{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:55:04Z","timestamp":1789728904537,"version":"4.0.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Although arthroplasty provides satisfactory pain relief, functional improvement, and reduced flexion contracture in patients with hemophilia arthropathy, bleeding remains the primary problem associated with hemophilic arthropathy joint replacement. We aimed to explore the differences in perioperative blood loss (PBL) associated with joint replacement surgery in patients with and without hemophilia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study retrospectively analyzed 61 cases of PBL in patients undergoing joint replacement surgery, including 37 patients with hemophilia and 24 patients without hemophilia. All patients demonstrated severe joint flexion contractures that seriously affected their daily lives and required surgical intervention. PBL was compared between the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In univariate analysis, the overall (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and hidden (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) blood losses were significantly higher for patients with hemophilia than those for patients without hemophilia. However, after adjustment for multiple factors, there was no significant difference in overall blood loss between the two groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.731). In addition, sex, age group, and surgical site did not affect blood loss in patients with hemophilia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Overt bleeding did not increase significantly in patients with hemophilia, compared with that in patients without hemophilia. In terms of blood loss, joint replacement surgery for patients with hemophilia is relatively safe. The results of this study must be verified by a prospective follow-up study with larger sample size.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic> Retrospectively registered.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-022-03217-y","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T10:03:02Z","timestamp":1655805782000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Perioperative blood loss during joint replacement: comparison between patients with and without hemophilia"],"prefix":"10.1186","volume":"17","author":[{"given":"Shanyou","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoli","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjia","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"issue":"23","key":"3217_CR1","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1056\/NEJM200106073442307","volume":"344","author":"PM Mannucci","year":"2001","unstructured":"Mannucci PM, Tuddenham EG. The hemophilias\u2013from royal genes to gene therapy. N Engl J Med. 2001;344(23):1773\u20139.","journal-title":"N Engl J Med"},{"issue":"8","key":"3217_CR2","doi-asserted-by":"publisher","first-page":"540","DOI":"10.7326\/M19-1208","volume":"171","author":"A Iorio","year":"2019","unstructured":"Iorio A, Stonebraker JS, Chambost H, Makris M, Coffin D, Herr C, et al. Establishing the prevalence and prevalence at birth of hemophilia in males: a meta-analytic approach using national registries. Ann Intern Med. 2019;171(8):540\u20136.","journal-title":"Ann Intern Med"},{"issue":"3","key":"3217_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.2106\/00004623-197759030-00001","volume":"59","author":"WD Arnold","year":"1977","unstructured":"Arnold WD, Hilgartner MW. Hemophilic arthropathy. Current concepts of pathogenesis and management. J Bone Joint Surg Am. 1977;59(3):287\u2013305.","journal-title":"J Bone Joint Surg Am."},{"issue":"1","key":"3217_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.joca.2014.09.008","volume":"23","author":"LF van Vulpen","year":"2015","unstructured":"van Vulpen LF, van Meegeren ME, Roosendaal G, Jansen NW, van Laar JM, Schutgens RE, et al. Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study. Osteoarthr Cartil. 2015;23(1):63\u20139.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"3217_CR5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1365-2516.2010.02373.x","volume":"17","author":"M Marshall Brooks","year":"2011","unstructured":"Marshall Brooks M, Tobase P, Karp S, Francis D, Fogarty PF. Outcomes in total elbow arthroplasty in patients with haemophilia at the University of California, San Francisco: a retrospective review. Haemophilia. 2011;17(1):118\u201323.","journal-title":"Haemophilia"},{"issue":"10","key":"3217_CR6","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.2106\/00004623-200710000-00009","volume":"89","author":"M Silva","year":"2007","unstructured":"Silva M, Luck JV Jr. Radial head excision and synovectomy in patients with hemophilia. J Bone Joint Surg Am. 2007;89(10):2156\u201362.","journal-title":"J Bone Joint Surg Am"},{"key":"3217_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/00003086-200111000-00054","volume":"392","author":"HJ Siegel","year":"2001","unstructured":"Siegel HJ, Luck JV Jr, Siegel ME, Quinones C. Phosphate-32 colloid radiosynovectomy in hemophilia: outcome of 125 procedures. Clin Orthop Relat Res. 2001;392:409\u201317.","journal-title":"Clin Orthop Relat Res"},{"issue":"19","key":"3217_CR8","doi-asserted-by":"publisher","first-page":"7292","DOI":"10.3390\/ijms21197292","volume":"21","author":"G Pasta","year":"2020","unstructured":"Pasta G, Annunziata S, Polizzi A, Caliogna L, Jannelli E, Minen A, et al. The progression of hemophilic arthropathy: the role of biomarkers. Int J Mol Sci. 2020;21(19):7292.","journal-title":"Int J Mol Sci"},{"key":"3217_CR9","unstructured":"Pasta G, Jannelli E, Ivone A, et al. The role of six biomarkers in diagnosis of hemophilic arthropathy: review of the literature. J Biol Regul Homeost Agents. 2020. 34 (3 Suppl. 2): 7\u201313. Advances in musculoskeletal diseases and infections - Sotimi 2019."},{"issue":"2","key":"3217_CR10","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/hae.13383","volume":"24","author":"SJ Song","year":"2018","unstructured":"Song SJ, Bae JK, Park CH, Yoo MC, Bae DK, Kim KI. Mid-term outcomes and complications of total knee arthroplasty in haemophilic arthropathy: a review of consecutive 131 knees between 2006 and 2015 in a single institute. Haemophilia. 2018;24(2):299\u2013306.","journal-title":"Haemophilia"},{"issue":"1","key":"3217_CR11","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jse.2017.09.009","volume":"27","author":"L Ernstbrunner","year":"2018","unstructured":"Ernstbrunner L, Hingsammer A, Imam MA, Sutter R, Brand B, Meyer DC, et al. Long-term results of total elbow arthroplasty in patients with hemophilia. J Shoulder Elbow Surg. 2018;27(1):126\u201332.","journal-title":"J Shoulder Elbow Surg"},{"issue":"2","key":"3217_CR12","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s12603-017-0907-2","volume":"22","author":"J Wang","year":"2018","unstructured":"Wang J, Taylor AW, Zhang T, Appleton S, Shi Z. Association between body mass index and all-cause mortality among oldest old Chinese. J Nutr Health Aging. 2018;22(2):262\u20138.","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"3217_CR13","first-page":"224","volume":"51","author":"SB Nadler","year":"1962","unstructured":"Nadler SB, Hidalgo JH, Bloch T. Prediction of blood volume in normal human adults. Surgery. 1962;51(2):224\u201332.","journal-title":"Surgery"},{"issue":"3","key":"3217_CR14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/00000542-198303000-00016","volume":"58","author":"JB Gross","year":"1983","unstructured":"Gross JB. Estimating allowable blood loss: corrected for dilution. Anesthesiology. 1983;58(3):277\u201380.","journal-title":"Anesthesiology"},{"issue":"1","key":"3217_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.arth.2009.11.013","volume":"26","author":"RG MacGillivray","year":"2011","unstructured":"MacGillivray RG, Tarabichi SB, Hawari MF, Raoof NT. Tranexamic acid to reduce blood loss after bilateral total knee arthroplasty: a prospective, randomized double blind study. J Arthroplasty. 2011;26(1):24\u20138.","journal-title":"J Arthroplasty"},{"issue":"5","key":"3217_CR16","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1046\/j.1365-2516.1998.00183.x","volume":"4","author":"M Heeg","year":"1998","unstructured":"Heeg M, Meyer K, Smid WM, Van Horn JR, Van der Meer J. Total knee and hip arthroplasty in haemophilic patients. Haemophilia. 1998;4(5):747\u201351.","journal-title":"Haemophilia"},{"issue":"6 Suppl. 1","key":"3217_CR17","first-page":"145","volume":"32","author":"G Pasta","year":"2018","unstructured":"Pasta G, Vanelli R, Jannelli E, et al. Primary total knee replacement in hemophiliacs: experience of a single institution over fourteen years of surgical procedures. J Biol Regul Homeost Agents. 2018;32(6 Suppl. 1):145\u201350.","journal-title":"J Biol Regul Homeost Agents"},{"issue":"1","key":"3217_CR18","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1186\/s13018-018-1038-0","volume":"13","author":"Y Hu","year":"2018","unstructured":"Hu Y, Li Q, Wei BG, Zhang XS, Torsha TT, Xiao J, et al. Blood loss of total knee arthroplasty in osteoarthritis: an analysis of influential factors. J Orthop Surg Res. 2018;13(1):325.","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"3217_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10517-016-3339-9","volume":"161","author":"ES Shurkhina","year":"2016","unstructured":"Shurkhina ES, Polyanskaya TY, Zorenko VY, Azimova MK, Nesterenko VM, Ataullakhanov FI. Effect of hematocrit and erythrocyte density on intraoperative blood loss in hemophilia a patients during total knee arthroplasty. Bull Exp Biol Med. 2016;161(1):37\u201340.","journal-title":"Bull Exp Biol Med."},{"issue":"9","key":"3217_CR20","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1001\/jama.1985.03350330077026","volume":"253","author":"CK Kasper","year":"1985","unstructured":"Kasper CK, Boylen AL, Ewing NP, Luck JV Jr, Dietrich SL. Hematologic management of hemophilia A for surgery. JAMA. 1985;253(9):1279\u201383.","journal-title":"JAMA"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-022-03217-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-022-03217-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-022-03217-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T10:12:26Z","timestamp":1655806346000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-022-03217-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3217"],"URL":"https:\/\/doi.org\/10.1186\/s13018-022-03217-y","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"assertion":[{"value":"3 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethical Committee of the Shenzhen Third People's Hospital; written informed consent was obtained from each participating patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and informed consent"}},{"value":"All authors are agreeing to publish this article in this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"324"}}