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Although Gamma Knife radiosurgery (GKRS) treats craniopharyngiomas effectively, dedicated PCP-only GKRS outcome series are scarce. We evaluated tumor control and prognostic factors following GKRS for PCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 34 patients with histologically confirmed PCP who underwent GKRS at Beijing Tiantan Hospital (2002\u20132025) for residual\/recurrent disease after surgery. Primary endpoint was progression-free survival (PFS). Kaplan-Meier and Cox regression analyses identified prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-four patients (18 males, mean age 41.7\u2009\u00b1\u200913.6 years) received GKRS with median marginal dose 12\u00a0Gy to median tumor volume 1.10\u00a0cm\u00b3. With a median clinical follow-up of 54.10 months, the 1-, 3-, and 5-year PFS rates were 91.18%, 82.35%, and 73.53%, respectively. Overall survival was 94.12%. Disease control rate was 70.59%. Exploratory analysis with limited statistical power (10 events, EPV\u2009=\u20093.3) suggested potential associations between tumor volume\u2009&gt;\u20091.1\u00a0cm\u00b3 (HR\u2009=\u20093.86,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.061) and preoperative hypogonadism (HR\u2009=\u20093.94,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.058) with progression, though these findings require validation in larger cohorts. Visual deterioration was significantly higher in progression group (80.0% vs. 16.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Most patients (61.8%) maintained good quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GKRS provides effective long-term tumor control for postoperative PCP patients with acceptable safety profile. Exploratory hypothesis-generating analysis suggested potential associations between tumor volume and preoperative gonadal function status with progression, though these findings require validation in adequately powered studies. These findings support GKRS as a valuable treatment option in the multimodal management of PCP, particularly for patients with residual or recurrent disease after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13014-026-02875-0","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:55:03Z","timestamp":1783529703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gamma Knife treatment of papillary craniopharyngioma: a single-center study of tumor control and predictors of progression"],"prefix":"10.1186","volume":"21","author":[{"given":"Yi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuanyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"2875_CR1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1093\/neuonc\/nos142","volume":"14","author":"BE Zacharia","year":"2012","unstructured":"Zacharia BE, Bruce SS, Goldstein H, Malone HR, Neugut AI, Bruce JN. 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