{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T21:07:26Z","timestamp":1776805646358,"version":"3.51.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Low back pain (LBP) affects a significant proportion of the adult population. Potent anti-resorptive drugs such as intravenous zoledronic acid have been demonstrated to reduce Modic changes (MCs) upon magnetic resonance imaging (MRI) of the spine and concomitantly decrease associated LBP. It is uncertain whether oral alendronic acid has a similar effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>82 subjects were recruited in this case-control study. Treatment subjects (<jats:italic>n<\/jats:italic>\u2009=\u200941) received oral alendronic acid treatment for at least 1-year and were matched by gender and age (\u00b1\u20092) to control subjects (<jats:italic>n<\/jats:italic>\u2009=\u200941) not receiving any anti-osteoporotic medication. The prevalence, type, and extent of MCs were quantified upon T1 and T2-weighted MRIs of the lumbosacral spine.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Treatment subjects received oral alendronic acid for 124.0\u2009\u00b1\u200962.1 weeks at the time of MRI assessment and exhibited a lower prevalence of MCs over the lumbosacral spine (18\/41 vs. 30\/41, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as compared to control subjects. Amongst both groups, type 2 MCs were predominant. Quantification of type 2 MCs in treatment subjects revealed a significant reduction in area (113\u2009\u00b1\u2009106 mm<jats:sup>2<\/jats:sup> vs. 231\u2009\u00b1\u2009144 mm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and volume (453\u2009\u00b1\u2009427 mm<jats:sup>3<\/jats:sup> vs. 925\u2009\u00b1\u2009575 mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) affected by type 2 MCs in comparison to matched controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Oral alendronic acid may be useful in the treatment of MC-associated LBP in patients with concomitant osteoporosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-024-04780-2","type":"journal-article","created":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:01:43Z","timestamp":1715533303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of long-term alendronic acid treatment on Modic changes in the lumbar spine: a gender and age-matched study"],"prefix":"10.1186","volume":"19","author":[{"given":"Kenneth","family":"Yiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjeong","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-371X","authenticated-orcid":false,"given":"Graham Ka-Hon","family":"Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"issue":"3","key":"4780_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/00002517-200006000-00003","volume":"13","author":"BF Walker","year":"2000","unstructured":"Walker BF. 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