{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:04:30Z","timestamp":1780340670162,"version":"3.54.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the relationship between serum high-density lipoprotein (HDL-C) and spinal bone mineral density (BMD) under different serum 25-hydroxyvitamin D (25 (OH) D) levels in adults over 40\u00a0years old and to explore its mechanism.\u00a0We include participants over the age of 40 with data on HDL-C, 25 (OH) D, spinal BMD, and other variables in the National Health and Nutrition Examination Survey 2007\u20132010 in the analysis. A weighted multiple linear regression model was used to evaluate the association between serum HDL-C and spinal BMD in different gender, ages, and serum 25 (OH) D levels. A total of 3599 subjects aged\u2009\u2265\u200940\u00a0years old were included in this study. Univariate analysis of the complete correction model showed a negative correlation between serum HDL-C and spinal BMD. In the two subgroups of serum 25 (OH) D, we found that the higher the serum HDL-C in the female with serum 25 (OH) D\u2009&lt;\u200975\u00a0nmol\/L aged 40\u201359\u00a0years old, the lower the total spinal BMD, and a similar relationship was found in the lumbar spine. However, no similar relationship was found in all populations with serum 25 (OH) D\u2009\u2265\u200975\u00a0nmol\/L and males with serum 25 (OH) D\u2009&lt;\u200975\u00a0nmol\/L. These results suggest that among Americans over the age of 40, the increase in serum HDL-C is related to decreased BMD of spine only in women aged 40\u201359\u00a0years with vitamin D insufficiency or deficiency.<\/jats:p>","DOI":"10.1186\/s13018-022-03491-w","type":"journal-article","created":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T11:02:37Z","timestamp":1673089357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study"],"prefix":"10.1186","volume":"18","author":[{"given":"Peng","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BaiHang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoHui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhanPeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WeiDong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,7]]},"reference":[{"issue":"10","key":"3491_CR1","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.3390\/ijms20102557","volume":"20","author":"Y Ukon","year":"2019","unstructured":"Ukon Y, Makino T, Kodama J, Tsukazaki H, Tateiwa D, Yoshikawa H, et al. Molecular-based treatment strategies for osteoporosis: a literature review. Int J Mol Sci. 2019;20(10):2557. https:\/\/doi.org\/10.3390\/ijms20102557.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3491_CR2","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1373\/clinchem.2016.259085","volume":"63","author":"MB Greenblatt","year":"2017","unstructured":"Greenblatt MB, Tsai JN, Wein MN. Bone turnover markers in the diagnosis and monitoring of metabolic bone disease. Clin Chem. 2017;63(2):464\u201374. https:\/\/doi.org\/10.1373\/clinchem.2016.259085.","journal-title":"Clin Chem"},{"issue":"3","key":"3491_CR3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jocd.2010.03.003","volume":"13","author":"S Cvijetic","year":"2010","unstructured":"Cvijetic S, Colic BI, Satalic Z. Influence of heredity and environment on peak bone density: a parent-offspring study. J Clin Densitom. 2010;13(3):301\u20136. https:\/\/doi.org\/10.1016\/j.jocd.2010.03.003.","journal-title":"J Clin Densitom"},{"issue":"1","key":"3491_CR4","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3390\/nu14010074","volume":"14","author":"M Rondanelli","year":"2022","unstructured":"Rondanelli M, Faliva MA, Barrile GC, Cavioni A, Mansueto F, Mazzola G, et al. Nutrition, physical activity, and dietary supplementation to prevent bone mineral density loss: a food pyramid. Nutrients. 2022;14(1):74. https:\/\/doi.org\/10.3390\/nu14010074.","journal-title":"Nutrients"},{"issue":"6","key":"3491_CR5","first-page":"512","volume":"58","author":"SZ Sambol","year":"2009","unstructured":"Sambol SZ, Stimac D, Orli\u0107 ZC, Guina T. Haematological, biochemical and bone density parameters in vegetarians and non-vegetarians. West Indian Med J. 2009;58(6):512\u20137.","journal-title":"West Indian Med J"},{"issue":"6","key":"3491_CR6","doi-asserted-by":"publisher","first-page":"378","DOI":"10.5455\/medarh.2012.66.378-381","volume":"66","author":"Z Begic","year":"2012","unstructured":"Begic Z, Balic D, Rizvanovic M. The association between lipid profile and bone density in postmenopausal women. Med Arch. 2012;66(6):378. https:\/\/doi.org\/10.5455\/medarh.2012.66.378-381.","journal-title":"Med Arch"},{"issue":"3","key":"3491_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1089\/jwh.2006.15.261","volume":"15","author":"RA Brownbill","year":"2006","unstructured":"Brownbill RA, Ilich JZ. Lipid profile and bone paradox: higher serum lipids are associated with higher bone mineral density in postmenopausal women. J Women\u2019s Health (Larchmont, NY 2002). 2006;15(3):261.","journal-title":"J Women\u2019s Health (Larchmont, NY 2002)."},{"issue":"2","key":"3491_CR8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.11138\/ccmbm\/2014.11.2.117","volume":"11","author":"D Sprini","year":"2014","unstructured":"Sprini D, Rini GB, Di Stefano L, Cianferotti L, Napoli N. Correlation between osteoporosis and cardiovascular disease. Clin Cases Miner Bone Metabol. 2014;11(2):117\u20139. https:\/\/doi.org\/10.11138\/ccmbm\/2014.11.2.117.","journal-title":"Clin Cases Miner Bone Metabol."},{"issue":"1","key":"3491_CR9","doi-asserted-by":"publisher","first-page":"e169122","DOI":"10.1371\/journal.pone.0169122","volume":"12","author":"A Alkhenizan","year":"2017","unstructured":"Alkhenizan A, Mahmoud A, Hussain A, Gabr A, Alsoghayer S, Eldali A. The relationship between 25 (OH) D levels (vitamin D) and bone mineral density (BMD) in a Saudi population in a community-based setting. PLoS ONE. 2017;12(1):e169122. https:\/\/doi.org\/10.1371\/journal.pone.0169122.","journal-title":"PLoS ONE"},{"issue":"3","key":"3491_CR10","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1111\/jcmm.14153","volume":"23","author":"J Sun","year":"2019","unstructured":"Sun J, Zhao M, Hou Y, Zhang C, Oh J, Sun Z, et al. Circulating serum vitamin D levels and total body bone mineral density: a Mendelian randomization study. J Cell Mol Med. 2019;23(3):2268\u201371. https:\/\/doi.org\/10.1111\/jcmm.14153.","journal-title":"J Cell Mol Med"},{"issue":"6","key":"3491_CR11","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.3892\/etm.2019.7518","volume":"17","author":"X Hu","year":"2019","unstructured":"Hu X, Ma S, Yang C, Wang W, Chen L. Relationship between senile osteoporosis and cardiovascular and cerebrovascular diseases. Exp Ther Med. 2019;17(6):4417\u201320. https:\/\/doi.org\/10.3892\/etm.2019.7518.","journal-title":"Exp Ther Med"},{"issue":"6","key":"3491_CR12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/00042192-200111000-00008","volume":"8","author":"P D\u2019Amelio","year":"2001","unstructured":"D\u2019Amelio P, Pescarmona GP, Gariboldi A, Isaia GC. High density lipoproteins (HDL) in women with postmenopausal osteoporosis: a preliminary study. Menopause. 2001;8(6):429\u201332. https:\/\/doi.org\/10.1097\/00042192-200111000-00008.","journal-title":"Menopause"},{"key":"3491_CR13","doi-asserted-by":"publisher","first-page":"c7254","DOI":"10.1136\/bmj.c7254","volume":"342","author":"T Winzenberg","year":"2011","unstructured":"Winzenberg T, Powell S, Shaw KA, Jones G. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis. BMJ (Clin Res ed). 2011;342:c7254. https:\/\/doi.org\/10.1136\/bmj.c7254.","journal-title":"BMJ (Clin Res ed.)"},{"issue":"5","key":"3491_CR14","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1080\/13685538.2019.1612869","volume":"23","author":"FM Sertpoyraz","year":"2020","unstructured":"Sertpoyraz FM, Deniz S. Bone mineral density and vitamin D levels in patients with group a COPD. Aging Male. 2020;23(5):873\u20138. https:\/\/doi.org\/10.1080\/13685538.2019.1612869.","journal-title":"Aging Male"},{"issue":"3","key":"3491_CR15","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/ajcn\/79.3.362","volume":"79","author":"MF Holick","year":"2004","unstructured":"Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79(3):362\u201371. https:\/\/doi.org\/10.1093\/ajcn\/79.3.362.","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"3491_CR16","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s11064-020-02994-4","volume":"45","author":"HH Leung","year":"2020","unstructured":"Leung HH, Galano J, Crauste C, Durand T, Lee JC. Combination of lutein and zeaxanthin, and DHA regulated polyunsaturated fatty acid oxidation in H2O2-stressed retinal cells. Neurochem Res. 2020;45(5):1007\u201319. https:\/\/doi.org\/10.1007\/s11064-020-02994-4.","journal-title":"Neurochem Res"},{"issue":"4","key":"3491_CR17","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1097\/GME.0000000000001082","volume":"25","author":"Z Maghbooli","year":"2018","unstructured":"Maghbooli Z, Khorrami-nezhad L, Adabi E, Ramezani M, Asadollahpour E, Razi F, et al. Negative correlation of high-density lipoprotein-cholesterol and bone mineral density in postmenopausal Iranian women with vitamin D deficiency. Menopause. 2018;25(4):458\u201364. https:\/\/doi.org\/10.1097\/GME.0000000000001082.","journal-title":"Menopause"},{"issue":"7","key":"3491_CR18","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society. J Clin Endocrinol Metabol. 2011;96(7):1911\u201330. https:\/\/doi.org\/10.1210\/jc.2011-0385.","journal-title":"J Clin Endocrinol Metabol"},{"issue":"2","key":"3491_CR19","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3390\/ijms19020360","volume":"19","author":"L Hu","year":"2018","unstructured":"Hu L, Yin C, Zhao F, Ali A, Ma J, Qian A. Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment. Int J Mol Sci. 2018;19(2):360. https:\/\/doi.org\/10.3390\/ijms19020360.","journal-title":"Int J Mol Sci"},{"key":"3491_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/1730978","volume":"2019","author":"V Paspaliaris","year":"2019","unstructured":"Paspaliaris V, Kolios G. Stem cells in osteoporosis: from biology to new therapeutic approaches. Stem Cells Int. 2019;2019:1\u201316. https:\/\/doi.org\/10.1155\/2019\/1730978.","journal-title":"Stem Cells Int."},{"issue":"02","key":"3491_CR21","first-page":"308","volume":"26","author":"WKSM Yabing","year":"2020","unstructured":"Yabing WKSM. Research progress in the mechanism of action of transforming growth factor-\u03b2 in bone metabolism. Chin J Osteoporos. 2020;26(02):308\u201312.","journal-title":"Chin J Osteoporos"},{"issue":"4","key":"3491_CR22","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1161\/01.ATV.17.4.680","volume":"17","author":"F Parhami","year":"1997","unstructured":"Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol. 1997;17(4):680\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"3491_CR23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/ajcn\/83.1.146","volume":"83","author":"Y Hsu","year":"2006","unstructured":"Hsu Y, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, et al. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006;83(1):146\u201354.","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"3491_CR24","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1359\/jbmr.040115","volume":"19","author":"HT Kha","year":"2004","unstructured":"Kha HT, Basseri B, Shouhed D, Richardson J, Tetradis S, Hahn TJ, et al. Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J Bone Miner Res. 2004;19(5):830\u201340. https:\/\/doi.org\/10.1359\/jbmr.040115.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"3491_CR25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/qjmed\/hcm023","volume":"100","author":"EM Dennison","year":"2007","unstructured":"Dennison EM, Syddall HE, Aihie Sayer A, Martin HJ, Cooper C. Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study. QJM. 2007;100(5):297\u2013303. https:\/\/doi.org\/10.1093\/qjmed\/hcm023.","journal-title":"QJM"},{"issue":"9","key":"3491_CR26","first-page":"857","volume":"82","author":"M Jirapinyo","year":"2003","unstructured":"Jirapinyo M, Theppisai U, Manonai J, Suchartwatnachai C, Jorgensen LN. Effect of combined oral estrogen\/progestogen preparation (Kliogest\u00ae) on bone mineral density, plasma lipids and postmenopausal symptoms in HRT-na\u00efve. Acta Obstet Gynecol Scan. 2003;82(9):857\u201366.","journal-title":"Acta Obstet Gynecol Scan"},{"key":"3491_CR27","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ijcard.2018.11.095","volume":"276","author":"M Mazidi","year":"2019","unstructured":"Mazidi M, Mikhailidis DP, Banach M. Associations between risk of overall mortality, cause-specific mortality and level of inflammatory factors with extremely low and high high-density lipoprotein cholesterol levels among American adults. Int J Cardiol. 2019;276:242\u20137. https:\/\/doi.org\/10.1016\/j.ijcard.2018.11.095.","journal-title":"Int J Cardiol"},{"key":"3491_CR28","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1530\/eje.0.1370495","volume":"137","author":"AM Heikkinen","year":"1997","unstructured":"Heikkinen AM, Tuppurainen MT, Niskanen L, Komulainen M, Penttil\u00e4 I, Saarikoski S. Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy. Eur J Endocrinol. 1997;137:495\u2013502.","journal-title":"Eur J Endocrinol"},{"issue":"13","key":"3491_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.02-0255fje","volume":"16","author":"H Shi","year":"2002","unstructured":"Shi H, Norman AW, Okamura WH, Sen A, Zemel MB. 1\u03b1,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J. 2002;16(13):1\u201320. https:\/\/doi.org\/10.1096\/fj.02-0255fje.","journal-title":"FASEB J"},{"issue":"1","key":"3491_CR30","first-page":"16","volume":"1737","author":"K Wehmeier","year":"2005","unstructured":"Wehmeier K, Beers A, Haas MJ, Wong NCW, Steinmeyer A, Zugel U, et al. Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3. Biochem Biophys Acta. 2005;1737(1):16\u201326.","journal-title":"Biochem Biophys Acta"},{"issue":"12","key":"3491_CR31","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1007\/s00198-005-1910-8","volume":"16","author":"DG von M\u00fchlen","year":"2005","unstructured":"von M\u00fchlen DG, Greendale GA, Garland CF, Wan L, Barrett-Connor E. Vitamin D, parathyroid hormone levels and bone mineral density in community-dwelling older women: the Rancho Bernardo Study. Osteoporos Int. 2005;16(12):1721\u20136. https:\/\/doi.org\/10.1007\/s00198-005-1910-8.","journal-title":"Osteoporos Int"},{"issue":"4","key":"3491_CR32","first-page":"543","volume":"68","author":"SM Nadeem","year":"2018","unstructured":"Nadeem SM, Rafique I, Hayder I, Irshad R, Bashir S, Ullah R, et al. Comparison of vitamin D levels with bone density, calcium, phosphate and alkaline phosphatase\u2014an insight from major cities of Pakistan. J Pak Med Assoc. 2018;68(4):543\u20137.","journal-title":"J Pak Med Assoc"},{"issue":"2","key":"3491_CR33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00223-012-9619-0","volume":"92","author":"MR Haussler","year":"2013","unstructured":"Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh J, et al. Molecular mechanisms of vitamin D action. Calcif Tissue Int. 2013;92(2):77\u201398. https:\/\/doi.org\/10.1007\/s00223-012-9619-0.","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"3491_CR34","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1359\/jbmr.081262","volume":"24","author":"PJ Buizert","year":"2009","unstructured":"Buizert PJ, van Schoor NM, Lips P, Deeg DJ, Eekhoff EM. Lipid levels: A link between cardiovascular disease and osteoporosis? J Bone Miner Res. 2009;24(6):1103\u20139. https:\/\/doi.org\/10.1359\/jbmr.081262.","journal-title":"J Bone Miner Res"},{"issue":"6","key":"3491_CR35","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00223-010-9427-3","volume":"87","author":"I Jeong","year":"2010","unstructured":"Jeong I, Cho SW, Kim SW, Choi HJ, Park KS, Kim SY, et al. Lipid profiles and bone mineral density in pre- and postmenopausal women in Korea. Calcif Tissue Int. 2010;87(6):507\u201312. https:\/\/doi.org\/10.1007\/s00223-010-9427-3.","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"3491_CR36","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.beem.2018.05.007","volume":"32","author":"RA Adler","year":"2018","unstructured":"Adler RA. Update on osteoporosis in men. Best Pract Res Clin Endocrinol. 2018;32(5):759\u201372. https:\/\/doi.org\/10.1016\/j.beem.2018.05.007.","journal-title":"Best Pract Res Clin Endocrinol"},{"issue":"5","key":"3491_CR37","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jbspin.2018.02.009","volume":"85","author":"K Briot","year":"2018","unstructured":"Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. 2018 update of French recommendations on the management of postmenopausal osteoporosis. Jt Bone Spine. 2018;85(5):519\u201330. https:\/\/doi.org\/10.1016\/j.jbspin.2018.02.009.","journal-title":"Jt Bone Spine."},{"issue":"6","key":"3491_CR38","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1073\/pnas.1220811110","volume":"110","author":"SH Windahl","year":"2013","unstructured":"Windahl SH, B\u00f6rjesson AE, Farman HH, Engdahl C, Mov\u00e9rare-Skrtic S, Sj\u00f6gren K, et al. Estrogen receptor-\u03b1 in osteocytes is important for trabecular bone formation in male mice. Proc Natl Acad Sci. 2013;110(6):2294\u20139. https:\/\/doi.org\/10.1073\/pnas.1220811110.","journal-title":"Proc Natl Acad Sci"},{"issue":"08","key":"3491_CR39","first-page":"1134","volume":"25","author":"G Kun","year":"2019","unstructured":"Kun G, Weiji Y, Quan L, Qinong M, Jinlong Y, Jinquan L, et al. Study on the relationship between the ratio of neutrophil to lymphocyte and osteoporosis. Chin J Osteoporos. 2019;25(08):1134\u20137.","journal-title":"Chin J Osteoporos"},{"issue":"04","key":"3491_CR40","first-page":"245","volume":"39","author":"SZ Wei","year":"2017","unstructured":"Wei SZ, Zhifen HZEA. Effects of estrogen on Wnt16, \u03b2-catenin, OPG, RANKL expression in bone tissue of ovariectomized rats. Zhejiang Med. 2017;39(04):245\u20139.","journal-title":"Zhejiang Med."},{"issue":"7","key":"3491_CR41","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.3390\/ijerph15071373","volume":"15","author":"J Schweiger","year":"2018","unstructured":"Schweiger J, Schweiger U, H\u00fcppe M, Kahl K, Greggersen W, Jauch-Chara K, et al. The use of antidepressive agents and bone mineral density in women: a meta-analysis. Int J Environ Res Public Health. 2018;15(7):1373. https:\/\/doi.org\/10.3390\/ijerph15071373.","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"3491_CR42","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/injuryprev-2014-041483","volume":"21","author":"Y Sheu","year":"2015","unstructured":"Sheu Y, Lanteigne A, St\u00fcrmer T, Pate V, Azrael D, Miller M. SSRI use and risk of fractures among perimenopausal women without mental disorders. Injury Prev. 2015;21(6):397\u2013403. https:\/\/doi.org\/10.1136\/injuryprev-2014-041483.","journal-title":"Injury Prev"},{"issue":"2","key":"3491_CR43","doi-asserted-by":"publisher","first-page":"158","DOI":"10.4415\/ANN_16_02_06","volume":"52","author":"R Var\u00ec","year":"2016","unstructured":"Var\u00ec R, Scazzocchio B, D\u2019Amore A, Giovannini C, Gessani S, Masella R. Gender-related differences in lifestyle may affect health status. Annali dell\u2019Istituto superiore di sanita. 2016;52(2):158\u201366. https:\/\/doi.org\/10.4415\/ANN_16_02_06.","journal-title":"Annali dell\u2019Istituto superiore di sanita."},{"issue":"2","key":"3491_CR44","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s11914-017-0349-0","volume":"15","author":"JW Nieves","year":"2017","unstructured":"Nieves JW. Sex-differences in skeletal growth and aging. Curr Osteoporos Rep. 2017;15(2):70\u20135. https:\/\/doi.org\/10.1007\/s11914-017-0349-0.","journal-title":"Curr Osteoporos Rep"},{"key":"3491_CR45","doi-asserted-by":"publisher","first-page":"8863","DOI":"10.2147\/IJGM.S334972","volume":"14","author":"P Niu","year":"2021","unstructured":"Niu P, Li H, Liu D, Zhang YF, Liu Y, Liang C. Association between HDL-C and bone mineral density: an cross-sectional analysis. Int J Gen Med. 2021;14:8863\u201372. https:\/\/doi.org\/10.2147\/IJGM.S334972.","journal-title":"Int J Gen Med"},{"key":"3491_CR46","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.maturitas.2021.03.001","volume":"147","author":"I Zolfaroli","year":"2021","unstructured":"Zolfaroli I, Ortiz E, Garc\u00eda-P\u00e9rez M, Hidalgo-Mora JJ, Tar\u00edn JJ, Cano A. Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women. Maturitas. 2021;147:41\u20136. https:\/\/doi.org\/10.1016\/j.maturitas.2021.03.001.","journal-title":"Maturitas"},{"key":"3491_CR47","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.2147\/CIA.S266722","volume":"15","author":"Q Zhang","year":"2020","unstructured":"Zhang Q, Zhou J, Wang Q, Lu C, Xu Y, Cao H, et al. Association between bone mineral density and lipid profile in Chinese women. Clin Interv Aging. 2020;15:1649\u201364. https:\/\/doi.org\/10.2147\/CIA.S266722.","journal-title":"Clin Interv Aging"},{"issue":"3","key":"3491_CR48","first-page":"301","volume":"35","author":"XGZX Bin","year":"2016","unstructured":"Bin XGZX. The related research of antero-posterior lumbar spine bone mineral density data of 2 205 healthy men in Shanghai. J Southeast Univ (Med Sci Ed). 2016;35(3):301\u20134.","journal-title":"J Southeast Univ (Med Sci Ed)"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-022-03491-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-022-03491-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-022-03491-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T11:02:54Z","timestamp":1673089374000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-022-03491-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,7]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3491"],"URL":"https:\/\/doi.org\/10.1186\/s13018-022-03491-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.04.12.22273773","asserted-by":"object"}]},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,7]]},"assertion":[{"value":"28 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The original survey was approved by the NCHS Research Ethics Review Board and all adult participants provided written informed consent. The present analysis was deemed exempt by the Institutional Review Board at our institution, as the dataset used in the analysis was completely de-identified.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests and have not received Grant support or research funding.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20"}}