":[{"value":"19 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We confirm that all methods were carried out in accordance with relevant guidelines and regulations. All animal proton irradiation and in vivo image acquisition protocols followed the animal guidelines established and approved by the Institutional Animal Care and Use Committee of Chang Gung Memorial Hospital, Taiwan (IACUC 2022010302). All the authors confirmed that the study was carried out in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"96"}}