{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:53:20Z","timestamp":1793962400082,"version":"4.8.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Mounting evidence indicates that circular RNAs (circRNAs) participate in the occurrence and development of various diseases, including osteoarthritis (OA). However, the effects and molecular mechanism of circ_0128846 in OA have not been reported.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The expression levels of circ_0128846, microRNA-127-5p (miR-127-5p), and nicotinamide phosphoribosyltransferase (NAMPT) were determined by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot assay. Cell viability was determined by Cell Counting Kit-8 (CCK-8) assay. Cell apoptosis was examined by flow cytometry and western blot assay. Inflammatory response and cartilage extracellular matrix (ECM) degradation were evaluated by western blot assay. The relationship between miR-127-5p and circ_0128846 or NAMPT was predicted by bioinformatics tools and verified by dual-luciferase reporter and RNA Immunoprecipitation (RIP) assays.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Circ_0128846 and NAMPT were upregulated and miR-127-5p was downregulated in OA cartilage tissues. Knockdown of circ_0128846 increased cell viability and inhibited apoptosis, inflammation and ECM degradation in OA chondrocytes, while these effects were reversed by downregulating miR-127-5p. Moreover, circ_0128846 positively regulated NAMPT expression by sponging miR-127-5p. Furthermore, miR-127-5p promoted cell viability and suppressed apoptosis, inflammation, and ECM degradation in OA chondrocytes by directly targeting NAMPT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Circ_0128846 knockdown might inhibit the progression of OA by upregulating miR-127-5p and downregulating NAMPT, offering a new insight into the potential application of circ_0128846 in OA treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-021-02428-z","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T05:04:26Z","timestamp":1620709466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Circular RNA circ_0128846 promotes the progression of osteoarthritis by regulating miR-127-5p\/NAMPT axis"],"prefix":"10.1186","volume":"16","author":[{"given":"Chao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"issue":"12","key":"2428_CR1","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/j.drudis.2016.08.011","volume":"21","author":"C Vinatier","year":"2016","unstructured":"Vinatier C, Merceron C, Guicheux J. Osteoarthritis: from pathogenic mechanisms and recent clinical developments to novel prospective therapeutic options. Drug discovery today. 2016;21(12):1932\u20137. https:\/\/doi.org\/10.1016\/j.drudis.2016.08.011.","journal-title":"Drug discovery today."},{"issue":"4","key":"2428_CR2","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3390\/jdb3040177","volume":"3","author":"H Akkiraju","year":"2015","unstructured":"Akkiraju H, Nohe A. Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration. J Dev Biol. 2015;3(4):177\u201392. https:\/\/doi.org\/10.3390\/jdb3040177.","journal-title":"J Dev Biol."},{"key":"2428_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.actbio.2019.03.010","volume":"93","author":"S Brown","year":"2019","unstructured":"Brown S, Kumar S, Sharma B. Intra-articular targeting of nanomaterials for the treatment of osteoarthritis. Acta Biomater. 2019;93:239\u201357. https:\/\/doi.org\/10.1016\/j.actbio.2019.03.010.","journal-title":"Acta Biomater."},{"issue":"1","key":"2428_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33\u201342. https:\/\/doi.org\/10.1038\/nrrheum.2010.196.","journal-title":"Nat Rev Rheumatol."},{"issue":"5","key":"2428_CR5","doi-asserted-by":"publisher","first-page":"312","DOI":"10.2174\/1389202916666150707161554","volume":"16","author":"L Chen","year":"2015","unstructured":"Chen L, Huang C, Wang X, Shan G. Circular RNAs in eukaryotic cells. Current Genomics. 2015;16(5):312\u20138. https:\/\/doi.org\/10.2174\/1389202916666150707161554.","journal-title":"Current Genomics."},{"issue":"7441","key":"2428_CR6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333\u20138. https:\/\/doi.org\/10.1038\/nature11928.","journal-title":"Nature."},{"issue":"6","key":"2428_CR7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/jmedgenet-2016-103758","volume":"53","author":"Y Chen","year":"2016","unstructured":"Chen Y, Li C, Tan C, Liu X. Circular RNAs: a new frontier in the study of human diseases. Journal of medical genetics. 2016;53(6):359\u201365. https:\/\/doi.org\/10.1136\/jmedgenet-2016-103758.","journal-title":"Journal of medical genetics."},{"issue":"4","key":"2428_CR8","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/bib\/bbw045","volume":"18","author":"X Meng","year":"2017","unstructured":"Meng X, Li X, Zhang P, Wang J, Zhou Y, Chen M. Circular RNA: an emerging key player in RNA world. Briefings in bioinformatics. 2017;18(4):547\u201357. https:\/\/doi.org\/10.1093\/bib\/bbw045.","journal-title":"Briefings in bioinformatics."},{"issue":"6","key":"2428_CR9","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1136\/annrheumdis-2018-214786","volume":"78","author":"S Shen","year":"2019","unstructured":"Shen S, Wu Y, Chen J, Xie Z, Huang K, Wang G, et al. CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene. Ann Rheum Dis. 2019;78(6):826\u201336. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214786.","journal-title":"Ann Rheum Dis."},{"issue":"4","key":"2428_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/s41419-020-2447-7","volume":"11","author":"H Zhu","year":"2020","unstructured":"Zhu H, Hu Y, Wang C, Zhang X, He D. CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-alpha in TMJ osteoarthritis. Cell Death Dis. 2020;11(4):284. https:\/\/doi.org\/10.1038\/s41419-020-2447-7.","journal-title":"Cell Death Dis."},{"issue":"7","key":"2428_CR11","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.26355\/eurrev_202004_20805","volume":"24","author":"JL Ni","year":"2020","unstructured":"Ni JL, Dang XQ, Shi ZB. CircPSM3 inhibits the proliferation and differentiation of OA chondrocytes by targeting miRNA-296-5p. European Rev Med Pharmacological Sciences. 2020;24(7):3467\u201375. https:\/\/doi.org\/10.26355\/eurrev_202004_20805.","journal-title":"European Rev Med Pharmacological Sciences."},{"issue":"10","key":"2428_CR12","doi-asserted-by":"publisher","first-page":"6554","DOI":"10.1111\/jcmm.14400","volume":"23","author":"Z Li","year":"2019","unstructured":"Li Z, Yuan B, Pei Z, Zhang K, Ding Z, Zhu S, et al. Circ_0136474 and MMP-13 suppressed cell proliferation by competitive binding to miR-127-5p in osteoarthritis. J Cell Mol Med. 2019;23(10):6554\u201364. https:\/\/doi.org\/10.1111\/jcmm.14400.","journal-title":"J Cell Mol Med"},{"issue":"7441","key":"2428_CR13","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","volume":"495","author":"TB Hansen","year":"2013","unstructured":"Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384\u20138. https:\/\/doi.org\/10.1038\/nature11993.","journal-title":"Nature."},{"key":"2428_CR14","first-page":"161","volume":"2","author":"AM Ardekani","year":"2010","unstructured":"Ardekani AM, Naeini MM. The role of microRNAs in human diseases. Avicenna J Medi Biotechnology. 2010;2:161.","journal-title":"Avicenna J Medi Biotechnology."},{"issue":"21","key":"2428_CR15","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.1242\/dev.02073","volume":"132","author":"I Alvarez-Garcia","year":"2005","unstructured":"Alvarez-Garcia I, Miska EA. MicroRNA functions in animal development and human disease. Development. 2005;132(21):4653\u201362. https:\/\/doi.org\/10.1242\/dev.02073.","journal-title":"Development."},{"issue":"1","key":"2428_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/147323001103900101","volume":"39","author":"C Yu","year":"2011","unstructured":"Yu C, Chen W, Wang X. MicroRNA in osteoarthritis. J International Med Res. 2011;39(1):1\u20139. https:\/\/doi.org\/10.1177\/147323001103900101.","journal-title":"J International Med Res"},{"issue":"1","key":"2428_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/bmb\/ldaa002","volume":"133","author":"L Giordano","year":"2020","unstructured":"Giordano L, Porta GD, Peretti GM, Maffulli N. Therapeutic potential of microRNA in tendon injuries. Br Med Bull. 2020;133(1):79\u201394. https:\/\/doi.org\/10.1093\/bmb\/ldaa002.","journal-title":"Br Med Bull."},{"issue":"1","key":"2428_CR18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/bmb\/ldz015","volume":"130","author":"A Oliviero","year":"2019","unstructured":"Oliviero A, Della Porta G, Peretti GM, Maffulli N. MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge. Br Med Bull. 2019;130(1):137\u201347. https:\/\/doi.org\/10.1093\/bmb\/ldz015.","journal-title":"Br Med Bull."},{"key":"2428_CR19","doi-asserted-by":"publisher","unstructured":"Gargano G, Oliviero A, Oliva F, Maffulli N. Small interfering RNAs in tendon homeostasis. Br Med Bull. 2021. https:\/\/doi.org\/10.1093\/bmb\/ldaa040.","DOI":"10.1093\/bmb\/ldaa040"},{"issue":"12","key":"2428_CR20","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1002\/art.38188","volume":"65","author":"SJ Park","year":"2013","unstructured":"Park SJ, Cheon EJ, Lee MH, Kim HA. MicroRNA-127-5p regulates matrix metalloproteinase 13 expression and interleukin-1beta-induced catabolic effects in human chondrocytes. Arthritis & Rheumatism. 2013;65(12):3141\u201352. https:\/\/doi.org\/10.1002\/art.38188.","journal-title":"Arthritis & Rheumatism."},{"issue":"3","key":"2428_CR21","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1136\/annrheumdis-2013-204355","volume":"74","author":"S Yang","year":"2015","unstructured":"Yang S, Ryu JH, Oh H, Jeon J, Kwak JS, Kim JH, et al. NAMPT (visfatin), a direct target of hypoxia-inducible factor-2alpha, is an essential catabolic regulator of osteoarthritis. Ann Rheum Dis. 2015;74(3):595\u2013602. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204355.","journal-title":"Ann Rheum Dis."},{"key":"2428_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar4467","volume":"16","author":"M Laiguillon","year":"2014","unstructured":"Laiguillon M, Houard X, Bougault C, et al. Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis. Arthritis Res Ther. 2014;16:1\u201312.","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"2428_CR23","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s10753-018-0750-6","volume":"41","author":"Z Wang","year":"2018","unstructured":"Wang Z, Hu J, Pan Y, Shan Y, Jiang L, Qi X, et al. miR-140-5p\/miR-149 affects chondrocyte proliferation, apoptosis, and autophagy by targeting FUT1 in osteoarthritis. Inflammation. 2018;41(3):959\u201371. https:\/\/doi.org\/10.1007\/s10753-018-0750-6.","journal-title":"Inflammation."},{"key":"2428_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-017-0012-9","volume":"9","author":"J Hu","year":"2018","unstructured":"Hu J, Wang Z, Shan Y, et al. Long non-coding RNA HOTAIR promotes osteoarthritis progression via miR-17-5p\/FUT2\/\u03b2-catenin axis. Cell Death Dis. 2018;9:1\u201312.","journal-title":"Cell Death Dis"},{"issue":"12","key":"2428_CR25","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3390\/genes8120353","volume":"8","author":"S Haque","year":"2017","unstructured":"Haque S, Harries LW. Circular RNAs (circRNAs) in health and disease. Genes. 2017;8(12):353. https:\/\/doi.org\/10.3390\/genes8120353.","journal-title":"Genes"},{"issue":"2","key":"2428_CR26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215\u201333. https:\/\/doi.org\/10.1016\/j.cell.2009.01.002.","journal-title":"Cell."},{"issue":"6","key":"2428_CR27","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1007\/s10067-015-3087-7","volume":"35","author":"D Pereira","year":"2016","unstructured":"Pereira D, Severo M, Santos RA, Barros H, Branco J, Lucas R, et al. Knee and hip radiographic osteoarthritis features: differences on pain, function and quality of life. Clinical rheumatology. 2016;35(6):1555\u201364. https:\/\/doi.org\/10.1007\/s10067-015-3087-7.","journal-title":"Clinical rheumatology."},{"key":"2428_CR28","doi-asserted-by":"crossref","unstructured":"Wojdasiewicz P, Poniatowski \u0141A, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflammation. 2014;2014.","DOI":"10.1155\/2014\/561459"},{"key":"2428_CR29","doi-asserted-by":"publisher","first-page":"R242","DOI":"10.1186\/ar4085","volume":"14","author":"J Qin","year":"2012","unstructured":"Qin J, Shang L, Ping AS, et al. TNF\/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1\u03b2-induced rat osteoarthritis chondrocytes in vitro. Arthritis Res Ther. 2012;14:R242.","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"2428_CR30","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","volume":"12","author":"LL Chen","year":"2015","unstructured":"Chen LL, Yang L. Regulation of circRNA biogenesis. RNA Biol. 2015;12(4):381\u20138. https:\/\/doi.org\/10.1080\/15476286.2015.1020271.","journal-title":"RNA Biol."},{"issue":"8","key":"2428_CR31","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/cr.2015.82","volume":"25","author":"Y Li","year":"2015","unstructured":"Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015;25(8):981\u20134. https:\/\/doi.org\/10.1038\/cr.2015.82.","journal-title":"Cell Res."},{"key":"2428_CR32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.omtn.2017.04.004","volume":"7","author":"Q Liu","year":"2017","unstructured":"Liu Q, Zhang X, Hu X, Yuan L, Cheng J, Jiang Y, et al. Emerging roles of circRNA Related to the mechanical stress in human cartilage degradation of osteoarthritis. Mol Ther Nucleic Acids. 2017;7:223\u201330. https:\/\/doi.org\/10.1016\/j.omtn.2017.04.004.","journal-title":"Mol Ther Nucleic Acids."},{"issue":"3","key":"2428_CR33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.ymthe.2019.01.006","volume":"27","author":"ZB Zhou","year":"2019","unstructured":"Zhou ZB, Huang GX, Fu Q, Han B, Lu JJ, Chen AM, et al. circRNA.33186 contributes to the pathogenesis of osteoarthritis by sponging miR-127-5p. Mol Ther. 2019;27(3):531\u201341. https:\/\/doi.org\/10.1016\/j.ymthe.2019.01.006.","journal-title":"Mol Ther."},{"key":"2428_CR34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s13577-017-0177-7","volume":"30","author":"L B-f","year":"2017","unstructured":"B-f L. Zhang Y, Xiao J, et al. Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R. Human cell. 2017;30:311\u20138.","journal-title":"Human cell."},{"key":"2428_CR35","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jbiotec.2016.09.011","volume":"238","author":"FR Kulcheski","year":"2016","unstructured":"Kulcheski FR, Christoff AP, Margis R. Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 2016;238:42\u201351. https:\/\/doi.org\/10.1016\/j.jbiotec.2016.09.011.","journal-title":"J Biotechnol."},{"issue":"8","key":"2428_CR36","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1002\/art.37990","volume":"65","author":"LT Le","year":"2013","unstructured":"Le LT, Swingler TE, Clark IM. Review: the role of microRNAs in osteoarthritis and chondrogenesis. Arthritis Rheumatism. 2013;65(8):1963\u201374. https:\/\/doi.org\/10.1002\/art.37990.","journal-title":"Arthritis Rheumatism."},{"key":"2428_CR37","first-page":"236","volume":"14","author":"K Felekkis","year":"2010","unstructured":"Felekkis K, Touvana E, Stefanou C, et al. microRNAs: a newly described class of encoded molecules that play a role in health and disease. Hippokratia. 2010;14:236.","journal-title":"Hippokratia"},{"issue":"5","key":"2428_CR38","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1002\/art.23431","volume":"58","author":"M Gosset","year":"2008","unstructured":"Gosset M, Berenbaum F, Salvat C, Sautet A, Pigenet A, Tahiri K, et al. Crucial role of visfatin\/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis & Rheumatism. 2008;58(5):1399\u2013409. https:\/\/doi.org\/10.1002\/art.23431.","journal-title":"Arthritis & Rheumatism."},{"issue":"5","key":"2428_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002267","volume":"3","author":"N Busso","year":"2008","unstructured":"Busso N, Karababa M, Nobile M, Rolaz A, van Gool F, Galli M, et al. Pharmacological inhibition of nicotinamide phosphoribosyltransferase\/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD. PLoS One. 2008;3(5):e2267. https:\/\/doi.org\/10.1371\/journal.pone.0002267.","journal-title":"PLoS One."},{"issue":"12","key":"2428_CR40","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1002\/cbin.10761","volume":"41","author":"Y Wu","year":"2017","unstructured":"Wu Y, Zhang Y, Zhang Y, Wang JJ. CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a. Cell Biol Int. 2017;41(12):1283\u20139. https:\/\/doi.org\/10.1002\/cbin.10761.","journal-title":"Cell Biol Int."}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02428-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-021-02428-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02428-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T05:05:54Z","timestamp":1620709554000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-021-02428-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,11]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2428"],"URL":"https:\/\/doi.org\/10.1186\/s13018-021-02428-z","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,11]]},"assertion":[{"value":"20 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the ethical review committee of 3201 Hospital. Written informed consent was obtained from all enrolled patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"307"}}