{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:45:55Z","timestamp":1783356355999,"version":"3.54.6"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","award":["20230083"],"award-info":[{"award-number":["20230083"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008238","name":"Hebei Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["216Z7708G"],"award-info":[{"award-number":["216Z7708G"]}],"id":[{"id":"10.13039\/501100008238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"DOI":"10.1186\/s13018-024-05376-6","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T08:39:32Z","timestamp":1735202372000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chronic intermittent hypobaric hypoxia alleviates early-stage posttraumatic osteoarthritis via NF-\u03baB\/Nrf2 pathway in mice"],"prefix":"10.1186","volume":"19","author":[{"given":"Guowei","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangquan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"5376_CR1","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/01.bot.0000246468.80635.ef","volume":"20","author":"TD Brown","year":"2006","unstructured":"Brown TD, Johnston RC, Saltzman CL, Marsh JL, Buckwalter JA. Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma. 2006;20:739\u201344.","journal-title":"J Orthop Trauma"},{"key":"5376_CR2","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter DJ, Bierma-Zeinstra S. Osteoarthr Lancet. 2019;393:1745\u201359.","journal-title":"Osteoarthr Lancet"},{"key":"5376_CR3","doi-asserted-by":"publisher","unstructured":"Gahunia H, Gross A, Pritzker K, Babyn P. Post-traumatic osteoarthritis: Improved understanding and opportunities for early interventio L (2020) Articular Cartilage of the Knee: Health, Disease and Therapy. https:\/\/doi.org\/10.1007\/978-1-4939-7587-7","DOI":"10.1007\/978-1-4939-7587-7"},{"key":"5376_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2016-000279","author":"L Punzi","year":"2016","unstructured":"Punzi L, Galozzi P, Luisetto R, Favero M, Ramonda R, Oliviero F, Scanu A. Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation. RMD Open. 2016. https:\/\/doi.org\/10.1136\/rmdopen-2016-000279.","journal-title":"RMD Open"},{"key":"5376_CR5","doi-asserted-by":"publisher","first-page":"E1560","DOI":"10.3390\/ijms21051560","volume":"21","author":"J Riegger","year":"2020","unstructured":"Riegger J, Brenner RE. Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a precarious environment. Int J Mol Sci. 2020;21:E1560.","journal-title":"Int J Mol Sci"},{"key":"5376_CR6","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/jor.21359","volume":"29","author":"DD Anderson","year":"2011","unstructured":"Anderson DD, Chubinskaya S, Guilak F, Martin JA, Oegema TR, Olson SA, Buckwalter JA. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res. 2011;29:802\u20139.","journal-title":"J Orthop Res"},{"key":"5376_CR7","doi-asserted-by":"publisher","first-page":"15040","DOI":"10.1038\/boneres.2015.40","volume":"4","author":"W Zhang","year":"2016","unstructured":"Zhang W, Ouyang H, Dass CR, Xu J. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Res. 2016;4:15040.","journal-title":"Bone Res"},{"key":"5376_CR8","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/cells10040902","volume":"10","author":"TM Pham","year":"2021","unstructured":"Pham TM, Erichsen JL, Kowal JM, Overgaard S, Schmal H. Elevation of pro-inflammatory cytokine levels following intra-articular Fractures-A systematic review. Cells. 2021;10:902.","journal-title":"Cells"},{"key":"5376_CR9","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1016\/j.joca.2012.08.011","volume":"20","author":"KS Santangelo","year":"2012","unstructured":"Santangelo KS, Nuovo GJ, Bertone AL. In vivo reduction or blockade of interleukin-1\u03b2 in primary osteoarthritis influences expression of mediators implicated in pathogenesis. Osteoarthritis Cartilage. 2012;20:1610\u20138.","journal-title":"Osteoarthritis Cartilage"},{"key":"5376_CR10","doi-asserted-by":"publisher","first-page":"8005","DOI":"10.3390\/ijms22158005","volume":"22","author":"CM Khella","year":"2021","unstructured":"Khella CM, Horvath JM, Asgarian R, Rolauffs B, Hart ML. Anti-inflammatory therapeutic approaches to prevent or Delay Post-traumatic Osteoarthritis (PTOA) of the knee joint with a focus on sustained delivery approaches. Int J Mol Sci. 2021;22:8005.","journal-title":"Int J Mol Sci"},{"key":"5376_CR11","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1089\/ars.2006.8.1485","volume":"8","author":"L Grange","year":"2006","unstructured":"Grange L, Nguyen MVC, Lardy B, Derouazi M, Campion Y, Trocme C, Paclet M-H, Gaudin P, Morel F. NAD(P)H oxidase activity of Nox4 in chondrocytes is both inducible and involved in collagenase expression. Antioxid Redox Signal. 2006;8:1485\u201396.","journal-title":"Antioxid Redox Signal"},{"key":"5376_CR12","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1093\/rheumatology\/36.5.522","volume":"36","author":"PJ Moulton","year":"1997","unstructured":"Moulton PJ, Hiran TS, Goldring MB, Hancock JT. Detection of protein and mRNA of various components of the NADPH oxidase complex in an immortalized human chondrocyte line. Br J Rheumatol. 1997;36:522\u20139.","journal-title":"Br J Rheumatol"},{"key":"5376_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110452","author":"M Ansari","year":"2020","unstructured":"Ansari M, Ahmad N, Haqqi T. Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacotherapy = Biomedecine Pharmacotherapie. 2020. https:\/\/doi.org\/10.1016\/j.biopha.2020.110452.","journal-title":"Biomed Pharmacotherapy = Biomedecine Pharmacotherapie"},{"key":"5376_CR14","doi-asserted-by":"publisher","first-page":"101059","DOI":"10.1016\/j.redox.2018.11.017","volume":"21","author":"F Sivandzade","year":"2018","unstructured":"Sivandzade F, Prasad S, Bhalerao A, Cucullo L. NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches. Redox Biol. 2018;21:101059.","journal-title":"Redox Biol"},{"key":"5376_CR15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41419-021-03765-x","volume":"12","author":"M Hou","year":"2021","unstructured":"Hou M, Zhang Y, Zhou X, Liu T, Yang H, Chen X, He F, Zhu X. Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a\/NRF2 axis. Cell Death Dis. 2021;12:483.","journal-title":"Cell Death Dis"},{"key":"5376_CR16","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","volume":"1863","author":"SMU Ahmed","year":"2017","unstructured":"Ahmed SMU, Luo L, Namani A, Wang XJ, Tang X. Nrf2 signaling pathway: pivotal roles in inflammation. Biochim Biophys Acta Mol Basis Dis. 2017;1863:585\u201397.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"5376_CR17","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","volume":"43","author":"JD Wardyn","year":"2015","unstructured":"Wardyn JD, Ponsford AH, Sanderson CM. Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways. Biochem Soc Trans. 2015;43:621\u20136.","journal-title":"Biochem Soc Trans"},{"key":"5376_CR18","doi-asserted-by":"publisher","first-page":"12653","DOI":"10.1523\/JNEUROSCI.6414-09.2010","volume":"30","author":"X-H Zhu","year":"2010","unstructured":"Zhu X-H, Yan H-C, Zhang J, et al. Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats. J Neurosci. 2010;30:12653\u201363.","journal-title":"J Neurosci"},{"key":"5376_CR19","doi-asserted-by":"publisher","first-page":"H1267","DOI":"10.1152\/ajpheart.00410.2009","volume":"298","author":"Y Guan","year":"2010","unstructured":"Guan Y, Gao L, Ma H-J, Li Q, Zhang H, Yuan F, Zhou Z-N, Zhang Y. Chronic intermittent hypobaric hypoxia decreases beta-adrenoceptor activity in right ventricular papillary muscle. Am J Physiol Heart Circ Physiol. 2010;298:H1267\u20131272.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"5376_CR20","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1159\/000363001","volume":"34","author":"H-J Ma","year":"2014","unstructured":"Ma H-J, Li Q, Ma H-J, Guan Y, Shi M, Yang J, Li D-P, Zhang Y. Chronic intermittent hypobaric Hypoxia ameliorates Ischemia\/Reperfusion-Induced Calcium overload in Heart via na + \/Ca 2+ exchanger in developing rats. Cell Physiol Biochem. 2014;34:313\u201324.","journal-title":"Cell Physiol Biochem"},{"key":"5376_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1248\/yakushi.130.63","volume":"130","author":"T Nomura","year":"2010","unstructured":"Nomura T, Abe Y, Yoshioka Y, Nakagawa S, Tsunoda S, Tsutsumi Y. [Creation of TNFR1-selective antagonist and its therapeutic effects]. Yakugaku Zasshi. 2010;130:63\u20138.","journal-title":"Yakugaku Zasshi"},{"key":"5376_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12950-015-0068-1","volume":"12","author":"M Shi","year":"2015","unstructured":"Shi M, Cui F, Liu A-J, Ma H-J, Cheng M, Song S-X, Yuan F, Li D-P, Zhang Y. The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats. J Inflamm (Lond). 2015;12:23.","journal-title":"J Inflamm (Lond)"},{"key":"5376_CR23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.diabres.2016.06.021","volume":"118","author":"Y-M Tian","year":"2016","unstructured":"Tian Y-M, Guan Y, Li N, Ma H-J, Zhang L, Wang S, Zhang Y. Chronic intermittent hypobaric hypoxia ameliorates diabetic nephropathy through enhancing HIF1 signaling in rats. Diabetes Res Clin Pract. 2016;118:90\u20137.","journal-title":"Diabetes Res Clin Pract"},{"key":"5376_CR24","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s00223-019-00614-0","volume":"106","author":"V Stiffel","year":"2020","unstructured":"Stiffel V, Rundle CH, Sheng MH-C, Das S, Lau K-HW. A mouse Noninvasive Intraarticular Tibial Plateau Compression Loading-Induced Injury Model of Posttraumatic Osteoarthritis. Calcif Tissue Int. 2020;106:158\u201371.","journal-title":"Calcif Tissue Int"},{"key":"5376_CR25","doi-asserted-by":"publisher","first-page":"582670","DOI":"10.3389\/fendo.2020.582670","volume":"11","author":"L Zhang","year":"2021","unstructured":"Zhang L, Jin L, Guo J, Bao K, Hu J, Zhang Y, Hou Z, Zhang L. Chronic intermittent hypobaric Hypoxia enhances Bone Fracture Healing. Front Endocrinol (Lausanne). 2021;11:582670.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5376_CR26","doi-asserted-by":"publisher","first-page":"116533","DOI":"10.1016\/j.lfs.2019.06.008","volume":"231","author":"W-J Cheng","year":"2019","unstructured":"Cheng W-J, Liu X, Zhang L, Guo X-Q, Wang F-W, Zhang Y, Tian Y-M. Chronic intermittent hypobaric hypoxia attenuates skeletal muscle ischemia-reperfusion injury in mice. Life Sci. 2019;231:116533.","journal-title":"Life Sci"},{"key":"5376_CR27","doi-asserted-by":"crossref","unstructured":"Khella CM, Asgarian R, Horvath JM, Rolauffs B, Hart ML. (2021) An Evidence-Based Systematic Review of Human Knee Post-Traumatic Osteoarthritis (PTOA): Timeline of Clinical Presentation and Disease Markers, Comparison of Knee Joint PTOA Models and Early Disease Implications. International Journal of Molecular Sciences 22:1996.","DOI":"10.3390\/ijms22041996"},{"key":"5376_CR28","doi-asserted-by":"crossref","unstructured":"Li S, Shi Y, Zhang S et al. (2022) Corynoline Alleviates Osteoarthritis Development via the Nrf2\/NF-\u03baB Pathway. Oxid Med Cell Longev 2022:2188145.","DOI":"10.1155\/2022\/2188145"},{"key":"5376_CR29","doi-asserted-by":"publisher","first-page":"112261","DOI":"10.1016\/j.jep.2019.112261","volume":"247","author":"J Hu","year":"2020","unstructured":"Hu J, Zhou J, Wu J, et al. Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-\u03baB activity and pyroptosis in chondrocytes. J Ethnopharmacol. 2020;247:112261.","journal-title":"J Ethnopharmacol"},{"key":"5376_CR30","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/01.bor.0000151406.64393.00","volume":"17","author":"EM Roos","year":"2005","unstructured":"Roos EM. Joint injury causes knee osteoarthritis in young adults. Curr Opin Rheumatol. 2005;17:195\u2013200.","journal-title":"Curr Opin Rheumatol"},{"key":"5376_CR31","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.joca.2015.02.021","volume":"23","author":"JL Whittaker","year":"2015","unstructured":"Whittaker JL, Woodhouse LJ, Nettel-Aguirre A, Emery CA. Outcomes associated with early post-traumatic osteoarthritis and other negative health consequences 3\u201310 years following knee joint injury in youth sport. Osteoarthritis Cartilage. 2015;23:1122\u20139.","journal-title":"Osteoarthritis Cartilage"},{"key":"5376_CR32","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s11914-021-00661-3","volume":"19","author":"F-U-R Bhatti","year":"2021","unstructured":"Bhatti F-U-R, Karydis A, Lee BS, Deguchi T, Kim D-G, Cho H. Understanding early-stage posttraumatic osteoarthritis for future prospects of diagnosis: from knee to Temporomandibular Joint. Curr Osteoporos Rep. 2021;19:166\u201374.","journal-title":"Curr Osteoporos Rep"},{"key":"5376_CR33","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.joca.2015.08.015","volume":"23","author":"J Lieberthal","year":"2015","unstructured":"Lieberthal J, Sambamurthy N, Scanzello CR. Inflammation in joint injury and post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015;23:1825\u201334.","journal-title":"Osteoarthritis Cartilage"},{"key":"5376_CR34","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.3390\/ijms21041340","volume":"21","author":"R Nishimura","year":"2020","unstructured":"Nishimura R, Hata K, Takahata Y, Murakami T, Nakamura E, Ohkawa M, Ruengsinpinya L. Role of Signal Transduction Pathways and transcription factors in cartilage and Joint diseases. Int J Mol Sci. 2020;21:1340.","journal-title":"Int J Mol Sci"},{"key":"5376_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/genes11080854","author":"D Primorac","year":"2020","unstructured":"Primorac D, Molnar V, Rod E, Jele\u010d \u017d, \u010cukelj F, Mati\u0161i\u0107 V, Vrdoljak T, Hudetz D, Hajsok H, Bori\u0107 I. Knee osteoarthritis: a review of Pathogenesis and State-Of-The-art non-operative therapeutic considerations. Genes. 2020. https:\/\/doi.org\/10.3390\/genes11080854.","journal-title":"Genes"},{"key":"5376_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1448062","author":"A Leonidou","year":"2018","unstructured":"Leonidou A, Lepetsos P, Mintzas M, Kenanidis E, Macheras G, Tzetis M, Potoupnis M, Tsiridis E. Inducible nitric oxide synthase as a target for osteoarthritis treatment. Expert Opin Ther Targets. 2018. https:\/\/doi.org\/10.1080\/14728222.2018.1448062.","journal-title":"Expert Opin Ther Targets"},{"key":"5376_CR37","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/ars.2007.1957","volume":"10","author":"D Trachootham","year":"2008","unstructured":"Trachootham D, Lu W, Ogasawara MA, Nilsa R-DV, Huang P. Redox regulation of cell survival. Antioxid Redox Signal. 2008;10:1343\u201374.","journal-title":"Antioxid Redox Signal"},{"key":"5376_CR38","doi-asserted-by":"publisher","unstructured":"Bolduc JA, Collins J, Loeser R. (2019) Reactive oxygen species, aging and articular cartilage homeostasis. Free radical biology & medicine. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.08.038","DOI":"10.1016\/j.freeradbiomed.2018.08.038"},{"key":"5376_CR39","doi-asserted-by":"crossref","unstructured":"Minguzzi M, Cetrullo S, D\u2019Adamo S, Silvestri Y, Flamigni F, Borz\u00ec RM. (2018) Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis. Oxid Med Cell Longev 2018:3075293.","DOI":"10.1155\/2018\/3075293"},{"key":"5376_CR40","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00441-018-2825-y","volume":"373","author":"K Bahrampour Juybari","year":"2018","unstructured":"Bahrampour Juybari K, Kamarul T, Najafi M, Jafari D, Sharifi AM. Restoring the IL-1\u03b2\/NF-\u03baB-induced impaired chondrogenesis by diallyl disulfide in human adipose-derived mesenchymal stem cells via attenuation of reactive oxygen species and elevation of antioxidant enzymes. Cell Tissue Res. 2018;373:407\u201319.","journal-title":"Cell Tissue Res"},{"key":"5376_CR41","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.3390\/ijms22052242","volume":"22","author":"K Maly","year":"2021","unstructured":"Maly K, Andres Sastre E, Farrell E, Meurer A, Zaucke F. COMP and TSP-4: functional roles in articular cartilage and relevance in Osteoarthritis. Int J Mol Sci. 2021;22:2242.","journal-title":"Int J Mol Sci"},{"key":"5376_CR42","doi-asserted-by":"publisher","unstructured":"Kumavat R, Kumar VL, Malhotra R, Pandit H, Jones E, Ponchel F, Biswas S. (2021) Biomarkers of Joint Damage in Osteoarthritis: Current Status and Future Directions. Mediators of inflammation. https:\/\/doi.org\/10.1155\/2021\/5574582","DOI":"10.1155\/2021\/5574582"},{"key":"5376_CR43","doi-asserted-by":"publisher","first-page":"e633","DOI":"10.1016\/S2665-9913(20)30279-4","volume":"2","author":"TL Vincent","year":"2020","unstructured":"Vincent TL. Of mice and men: converging on a common molecular understanding of osteoarthritis. Lancet Rheumatol. 2020;2:e633\u201345.","journal-title":"Lancet Rheumatol"},{"key":"5376_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070734","author":"M-C Choi","year":"2019","unstructured":"Choi M-C, Jo J, Park J, Kang H, Park Y. NF-\u03baB Signaling pathways in Osteoarthritic Cartilage Destruction. Cells. 2019. https:\/\/doi.org\/10.3390\/cells8070734.","journal-title":"Cells"},{"key":"5376_CR45","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1097\/BOT.0000000000001472","volume":"33","author":"J Borrelli","year":"2019","unstructured":"Borrelli J, Olson SA, Godbout C, Schemitsch EH, Stannard JP, Giannoudis PV. Understanding articular cartilage Injury and potential treatments. J Orthop Trauma. 2019;33:S6\u201312.","journal-title":"J Orthop Trauma"},{"key":"5376_CR46","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1016\/j.biocel.2013.08.018","volume":"45","author":"S Rigoglou","year":"2013","unstructured":"Rigoglou S, Papavassiliou AG. The NF-\u03baB signalling pathway in osteoarthritis. Int J Biochem Cell Biol. 2013;45:2580\u20134.","journal-title":"Int J Biochem Cell Biol"},{"key":"5376_CR47","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1124\/pr.110.004333","volume":"64","author":"Q Ma","year":"2012","unstructured":"Ma Q, He X. Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev. 2012;64:1055\u201381.","journal-title":"Pharmacol Rev"},{"key":"5376_CR48","doi-asserted-by":"publisher","first-page":"120111","DOI":"10.1016\/j.lfs.2021.120111","volume":"291","author":"AV Ulasov","year":"2022","unstructured":"Ulasov AV, Rosenkranz AA, Georgiev GP, Sobolev AS. Nrf2\/Keap1\/ARE signaling: towards specific regulation. Life Sci. 2022;291:120111.","journal-title":"Life Sci"},{"key":"5376_CR49","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.fct.2014.07.038","volume":"72","author":"CLL Saw","year":"2014","unstructured":"Saw CLL, Guo Y, Yang AY, Paredes-Gonzalez X, Ramirez C, Pung D, Kong A-NT. The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway. Food Chem Toxicol. 2014;72:303\u201311.","journal-title":"Food Chem Toxicol"},{"key":"5376_CR50","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.freeradbiomed.2019.12.007","volume":"157","author":"MJ Alcaraz","year":"2020","unstructured":"Alcaraz MJ, Ferr\u00e1ndiz ML. Relevance of Nrf2 and heme oxygenase-1 in articular diseases. Free Radic Biol Med. 2020;157:83\u201393.","journal-title":"Free Radic Biol Med"},{"key":"5376_CR51","doi-asserted-by":"publisher","first-page":"6730","DOI":"10.4049\/jimmunol.181.10.6730","volume":"181","author":"SA Rushworth","year":"2008","unstructured":"Rushworth SA, MacEwan DJ, O\u2019Connell MA. Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J Immunol. 2008;181:6730\u20137.","journal-title":"J Immunol"},{"key":"5376_CR52","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1089\/ars.2010.3216","volume":"13","author":"N Wakabayashi","year":"2010","unstructured":"Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW. When NRF2 talks, who\u2019s listening? Antioxid Redox Signal. 2010;13:1649\u201363.","journal-title":"Antioxid Redox Signal"},{"key":"5376_CR53","doi-asserted-by":"publisher","first-page":"105742","DOI":"10.1016\/j.intimp.2019.105742","volume":"75","author":"X Pan","year":"2019","unstructured":"Pan X, Chen T, Zhang Z, Chen X, Chen C, Chen L, Wang X, Ying X. Activation of Nrf2\/HO-1 signal with Myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis. Int Immunopharmacol. 2019;75:105742.","journal-title":"Int Immunopharmacol"},{"key":"5376_CR54","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.joca.2023.07.012","volume":"32","author":"RF Bergman","year":"2024","unstructured":"Bergman RF, Lammlin L, Junginger L, et al. Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury. Osteoarthritis Cartilage. 2024;32:1060\u201373.","journal-title":"Osteoarthritis Cartilage"},{"key":"5376_CR55","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1002\/art.38375","volume":"66","author":"P Wu","year":"2014","unstructured":"Wu P, Holguin N, Silva MJ, Fu M, Liao W, Sandell LJ. Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets. Arthritis Rheumatol. 2014;66:1256\u201365.","journal-title":"Arthritis Rheumatol"},{"key":"5376_CR56","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.3390\/antiox11091783","volume":"11","author":"F-U-R Bhatti","year":"2022","unstructured":"Bhatti F-U-R, Jeong Y-H, Kim D-G, Yi A-K, Brand DD, Hasty KA, Cho H. Characterization of non-invasively Induced Post-traumatic Osteoarthritis in mice. Antioxid (Basel). 2022;11:1783.","journal-title":"Antioxid (Basel)"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-05376-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-024-05376-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-05376-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T10:03:50Z","timestamp":1735207430000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-024-05376-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5376"],"URL":"https:\/\/doi.org\/10.1186\/s13018-024-05376-6","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"24 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experiment was approved by the Ethics Committee of the Third Hospital of Hebei Medical University (Approval file ID Z2021-020-2).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"878"}}