{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:12:14Z","timestamp":1788282734615,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Grant-Aid-Program of Seoul National University Hospital","award":["06 2015 3460"],"award-info":[{"award-number":["06 2015 3460"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13018-019-1246-2","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T14:03:15Z","timestamp":1561471395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of a poloxamer-based thermosensitive gel on rotator cuff repair in a rabbit model: a controlled laboratory study"],"prefix":"10.1186","volume":"14","author":[{"given":"Tae In","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whanik","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Young","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunseok","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-350X","authenticated-orcid":false,"given":"Sae Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"1246_CR1","unstructured":"Risberg B. Adhesions: preventive strategies. Eur J Surg Suppl. 1997;(577):32\u20139."},{"issue":"11","key":"1246_CR2","doi-asserted-by":"publisher","first-page":"e0143359","DOI":"10.1371\/journal.pone.0143359","volume":"10","author":"H Kang","year":"2015","unstructured":"Kang H, Chung YS, Kim SW, Choi GJ, Kim BG, Park SW, Seok JW, Hong J. Effect of temperature-sensitive poloxamer solution\/gel material on pericardial adhesion prevention: supine rabbit model study mimicking cardiac surgery. PLoS One. 2015;10(11):e0143359.","journal-title":"PLoS One"},{"issue":"1","key":"1246_CR3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4055\/cios.2011.3.1.55","volume":"3","author":"CH Oh","year":"2011","unstructured":"Oh CH, Oh JH, Kim SH, Cho JH, Yoon JP, Kim JY. Effectiveness of subacromial anti-adhesive agent injection after arthroscopic rotator cuff repair: prospective randomized comparison study. Clin Orthop Surg. 2011;3(1):55\u201361.","journal-title":"Clin Orthop Surg"},{"issue":"2","key":"1246_CR4","doi-asserted-by":"publisher","first-page":"230949901771890","DOI":"10.1177\/2309499017718908","volume":"25","author":"JY Jeong","year":"2017","unstructured":"Jeong JY, Chung PK, Yoo JC. Effect of sodium hyaluronate\/carboxymethyl cellulose (Guardix-sol) on retear rate and postoperative stiffness in arthroscopic rotator cuff repair patients: a prospective cohort study. J Orthop Surg (Hong Kong). 2017;25(2):2309499017718908.","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"1246_CR5","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.msec.2016.05.088","volume":"68","author":"ACS Akkari","year":"2016","unstructured":"Akkari ACS, Papini JZB, Garcia GK, Franco MKKD, Cavalcanti LP, Gasperini A, Alkschbirs MI, Yokaichyia F, de Paula E, Tofoli GR, de Araujo DR. Poloxamer 407\/188 binary thermosensitive hydrogels as delivery systems for infiltrative local anesthesia: physico-chemical characterization and pharmacological evaluation. Mater Sci Eng C Mater Biol Appl. 2016;68:299\u2013307.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"Pt B","key":"1246_CR6","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.ejpb.2015.05.017","volume":"97","author":"L Klouda","year":"2015","unstructured":"Klouda L. Thermoresponsive hydrogels in biomedical applications: a seven-year update. Eur J Pharm Biopharm. 2015;97(Pt B):338\u201349.","journal-title":"Eur J Pharm Biopharm"},{"issue":"7","key":"1246_CR7","doi-asserted-by":"publisher","first-page":"15516","DOI":"10.1016\/j.matpr.2018.04.158","volume":"5","author":"P Zarrintaj","year":"2018","unstructured":"Zarrintaj P, Ahmadi Z, Reza Saeb M, Mozafari M. Poloxamer-based stimuli-responsive biomaterials. Mater Today Proc. 2018;5(7):15516\u201323.","journal-title":"Mater Today Proc"},{"issue":"29","key":"1246_CR8","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1016\/j.biomaterials.2009.05.084","volume":"30","author":"CZ Wei","year":"2009","unstructured":"Wei CZ, Hou CL, Gu QS, Jiang LX, Zhu B, Sheng AL. A thermosensitive chitosan-based hydrogel barrier for post-operative adhesions\u2019 prevention. Biomaterials. 2009;30(29):5534\u201340.","journal-title":"Biomaterials"},{"issue":"5","key":"1246_CR9","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1067\/mse.2002.126760","volume":"11","author":"HK Uhthoff","year":"2002","unstructured":"Uhthoff HK, Seki M, Backman DS, Trudel G, Himori K, Sano H. Tensile strength of the supraspinatus after reimplantation into a bony trough: an experimental study in rabbits. J Shoulder Elb Surg. 2002;11(5):504\u20139.","journal-title":"J Shoulder Elb Surg"},{"issue":"3","key":"1246_CR10","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3340\/jkns.2016.59.3.250","volume":"59","author":"JW Park","year":"2016","unstructured":"Park JW, Bak KH, Cho TK, Chun HJ, Ryu JI. Effects of a temperature-sensitive, anti-adhesive agent on the reduction of adhesion in a rabbit laminectomy model. J Korean Neurosurg Soc. 2016;59(3):250\u20138.","journal-title":"J Korean Neurosurg Soc"},{"issue":"12","key":"1246_CR11","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1007\/s10856-014-5292-3","volume":"25","author":"JD Cabral","year":"2014","unstructured":"Cabral JD, Roxburgh M, Shi Z, Liu L, McConnell M, Williams G, Evans N, Hanton LR, Simpson J, Moratti SC, Robinson BH, Wormald PJ, Robinson S. Synthesis, physiochemical characterization, and biocompatibility of a chitosan\/dextran-based hydrogel for postsurgical adhesion prevention. J Mater Sci Mater Med. 2014;25(12):2743\u201356.","journal-title":"J Mater Sci Mater Med"},{"issue":"11","key":"1246_CR12","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1007\/s00586-014-3438-0","volume":"23","author":"CB Li","year":"2014","unstructured":"Li CB, Wang H, Liu HF, Yin JB, Cui L, Chen ZG. The prevention effect of poly (l-glutamic acid)\/chitosan on spinal epidural fibrosis and peridural adhesion in the post-laminectomy rabbit model. Eur Spine J. 2014;23(11):2423\u201331.","journal-title":"Eur Spine J"},{"issue":"1","key":"1246_CR13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/mt.2008.220","volume":"17","author":"KA Howard","year":"2009","unstructured":"Howard KA, Paludan SR, Behlke MA, Besenbacher F, Deleuran B, Kjems J. Chitosan\/siRNA nanoparticle\u2013mediated TNF-\u03b1 knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol Ther. 2009;17(1):162\u20138.","journal-title":"Mol Ther"},{"issue":"2","key":"1246_CR14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.foodhyd.2010.03.003","volume":"25","author":"W Xia","year":"2011","unstructured":"Xia W, Liu P, Zhang J, Chen J. Biological activities of chitosan and chitooligosaccharides. Food Hydrocoll. 2011;25(2):170\u20139.","journal-title":"Food Hydrocoll"},{"issue":"14","key":"1246_CR15","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1016\/S0142-9612(01)00418-5","volume":"23","author":"S Matsuda","year":"2002","unstructured":"Matsuda S, Se N, Iwata H, Ikada Y. Evaluation of the antiadhesion potential of UV cross-linked gelatin films in a rat abdominal model. Biomaterials. 2002;23(14):2901\u20138.","journal-title":"Biomaterials"},{"issue":"4","key":"1246_CR16","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.jse.2013.07.054","volume":"23","author":"JH Oh","year":"2014","unstructured":"Oh JH, Chung SW, Kim SH, Chung JY, Kim JY. 2013 Neer Award: effect of the adipose-derived stem cell for the improvement of fatty degeneration and rotator cuff healing in rabbit model. J Shoulder Elb Surg. 2014;23(4):445\u201355.","journal-title":"J Shoulder Elb Surg"},{"issue":"10","key":"1246_CR17","first-page":"2091","volume":"46","author":"JP Watkins","year":"1985","unstructured":"Watkins JP, Auer J, Gay S, Morgan S. Healing of surgically created defects in the equine superficial digital flexor tendon: collagen-type transformation and tissue morphologic reorganization. Am J Vet Res. 1985;46(10):2091\u20136.","journal-title":"Am J Vet Res"},{"issue":"3","key":"1246_CR18","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jse.2009.01.013","volume":"18","author":"J Ide","year":"2009","unstructured":"Ide J, Kikukawa K, Hirose J, Iyama K, Sakamoto H, Fujimoto T, Mizuta H. The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon. J Shoulder Elb Surg. 2009;18(3):391\u20138.","journal-title":"J Shoulder Elb Surg"},{"issue":"11","key":"1246_CR19","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s10856-016-5773-7","volume":"27","author":"SJ Shin","year":"2016","unstructured":"Shin SJ, Lee JH, So J, Min K. Anti-adhesive effect of poloxamer-based thermo-sensitive sol-gel in rabbit laminectomy model. J Mater Sci Mater Med. 2016;27(11):162.","journal-title":"J Mater Sci Mater Med"},{"issue":"2","key":"1246_CR20","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1053\/jhsu.2001.22524","volume":"26","author":"GY Ozgenel","year":"2001","unstructured":"Ozgenel GY, Samli B, Ozcan M. Effects of human amniotic fluid on peritendinous adhesion formation and tendon healing after flexor tendon surgery in rabbits. J Hand Surg Am. 2001;26(2):332\u20139.","journal-title":"J Hand Surg Am"},{"key":"1246_CR21","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.actbio.2016.07.009","volume":"43","author":"RM Raftery","year":"2016","unstructured":"Raftery RM, Woods B, Marques AL, Moreira-Silva J, Silva TH, Cryan SA, Reis RL, O'Brien FJ. Multifunctional biomaterials from the sea: assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality. Acta Biomater. 2016;43:160\u20139.","journal-title":"Acta Biomater"},{"issue":"3","key":"1246_CR22","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/S0736-0266(00)90016-0","volume":"19","author":"N Fukui","year":"2001","unstructured":"Fukui N, Fukuda A, Kojima K, Nakajima K, Oda H, Nakamura K. Suppression of fibrous adhesion by proteoglycan decorin. J Orthop Res. 2001;19(3):456\u201362.","journal-title":"J Orthop Res"},{"issue":"1","key":"1246_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13018-016-0375-0","volume":"11","author":"S Zhao","year":"2016","unstructured":"Zhao S, Sun Y, Li X, Wang J, Yan L, Chen H, Wang D, Dai J, He J. Reduction of intraarticular adhesion of knee by local application of rapamycin in rabbits via inhibition of fibroblast proliferation and collagen synthesis. J Orthop Surg Res. 2016;11(1):45.","journal-title":"J Orthop Surg Res"},{"key":"1246_CR24","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jconrel.2017.06.020","volume":"261","author":"W Wu","year":"2017","unstructured":"Wu W, Cheng R, das Neves J, Tang J, Xiao J, Ni Q, Liu X, Pan G, Li D, Cui W, Sarmento B. Advances in biomaterials for preventing tissue adhesion. J Control Release. 2017;261:318\u201336.","journal-title":"J Control Release"},{"issue":"3","key":"1246_CR25","doi-asserted-by":"publisher","first-page":"4598","DOI":"10.3892\/mmr.2015.4007","volume":"12","author":"Q Chen","year":"2015","unstructured":"Chen Q, Lu H, Yang H. Chitosan prevents adhesion during rabbit flexor tendon repair via the sirtuin 1 signaling pathway. Mol Med Rep. 2015;12(3):4598\u2013603.","journal-title":"Mol Med Rep"},{"issue":"6","key":"1246_CR26","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1007\/s11605-011-1819-9","volume":"16","author":"C Brochhausen","year":"2012","unstructured":"Brochhausen C, Schmitt VH, Planck CN, Rajab TK, Hollemann D, Tapprich C, Kramer B, Wallwiener C, Hierlemann H, Zehbe R, Planck H, Kirkpatrick CJ. Current strategies and future perspectives for intraperitoneal adhesion prevention. J Gastrointest Surg. 2012;16(6):1256\u201374.","journal-title":"J Gastrointest Surg"},{"issue":"6","key":"1246_CR27","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/humupd\/7.6.547","volume":"7","author":"GS diZerega","year":"2001","unstructured":"diZerega GS, Campeau JD. Peritoneal repair and post-surgical adhesion formation. Hum Reprod Update. 2001;7(6):547\u201355.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"1246_CR28","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.jse.2015.08.035","volume":"25","author":"SH Kim","year":"2016","unstructured":"Kim SH, Kim J, Choi YE, Lee HR. Healing disturbance with suture bridge configuration repair in rabbit rotator cuff tear. J Shoulder Elb Surg. 2016;25(3):478\u201386.","journal-title":"J Shoulder Elb Surg"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-019-1246-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13018-019-1246-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-019-1246-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T23:10:30Z","timestamp":1592953830000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-019-1246-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1246"],"URL":"https:\/\/doi.org\/10.1186\/s13018-019-1246-2","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,25]]},"assertion":[{"value":"22 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was performed at Seoul National University Hospital under permission of Institutional Animal Care and Use Committee at the Clinical Research Institute (IACUC no. 15-0010-C1A0).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"190"}}