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Parathyroid hormone (PTH) (1\u201334) is commonly used to treat osteoporosis. However, little is known about its effects on FJD induced by estrogen deficiency. This study aims to investigate the effects of PTH (1\u201334) on FJD induced by estrogen deficiency and the underlying pathogenesis of the disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty 3-month-old female Sprague-Dawley rats were randomly divided into four groups: 30 received bilateral ovariectomy (OVX) followed by 12 weeks of treatment with normal saline, PTH (1\u201334) or 17\u03b2-estradiol (E2), and 10 received sham surgery followed by administration of normal saline. Status and Wnt\/\u03b2-catenin signaling activity in the cartilage and subchondral bone of the L4\u2013L5 FJs and serum biomarkers were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Administration of PTH (1\u201334) and E2 ameliorated cartilage lesions, and significantly decreased MMP-13 and caspase-3 levels and chondrocyte apoptosis. PTH (1\u201334) but not E2 significantly increased cartilage thickness, number of chondrocytes, and the expression of aggrecan. PTH (1\u201334) significantly improved microarchitecture parameters of subchondral bone, increased the expression of collagen I and osteocalcin, and decreased RANKL\/OPG ratio. E2 treatment significantly increased the OPG level and decreased the RANKL\/OPG ratio in the subchondral bone of ovariectomized rats, but it did not significantly improve the microarchitecture parameters of subchondral bone. Wnt3a and \u03b2-catenin expression was significantly reduced in the articular cartilage and subchondral bone in OVX rats, but PTH (1\u201334) could increase the expression of these proteins. E2 significantly increased the activity of Wnt\/\u03b2-catenin pathway only in cartilage, but not in subchondral bone. The restoration of Wnt\/\u03b2-catenin signaling had an obvious correlation with the improvement of some parameters associated with the FJs status.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Wnt\/\u03b2-catenin signaling may be a potential therapeutic target for FJD induced by estrogen deficiency. PTH (1\u201334) is effective in treating this disease with better efficacy than 17\u03b2-estradiol, and the efficacy may be attributed to its restoration of Wnt\/\u03b2-catenin signaling.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-024-04817-6","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:06:48Z","timestamp":1718352408000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Parathyroid hormone (1\u201334) retards the lumbar facet joint degeneration and activates Wnt\/\u03b2-catenin signaling pathway in ovariectomized rats"],"prefix":"10.1186","volume":"19","author":[{"given":"Yu","family":"Gou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hetong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faming","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"issue":"10070","key":"4817_CR1","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0140-6736(16)30970-9","volume":"389","author":"C Maher","year":"2017","unstructured":"Maher C, Underwood M, Buchbinder R. 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