{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:19:12Z","timestamp":1788805152829,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japanese Association for Acute Medicine","award":["2014-01"],"award-info":[{"award-number":["2014-01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Emerg Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Information on hyperoxemia among patients with trauma has been limited, other than traumatic brain injuries. This study aimed to elucidate whether hyperoxemia during resuscitation of patients with trauma was associated with unfavorable outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A post hoc analysis of a prospective observational study was carried out at 39 tertiary hospitals in 2016\u20132018 in adult patients with trauma and injury severity score (ISS) of &gt; 15. Hyperoxemia during resuscitation was defined as PaO<jats:sub>2<\/jats:sub> of \u2265 300 mmHg on hospital arrival and\/or 3 h after arrival. Intensive care unit (ICU)-free days were compared between patients with and without hyperoxemia. An inverse probability of treatment weighting (IPW) analysis was conducted to adjust patient characteristics including age, injury mechanism, comorbidities, vital signs on presentation, chest injury severity, and ISS. Analyses were stratified with intubation status at the emergency department (ED). The association between biomarkers and ICU length of stay were then analyzed with multivariate models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 295 severely injured trauma patients registered, 240 were eligible for analysis. Patients in the hyperoxemia group (<jats:italic>n<\/jats:italic> = 58) had shorter ICU-free days than those in the non-hyperoxemia group [17 (10\u201321) vs 23 (16\u201326), <jats:italic>p<\/jats:italic> &lt; 0.001]. IPW analysis revealed the association between hyperoxemia and prolonged ICU stay among patients not intubated at the ED [ICU-free days = 16 (12\u201322) vs 23 (19\u201326), <jats:italic>p<\/jats:italic> = 0.004], but not among those intubated at the ED [18 (9\u201320) vs 15 (8\u201323), <jats:italic>p<\/jats:italic> = 0.777]. In the hyperoxemia group, high inflammatory markers such as soluble RAGE and HMGB-1, as well as low lung-protective proteins such as surfactant protein D and Clara cell secretory protein, were associated with prolonged ICU stay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Hyperoxemia until 3 h after hospital arrival was associated with prolonged ICU stay among severely injured trauma patients not intubated at the ED.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>UMIN-CTR, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000022645\">UMIN000019588<\/jats:ext-link>. Registered on November 15, 2015.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13017-021-00363-2","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:03:07Z","timestamp":1619690587000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperoxemia during resuscitation of trauma patients and increased intensive care unit length of stay: inverse probability of treatment weighting analysis"],"prefix":"10.1186","volume":"16","author":[{"name":"on behalf of the Japanese Association for Acute Medicine (JAAM) Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis and Trauma (FORECAST) Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-8440","authenticated-orcid":false,"given":"Seitaro","family":"Fujishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Gando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizoh","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Kushimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Mayumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taka-aki","family":"Nakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasukazu","family":"Shiino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Tarui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ichiro","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotsugu","family":"Takuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Masuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Takeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ueyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Hifumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Otomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"issue":"7","key":"363_CR1","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1097\/CCM.0000000000000998","volume":"43","author":"HJF Helmerhorst","year":"2015","unstructured":"Helmerhorst HJF, Roos-Blom MJ, van Westerloo DJ, de Jonge E. Association between arterial hyperoxia and outcome in subsets of critical illness: a systematic review, meta-analysis, and meta-regression of cohort studies. Crit Care Med. 2015;43(7):1508\u201319. https:\/\/doi.org\/10.1097\/CCM.0000000000000998.","journal-title":"Crit Care Med."},{"issue":"11","key":"363_CR2","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1056\/NEJMe2000800","volume":"382","author":"DC Angus","year":"2020","unstructured":"Angus DC. Oxygen therapy for the critically ill. N Engl J Med. 2020;382(11):1054\u20136. https:\/\/doi.org\/10.1056\/NEJMe2000800.","journal-title":"N Engl J Med."},{"issue":"6","key":"363_CR3","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1186\/s13054-014-0711-x","volume":"18","author":"E Damiani","year":"2014","unstructured":"Damiani E, Adrario E, Girardis M, Romano R, Pelaia P, Singer M, et al. Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis. Crit Care. 2014;18(6):711. https:\/\/doi.org\/10.1186\/s13054-014-0711-x.","journal-title":"Crit Care."},{"key":"363_CR4","doi-asserted-by":"publisher","unstructured":"Barbateskovic M, Schj\u00f8rring OL, Russo Krauss S, Jakobsen JC, Meyhoff CS, Dahl RM, et al. Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit. Cochrane Database Syst Rev. 2019;2019(11):CD012631. https:\/\/doi.org\/10.1002\/14651858.CD012631.pub2.","DOI":"10.1002\/14651858.CD012631.pub2"},{"issue":"11","key":"363_CR5","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1164\/rccm.201904-0849OC","volume":"200","author":"E Palmer","year":"2019","unstructured":"Palmer E, Post B, Klapaukh R, Marra G, MacCallum NS, Brealey D, et al. The association between supraphysiologic arterial oxygen levels and mortality in critically ill patients a multicenter observational cohort study. Am J Respir Crit Care Med. 2019;200(11):1373\u201380. https:\/\/doi.org\/10.1164\/rccm.201904-0849OC.","journal-title":"Am J Respir Crit Care Med."},{"issue":"2","key":"363_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/MCC.0b013e3282f57552","volume":"14","author":"MN Diringer","year":"2008","unstructured":"Diringer MN. Hyperoxia: good or bad for the injured brain? Curr Opin Crit Care. 2008;14(2):167\u201371. https:\/\/doi.org\/10.1097\/MCC.0b013e3282f57552.","journal-title":"Curr Opin Crit Care."},{"key":"363_CR7","first-page":"435","volume":"101","author":"CM Tolias","year":"2004","unstructured":"Tolias CM, Reinert M, Seiler R, Gilman C, Scharf A, Bullock MR. Normobaric hyperoxia-induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study. J Neurol Surg. 2004;101:435\u201344.","journal-title":"J Neurol Surg."},{"issue":"20","key":"363_CR8","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1161\/CIRCULATIONAHA.117.032054","volume":"137","author":"BW Roberts","year":"2018","unstructured":"Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Pierce L, Donnino M, et al. Association between early hyperoxia exposure after resuscitation from cardiac arrest and neurological disability: prospective multicenter protocol-directed cohort study. Circulation. 2018;137(20):2114\u201324. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.032054.","journal-title":"Circulation."},{"key":"363_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.resuscitation.2018.04.008","volume":"127","author":"JK Patel","year":"2018","unstructured":"Patel JK, Kataya A, Parikh PB. Association between intra- and post-arrest hyperoxia on mortality in adults with cardiac arrest: a systematic review and meta-analysis. Resuscitation. 2018;127:83\u20138. https:\/\/doi.org\/10.1016\/j.resuscitation.2018.04.008.","journal-title":"Resuscitation."},{"issue":"6","key":"363_CR10","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1177\/0310057X1404200608","volume":"42","author":"ADJ Sutton","year":"2014","unstructured":"Sutton ADJ, Bailey M, Bellomo R, Eastwood GM, Pilcher DV. The association between early arterial oxygenation in the ICU and mortality following cardiac surgery. Anaesthesiol Intensive Care. 2014;42(6):730\u20135. https:\/\/doi.org\/10.1177\/0310057X1404200608.","journal-title":"Anaesthesiol Intensive Care."},{"issue":"15","key":"363_CR11","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1001\/jama.2016.11993","volume":"316","author":"M Girardis","year":"2016","unstructured":"Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit the oxygen-icu randomized clinical trial. JAMA. 2016;316(15):1583\u20139. https:\/\/doi.org\/10.1001\/jama.2016.11993.","journal-title":"JAMA."},{"issue":"10131","key":"363_CR12","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/S0140-6736(18)30479-3","volume":"391","author":"DK Chu","year":"2018","unstructured":"Chu DK, Kim LHY, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet. 2018;391(10131):1693\u2013705. https:\/\/doi.org\/10.1016\/S0140-6736(18)30479-3.","journal-title":"Lancet."},{"issue":"1","key":"363_CR13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00134-019-05857-x","volume":"46","author":"P Young","year":"2020","unstructured":"Young P, Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, et al. Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX). Intensive Care Med. 2020;46(1):17\u201326. https:\/\/doi.org\/10.1007\/s00134-019-05857-x.","journal-title":"Intensive Care Med."},{"issue":"3","key":"363_CR14","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S2213-2600(17)30046-2","volume":"5","author":"P Asfar","year":"2017","unstructured":"Asfar P, Schortgen F, Boisram\u00e9-Helms J, Charpentier J, Gu\u00e9rot E, Megarbane B, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017;5(3):180\u201390. https:\/\/doi.org\/10.1016\/S2213-2600(17)30046-2.","journal-title":"Lancet Respir Med."},{"issue":"3","key":"363_CR15","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/00003643-200003000-00004","volume":"17","author":"NA Watson","year":"2000","unstructured":"Watson NA, Beards SC, Altaf N, Kassner A, Jackson A. The effect of hyperoxia on cerebral blood flow: a study in healthy volunteers using magnetic resonance phase-contrast angiography. Eur J Anaesthesiol. 2000;17(3):152\u20139. https:\/\/doi.org\/10.1097\/00003643-200003000-00004.","journal-title":"Eur J Anaesthesiol."},{"issue":"3","key":"363_CR16","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1378\/chest.99.3.690","volume":"99","author":"K Reinhart","year":"1991","unstructured":"Reinhart K, Bloos F, K\u00f6nig F, Bredle D, Hannemann L. Reversible decrease of oxygen consumption by hyperoxia. Chest. 1991;99(3):690\u20134. https:\/\/doi.org\/10.1378\/chest.99.3.690.","journal-title":"Chest."},{"key":"363_CR17","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1016\/S0300-9572(11)70151-4","volume":"82","author":"MG Angelos","year":"2011","unstructured":"Angelos MG, Yeh ST, Aune SE. Post-cardiac arrest hyperoxia and mitochondrial function. Resuscitation. 2011;82:S48\u201351. https:\/\/doi.org\/10.1016\/S0300-9572(11)70151-4.","journal-title":"Resuscitation."},{"issue":"12","key":"363_CR18","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1097\/01.CCM.0000148231.04642.8D","volume":"32","author":"SE Sinclair","year":"2004","unstructured":"Sinclair SE, Altemeier WA, Matute-Bello G, Chi EY. Augmented lung injury due to interaction between hyperoxia and mechanical ventilation. Crit Care Med. 2004;32(12):2496\u2013501. https:\/\/doi.org\/10.1097\/01.CCM.0000148231.04642.8D.","journal-title":"Crit Care Med."},{"key":"363_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.rmed.2016.08.010","volume":"119","author":"F Dias-Freitas","year":"2016","unstructured":"Dias-Freitas F, Metelo-Coimbra C, Roncon-Albuquerque R. Molecular mechanisms underlying hyperoxia acute lung injury. Respir Med. 2016;119:23\u20138. https:\/\/doi.org\/10.1016\/j.rmed.2016.08.010.","journal-title":"Respir Med."},{"issue":"10","key":"363_CR20","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1089\/ars.2011.4377","volume":"17","author":"ML Locy","year":"2012","unstructured":"Locy ML, Rogers LK, Prigge JR, Schmidt EE, Arn\u00e9r ES, Tipple TE. Thioredoxin reductase inhibition elicits Nrf2-mediated responses in clara cells: implications for oxidant-induced lung injury. Antioxid Redox Signal. 2012;17(10):1407\u201316. https:\/\/doi.org\/10.1089\/ars.2011.4377.","journal-title":"Antioxid Redox Signal."},{"issue":"4","key":"363_CR21","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.ajem.2019.06.005","volume":"38","author":"JF Naylor","year":"2020","unstructured":"Naylor JF, Borgman MA, April MD, Hill GJ, Schauer SG. Normobaric hyperoxia in wartime pediatric trauma casualties. Am J Emerg Med. 2020;38(4):709\u201314. https:\/\/doi.org\/10.1016\/j.ajem.2019.06.005.","journal-title":"Am J Emerg Med."},{"issue":"1","key":"363_CR22","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1186\/s13054-020-03274-x","volume":"24","author":"JS Baekgaard","year":"2020","unstructured":"Baekgaard JS, Abback PS, Boubaya M, Moyer JD, Garrigue D, Raux M, et al. Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry. Crit Care. 2020;24(1):604. https:\/\/doi.org\/10.1186\/s13054-020-03274-x.","journal-title":"Crit Care."},{"issue":"9","key":"363_CR23","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1111\/jth.14931","volume":"18","author":"S Gando","year":"2020","unstructured":"Gando S, Shiraishi A, Wada T, Yamakawa K, Fujishima S, Saitoh D, et al. A multicenter prospective validation study on disseminated intravascular coagulation in trauma-induced coagulopathy. J Thromb Haemost. 2020;18(9):2232\u201344. https:\/\/doi.org\/10.1111\/jth.14931.","journal-title":"J Thromb Haemost."},{"issue":"5","key":"363_CR24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373\u201383. https:\/\/doi.org\/10.1016\/0021-9681(87)90171-8.","journal-title":"J Chronic Dis."},{"issue":"4","key":"363_CR25","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1177\/0962280215584401","volume":"26","author":"PC Austin","year":"2017","unstructured":"Austin PC, Stuart EA. The performance of inverse probability of treatment weighting and full matching on the propensity score in the presence of model misspecification when estimating the effect of treatment on survival outcomes. Stat Methods Med Res. 2017;26(4):1654\u201370. https:\/\/doi.org\/10.1177\/0962280215584401.","journal-title":"Stat Methods Med Res."},{"issue":"3","key":"363_CR26","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1080\/00273171.2011.568786","volume":"46","author":"PC Austin","year":"2011","unstructured":"Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivariate Behav Res. 2011;46(3):399\u2013424. https:\/\/doi.org\/10.1080\/00273171.2011.568786.","journal-title":"Multivariate Behav Res."},{"issue":"6","key":"363_CR27","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.amjsurg.2020.07.017","volume":"220","author":"R Yamamoto","year":"2020","unstructured":"Yamamoto R, Cestero RF, Muir MT, Jenkins DH, Eastridge BJ, Funabiki T, et al. Delays in surgical intervention and temporary hemostasis using resuscitative endovascular balloon occlusion of the aorta (REBOA): influence of time to operating room on mortality. Am J Surg. 2020;220(6):1485\u201391. https:\/\/doi.org\/10.1016\/j.amjsurg.2020.07.017.","journal-title":"Am J Surg."},{"key":"363_CR28","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1097\/01.ta.0000199961.02677.19","volume":"60","author":"DS Kauvar","year":"2006","unstructured":"Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma Inj Infect Crit Care. 2006;60:S3\u2013S11.","journal-title":"J Trauma Inj Infect Crit Care."},{"issue":"3","key":"363_CR29","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1097\/01.ta.0000197906.28846.87","volume":"61","author":"L Moore","year":"2006","unstructured":"Moore L, Lavoie A, Abdous B, Le Sage N, Liberman M, Bergeron E, et al. Unification of the revised trauma score. J Trauma Inj Infect Crit Care. 2006;61(3):718\u201322; discussion 722. https:\/\/doi.org\/10.1097\/01.ta.0000197906.28846.87.","journal-title":"J Trauma Inj Infect Crit Care."},{"issue":"12","key":"363_CR30","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1089\/neu.2009.0940","volume":"26","author":"DP Davis","year":"2009","unstructured":"Davis DP, Meade W, Sise MJ, Kennedy F, Simon F, Tominaga G, et al. Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma. 2009;26(12):2217\u201323. https:\/\/doi.org\/10.1089\/neu.2009.0940.","journal-title":"J Neurotrauma."},{"issue":"4","key":"363_CR31","doi-asserted-by":"publisher","first-page":"R177","DOI":"10.1186\/cc12856","volume":"17","author":"R Raj","year":"2013","unstructured":"Raj R, Bendel S, Reinikainen M, Kivisaari R, Siironen J, L\u00e5ng M, et al. Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care. 2013;17(4):R177. https:\/\/doi.org\/10.1186\/cc12856.","journal-title":"Crit Care."},{"issue":"5","key":"363_CR32","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/BF03008204","volume":"38","author":"B Bissonnette","year":"1991","unstructured":"Bissonnette B, Bickler PE, Gregory GA, Severinghaus JW. Intracranial pressure and brain redox balance in rabbits. Can J Anesth. 1991;38(5):654\u20139. https:\/\/doi.org\/10.1007\/BF03008204.","journal-title":"Can J Anesth."},{"issue":"6","key":"363_CR33","doi-asserted-by":"publisher","first-page":"L1066","DOI":"10.1152\/ajplung.90486.2008","volume":"295","author":"AB Fisher","year":"2008","unstructured":"Fisher AB, Beers MF. Hyperoxia and acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008;295(6):L1066. https:\/\/doi.org\/10.1152\/ajplung.90486.2008.","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"issue":"11","key":"363_CR34","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1056\/NEJMoa1916431","volume":"382","author":"L Barrot","year":"2020","unstructured":"Barrot L, Asfar P, Mauny F, Winiszewski H, Montini F, Badie J, et al. Liberal or conservative oxygen therapy for acute respiratory distress syndrome. N Engl J Med. 2020;382(11):999\u20131008. https:\/\/doi.org\/10.1056\/NEJMoa1916431.","journal-title":"N Engl J Med"},{"key":"363_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1749-6632.2000.tb05520.x","volume":"923","author":"F Broeckaert","year":"2000","unstructured":"Broeckaert F, Clippe A, Knoops B, Hermans C, Bernard A. Clara cell secretory protein (CC16): features as a peripheral lung biomarker. Ann NY Acad Sci. 2000;923:68\u201377. https:\/\/doi.org\/10.1111\/j.1749-6632.2000.tb05520.x.","journal-title":"Ann NY Acad Sci."},{"issue":"1","key":"363_CR36","doi-asserted-by":"publisher","first-page":"15393","DOI":"10.1038\/s41598-018-33828-7","volume":"8","author":"J Du","year":"2018","unstructured":"Du J, Abdel-Razek O, Shi Q, Hu F, Ding G, Cooney RN, et al. Surfactant protein D attenuates acute lung and kidney injuries in pneumonia-induced sepsis through modulating apoptosis, inflammation and NF-\u03baB signaling. Sci Rep. 2018;8(1):15393. https:\/\/doi.org\/10.1038\/s41598-018-33828-7.","journal-title":"Sci Rep."},{"issue":"1","key":"363_CR37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40635-019-0233-6","volume":"7","author":"FS Bezerra","year":"2019","unstructured":"Bezerra FS, Ramos CO, Castro TF, Ara\u00fajo NPDS, de Souza ABF, Bandeira ACB, et al. Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice. Intensive Care Med Exp. 2019;7(1):19. https:\/\/doi.org\/10.1186\/s40635-019-0233-6.","journal-title":"Intensive Care Med Exp."},{"issue":"4","key":"363_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175129","volume":"12","author":"T Kawaguchi","year":"2017","unstructured":"Kawaguchi T, Yanagihara T, Yokoyama T, Suetsugu-Ogata S, Hamada N, Harada-Ikeda C, et al. Probucol attenuates hyperoxia-induced lung injury in mice. PLOS ONE. 2017;12(4):e0175129. https:\/\/doi.org\/10.1371\/journal.pone.0175129.","journal-title":"PLOS ONE."},{"issue":"1","key":"363_CR39","doi-asserted-by":"publisher","first-page":"14268","DOI":"10.1038\/s41598-017-14667-4","volume":"7","author":"F Zhang","year":"2017","unstructured":"Zhang F, Su X, Huang G, Xin XF, Cao EH, Shi Y, et al. sRAGE alleviates neutrophilic asthma by blocking HMGB1\/RAGE signalling in airway dendritic cells. Sci Rep. 2017;7(1):14268. https:\/\/doi.org\/10.1038\/s41598-017-14667-4.","journal-title":"Sci Rep."},{"issue":"6","key":"363_CR40","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.4049\/jimmunol.165.6.2950","volume":"165","author":"E Abraham","year":"2000","unstructured":"Abraham E, Arcaroli J, Carmody A, Wang H, Tracey KJ. HMG-1 as a mediator of acute lung inflammation. J Immunol. 2000;165(6):2950\u20134. https:\/\/doi.org\/10.4049\/jimmunol.165.6.2950.","journal-title":"J Immunol."},{"issue":"1","key":"363_CR41","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s40560-020-00477-w","volume":"8","author":"R Yamamoto","year":"2020","unstructured":"Yamamoto R, Yoshizawa J. Oxygen administration in patients recovering from cardiac arrest: a narrative review. J Intensive Care. 2020;8(1):60. https:\/\/doi.org\/10.1186\/s40560-020-00477-w.","journal-title":"J Intensive Care."},{"issue":"9","key":"363_CR42","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.resuscitation.2014.05.021","volume":"85","author":"CH Wang","year":"2014","unstructured":"Wang CH, Chang WT, Huang CH, Tsai MS, Yu PH, Wang AY, et al. The effect of hyperoxia on survival following adult cardiac arrest: a systematic review and meta-analysis of observational studies. Resuscitation. 2014;85(9):1142\u20138. https:\/\/doi.org\/10.1016\/j.resuscitation.2014.05.021.","journal-title":"Resuscitation"}],"container-title":["World Journal of Emergency Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13017-021-00363-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13017-021-00363-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13017-021-00363-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:22:59Z","timestamp":1619691779000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjes.biomedcentral.com\/articles\/10.1186\/s13017-021-00363-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["363"],"URL":"https:\/\/doi.org\/10.1186\/s13017-021-00363-2","relation":{},"ISSN":["1749-7922"],"issn-type":[{"value":"1749-7922","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]},"assertion":[{"value":"24 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All collaborating hospitals obtained approval of their individual Institutional Review Board (IRB) for conducting research with human participants (approval number JAAM, 2014-01 from Japanese Association for Acute Medicine; approval number 014-0307 from Hokkaido University Graduate School of Medicine, head institute of the FORECAST group; and approval number 20150056 from the Keio University School of Medicine Keio, institute of the corresponding author).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Dr. Fujishima reports grants and personal fees from Asahi Kasei Japan Co.; grants from Shionogi Co, Ltd.; grants from Chugai Pharmaceuticals Co., Ltd.; grants from Otsuka Pharmaceutical Co., Ltd.; grants from Teijin Pharma, Ltd.; grants from Pfizer Inc.; grants from Tsumura & Co.; grants from Astellas Pharma Inc.; and personal fees from Takeda Pharmaceutical Co., Ltd., outside the submitted work. Dr. Gando reports personal fees from ASAHIKASEI PHARMA AMERICA, personal fees from ASAHIKASEI PHARMA JAPAN, and personal fees from GRIFOLS, outside the submitted work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19"}}