{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:44:28Z","timestamp":1783651468044,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13018-017-0564-5","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T12:41:31Z","timestamp":1493210491000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prospective clinical and radiographic evaluation of an allogeneic bone matrix containing stem cells (Trinity Evolution\u00ae Viable Cellular Bone Matrix) in patients undergoing two-level anterior cervical discectomy and fusion"],"prefix":"10.1186","volume":"12","author":[{"given":"Timothy A.","family":"Peppers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Bullard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed S.","family":"Vanichkachorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott K.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik I.","family":"Waldorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent L.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Ryaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Linovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"issue":"5","key":"564_CR1","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3340\/jkns.2012.52.5.452","volume":"52","author":"S-B Lee","year":"2012","unstructured":"Lee S-B, Cho K-S, Kim J-Y, Yoo D-S, Lee T-G, Huh P-W. Hybrid surgery of multilevel cervical degenerative disc disease: review of literature and clinical results. J Korean Neurosurg Soc. 2012;52(5):452\u20138.","journal-title":"J Korean Neurosurg Soc"},{"issue":"9","key":"564_CR2","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1097\/00007632-199905010-00004","volume":"24","author":"GJ Martin","year":"1999","unstructured":"Martin GJ, Haid RW, MacMillan M, Rodts GE, Berkman R. Anterior cervical discectomy with freeze dried fibula allograft. Overview of 317 cases and literature review. Spine. 1999;24(9):852\u20138.","journal-title":"Spine"},{"issue":"3","key":"564_CR3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/02688690410001732643","volume":"18","author":"AP Nirala","year":"2004","unstructured":"Nirala AP, Husain M, Vatsal DK. A retrospective study of multiple interbody grafting and long segment strut grafting following multilevel anterior cervical decompression. British J Neurosurg. 2004;18(3):227\u201332.","journal-title":"British J. Neurosurg."},{"issue":"6","key":"564_CR4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s00586-003-0667-z","volume":"13","author":"P Suchomel","year":"2004","unstructured":"Suchomel P, Barsa P, Buchvald P, Svobodnik A, Vanickova E. Autologous versus allogenic bone grafts in instrumented anterior cervical discectomy and fusion: a prospective study with respect to bone union pattern. Eur Spine J. 2004;13(6):510\u20135.","journal-title":"Eur Spine J"},{"issue":"7","key":"564_CR5","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.spinee.2013.07.474","volume":"14","author":"A Veeravagu","year":"2014","unstructured":"Veeravagu A, Cole T, Jiang B, Ratliff JK. Revision rates and complication incidence in single- and multilevel anterior cervical discectomy and fusion procedures: an administrative database study. Spine J. 2014;14(7):1125\u201331.","journal-title":"Spine J"},{"issue":"1","key":"564_CR6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/00007632-200001010-00009","volume":"25","author":"JC Wang","year":"2000","unstructured":"Wang JC, McDonough PW, Endow KK, Delamarter RB. Increased fusion rates with cervical plating for two-level anterior cervical discectomy and fusion. Spine. 2000;25(1):41\u20135.","journal-title":"Spine"},{"issue":"20","key":"564_CR7","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1097\/00007632-200010150-00011","volume":"25","author":"SD Glassman","year":"2000","unstructured":"Glassman SD, Anagnost SC, Parker A, Burke D, Johnson JR, Dimar JR. The effect of cigarette smoking and smoking cessation on spinal fusion. Spine. 2000;25(20):2608\u201315.","journal-title":"Spine"},{"issue":"5","key":"564_CR8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2106\/00004623-200105000-00004","volume":"83-A","author":"AS Hilibrand","year":"2001","unstructured":"Hilibrand AS, Fye MA, Emery SE, Palumbo MA, Bohlman HH. Impact of smoking on the outcome of anterior cervical arthrodesis with interbody or strut-grafting. JBJS. 2001;83-A(5):668\u201373.","journal-title":"JBJS"},{"key":"564_CR9","first-page":"s571","volume":"25","author":"AR Vaccaro","year":"2002","unstructured":"Vaccaro AR. The role of the osteoconductive scaffold in synthetic bone graft. Orthopedics. 2002;25:s571\u2013578.","journal-title":"Orthopedics"},{"key":"564_CR10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1177\/1938640010369638","volume":"3","author":"SM Rush","year":"2010","unstructured":"Rush SM. Trinity Evolution: mesenchymal stem cell allografting in foot and ankle surgery. Foot Ankle Specialist. 2010;3:140\u20133.","journal-title":"Foot Ankle Specialist"},{"issue":"7","key":"564_CR11","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1007\/s00586-016-4414-7","volume":"25","author":"J Vanichkachorn","year":"2016","unstructured":"Vanichkachorn J, Peppers T, Bullard D, Stanley SK, Linovitz RJ, Ryaby JT. A prospective clinical and radiographic 12-month outcome study of patients undergoing single-level anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (Trinity Evolution\u00ae) with a comparison to historical controls. Eur Spine J. 2016;25(7):2233\u20138.","journal-title":"Eur Spine J"},{"key":"564_CR12","doi-asserted-by":"publisher","first-page":"E221","DOI":"10.1097\/00007632-200406010-00022","volume":"29","author":"CA Reitman","year":"2004","unstructured":"Reitman CA, Hipp JA, Nguyen L, Esses SI. Changes in segmental intervertebral motion adjacent to cervical arthrodesis. A prospective study. Spine. 2004;29:E221\u20136.","journal-title":"Spine"},{"key":"564_CR13","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1097\/01.brs.0000147740.69525.58","volume":"29","author":"CA Reitman","year":"2004","unstructured":"Reitman CA, Mauro KM, Nguyen L, Ziegler JM, Hipp JA. Intervertebral motion between flexion and extension in asymptomatic individuals. Spine. 2004;29:2832\u201343.","journal-title":"Spine"},{"key":"564_CR14","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s00586-008-0869-5","volume":"18","author":"K Topuz","year":"2009","unstructured":"Topuz K, Colak A, Kaya S, et al. Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up. Eur Spine J. 2009;18:238\u201343.","journal-title":"Eur Spine J."},{"key":"564_CR15","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00264-014-2610-9","volume":"39","author":"Y Xie","year":"2015","unstructured":"Xie Y, Li H, Yuan J, et al. A prospective randomized comparison of PEEK cage containing calcium sulphate or demineralized bone matrix with autograft in anterior cervical interbody fusion. Int Orthop. 2015;39:1129\u201336.","journal-title":"Int Orthop."},{"issue":"6","key":"564_CR16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3171\/SPI\/2008\/8\/6\/529","volume":"8","author":"LM Tumialan","year":"2008","unstructured":"Tumialan LM, Pan J, Rodts GE, et al. The safety and efficacy of anterior cervical discectomy and fusion with polyetheretherketone spacer and recombinant human bone morphogenetic protein-2: a review of 200 patients. J Neurosurg Spine. 2008;8(6):529\u201335.","journal-title":"J Neurosurg Spine"},{"issue":"5","key":"564_CR17","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3171\/spi.2005.2.5.0521","volume":"2","author":"M Boakye","year":"2005","unstructured":"Boakye M, Mummaneni PV, Garrett M, et al. Anterior cervical discectomy and fusion involving polyetheretherketone spacer and bone morphogenetic protein. J Neurosurg Spine. 2005;2(5):521\u20135.","journal-title":"J Neurosurg Spine"},{"key":"564_CR18","unstructured":"Lovasik BP, Holland CM, Howard BM et al. Anterior cervical discectomy and fusion: comparison of fusion, dysphagia, and complication rates between recombinant human bone morphogenetic protein-2 and beta-tricalcium phosphate. World Neurosurg. Epub ahead of print."},{"issue":"Suppl 2","key":"564_CR19","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.injury.2011.06.015","volume":"42","author":"R Dimitriou","year":"2011","unstructured":"Dimitriou R, Mataliotakis GI, Angoules AG, et al. Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review. Injury. 2011;42 Suppl 2:S3\u201315.","journal-title":"Injury."},{"key":"564_CR20","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1097\/00007632-198912000-00009","volume":"14","author":"LT Kurtz","year":"1989","unstructured":"Kurtz LT, Garfin SR, Booth RE. Harvesting autogenous iliac bone grafts. A review of complications and techniques. Spine. 1989;14:1324\u201331.","journal-title":"Spine"},{"key":"564_CR21","first-page":"163","volume":"8","author":"AR Gupta","year":"2001","unstructured":"Gupta AR, Shah NR, Patel TC, et al. Perioperative and long-term complications of iliac crest bone graft harvesting for spinal surgery: a quantitative review of the literature. Int Med J. 2001;8:163\u20136.","journal-title":"Int Med J."},{"issue":"2","key":"564_CR22","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3171\/jns.1998.88.2.0255","volume":"88","author":"PD Sawin","year":"1998","unstructured":"Sawin PD, Traynelis VC, Menezes AH. A comparative analysis of fusion rates and donor site morbidity for autogeneic rib and iliac crest bone grafts in posterior cervical fusions. J Neurosurg. 1998;88(2):255\u201365.","journal-title":"J Neurosurg"},{"key":"564_CR23","first-page":"667","volume":"71B","author":"BN Summers","year":"1989","unstructured":"Summers BN, Eisenstein SM. Donor site pain from the ilium: a complication of the lumbar spine fusion. J Bone Joint Surg. 1989;71B:667\u201380.","journal-title":"J Bone Joint Surg."}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-017-0564-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T12:42:00Z","timestamp":1493210520000},"score":1,"resource":{"primary":{"URL":"http:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-017-0564-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,26]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["564"],"URL":"https:\/\/doi.org\/10.1186\/s13018-017-0564-5","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,26]]},"article-number":"67"}}