{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:13:52Z","timestamp":1782360832937,"version":"3.54.5"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20H270002"],"award-info":[{"award-number":["LY20H270002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["2021ZB060"],"award-info":[{"award-number":["2021ZB060"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the clinical effect of gastrocnemius muscle flaps combined with vancomycin\/gentamicin-calcium sulfate combined and autologous iliac bone graft in the phase I treatment of traumatic focal osteomyelitis (Cierny-Mader type III) after tibial plateau fracture surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From July 2009 to January 2018, 35 patients with localized osteomyelitis (Cierny-Mader type III) who met the inclusion criteria were followed up and treated. All patients were infected after undergoing internal fracture fixation surgery. Among them, 18 cases were plate-exposed, 14 cases were due to sinus tracts, two were due to skin necrosis, and one was bone-exposed. We treated patients with several measures. All cases were then followed up. The follow-up indicators included Hospital for Special Surgery knee scores (HSS), the time of laying drainage pipe, bone healing time, infection control rate, and the incidence of nonunion and other complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were followed up for 24\u201360\u2009months. None of them underwent amputation. For repairing soft tissue defects, 17 cases were covered with a muscle flap using the medial head of gastrocnemius alone, 15 cases were treated with the lateral head of gastrocnemius muscle, and three cases were covered with the combination of the two heads. Compared to the preoperative score, we found that the average HSS improved at the 1-year and 2-year follow-up (54 vs. 86 vs. 87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using a gastrocnemius muscle flap combined with vancomycin\/gentamicin-calcium sulfate and autogenous iliac bone was an effective method for the phase I treatment of osteomyelitis (Cierny-Mader type III) after tibial plateau fracture surgery. In the primary treatment of focal traumatic osteomyelitis, it can decrease the treatment time, number of surgeries, pain of patients, time of bone healing, postoperative exudation, and infection recurrence rate and increase the healing bone\u2019s strength.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13018-021-02496-1","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T08:02:56Z","timestamp":1622102576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Gastrocnemius muscle flap with vancomycin\/gentamicin-calcium sulfate and autogenous iliac bone graft for the phase I treatment of localized osteomyelitis after tibial plateau fracture surgery"],"prefix":"10.1186","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-5763","authenticated-orcid":false,"given":"Weiwei","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaofeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-2661","authenticated-orcid":false,"given":"Bingyuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"issue":"6","key":"2496_CR1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1055\/s-0036-1581132","volume":"29","author":"Y Wang","year":"2016","unstructured":"Wang Y, Cao F, Liu M, Wang J, Jia S. Incidence of soft-tissue injuries in patients with posterolateral tibial plateau fractures: a retrospective review from 2009 to 2014. J Knee Surg. 2016;29(6):451\u20137. https:\/\/doi.org\/10.1055\/s-0036-1581132.","journal-title":"J Knee Surg."},{"issue":"12","key":"2496_CR2","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1007\/s00264-017-3607-y","volume":"41","author":"WJ Metsemakers","year":"2017","unstructured":"Metsemakers WJ, Onsea J, Neutjens E, Steffens E, Schuermans A, McNally M, et al. Prevention of fracturerelated infection: a multidisciplinary care package. Int Orthop. 2017;41(12):2457\u201369. https:\/\/doi.org\/10.1007\/s00264-017-3607-y.","journal-title":"Int Orthop."},{"issue":"10","key":"2496_CR3","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2106\/JBJS.N.01350","volume":"97","author":"HM Kremers","year":"2015","unstructured":"Kremers HM, Nwojo ME, Ransom JE, Wood-Wentz CM, Melton LJ, Huddleston PM. Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009. J Bone Joint Surg Am. 2015;97(10):837\u201345.","journal-title":"J Bone Joint Surg Am"},{"issue":"9431","key":"2496_CR4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0140-6736(04)16727-5","volume":"364","author":"DP Lew","year":"2004","unstructured":"Lew DP, Waldvogel FA. Osteomyelitis. Lancet. 2004;364(9431):369\u201379. https:\/\/doi.org\/10.1016\/S0140-6736(04)16727-5.","journal-title":"Lancet."},{"issue":"3","key":"2496_CR5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.7150\/jbji.34452","volume":"4","author":"M Sabater-Martos","year":"2019","unstructured":"Sabater-Martos M, Sigmund IK, Loizou C, McNally M. Surgical treatment and outcomes of calcaneal osteomyelitis in adults: a systematic review. J Bone Jt Infect. 2019;4(3):146\u201354. https:\/\/doi.org\/10.7150\/jbji.34452.","journal-title":"J Bone Jt Infect."},{"issue":"5","key":"2496_CR6","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1177\/1071100718822978","volume":"40","author":"FWA Waibel","year":"2019","unstructured":"Waibel FWA, Klammer A, Gotschi T, Uckay I, Boni T, Berli MC. Outcome after surgical treatment of calcaneal osteomyelitis. Foot Ankle Int. 2019;40(5):562\u20137. https:\/\/doi.org\/10.1177\/1071100718822978.","journal-title":"Foot Ankle Int."},{"key":"2496_CR7","doi-asserted-by":"crossref","unstructured":"L\u2009J Papineau, A Alfageme, J P Dalcourt, et al. Ost\u00e9omy\u00e9lite chronique: Excision et greffe de spongieux a l\u2019air libre apr\u00e8s mises a plat extensives. Int Orthop. 1979;3:165.","DOI":"10.1007\/BF00265708"},{"key":"2496_CR8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00003086-198404000-00043","volume":"184","author":"BL Sachs","year":"1984","unstructured":"Sachs BL, Shaffer JW. A staged Papineau protocol for chronic osteomyelitis. Clin Orthop Relat Res. 1984;184:256\u201363.","journal-title":"Clin Orthop Relat Res."},{"issue":"5","key":"2496_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3109\/17453679508995585","volume":"66","author":"A Emami","year":"1995","unstructured":"Emami A, Mj\u00f6berg B, Larsson S. Infected tibial nonunion: good results after open cancellous bone grafting in 37 cases. Acta Orthop Scand. 1995;66(5):447\u201351. https:\/\/doi.org\/10.3109\/17453679508995585.","journal-title":"Acta Orthop Scand."},{"issue":"3","key":"2496_CR10","first-page":"346","volume":"45","author":"AC Masquelet","year":"2000","unstructured":"Masquelet AC, Fitoussi F, Begue T, Muller GP. Reconstruction of the long bones by the induced membrane and spongy autograft. Ann Chir Plast Esthet. 2000;45(3):346\u201353.","journal-title":"Ann Chir Plast Esthet."},{"issue":"12","key":"2496_CR11","first-page":"229","volume":"14","author":"LYA El-latief","year":"2016","unstructured":"El-latief LYA, Morsy MAE, Abdallah OG. Comparative study between Ilizarov techniques and induced membrane technique in management of bone defects in the tibia. Nat Sci. 2016;14(12):229\u201337.","journal-title":"Nat Sci."},{"issue":"7","key":"2496_CR12","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/j.injury.2017.03.042","volume":"48","author":"K Tong","year":"2017","unstructured":"Tong K, Zhong Z, Peng Y, Lin C, Cao S, Yang YP, et al. Masquelet technique versus Ilizarov bone transport for reconstruction of lower extremity bone defects following posttraumatic osteomyelitis. Injury. 2017;48(7):1616\u201322. https:\/\/doi.org\/10.1016\/j.injury.2017.03.042.","journal-title":"Injury."},{"issue":"3","key":"2496_CR13","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.injury.2017.08.040","volume":"49","author":"WJ Metsemakers","year":"2018","unstructured":"Metsemakers WJ, Morgenstern M, McNally MA, et al. Fracture-related infection: a consensus on definition from an international expert group. Injury. 2018;49(3):505\u201310. https:\/\/doi.org\/10.1016\/j.injury.2017.08.040.","journal-title":"Injury."},{"issue":"5","key":"2496_CR14","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.cmi.2019.08.006","volume":"26","author":"M Depypere","year":"2020","unstructured":"Depypere M, Morgenstern M, Kuehl R, Senneville E, Moriarty TF, Obremskey WT, et al. Pathogenesis and management of fracture-related infection. Clin Microbiol Infect. 2020;26(5):572\u20138. https:\/\/doi.org\/10.1016\/j.cmi.2019.08.006.","journal-title":"Clin Microbiol Infect."},{"issue":"12","key":"2496_CR15","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1302\/0301-620X.102B12.BJJ-2020-1125.R1","volume":"102-B","author":"B Fung","year":"2020","unstructured":"Fung B, Hoit G, Schemitsch E, Godbout C, Nauth A. The induced membrane technique for the management of long bone defects. Bone Joint J. 2020;102-B(12):1723\u201334. https:\/\/doi.org\/10.1302\/0301-620X.102B12.BJJ-2020-1125.R1.","journal-title":"Bone Joint J."},{"issue":"1","key":"2496_CR16","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s13018-019-1388-2","volume":"14","author":"B Pincher","year":"2019","unstructured":"Pincher B, Fenton C, Jeyapalan R, Barlow G, Sharma HK. A systematic review of the single-stage treatment of chronic osteomyelitis. J Orthop Surg Res. 2019;14(1):393. https:\/\/doi.org\/10.1186\/s13018-019-1388-2.","journal-title":"J Orthop Surg Res."},{"issue":"1","key":"2496_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2174\/1874325001812010153","volume":"12","author":"K Jerzy","year":"2018","unstructured":"Jerzy K, Francis H. Chronic osteomyelitis - bacterial flora, antibiotic sensitivity and treatment Challenges. Open Orthop J. 2018;12(1):153\u201363. https:\/\/doi.org\/10.2174\/1874325001812010153.","journal-title":"Open Orthop J."},{"issue":"3","key":"2496_CR18","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1080\/17453674.2020.1745423","volume":"91","author":"N Jiang","year":"2020","unstructured":"Jiang N, Zhao XQ, Wang L, Lin QR, Hu YJ, Yu B. Single-stage debridement with implantation of antibiotic-loaded calcium sulphate in 34 cases of localized calcaneal osteomyelitis. Acta Orthop. 2020;91(3):353\u20139. https:\/\/doi.org\/10.1080\/17453674.2020.1745423.","journal-title":"Acta Orthop."},{"issue":"9","key":"2496_CR19","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1302\/0301-620X.98B9.38057","volume":"98-B","author":"MA McNally","year":"2016","unstructured":"McNally MA, Ferguson JY, Lau AC, Diefenbeck M, Scarborough M, Ramsden AJ, et al. Single-stage treatment of chronic osteomyelitis with a new absorbable, gentamicin-loaded, calcium sulphate\/hydroxyapatite biocomposite: a prospective series of 100 cases. Bone Joint J. 2016;98-B(9):1289\u201396. https:\/\/doi.org\/10.1302\/0301-620X.98B9.38057.","journal-title":"Bone Joint J."},{"issue":"3","key":"2496_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s11751-014-0206-y","volume":"9","author":"G Humm","year":"2014","unstructured":"Humm G, Noor S, Bridgeman P, David M, Bose D. Adjuvant treatment of chronic osteomyelitis of the tibia following exogenous trauma using OSTEOSET\u00ae-T: a review of 21 patients in a regional trauma centre. Strateg Trauma Limb Reconstr. 2014;9(3):157\u201361. https:\/\/doi.org\/10.1007\/s11751-014-0206-y.","journal-title":"Strateg Trauma Limb Reconstr."},{"issue":"1","key":"2496_CR21","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jor.2019.08.017","volume":"17","author":"E Drampalos","year":"2020","unstructured":"Drampalos E, Mohammad HR, Pillai A. Augmented debridement for implant related chronic osteomyelitis with an absorbable, gentamycin loaded calcium sulfate\/hydroxyapatite biocomposite. J Orthop. 2020;17(1):173\u20139. https:\/\/doi.org\/10.1016\/j.jor.2019.08.017.","journal-title":"J Orthop."},{"issue":"5","key":"2496_CR22","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s00264-018-4063-z","volume":"43","author":"AA Badie","year":"2019","unstructured":"Badie AA, Arafa MS. One-stage surgery for adult chronic osteomyelitis: concomitant use of antibiotic-loaded calcium sulphate and bone marrow aspirate. Int Orthop. 2019;43(5):1061\u201370. https:\/\/doi.org\/10.1007\/s00264-018-4063-z.","journal-title":"Int Orthop."},{"issue":"5","key":"2496_CR23","first-page":"272","volume":"9","author":"LU Wei-ju","year":"2006","unstructured":"Wei-ju LU, Bin LI, Ni-rong BAO, et al. Treatment of chronic osteomyelitis with one-stage allograft. Chin J Trauma (English version). 2006;9(5):272\u20135.","journal-title":"Chin J Trauma (English version)."},{"issue":"2","key":"2496_CR24","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.injury.2018.10.036","volume":"50","author":"CH Qin","year":"2019","unstructured":"Qin CH, Zhang HA, Chee YH, Pitarini A, Adem AA. Comparison of the use of antibiotic-loaded calcium sulphate and wound irrigation-suction in the treatment of lower limb chronic osteomyelitis. Injury. 2019;50(2):508\u201314. https:\/\/doi.org\/10.1016\/j.injury.2018.10.036.","journal-title":"Injury."},{"issue":"2","key":"2496_CR25","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/jbm.b.31269","volume":"88","author":"MV Thomas","year":"2009","unstructured":"Thomas MV, Puleo DA. Calcium sulfate: Properties and clinical applications. J Biomed Mater Res B Appl Biomater. 2009;88(2):597\u2013610.","journal-title":"J Biomed Mater Res B Appl Biomater."},{"issue":"6","key":"2496_CR26","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.jinf.2014.12.016","volume":"70","author":"P Vergidis","year":"2015","unstructured":"Vergidis P, Schmidt-Malan SM, Mandrekar JN, Steckelberg JM, Patel R. Comparative activities of vancomycin, tigecycline and rifampin in a rat model of methicillin-resistant Staphylococcus aureus osteomyelitis. J Infect. 2015;70(6):609\u201315. https:\/\/doi.org\/10.1016\/j.jinf.2014.12.016.","journal-title":"J Infect."},{"issue":"3","key":"2496_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00011-011-0402-x","volume":"61","author":"JL Jiang","year":"2012","unstructured":"Jiang JL, Li YF, Fang TL, Zhou J, Li XL, Wang YC, et al. Vancomycin-loaded nano-hydroxyapatite pellets to treat MRSA-induced chronic osteomyelitis with bone defect in rabbits. Inflamm Res. 2012;61(3):207\u201315. https:\/\/doi.org\/10.1007\/s00011-011-0402-x.","journal-title":"Inflamm Res."},{"issue":"7","key":"2496_CR28","doi-asserted-by":"publisher","first-page":"3897","DOI":"10.1128\/AAC.00080-16","volume":"60","author":"D Pf\u00f6rringer","year":"2016","unstructured":"Pf\u00f6rringer D, Obermeier A, Kiokekli M, B\u00fcchner H, Vogt S, Stemberger A, et al. Antimicrobial formulations of absorbable bone substitute materials as drug carriers based on calcium sulfate. Antimicrob Agents Chemother. 2016;60(7):3897\u2013905.","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"2496_CR29","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s11095-010-0166-y","volume":"27","author":"B Kundu","year":"2010","unstructured":"Kundu B, Soundrapandian C, Nandi SK, Mukherjee P, Dandapat N, Roy S, et al. Development of new localized drug delivery system based on ceftriaxone-sulbactam composite drug impregnated porous hydroxyapatite: a systematic approach for in vitro and in vivo animal trial. Pharm Res. 2010;27(8):1659\u201376. https:\/\/doi.org\/10.1007\/s11095-010-0166-y.","journal-title":"Pharm Res."},{"key":"2496_CR30","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/00003086-200301000-00033","volume":"406","author":"WR Walsh","year":"2003","unstructured":"Walsh WR, Morberg P, Yu Y, Yang JL, Haggard W, Sheath PC, et al. Response of a calcium sulfate bone graft substitute in a confined cancellous defect. Clin Orthop Relat Res. 2003;406:228\u201336. https:\/\/doi.org\/10.1097\/00003086-200301000-00033.","journal-title":"Clin Orthop Relat Res."},{"issue":"3","key":"2496_CR31","doi-asserted-by":"publisher","first-page":"E608","DOI":"10.1152\/ajpendo.00229.2004","volume":"288","author":"M Yamauchi","year":"2005","unstructured":"Yamauchi M, Yamaguchi T, Kaji H, Sugimoto T, Chihara K. Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells. Am J Physiol Endocrinol Metab. 2005;288(3):E608\u201316. https:\/\/doi.org\/10.1152\/ajpendo.00229.2004.","journal-title":"Am J Physiol Endocrinol Metab."},{"issue":"7","key":"2496_CR32","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1002\/jbm.b.32747","volume":"100","author":"T Fang","year":"2012","unstructured":"Fang T, Wen J, Zhou J, Shao Z, Dong J. Poly (\u03b5-caprolactone) coating delays vancomycin delivery from porous chitosan\/\u03b2-tricalcium phosphate composites. J Biomed Mater Res B Appl Biomater. 2012;100(7):1803\u201311.","journal-title":"J Biomed Mater Res B Appl Biomater."},{"issue":"3","key":"2496_CR33","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s10856-010-4221-3","volume":"22","author":"B Kundu","year":"2011","unstructured":"Kundu B, Nandi SK, Dasgupta S, Datta S, Mukherjee P, Roy S, et al. Macro-to-micro porous special bioactive glass and ceftriaxone-sulbactam composite drug delivery system for treatment of chronic osteomyelitis: an investigation through in vitro and in vivo animal trial. J Mater Sci Mater Med. 2011;22(3):705\u201320. https:\/\/doi.org\/10.1007\/s10856-010-4221-3.","journal-title":"J Mater Sci Mater Med."},{"issue":"2","key":"2496_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.7150\/jbji.31592","volume":"4","author":"J Ferguson","year":"2019","unstructured":"Ferguson J, Athanasou N, Diefenbeck M, McNally M. Radiographic and histological analysis of a synthetic bone graft substitute eluting gentamicin in the treatment of chronic osteomyelitis. J Bone Jt Infect. 2019;4(2):76\u201384. https:\/\/doi.org\/10.7150\/jbji.31592.","journal-title":"J Bone Jt Infect."},{"issue":"7","key":"2496_CR35","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/jor.21343","volume":"29","author":"CR Rathbone","year":"2011","unstructured":"Rathbone CR, Cross JD, Brown KV, Murray CK, Wenke JC. Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Res. 2011;29(7):1070\u20134. https:\/\/doi.org\/10.1002\/jor.21343.","journal-title":"J Orthop Res."},{"key":"2496_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1472-6750-13-65","volume":"13","author":"OB Betz","year":"2013","unstructured":"Betz OB, Betz VM, Schr\u00f6der C, Penzkofer R, G\u00f6ttlinger M, Mayer-Wagner S, et al. Repair of large segmental bone defects: BMP-2 gene activated muscle grafts vs. autologous bone grafting. BMC Biotechnol. 2013;13:65.","journal-title":"BMC Biotechnol"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02496-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-021-02496-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02496-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T19:04:39Z","timestamp":1672254279000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-021-02496-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2496"],"URL":"https:\/\/doi.org\/10.1186\/s13018-021-02496-1","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]},"assertion":[{"value":"27 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee of the Zhejiang Academy of Traditional Chinese Medicine (No. KTSC093) and in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Due to the study\u2019s retrospective design, all patients or their legal guardians need not provide an informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"341"}}