{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:21:41Z","timestamp":1771611701493,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772384"],"award-info":[{"award-number":["81772384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572174"],"award-info":[{"award-number":["81572174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902242"],"award-info":[{"award-number":["81902242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["NO. 2019M663268"],"award-info":[{"award-number":["NO. 2019M663268"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Science and Technology planning Project of Zhuhai, China","award":["ZH2201200003HJL"],"award-info":[{"award-number":["ZH2201200003HJL"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disease, which commonly affects women. Accumulating evidence shows that differentially expressed circular RNAs (circRNAs) play crucial roles in the progress of RA. However, the roles of circRNAs in female RA remains unclear. This study explores potential role and diagnostic value of hsa_circ_0140271 from peripheral blood mononuclear cells (PBMC) in female RA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Differential expression of circRNAs was determined by RNA-sequencing in PBMC from 4 healthy controls (HC) and 4 RA patients, and we further measured the level of hsa_circ_0140271 in a validation cohort consisting of 47 RA and 47 HC via RT-qPCR. Besides, correlation studies with clinical variables were also examined. What\u2019s more, we performed bioinformatics analysis to predict the potential role of hsa_circ_0140271.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>PBMC expression of hsa_circ_0140271 of female RA was significantly higher than that of female HC, and it was positively correlated with antistreptolysin (ASO). Furthermore, the receiver operating characteristic (ROC) curve indicated that hsa_circ_0140271 could distinguish female RA from female HC and female patients with ankylosing spondylitis (AS) or osteoarthritis (OA). Besides, the combined diagnosis anti-cyclic citrullinated peptide (Anti-CCP)\u2009+\u2009hsa_circ_0140271 could improve diagnostic accuracy with an area under the curve (AUC) of 0.818 to compared with Anti-CCP. Furthermore, KEGG pathway enrichment analysis indicated hsa_circ_0140271 may act as microRNA sponge and participate in fatty acid metabolism pathways.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Hsa_circ_0140271 was likely to be used as a promising diagnostic biomarker for female RA; it may act as microRNA sponge to regulate fatty acid metabolism pathways in RA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-021-02794-8","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T11:02:43Z","timestamp":1635591763000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Identification of circular RNAs hsa_circ_0140271 in peripheral blood mononuclear cells as a novel diagnostic biomarker for female rheumatoid arthritis"],"prefix":"10.1186","volume":"16","author":[{"given":"Yufeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghe","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuegang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuping","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huading","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"2794_CR1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388:2023\u201338. https:\/\/doi.org\/10.1016\/S0140-6736(16)30173-8.","journal-title":"Lancet"},{"key":"2794_CR2","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201901010","author":"JA Sparks","year":"2019","unstructured":"Sparks JA. Rheumatoid arthritis. Ann Intern Med. 2019. https:\/\/doi.org\/10.7326\/AITC201901010.","journal-title":"Ann Intern Med"},{"key":"2794_CR3","doi-asserted-by":"publisher","first-page":"J254","DOI":"10.1016\/j.jaut.2011.12.001","volume":"38","author":"S Amur","year":"2012","unstructured":"Amur S, Parekh A, Mummaneni P. Sex differences and genomics in autoimmune diseases. J Autoimmun. 2012;38:J254-265. https:\/\/doi.org\/10.1016\/j.jaut.2011.12.001.","journal-title":"J Autoimmun"},{"key":"2794_CR4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1136\/ard.2011.200059","volume":"71","author":"M Pikwer","year":"2012","unstructured":"Pikwer M, Bergstrom U, Nilsson JA, Jacobsson L, Turesson C. Early menopause is an independent predictor of rheumatoid arthritis. Ann Rheumatic Dis. 2012;71:378\u201381. https:\/\/doi.org\/10.1136\/ard.2011.200059.","journal-title":"Ann Rheumatic Dis."},{"key":"2794_CR5","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/ar2759","volume":"11","author":"G Chabchoub","year":"2009","unstructured":"Chabchoub G, Uz E, Maalej A, Mustafa CA, Rebai A, Mnif M, et al. Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases. Arthritis Res Ther. 2009;11:R106. https:\/\/doi.org\/10.1186\/ar2759.","journal-title":"Arthritis Res Ther"},{"key":"2794_CR6","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/art.37804","volume":"65","author":"TU Han","year":"2013","unstructured":"Han TU, Cho SK, Kim T, Joo YB, Bae SC, Kang C. Association of an activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype with increased susceptibility to rheumatoid arthritis. Arthritis Rheum. 2013;65:590\u20138. https:\/\/doi.org\/10.1002\/art.37804.","journal-title":"Arthritis Rheum"},{"key":"2794_CR7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.tcb.2019.12.004","volume":"30","author":"MS Xiao","year":"2020","unstructured":"Xiao MS, Ai Y, Wilusz JE. Biogenesis and functions of circular RNAs come into focus. Trends Cell Biol. 2020;30:226\u201340. https:\/\/doi.org\/10.1016\/j.tcb.2019.12.004.","journal-title":"Trends Cell Biol"},{"key":"2794_CR8","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.molcel.2018.06.034","volume":"71","author":"X Li","year":"2018","unstructured":"Li X, Yang L, Chen LL. The biogenesis, functions, and challenges of circular RNAs. Mol Cell. 2018;71:428\u201342. https:\/\/doi.org\/10.1016\/j.molcel.2018.06.034.","journal-title":"Mol Cell"},{"key":"2794_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12575-020-00122-8","volume":"22","author":"PT Mumtaz","year":"2020","unstructured":"Mumtaz PT, Taban Q, Dar MA, Mir S, Haq ZU, Zargar SM, et al. Deep insights in circular RNAs: from biogenesis to therapeutics. Biol Proced. 2020;22:10. https:\/\/doi.org\/10.1186\/s12575-020-00122-8.","journal-title":"Biol Proced."},{"key":"2794_CR10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41419-019-1744-5","volume":"10","author":"Z Zhou","year":"2019","unstructured":"Zhou Z, Sun B, Huang S, Zhao L. Roles of circular RNAs in immune regulation and autoimmune diseases. Cell Death Dis. 2019;10:503. https:\/\/doi.org\/10.1038\/s41419-019-1744-5.","journal-title":"Cell Death Dis"},{"key":"2794_CR11","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9:357\u20139. https:\/\/doi.org\/10.1038\/nmeth.1923.","journal-title":"Nat Methods"},{"key":"2794_CR12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinform. 2011;12:323. https:\/\/doi.org\/10.1186\/1471-2105-12-323.","journal-title":"BMC Bioinform"},{"key":"2794_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15\u201321. https:\/\/doi.org\/10.1093\/bioinformatics\/bts635.","journal-title":"Bioinformatics"},{"key":"2794_CR14","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1093\/bioinformatics\/btv656","volume":"32","author":"J Cheng","year":"2016","unstructured":"Cheng J, Metge F, Dieterich C. Specific identification and quantification of circular RNAs from sequencing data. Bioinformatics (Oxford, England). 2016;32:1094\u20136. https:\/\/doi.org\/10.1093\/bioinformatics\/btv656.","journal-title":"Bioinformatics (Oxford, England)."},{"key":"2794_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139\u201340. https:\/\/doi.org\/10.1093\/bioinformatics\/btp616.","journal-title":"Bioinformatics"},{"key":"2794_CR16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/ncprheum0020","volume":"1","author":"IB McInnes","year":"2005","unstructured":"McInnes IB, Liew FY. Cytokine networks\u2013towards new therapies for rheumatoid arthritis. Nat Clin Practice Rheumatol. 2005;1:31\u20139. https:\/\/doi.org\/10.1038\/ncprheum0020.","journal-title":"Nat Clin Practice Rheumatol."},{"key":"2794_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jbiotec.2016.09.011","volume":"238","author":"FR Kulcheski","year":"2016","unstructured":"Kulcheski FR, Christoff AP, Margis R. Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 2016;238:42\u201351. https:\/\/doi.org\/10.1016\/j.jbiotec.2016.09.011.","journal-title":"J Biotechnol"},{"key":"2794_CR18","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1080\/15476286.2016.1220473","volume":"14","author":"S Qu","year":"2017","unstructured":"Qu S, Zhong Y, Shang R, Zhang X, Song W, Kjems J, et al. The emerging landscape of circular RNA in life processes. RNA Biol. 2017;14:992\u20139. https:\/\/doi.org\/10.1080\/15476286.2016.1220473.","journal-title":"RNA Biol"},{"key":"2794_CR19","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.berh.2016.02.003","volume":"29","author":"H Brouwers","year":"2015","unstructured":"Brouwers H, von Hegedus J, Toes R, Kloppenburg M, Ioan-Facsinay A. Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis. Best Pract Res Clin Rheumatol. 2015;29:741\u201355. https:\/\/doi.org\/10.1016\/j.berh.2016.02.003.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2794_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1136\/ard.2006.051672","volume":"66","author":"VP van Halm","year":"2007","unstructured":"van Halm VP, Nielen MM, Nurmohamed MT, van Schaardenburg D, Reesink HW, Voskuyl AE, et al. Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis. Ann Rheum Dis. 2007;66:184\u20138. https:\/\/doi.org\/10.1136\/ard.2006.051672.","journal-title":"Ann Rheum Dis"},{"key":"2794_CR21","first-page":"1701","volume":"26","author":"YB Park","year":"1999","unstructured":"Park YB, Lee SK, Lee WK, Suh CH, Lee CW, Lee CH, et al. Lipid profiles in untreated patients with rheumatoid arthritis. J Rheumatol. 1999;26:1701\u20134.","journal-title":"J Rheumatol"},{"key":"2794_CR22","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1136\/ard.2010.135871","volume":"70","author":"E Myasoedova","year":"2011","unstructured":"Myasoedova E, Crowson CS, Kremers HM, Roger VL, Fitz-Gibbon PD, Therneau TM, et al. Lipid paradox in rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease. Ann Rheumatic Dis. 2011;70:482\u20137. https:\/\/doi.org\/10.1136\/ard.2010.135871.","journal-title":"Ann Rheumatic Dis"},{"key":"2794_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1","author":"JS Smolen","year":"2018","unstructured":"Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, et al. Rheumatoid arthritis. Nat Revi Dis Primers. 2018. https:\/\/doi.org\/10.1038\/nrdp.2018.1.","journal-title":"Nat Revi Dis Primers."},{"key":"2794_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/bmb\/ldz015","volume":"130","author":"A Oliviero","year":"2019","unstructured":"Oliviero A, Della Porta G, Peretti GM, Maffulli N. MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge. Br Med Bull. 2019;130:137\u201347. https:\/\/doi.org\/10.1093\/bmb\/ldz015.","journal-title":"Br Med Bull"},{"key":"2794_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/bmb\/ldaa002","volume":"133","author":"L Giordano","year":"2020","unstructured":"Giordano L, Porta GD, Peretti GM, Maffulli N. Therapeutic potential of microRNA in tendon injuries. Br Med Bull. 2020;133:79\u201394. https:\/\/doi.org\/10.1093\/bmb\/ldaa002.","journal-title":"Br Med Bull"},{"key":"2794_CR26","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s12016-017-8631-6","volume":"56","author":"M Krasselt","year":"2019","unstructured":"Krasselt M, Baerwald C. Sex, symptom severity, and quality of life in rheumatology. Clin Rev Allergy Immunol. 2019;56:346\u201361. https:\/\/doi.org\/10.1007\/s12016-017-8631-6.","journal-title":"Clin Rev Allergy Immunol"},{"key":"2794_CR27","doi-asserted-by":"publisher","first-page":"A531","DOI":"10.1016\/j.autrev.2011.11.024","volume":"11","author":"C Selmi","year":"2012","unstructured":"Selmi C, Brunetta E, Raimondo MG, Meroni PL. The X chromosome and the sex ratio of autoimmunity. Autoimmun Rev. 2012;11:A531-537. https:\/\/doi.org\/10.1016\/j.autrev.2011.11.024.","journal-title":"Autoimmun Rev"},{"key":"2794_CR28","doi-asserted-by":"publisher","first-page":"4867","DOI":"10.1093\/bioinformatics\/btz705","volume":"35","author":"C Liu","year":"2019","unstructured":"Liu C, Liu YC, Huang HD, Wang W. Biogenesis mechanisms of circular RNA can be categorized through feature extraction of a machine learning model. Bioinformatics. 2019;35:4867\u201370. https:\/\/doi.org\/10.1093\/bioinformatics\/btz705.","journal-title":"Bioinformatics"},{"key":"2794_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05255-5","author":"M Vecellio","year":"2020","unstructured":"Vecellio M, Wu H, Lu Q, Selmi C. The multifaceted functional role of DNA methylation in immune-mediated rheumatic diseases. Clin Rheumatol. 2020. https:\/\/doi.org\/10.1007\/s10067-020-05255-5.","journal-title":"Clin Rheumatol"},{"key":"2794_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","volume":"6","author":"Q Guo","year":"2018","unstructured":"Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018;6:15. https:\/\/doi.org\/10.1038\/s41413-018-0016-9.","journal-title":"Bone Res"},{"key":"2794_CR31","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1136\/annrheumdis-2012-203130","volume":"73","author":"JA van Nies","year":"2014","unstructured":"van Nies JA, Krabben A, Schoones JW, Huizinga TW, Kloppenburg M, van der Helm-van Mil AH. What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review. Ann Rheumatic Dis. 2014;73:861\u201370. https:\/\/doi.org\/10.1136\/annrheumdis-2012-203130.","journal-title":"Ann Rheumatic Dis"},{"key":"2794_CR32","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/acr.21641","volume":"64","author":"JA Singh","year":"2012","unstructured":"Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res. 2012;64:625\u201339. https:\/\/doi.org\/10.1002\/acr.21641.","journal-title":"Arthritis Care Res"},{"key":"2794_CR33","doi-asserted-by":"publisher","first-page":"R196","DOI":"10.1186\/ar3168","volume":"12","author":"R Cascao","year":"2010","unstructured":"Cascao R, Moura RA, Perpetuo I, Canhao H, Vieira-Sousa E, Mourao AF, et al. Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis. Arthritis Res Ther. 2010;12:R196. https:\/\/doi.org\/10.1186\/ar3168.","journal-title":"Arthritis Res Ther"},{"key":"2794_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1001\/archinte.160.4.437","volume":"160","author":"DA Fox","year":"2000","unstructured":"Fox DA. Cytokine blockade as a new strategy to treat rheumatoid arthritis: inhibition of tumor necrosis factor. Archiv Intern Med. 2000;160:437\u201344. https:\/\/doi.org\/10.1001\/archinte.160.4.437.","journal-title":"Archiv Intern Med"},{"key":"2794_CR35","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrrheum.2014.121","volume":"10","author":"G Kerekes","year":"2014","unstructured":"Kerekes G, Nurmohamed MT, Gonzalez-Gay MA, Seres I, Paragh G, Kardos Z, et al. Rheumatoid arthritis and metabolic syndrome. Nat Rev Rheumatol. 2014;10:691\u20136. https:\/\/doi.org\/10.1038\/nrrheum.2014.121.","journal-title":"Nat Rev Rheumatol"},{"key":"2794_CR36","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1136\/ard.2008.101964","volume":"68","author":"E Choy","year":"2009","unstructured":"Choy E, Sattar N. Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions. Ann Rheum Dis. 2009;68:460\u20139. https:\/\/doi.org\/10.1136\/ard.2008.101964.","journal-title":"Ann Rheum Dis"},{"key":"2794_CR37","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1136\/ard.2009.122374","volume":"69","author":"E Myasoedova","year":"2010","unstructured":"Myasoedova E, Crowson CS, Kremers HM, Fitz-Gibbon PD, Therneau TM, Gabriel SE. Total cholesterol and LDL levels decrease before rheumatoid arthritis. Ann Rheumatic Dis. 2010;69:1310\u20134. https:\/\/doi.org\/10.1136\/ard.2009.122374.","journal-title":"Ann Rheumatic Dis"},{"key":"2794_CR38","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-981-13-1426-1_7","volume":"1087","author":"R Bose","year":"2018","unstructured":"Bose R, Ain R. Regulation of Transcription by Circular RNAs. Adv Exp Med Biol. 2018;1087:81\u201394. https:\/\/doi.org\/10.1007\/978-981-13-1426-1_7.","journal-title":"Adv Exp Med Biol"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-021-02794-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-021-02794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T11:09:58Z","timestamp":1635592198000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-021-02794-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2794"],"URL":"https:\/\/doi.org\/10.1186\/s13018-021-02794-8","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,30]]},"assertion":[{"value":"8 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethics committee of Fifth Affiliated Hospital of Sun Yat-sen University approved the study in accordance with the relevant guidelines and regulations. Informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"647"}}