{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T15:54:36Z","timestamp":1794066876590,"version":"4.8.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Managing periprosthetic joint infections are variable in practices. Debridement, antibiotics, and implant retention (DAIR) is one of the favorable interventions. Given that the success rate of the two-stage revision total knee arthroplasty (rTKA) might be overestimated. The purpose of this study is to compare the success rate between DAIR and standard two-stage rTKA with a comparable intervention time.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively reviewed the consecutive knee periprosthetic joint infection cases which underwent DAIR or two-stage rTKA (all procedures were performed by the senior author) within 12\u00a0weeks since their primary TKA between July 2009 and October 2019. Average follow-up was 72.20\u00a0\u00b1\u00a040.70 months (range 29\u2013148 months) in the DAIR group compared to 89.14\u00a0\u00b1\u00a043.06 months after spacer insertion (range 29\u2013163 months) in the two-stage revision group (<jats:italic>P<\/jats:italic> = 0.156). According to different interventions, demographic data; timing of surgical intervention; hospital for special surgery knee score; and success rate were collected and compared between the DAIR group and two-stage revision group. Failure of treatment was based on the Delphi consensus and the fate of spacers. The pathogen types and failure cases were also recorded and analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Average follow-up was 72.20\u2009\u00b1\u200940.70\u00a0months (range 29\u2013148\u00a0months) in the DAIR group compared to 89.14\u2009\u00b1\u200943.06\u00a0months after spacer insertion (range 29\u2013163\u00a0months) in the two-stage revision group. Time from index surgery was 3.90\u2009\u00b1\u20092.92\u00a0weeks (range 0\u201312\u00a0weeks) in the DAIR group, and 5.11\u2009\u00b1\u20092.86\u00a0weeks (range 0\u201312\u00a0weeks) in the 2-stage exchange group, respectively. The success rate was 70.0% and 75.0% in the DAIR group and two-stage revision group, respectively. But no significant differences were observed between the two groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>DAIR demonstrated comparable effectiveness with two-stage rTKA.  We recommended DAIR as a choice for patients with current infection within 12\u00a0weeks after primary TKA. For methicillin-resistant staphylococcal infections and fungal infections, two-stage rTKA might be preferred.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-022-03218-x","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T08:05:18Z","timestamp":1656317118000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A comparsion\u00a0study between debridement, antibiotics, and implant retention and two-stage revision total knee arthroplasty for the management of periprosthetic joint infection occurring within 12\u00a0weeks from index total knee arthroplasty"],"prefix":"10.1186","volume":"17","author":[{"given":"Yanchao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ti","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoqi","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"issue":"14","key":"3218_CR1","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.2106\/JBJS.20.00363","volume":"102","author":"TK Fehring","year":"2020","unstructured":"Fehring TK, Fehring KA, Hewlett A, Higuera CA, Otero JE, Tande AJ. 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