{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:44:50Z","timestamp":1790023490000,"version":"4.0.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 51771069"],"award-info":[{"award-number":["No. 51771069"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 51771069"],"award-info":[{"award-number":["No. 51771069"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 51771069"],"award-info":[{"award-number":["No. 51771069"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 51771069"],"award-info":[{"award-number":["No. 51771069"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 51771069"],"award-info":[{"award-number":["No. 51771069"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Open fractures are challenging due to susceptibility to Staphylococcus aureus infections. This study examines the impact of Vancomycin-Loaded Calcium Sulfate (VLCS) and negative pressure wound therapy (NPWT) on macrophage behavior in enhancing healing and infection resistance. Both VLCS and NPWT were evaluated individually and in combination to determine their effects on macrophage polarization and infection resistance in open fractures.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Through single-cell RNA sequencing, genomic expressions in macrophages from open fracture patients treated with VLCS and NPWT were compared to a control group. The analysis focused on MBD2 gene changes related to macrophage polarization.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Remarkable modifications in MBD2 expression in the treatment group indicate a shift towards M2 macrophage polarization. Additionally, the combined treatment group exhibited greater improvements in infection resistance and healing compared to the individual treatments. This shift suggests a healing-promoting atmosphere with improved infection resilience.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>VLCS and NPWT demonstrate the ability to alter macrophage behavior toward M2 polarization, which is crucial for infection prevention in open fractures. The synergistic effect of their combined use shows even greater promise in enhancing outcomes in orthopedic trauma care.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13018-024-04931-5","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:02:00Z","timestamp":1724889720000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel insights into vancomycin-loaded calcium sulfate and negative pressure wound therapy in preventing infections in open fractures"],"prefix":"10.1186","volume":"19","author":[{"given":"Bei","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"issue":"4","key":"4931_CR1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.4103\/ortho.IJOrtho_344_16","volume":"52","author":"R Hu","year":"2018","unstructured":"Hu R, Ren YJ, Yan L, et al. Analysis of staged treatment for Gustilo Anderson IIIB\/C Open Tibial fractures. Indian J Orthop. 2018;52(4):411\u20137. https:\/\/doi.org\/10.4103\/ortho.IJOrtho_344_16.","journal-title":"Indian J Orthop"},{"key":"4931_CR2","doi-asserted-by":"publisher","unstructured":"Maciel-Vergara G, Jensen AB, Eilenberg J. Cannibalism as a Possible Entry Route for Opportunistic Pathogenic Bacteria to Insect Hosts, Exemplified by Pseudomonas aeruginosa, a Pathogen of the Giant Mealworm Zophobas morio. Insects. 2018;9(3):88. Published 2018 Jul 24. https:\/\/doi.org\/10.3390\/insects9030088.","DOI":"10.3390\/insects9030088"},{"key":"4931_CR3","unstructured":"Macneal P, Milroy C. Paronychia Drainage. In: StatPearls. Treasure Island (FL): StatPearls Publishing; June 5, 2023."},{"issue":"4","key":"4931_CR4","doi-asserted-by":"publisher","first-page":"e210","DOI":"10.1097\/OI9.0000000000000210","volume":"5","author":"A Aneja","year":"2022","unstructured":"Aneja A, Kavolus MW, Teasdall RJ, et al. Does prophylactic local tobramycin injection lower open fracture infection rates? OTA Int. 2022;5(4):e210. https:\/\/doi.org\/10.1097\/OI9.0000000000000210. Published 2022 Nov 16.","journal-title":"OTA Int"},{"issue":"Suppl 1","key":"4931_CR5","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1086\/491712","volume":"42","author":"MJ Rybak","year":"2006","unstructured":"Rybak MJ. The pharmacokinetic and pharmacodynamic properties of Vancomycin. Clin Infect Dis. 2006;42(Suppl 1):S35\u20139. https:\/\/doi.org\/10.1086\/491712.","journal-title":"Clin Infect Dis"},{"issue":"6","key":"4931_CR6","doi-asserted-by":"publisher","first-page":"550","DOI":"10.12200\/j.issn.1003-0034.2021.06.014","volume":"34","author":"K Huang","year":"2021","unstructured":"Huang K, Lin BY, Ren HY, et al. Zhongguo Gu Shang. 2021;34(6):550\u20133. https:\/\/doi.org\/10.12200\/j.issn.1003-0034.2021.06.014.","journal-title":"Zhongguo Gu Shang"},{"issue":"12","key":"4931_CR7","doi-asserted-by":"publisher","first-page":"e2004172","DOI":"10.1002\/adma.202004172","volume":"33","author":"J Li","year":"2021","unstructured":"Li J, Jiang X, Li H, Gelinsky M, Gu Z. Tailoring materials for modulation of macrophage fate. Adv Mater. 2021;33(12):e2004172. https:\/\/doi.org\/10.1002\/adma.202004172.","journal-title":"Adv Mater"},{"issue":"1","key":"4931_CR8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12974-020-02041-7","volume":"18","author":"H Wu","year":"2021","unstructured":"Wu H, Zheng J, Xu S, et al. Mer regulates microglial\/macrophage M1\/M2 polarization and alleviates neuroinflammation following traumatic brain injury. J Neuroinflammation. 2021;18(1):2. https:\/\/doi.org\/10.1186\/s12974-020-02041-7. Published 2021 Jan 5.","journal-title":"J Neuroinflammation"},{"key":"4931_CR9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.trsl.2021.05.006","volume":"236","author":"AE Louiselle","year":"2021","unstructured":"Louiselle AE, Niemiec SM, Zgheib C, Liechty KW. Macrophage polarization and diabetic wound healing. Transl Res. 2021;236:109\u201316. https:\/\/doi.org\/10.1016\/j.trsl.2021.05.006.","journal-title":"Transl Res"},{"issue":"5","key":"4931_CR10","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/j.jcmgh.2022.02.006","volume":"13","author":"GQ Zhu","year":"2022","unstructured":"Zhu GQ, Wang Y, Wang B, et al. Targeting HNRNPM inhibits Cancer Stemness and enhances Antitumor Immunity in wnt-activated Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol. 2022;13(5):1413\u201347. https:\/\/doi.org\/10.1016\/j.jcmgh.2022.02.006.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"4931_CR11","doi-asserted-by":"publisher","first-page":"930103","DOI":"10.3389\/fimmu.2022.930103","volume":"13","author":"GR Wu","year":"2022","unstructured":"Wu GR, Zhou M, Wang Y, et al. Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production. Front Immunol. 2022;13:930103. https:\/\/doi.org\/10.3389\/fimmu.2022.930103. Published 2022 Aug 25.","journal-title":"Front Immunol"},{"issue":"3","key":"4931_CR12","doi-asserted-by":"publisher","first-page":"e026345","DOI":"10.1136\/bmjopen-2018-026345","volume":"10","author":"D Seidel","year":"2020","unstructured":"Seidel D, Storck M, Lawall H, et al. Negative pressure wound therapy compared with standard moist wound care on diabetic foot ulcers in real-life clinical practice: results of the German DiaFu-RCT. BMJ Open. 2020;10(3):e026345. https:\/\/doi.org\/10.1136\/bmjopen-2018-026345. Published 2020 Mar 24.","journal-title":"BMJ Open"},{"key":"4931_CR13","unstructured":"Rodziewicz TL, Houseman B, Vaqar S, Hipskind JE. Medical error reduction and Prevention. StatPearls. Treasure Island (FL). Volume 12. StatPearls Publishing; 2024."},{"issue":"15","key":"4931_CR14","doi-asserted-by":"publisher","first-page":"8660","DOI":"10.3390\/ijms23158660","volume":"23","author":"A Kawase","year":"2022","unstructured":"Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M. Diclofenac-Induced cytotoxicity in Direct and Indirect Co-culture of HepG2 cells with differentiated THP-1 cells. Int J Mol Sci. 2022;23(15):8660. https:\/\/doi.org\/10.3390\/ijms23158660. Published 2022 Aug 4.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4931_CR15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s10856-016-5671-z","volume":"27","author":"J Gu","year":"2016","unstructured":"Gu J, Wang T, Fan G, Ma J, Hu W, Cai X. Biocompatibility of artificial bone based on Vancomycin loaded mesoporous silica nanoparticles and calcium sulfate composites. J Mater Sci Mater Med. 2016;27(4):64. https:\/\/doi.org\/10.1007\/s10856-016-5671-z.","journal-title":"J Mater Sci Mater Med"},{"issue":"2","key":"4931_CR16","doi-asserted-by":"publisher","first-page":"R23","DOI":"10.1186\/bcr3622","volume":"16","author":"Lustberg","year":"2014","unstructured":"Lustberg MB, Balasubramanian P, Miller B, et al. Heterogeneous atypical cell populations are present in blood of metastatic breast cancer patients. Breast Cancer Res. 2014;16(2):R23. https:\/\/doi.org\/10.1186\/bcr3622. Published 2014 Mar 6.","journal-title":"Breast Cancer Res"},{"issue":"7832","key":"4931_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41586-020-2856-x","volume":"587","author":"W Sun","year":"2020","unstructured":"Sun W, Dong H, Balaz M, et al. snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature. 2020;587(7832):98\u2013102. https:\/\/doi.org\/10.1038\/s41586-020-2856-x.","journal-title":"Nature"},{"issue":"5","key":"4931_CR18","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1136\/gutjnl-2021-326070","volume":"72","author":"L Wang","year":"2023","unstructured":"Wang L, Liu Y, Dai Y, et al. Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment. Gut. 2023;72(5):958\u201371. https:\/\/doi.org\/10.1136\/gutjnl-2021-326070.","journal-title":"Gut"},{"issue":"10","key":"4931_CR19","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.3390\/genes13101760","volume":"13","author":"K Chen","year":"2022","unstructured":"Chen K, Wang Q, Liu X, et al. Single cell RNA-Seq identifies Immune-related Prognostic Model and Key Signature-SPP1 in pancreatic ductal adenocarcinoma. Genes (Basel). 2022;13(10):1760. https:\/\/doi.org\/10.3390\/genes13101760. Published 2022 Sep 29.","journal-title":"Genes (Basel)"},{"key":"4931_CR20","doi-asserted-by":"publisher","unstructured":"Qi J, Sun H, Zhang Y et al. Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nat Commun. 2022;13(1):1742. Published 2022 Apr 1. https:\/\/doi.org\/10.1038\/s41467-022-29366-6.","DOI":"10.1038\/s41467-022-29366-6"},{"key":"4931_CR21","doi-asserted-by":"publisher","unstructured":"Di Z, Zhou S, Xu G et al. Single-cell and WGCNA uncover a prognostic model and potential oncogenes in colorectal cancer. Biol Proced Online. 2022;24(1):13. Published 2022 Sep 19. https:\/\/doi.org\/10.1186\/s12575-022-00175-x.","DOI":"10.1186\/s12575-022-00175-x"},{"key":"4931_CR22","doi-asserted-by":"publisher","first-page":"8060477","DOI":"10.1155\/2021\/8060477","volume":"2021","author":"W Lin","year":"2021","unstructured":"Lin W, Wang Y, Chen Y, Wang Q, Gu Z, Zhu Y. Role of Calcium Signaling Pathway-Related Gene Regulatory Networks in ischemic stroke based on multiple WGCNA and single-cell analysis. Oxid Med Cell Longev. 2021;2021:8060477. https:\/\/doi.org\/10.1155\/2021\/8060477. Published 2021 Dec 26.","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"4931_CR23","doi-asserted-by":"publisher","first-page":"331","DOI":"10.7150\/ijbs.72538","volume":"19","author":"X He","year":"2023","unstructured":"He X, Chen H, Zhong X, et al. BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer. Int J Biol Sci. 2023;19(1):331\u201345. https:\/\/doi.org\/10.7150\/ijbs.72538. Published 2023 Jan 1.","journal-title":"Int J Biol Sci"},{"issue":"2","key":"4931_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/jor.24965","volume":"39","author":"SV Cahill","year":"2021","unstructured":"Cahill SV, Kwon HK, Back J, et al. Locally delivered adjuvant biofilm-penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection. J Orthop Res. 2021;39(2):402\u201314. https:\/\/doi.org\/10.1002\/jor.24965.","journal-title":"J Orthop Res"},{"key":"4931_CR25","doi-asserted-by":"publisher","unstructured":"Stavrakis AI, Zhu S, Loftin AH et al. Controlled release of Vancomycin and Tigecycline from an Orthopaedic Implant Coating prevents Staphylococcus aureus infection in an Open Fracture Animal Model. Biomed Res Int. 2019;2019:1638508. Published 2019 Dec 12. https:\/\/doi.org\/10.1155\/2019\/1638508.","DOI":"10.1155\/2019\/1638508"},{"issue":"5","key":"4931_CR26","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1159\/000492545","volume":"48","author":"J Liu","year":"2018","unstructured":"Liu J, Jiang J, Hui X, Wang W, Fang D, Ding L. Mir-758-5p suppresses Glioblastoma Proliferation, Migration and Invasion by Targeting ZBTB20. Cell Physiol Biochem. 2018;48(5):2074\u201383. https:\/\/doi.org\/10.1159\/000492545.","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"4931_CR27","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3892\/ijmm.2019.4263","volume":"44","author":"Q Jia","year":"2019","unstructured":"Jia Q, Cao H, Shen D, et al. Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPAR\u03b3, LXR\u03b1 and ABCA1. Int J Mol Med. 2019;44(3):893\u2013902. https:\/\/doi.org\/10.3892\/ijmm.2019.4263.","journal-title":"Int J Mol Med"},{"key":"4931_CR28","doi-asserted-by":"publisher","first-page":"100869","DOI":"10.1016\/j.bbrep.2020.100869","volume":"24","author":"J Zhang","year":"2020","unstructured":"Zhang J, Wu J, Sun M, et al. Phospholipase C epsilon mediates cytokine cascade induced by acute disruption of epidermal permeability barrier in mice. Biochem Biophys Rep. 2020;24:100869. https:\/\/doi.org\/10.1016\/j.bbrep.2020.100869. Published 2020 Dec 9.","journal-title":"Biochem Biophys Rep"},{"issue":"4","key":"4931_CR29","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1097\/PRS.0b013e31820a63cb","volume":"127","author":"P Dastouri","year":"2011","unstructured":"Dastouri P, Helm DL, Scherer SS, Pietramaggiori G, Younan G, Orgill DP. Waveform modulation of negative-pressure wound therapy in the murine model. Plast Reconstr Surg. 2011;127(4):1460\u20136. https:\/\/doi.org\/10.1097\/PRS.0b013e31820a63cb.","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"4931_CR30","doi-asserted-by":"publisher","first-page":"e275","DOI":"10.1097\/PRS.0000000000008142","volume":"148","author":"CK Sen","year":"2021","unstructured":"Sen CK, Roy S, Mathew-Steiner SS, Gordillo GM. Biofilm Management in Wound Care. Plast Reconstr Surg. 2021;148(2):e275\u201388. https:\/\/doi.org\/10.1097\/PRS.0000000000008142.","journal-title":"Plast Reconstr Surg"},{"issue":"13","key":"4931_CR31","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1093\/cvr\/cvab303","volume":"117","author":"P Libby","year":"2021","unstructured":"Libby P. Inflammation during the life cycle of the atherosclerotic plaque. Cardiovasc Res. 2021;117(13):2525\u201336. https:\/\/doi.org\/10.1093\/cvr\/cvab303.","journal-title":"Cardiovasc Res"},{"issue":"9","key":"4931_CR32","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s00011-022-01616-9","volume":"71","author":"L Sapra","year":"2022","unstructured":"Sapra L, Saini C, Garg B, et al. Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics. Inflamm Res. 2022;71(9):1025\u201340. https:\/\/doi.org\/10.1007\/s00011-022-01616-9.","journal-title":"Inflamm Res"},{"issue":"2","key":"4931_CR33","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/1346-8138.16654","volume":"50","author":"H Ujiie","year":"2023","unstructured":"Ujiie H. What\u2019s new in the pathogeneses and triggering factors of bullous pemphigoid. J Dermatol. 2023;50(2):140\u20139. https:\/\/doi.org\/10.1111\/1346-8138.16654.","journal-title":"J Dermatol"},{"issue":"9","key":"4931_CR34","doi-asserted-by":"publisher","first-page":"e005323","DOI":"10.1136\/jitc-2022-005323","volume":"10","author":"A Franken","year":"2022","unstructured":"Franken A, Van Mol P, Vanmassenhove S, et al. Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis. J Immunother Cancer. 2022;10(9):e005323. https:\/\/doi.org\/10.1136\/jitc-2022-005323.","journal-title":"J Immunother Cancer"},{"issue":"14","key":"4931_CR35","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1093\/hmg\/ddac043","volume":"31","author":"AP Voigt","year":"2022","unstructured":"Voigt AP, Mullin NK, Mulfaul K, et al. Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration. Hum Mol Genet. 2022;31(14):2406\u201323. https:\/\/doi.org\/10.1093\/hmg\/ddac043.","journal-title":"Hum Mol Genet"},{"key":"4931_CR36","doi-asserted-by":"publisher","first-page":"812774","DOI":"10.3389\/fimmu.2022.812774","volume":"13","author":"T Duan","year":"2022","unstructured":"Duan T, Du Y, Xing C, Wang HY, Wang RF. Toll-like receptor signaling and its role in cell-mediated immunity. Front Immunol. 2022;13:812774. https:\/\/doi.org\/10.3389\/fimmu.2022.812774. Published 2022 Mar 3.","journal-title":"Front Immunol"},{"key":"4931_CR37","doi-asserted-by":"publisher","unstructured":"Wang X, Zhao C, Zhang C et al. Increased HERV-E clone 4\u2009\u2013\u20091 expression contributes to DNA hypomethylation and IL-17 release from CD4+ T cells via miR-302d\/MBD2 in systemic lupus erythematosus. Cell Commun Signal. 2019;17(1):94. Published 2019 Aug 14. https:\/\/doi.org\/10.1186\/s12964-019-0416-5.","DOI":"10.1186\/s12964-019-0416-5"},{"issue":"8","key":"4931_CR38","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1080\/15384047.2018.1450113","volume":"19","author":"L Cheng","year":"2018","unstructured":"Cheng L, Tang Y, Chen X, et al. Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells. Cancer Biol Ther. 2018;19(8):676\u201386. https:\/\/doi.org\/10.1080\/15384047.2018.1450113.","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"4931_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/jhrm.21399","volume":"40","author":"K McDonald","year":"2020","unstructured":"McDonald K, Vonnes C, Hartranft S. Direct care nurses and support staff thoughts and feelings about the reasons patients fall at a cancer center. J Healthc Risk Manag. 2020;40(1):17\u201323. https:\/\/doi.org\/10.1002\/jhrm.21399.","journal-title":"J Healthc Risk Manag"},{"issue":"1","key":"4931_CR40","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1080\/21505594.2022.2119657","volume":"13","author":"M Asai","year":"2022","unstructured":"Asai M, Li Y, Spiropoulos J, et al. Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv. Virulence. 2022;13(1):1543\u201357. https:\/\/doi.org\/10.1080\/21505594.2022.2119657.","journal-title":"Virulence"},{"key":"4931_CR41","doi-asserted-by":"publisher","unstructured":"Njau F, Shushakova N, Schenk H et al. Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice [published correction appears in PLoS One. 2020;15(12):e0244353. doi: 10.1371\/journal.pone.0244353]. PLoS One. 2020;15(1):e0218494. Published 2020 Jan 14. https:\/\/doi.org\/10.1371\/journal.pone.0218494.","DOI":"10.1371\/journal.pone.0218494"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-04931-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-024-04931-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-04931-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:02:23Z","timestamp":1724889743000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-024-04931-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4931"],"URL":"https:\/\/doi.org\/10.1186\/s13018-024-04931-5","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"16 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All clinical samples were collected with the approval of the relevant Hebei Medical University Third Hospital\u2019s ethics committee, and patients provided informed consent. Animal experiments adhered to the \u201cEthical Regulations for Animal Experiments\u201d and followed the guidelines of Hebei Medical University Third Hospital\u2019s animal experiment committee, which granted approval for all experimental procedures. We are committed to minimizing animal suffering during the experiments, and all animals will be handled in a humane manner following the conclusion of the experiments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The author declares no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"517"}}