{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:39:27Z","timestamp":1792121967122,"version":"4.4.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["No. 81403027"],"award-info":[{"award-number":["No. 81403027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010846","name":"health and family planning commission of hubei province","doi-asserted-by":"publisher","award":["No. WJ2019Q051"],"award-info":[{"award-number":["No. WJ2019Q051"]}],"id":[{"id":"10.13039\/501100010846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To explore the risk factors of preoperative hypoalbuminemia and its\u2019 effects on complications in the elderly with primary hip arthroplasty.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 211 elderly inpatients who underwent hip arthroplasty were collected. All patients were divided into the control group (preoperative serum albumin \u226535 g\/L) and case group (preoperative serum albumin &lt;35 g\/L). The risk factors of preoperative hypoalbuminemia and the postoperative complications were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Compared to controls, hypoalbuminemia patients were older (<jats:italic>P<\/jats:italic> = 0.026), had lower BMI (<jats:italic>P<\/jats:italic> = 0.045), higher cardiac function score (<jats:italic>P<\/jats:italic> &lt; 0.0001), higher ASA scores (<jats:italic>P<\/jats:italic> = 0.023), and longer hospital stay (<jats:italic>P<\/jats:italic> &lt; 0.001). The intraoperative albumin loss in the case group was significantly higher than that of in control group (<jats:italic>P<\/jats:italic> &lt; 0.001), but there was no significant difference in operation time and intraoperative blood loss between the two groups (<jats:italic>P<\/jats:italic> &gt;0.05). Compared to controls, hypoalbuminemia patients had a higher risk for any complication (<jats:italic>P<\/jats:italic> = 0.014), such as delayed wound healing, pleural effusion, and pneumonia. The risk of postoperative complications increased by 6.9% with every 1 year old is increasing (age &gt; 60). The risk of postoperative complications in the case group was 1.89 times higher than that in the control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients with older age, poor nutritional status, and more than 2 concomitant diseases are more likely to develop preoperative hypoalbuminemia. Preoperative hypoalbuminemia is related to the increased incidence of postoperative complications. Perioperative albumin loss is not only due to perioperative blood loss, but also related to vascular permeability and abnormal albumin metabolism.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-021-02702-0","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:04:18Z","timestamp":1631700258000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The effect of preoperative hypoalbuminemia on complications after primary hip arthroplasty"],"prefix":"10.1186","volume":"16","author":[{"given":"Yang","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hankun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaobin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"issue":"3","key":"2702_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1054\/clnu.2001.0439","volume":"20","author":"PE Ballmer","year":"2001","unstructured":"Ballmer PE. Causes and mechanisms of hypoalbuminaemia. Clin Nutr. 2001;20(3):271\u20133. https:\/\/doi.org\/10.1054\/clnu.2001.0439.","journal-title":"Clin Nutr"},{"issue":"Suppl 3","key":"2702_CR2","doi-asserted-by":"publisher","first-page":"S193","DOI":"10.1007\/s11739-012-0802-0","volume":"7","author":"A Gatta","year":"2012","unstructured":"Gatta A, Verardo A, Bolognesi M. Hypoalbuminemia. Intern Emerg Med. 2012;7(Suppl 3):S193\u20139. https:\/\/doi.org\/10.1007\/s11739-012-0802-0.","journal-title":"Intern Emerg Med"},{"issue":"7S","key":"2702_CR3","doi-asserted-by":"publisher","first-page":"S167","DOI":"10.1016\/j.arth.2017.08.030","volume":"33","author":"AJ Boniello","year":"2018","unstructured":"Boniello AJ, Simon MS, Emenari CC, Courtney PM. Complications and mortality following total hip arthroplasty in the octogenarians: an analysis of a national database. J Arthroplasty. 2018;33(7S):S167\u201371. https:\/\/doi.org\/10.1016\/j.arth.2017.08.030.","journal-title":"J Arthroplasty"},{"issue":"3","key":"2702_CR4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1055\/s-0036-1584575","volume":"30","author":"AF Kamath","year":"2017","unstructured":"Kamath AF, Nelson CL, Elkassabany N, Guo Z, Liu J. Low albumin is a risk factor for complications after revision total knee arthroplasty. J Knee Surg. 2017;30(3):269\u201375. https:\/\/doi.org\/10.1055\/s-0036-1584575.","journal-title":"J Knee Surg"},{"issue":"1","key":"2702_CR5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jhin.2019.04.020","volume":"103","author":"AG Tsantes","year":"2019","unstructured":"Tsantes AG, Papadopoulos DV, Lytras T, Tsantes AE, Mavrogenis AF, Korompilias AV, et al. Association of malnutrition with periprosthetic joint and surgical site infections after total joint arthroplasty: a systematic review and meta-analysis. J Hosp Infect. 2019;103(1):69\u201377. https:\/\/doi.org\/10.1016\/j.jhin.2019.04.020.","journal-title":"J Hosp Infect"},{"issue":"5","key":"2702_CR6","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1177\/1120700019862977","volume":"30","author":"JM Newman","year":"2020","unstructured":"Newman JM, Sodhi N, Khlopas A, Piuzzi NS, Yakubek GA, Sultan AA, et al. Malnutrition increases the 30-day complication and re-operation rates in hip fracture patients treated with total hip arthroplasty. Hip Int. 2020;30(5):635\u201340. https:\/\/doi.org\/10.1177\/1120700019862977.","journal-title":"Hip Int"},{"issue":"5","key":"2702_CR7","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3109\/10715762.2013.779373","volume":"47","author":"A Popolo","year":"2013","unstructured":"Popolo A, Autore G, Pinto A, Marzocco S. Oxidative stress in patients with cardiovascular disease and chronic renal failure. Free Radic Res. 2013;47(5):346\u201356. https:\/\/doi.org\/10.3109\/10715762.2013.779373.","journal-title":"Free Radic Res"},{"issue":"11","key":"2702_CR8","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1097\/HJH.0b013e3282ef1c5f","volume":"25","author":"M Bohm","year":"2007","unstructured":"Bohm M, Thoenes M, Danchin N, Bramlage P, La Puerta P, Volpe M. Association of cardiovascular risk factors with microalbuminuria in hypertensive individuals: the i-SEARCH global study. J Hypertens. 2007;25(11):2317\u201324. https:\/\/doi.org\/10.1097\/HJH.0b013e3282ef1c5f.","journal-title":"J Hypertens"},{"key":"2702_CR9","doi-asserted-by":"publisher","unstructured":"Wang L, Zhang D, Xu J. Association between the Geriatric Nutritional Risk Index, bone mineral density and osteoporosis in type 2 diabetes patients. J Diabetes Investig. 2019. https:\/\/doi.org\/10.1111\/jdi.13196.","DOI":"10.1111\/jdi.13196"},{"issue":"9","key":"2702_CR10","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1016\/j.arth.2018.04.027","volume":"33","author":"K Blevins","year":"2018","unstructured":"Blevins K, Aalirezaie A, Shohat N, Parvizi J. Malnutrition and the development of periprosthetic joint infection in patients undergoing primary elective total joint arthroplasty. J Arthroplasty. 2018;33(9):2971\u20135. https:\/\/doi.org\/10.1016\/j.arth.2018.04.027.","journal-title":"J Arthroplasty"},{"issue":"3","key":"2702_CR11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/230949901202000313","volume":"20","author":"JA Nicholson","year":"2012","unstructured":"Nicholson JA, Dowrick AS, Liew SM. Nutritional status and short-term outcome of hip arthroplasty. J Orthop Surg (Hong Kong). 2012;20(3):331\u20135. https:\/\/doi.org\/10.1177\/230949901202000313.","journal-title":"J Orthop Surg (Hong Kong)"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02702-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-021-02702-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02702-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:11:37Z","timestamp":1631700697000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-021-02702-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2702"],"URL":"https:\/\/doi.org\/10.1186\/s13018-021-02702-0","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"23 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of Wuhan University Affiliated Zhongnan Hospital concluded that no approval is necessary for the study based on its retrospective design. All patients agreed to the use of data in the study by oral consent. The oral consent approval was documented in the patients\u2019 files, which was approved by the Ethics Committee of Wuhan University Affiliated Zhongnan Hospital (No. 2019063). All clinical investigations were conducted in accordance with the guidelines of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests associated with this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"562"}}