{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:54:22Z","timestamp":1774511662768,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB4706300"],"award-info":[{"award-number":["2023YFB4706300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB4706300"],"award-info":[{"award-number":["2023YFB4706300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB4706300"],"award-info":[{"award-number":["2023YFB4706300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB4706300"],"award-info":[{"award-number":["2023YFB4706300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB4706300"],"award-info":[{"award-number":["2023YFB4706300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["L212042"],"award-info":[{"award-number":["L212042"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["L212042"],"award-info":[{"award-number":["L212042"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["L212042"],"award-info":[{"award-number":["L212042"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["L212042"],"award-info":[{"award-number":["L212042"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["L212042"],"award-info":[{"award-number":["L212042"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"DOI":"10.1186\/s13018-024-05098-9","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T08:02:03Z","timestamp":1727942523000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The clinical outcomes and prognostic factors of dedifferentiated central chondrosarcoma in extremities"],"prefix":"10.1186","volume":"19","author":[{"given":"Zhuoyu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"5098_CR1","unstructured":"Inwards CY, Bloem JL, Hogendoorn PCW. WHO Classification of Tumours. 5th ed. International Arctic Research Center; Lyon, France: 2020. Dedifferentiated chondrosarcoma; pp. 388\u2013390. Soft Tissue and Bone Tumours. The WHO Classification of Tumours Editorial Board."},{"issue":"2","key":"5098_CR2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/1097-0142(197108)28:2<461::AID-CNCR2820280227>3.0.CO;2-U","volume":"28","author":"DC Dahlin","year":"1971","unstructured":"Dahlin DC, Beabout JW. Dedifferentiation of low-grade chondrosarcomas. Cancer. 1971;28(2):461\u20136.","journal-title":"Cancer"},{"key":"5098_CR3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1302\/0301-620X.82B1.0820055","volume":"82","author":"AD Mitchell","year":"2000","unstructured":"Mitchell AD, Ayoub K, Mangham DC, Grimer RJ, Carter SR, Tillman RM. Experience in the treatment of dedifferentiated chondrosarcoma. J Bone Joint Surg Br. 2000;82:55\u201361.","journal-title":"J Bone Joint Surg Br"},{"key":"5098_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.2106\/00004623-198870010-00010","volume":"70","author":"R Capanna","year":"1988","unstructured":"Capanna R, Bertoni F, Bettelli G, Picci P, Bacchini P, Present D, Giunti A, Campanacci M. Dedifferentiated chondrosarcoma. J Bone Joint Surg Am. 1988;70:60\u20139.","journal-title":"J Bone Joint Surg Am"},{"key":"5098_CR5","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.ejca.2007.06.016","volume":"43","author":"RJ Grimer","year":"2007","unstructured":"Grimer RJ, Gosheger G, Taminiau A, et al. Dedifferentiated chondrosarcoma: prognostic factors and outcome from a European group. Eur J Cancer. 2007;43:2060\u20135.","journal-title":"Eur J Cancer"},{"key":"5098_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/jso.24650","volume":"116","author":"PK Strotman","year":"2017","unstructured":"Strotman PK, Reif TJ, Kliethermes SA, et al. Dedifferentiated chondrosarcoma: a survival analysis of 159 cases from the SEER database (2001\u20132011). J Surg Oncol. 2017;116:252\u20137.","journal-title":"J Surg Oncol"},{"key":"5098_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/BF00941235","volume":"24","author":"M Mercuri","year":"1995","unstructured":"Mercuri M, Picci P, Campanacci L, Rulli E. Dedifferentiated chondrosarcoma. Skel Radiol. 1995;24:409\u201316.","journal-title":"Skel Radiol"},{"issue":"11","key":"5098_CR8","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.2106\/00004623-200411000-00008","volume":"86","author":"ID Dickey","year":"2004","unstructured":"Dickey ID, Rose PS, Fuchs B, et al. Dedifferentiated chondrosarcoma: the role of chemotherapy with updated outcomes. J Bone Joint Surg Am. 2004;86(11):2412\u20138.","journal-title":"J Bone Joint Surg Am"},{"issue":"6","key":"5098_CR9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00432-004-0648-6","volume":"131","author":"J Bruns","year":"2005","unstructured":"Bruns J, Fiedler W, Werner M, Delling G. Dedifferentiated chondrosarcoma?a fatal disease. J Cancer Res Clin Oncol. 2005;131(6):333\u20139.","journal-title":"J Cancer Res Clin Oncol"},{"issue":"5","key":"5098_CR10","doi-asserted-by":"publisher","first-page":"987","DOI":"10.2106\/JBJS.F.00288","volume":"89","author":"EL Staals","year":"2007","unstructured":"Staals EL, Bacchini P, Mercuri M, Bertoni F. Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. J Bone Joint Surg Am. 2007;89(5):987\u201393.","journal-title":"J Bone Joint Surg Am"},{"issue":"12","key":"5098_CR11","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1302\/0301-620X.102B12.BJJ-2020-0810.R1","volume":"102\u2013B","author":"Y Tsuda","year":"2020","unstructured":"Tsuda Y, Tsoi K, Stevenson JD, et al. Development and external validation of nomograms to predict sarcoma-specific death and disease progression after surgical resection of localized high-grade conventional primary central chondrosarcoma and dedifferentiated chondrosarcoma. Bone Joint J. 2020;102\u2013B(12):1752\u20139.","journal-title":"Bone Joint J"},{"key":"5098_CR12","doi-asserted-by":"publisher","first-page":"746909","DOI":"10.3389\/fmed.2021.746909","volume":"8","author":"LH Gong","year":"2021","unstructured":"Gong LH, Su YB, Zhang W, Liu WF, Dong RF, Sun XQ, Zhang M, Ding Y. Dedifferentiated Central Chondrosarcoma: a clinical, histopathological, and immunohistochemical analysis of 57 cases. Front Med (Lausanne). 2021;8:746909.","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"5098_CR13","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1302\/0301-620X.103B5.BJJ-2020-1082.R2","volume":"103\u2013B","author":"MK Laitinen","year":"2021","unstructured":"Laitinen MK, Evans S, Stevenson J, et al. Clinical differences between central and peripheral chondrosarcomas. Bone Joint J. 2021;103\u2013B(5):984\u201390.","journal-title":"Bone Joint J"},{"issue":"10","key":"5098_CR14","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1302\/0301-620X.101B9.BJJ-2019-0190.R1","volume":"101\u2013B","author":"Y Tsuda","year":"2019","unstructured":"Tsuda Y, Gregory JJ, Fujiwara T, Abudu S. Secondary chondrosarcoma arising from osteochondroma: outcomes and prognostic factors. Bone Joint J. 2019;101\u2013B(10):1313\u201320.","journal-title":"Bone Joint J"},{"key":"5098_CR15","doi-asserted-by":"publisher","first-page":"9069272","DOI":"10.1155\/2019\/9069272","volume":"2019","author":"R Miao","year":"2019","unstructured":"Miao R, Choy E, Raskin KA, et al. Prognostic factors in dedifferentiated chondrosarcoma: a retrospective analysis of a large series treated at a single institution. Sarcoma. 2019;2019:9069272.","journal-title":"Sarcoma"},{"issue":"3","key":"5098_CR16","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1302\/0301-620X.101B3.BJJ-2018-0881.R1","volume":"101\u2013B","author":"MK Laitinen","year":"2019","unstructured":"Laitinen MK, Parry MC, Le Nail LR, Wigley CH, Stevenson JD, Jeys LM. Locally recurrent chondrosarcoma of the pelvis and limbs can only be controlled by wide local excision. Bone Joint J. 2019;101\u2013B(3):266\u201371.","journal-title":"Bone Joint J"},{"issue":"4","key":"5098_CR17","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1097\/CORR.0000000000002011","volume":"480","author":"LD Cranmer","year":"2022","unstructured":"Cranmer LD, Chau B, Mantilla JG, et al. Is Chemotherapy Associated with Improved overall survival in patients with Dedifferentiated Chondrosarcoma? A SEER database analysis. Clin Orthop Relat Res. 2022;480(4):748\u201358.","journal-title":"Clin Orthop Relat Res"},{"issue":"Suppl","key":"5098_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/BF00625054","volume":"106","author":"G Rosen","year":"1983","unstructured":"Rosen G, Marcove RC, Huvos AG, Caparros BI, Lane JM, Nirenberg A, Cacavio A, Groshen S. Primary osteogenic sarcoma: eight-year experience with adjuvant chemotherapy. J Cancer Res Clin Oncol. 1983;106(Suppl):55\u201367.","journal-title":"J Cancer Res Clin Oncol"},{"key":"5098_CR19","doi-asserted-by":"crossref","unstructured":"Enneking WF, Spanier SS, Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res. 1980;(153):106\u201320.","DOI":"10.1097\/00003086-198011000-00013"},{"key":"5098_CR20","doi-asserted-by":"crossref","unstructured":"Enneking WF, Dunham W, Gebhardt MC, Malawar M, Pritchard DJ. A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop Relat Res. 1993;(286):241\u20136.","DOI":"10.1097\/00003086-199301000-00035"},{"key":"5098_CR21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ejca.2021.04.017","volume":"151","author":"I Hompland","year":"2021","unstructured":"Hompland I, Ferrari S, Bielack S, et al. Outcome in dedifferentiated chondrosarcoma for patients treated with multimodal therapy: results from the EUROpean Bone over 40 Sarcoma Study. Eur J Cancer. 2021;151:150\u20138.","journal-title":"Eur J Cancer"},{"issue":"1","key":"5098_CR22","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3390\/curroncol31010040","volume":"31","author":"S Tsukamoto","year":"2024","unstructured":"Tsukamoto S, Mavrogenis AF, Nitta Y, et al. A systematic review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma. Curr Oncol. 2024;31(1):566\u201378.","journal-title":"Curr Oncol"},{"key":"5098_CR23","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1002\/cncr.21936","volume":"106","author":"EL Staals","year":"2006","unstructured":"Staals EL, Bacchini P, Bertoni F. Dedifferentiated central chondrosarcoma. Cancer. 2006;106:2682\u201391.","journal-title":"Cancer"},{"key":"5098_CR24","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s11999-013-3360-5","volume":"472","author":"S Kawaguchi","year":"2014","unstructured":"Kawaguchi S, Sun T, Lin PP, et al. Does ifosfamide therapy improve survival of patients with dedifferentiated chondrosarcoma? Clin Orthop Relat Res. 2014;472:983\u20139.","journal-title":"Clin Orthop Relat Res"},{"issue":"11","key":"5098_CR25","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1097\/CORR.0000000000000926","volume":"477","author":"Y Tsuda","year":"2019","unstructured":"Tsuda Y, Evans S, Stevenson JD, et al. Is the Width of a Surgical Margin Associated with the outcome of Disease in patients with Peripheral Chondrosarcoma of the Pelvis? A Multicenter Study. Clin Orthop Relat Res. 2019;477(11):2432\u201340.","journal-title":"Clin Orthop Relat Res"},{"issue":"7","key":"5098_CR26","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1111\/cas.15382","volume":"113","author":"E Kozawa","year":"2022","unstructured":"Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H. Clinical features and treatment outcomes of dedifferentiated and grade 3 chondrosarcoma: a multi-institutional study. Cancer Sci. 2022;113(7):2397\u2013408.","journal-title":"Cancer Sci"},{"key":"5098_CR27","doi-asserted-by":"publisher","first-page":"e0173665","DOI":"10.1371\/journal.pone.0173665","volume":"12","author":"C Liu","year":"2017","unstructured":"Liu C, Xi Y, Li M, et al. Dedifferentiated chondrosarcoma: radiological features, prognostic factors and survival statistics in 23 patients. PLoS ONE. 2017;12:e0173665.","journal-title":"PLoS ONE"},{"key":"5098_CR28","doi-asserted-by":"crossref","unstructured":"Dry SM. Dedifferentiation in bone and soft tissue sarcomas: how do we define it? What is prognostically relevant? Hum Pathol Published Online Febr 2, 2024.","DOI":"10.1016\/j.humpath.2024.02.001"},{"key":"5098_CR29","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jos.2020.04.013","volume":"26","author":"A Sambri","year":"2021","unstructured":"Sambri A, Tuzzato G, Donati DM, De Paolis M, Bianchi G. Pathological fracture does not affect prognosis in dedifferentiated chondrosarcoma of the limbs. J Orthop Sci. 2021;26:473\u20137.","journal-title":"J Orthop Sci"},{"issue":"1","key":"5098_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13569-018-0110-1","volume":"8","author":"JR Lex","year":"2018","unstructured":"Lex JR, Evans S, Stevenson JD, et al. Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment. Clin Sarcoma Res. 2018;8(1):23.","journal-title":"Clin Sarcoma Res"},{"issue":"1","key":"5098_CR31","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1634\/theoncologist.2017-0574","volume":"24","author":"A van Maldegem","year":"2019","unstructured":"van Maldegem A, Conley AP, Rutkowski P, et al. Outcome of first-line systemic treatment for unresectable conventional, dedifferentiated, mesenchymal, and clear cell chondrosarcoma. Oncologist. 2019;24(1):110\u20136.","journal-title":"Oncologist"},{"issue":"1","key":"5098_CR32","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1749-799X-7-38","volume":"7","author":"K Yokota","year":"2012","unstructured":"Yokota K, Sakamoto A, Matsumoto Y, et al. Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute. J Orthop Surg Res. 2012;7(1):38.","journal-title":"J Orthop Surg Res"},{"issue":"5","key":"5098_CR33","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00264-015-2706-x","volume":"39","author":"JI Albergo","year":"2015","unstructured":"Albergo JI, Gaston CL, Jeys LM, et al. Management and prognostic significance of pathological fractures through chondrosarcoma of the femur. Int Orthop. 2015;39(5):943\u20136.","journal-title":"Int Orthop"},{"issue":"13","key":"5098_CR34","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1016\/j.ejca.2007.07.004","volume":"43","author":"JAM Bramer","year":"2007","unstructured":"Bramer JAM, Abudu A, Grimer RJ, et al. Do pathological fractures influence survival and local recurrence rate in bony sarcomas? Eur J Cancer. 2007;43(13):1944\u201351.","journal-title":"Eur J Cancer"},{"issue":"11","key":"5098_CR35","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1093\/annonc\/mdt374","volume":"24","author":"A Italiano","year":"2013","unstructured":"Italiano A, Mir O, Cioffi A, et al. Advanced chondrosarcomas: role of chemotherapy and survival. Ann Oncol. 2013;24(11):2916\u201322.","journal-title":"Ann Oncol"},{"key":"5098_CR36","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1159\/000487803","volume":"41","author":"BS Dhinsa","year":"2018","unstructured":"Dhinsa BS, DeLisa M, Pollock R, et al. Dedifferentiated chondrosarcoma demonstrating osteosarcomatous differentiation. Oncol Res Treat. 2018;41:456\u201360.","journal-title":"Oncol Res Treat"},{"key":"5098_CR37","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.3390\/cancers15092617","volume":"15","author":"N Bui","year":"2023","unstructured":"Bui N, Dietz H, Farag S, Hirbe AC, Wagner MJ, Van Tine BA, Ganjoo K, Jones RL, Keedy VL, Davis E. J. A retrospective multi-institutional cohort analysis of clinical characteristics and outcomes in dedifferentiated chondrosarcoma. Cancers. 2023;15:2617.","journal-title":"Cancers"},{"issue":"2","key":"5098_CR38","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/jor.24463","volume":"38","author":"KM Amer","year":"2020","unstructured":"Amer KM, Munn M, Congiusta D, Abraham JA, Basu Mallick A. Survival and prognosis of Chondrosarcoma subtypes: SEER Database Analysis. J Orthop Res. 2020;38(2):311\u20139.","journal-title":"J Orthop Res"},{"issue":"1","key":"5098_CR39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/cncr.32515","volume":"126","author":"W Chow","year":"2020","unstructured":"Chow W, Frankel P, Ruel C, et al. Results of a prospective phase 2 study of pazopanib in patients with surgically unresectable or metastatic chondrosarcoma. Cancer. 2020;126(1):105\u201311.","journal-title":"Cancer"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-05098-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-024-05098-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-05098-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T08:06:53Z","timestamp":1727942813000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-024-05098-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5098"],"URL":"https:\/\/doi.org\/10.1186\/s13018-024-05098-9","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"24 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Ethics Review Board of Beijing Jishuitan Hospital. All methods were performed in accordance with the 1964 Declaration of Helsinki and its later amendments, and the ethical standards of the institutional research committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"621"}}