{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:53:28Z","timestamp":1782449608944,"version":"3.54.5"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Key Project of Excellent Young Talents Support Foundation of Anhui Province University","award":["gzyqZD2021143"],"award-info":[{"award-number":["gzyqZD2021143"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"DOI":"10.1186\/s13018-024-05396-2","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T21:00:08Z","timestamp":1735851608000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adipose-derived mesenchymal stem cells combined with platelet-rich plasma are superior options for the treatment of osteoarthritis"],"prefix":"10.1186","volume":"20","author":[{"given":"Weijie","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"5396_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.11.014","author":"AE Nelson","year":"2018","unstructured":"Nelson AE. Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartilage. 2018. https:\/\/doi.org\/10.1016\/j.joca.2017.11.014.","journal-title":"Osteoarthritis Cartilage"},{"key":"5396_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.10.007","author":"B Abramoff","year":"2020","unstructured":"Abramoff B, Caldera FE, Osteoarthritis. Pathology, diagnosis, and Treatment options. Med Clin North Am. 2020. https:\/\/doi.org\/10.1016\/j.mcna.2019.10.007.","journal-title":"Med Clin North Am"},{"key":"5396_CR3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22171","author":"JN Katz","year":"2021","unstructured":"Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and KneeOsteoarthritis: a review. JAMA. 2021. https:\/\/doi.org\/10.1001\/jama.2020.22171.","journal-title":"JAMA"},{"key":"5396_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/msc.1593","author":"A Boffa","year":"2022","unstructured":"Boffa A, Perucca Orfei C, Sourugeon Y, Laver L, Magalon J, S\u00e1nchez M, et al. The relationship between multisite peripheral joint pain and physical activity levels in older adults: a cross-sectional survey. Musculoskelet Care. 2022. https:\/\/doi.org\/10.1002\/msc.1593.","journal-title":"Musculoskelet Care"},{"key":"5396_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-023-07320-3","author":"A Boffa","year":"2023","unstructured":"Boffa A, Perucca Orfei C, Sourugeon Y, Laver L, Magalon J, S\u00e1nchez M, et al. Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 2: bone marrow-derived cell-based injectable therapies. Knee Surg Sports Traumatol Arthrosc. 2023. https:\/\/doi.org\/10.1007\/s00167-023-07320-3.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"5396_CR6","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S365187","author":"S Katherine","year":"2022","unstructured":"Katherine S, Norman,Adam P, Goode,Carolina Alvarez D, Hu,Steven Z, George,Todd A, Schwartz, et al. Association of Biomarkers with individual and multiple body sites of Pain: the Johnston County Osteoarthritis Project. J Pain Res. 2022. https:\/\/doi.org\/10.2147\/JPR.S365187.","journal-title":"J Pain Res"},{"key":"5396_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.06.005","author":"A De Roover","year":"2023","unstructured":"De Roover A, Escribano-N\u00fa\u00f1ez A, Monteagudo S, Lories R. Fundamentals of osteoarthritis: inflammatory mediators in osteoarthritis. Osteoarthritis Cartilage. 2023. https:\/\/doi.org\/10.1016\/j.joca.2023.06.005.","journal-title":"Osteoarthritis Cartilage"},{"key":"5396_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179208","author":"V Molnar","year":"2021","unstructured":"Molnar V, Mati\u0161i\u0107 V, Kodvanj I, Bjelica R, Jele\u010d \u017d, Hudetz D, et al. Cytokines and chemokines involved in Osteoarthritis Pathogenesis. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22179208.","journal-title":"Int J Mol Sci"},{"key":"5396_CR9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.p24","author":"G Wood","year":"2023","unstructured":"Wood G, Neilson J, Cottrell E, Hoole SP, Guideline Committee. Osteoarthritis in people over 16: diagnosis and management-updated summary of NICE guidance. BMJ. 2023. https:\/\/doi.org\/10.1136\/bmj.p24.","journal-title":"BMJ"},{"key":"5396_CR10","doi-asserted-by":"publisher","DOI":"10.1024\/0040-5930\/a001401","author":"P Rossbach","year":"2023","unstructured":"Rossbach P. Arthrose [Osteoarthritis - therapy and management]. Ther Umsch. 2023. https:\/\/doi.org\/10.1024\/0040-5930\/a001401.","journal-title":"Ther Umsch"},{"key":"5396_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldae016","author":"F Migliorini","year":"2024","unstructured":"Migliorini F, Pilone M, Ascani J, Sch\u00e4fer L, Jeyaraman M, Maffulli N. Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review. Br Med Bull. 2024. https:\/\/doi.org\/10.1093\/bmb\/ldae016.","journal-title":"Br Med Bull"},{"key":"5396_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-024-00661-y","author":"A Gupta","year":"2024","unstructured":"Gupta A, Maffulli N. Platelet lysate and osteoarthritis of the knee: a review of current clinical evidence. Pain Ther. 2024. https:\/\/doi.org\/10.1007\/s40122-024-00661-y.","journal-title":"Pain Ther"},{"key":"5396_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-024-01172-w","author":"A Gupta","year":"2024","unstructured":"Gupta A, Maffulli N. Growth factor Concentrate (GFC) for the management of Osteoarthritis of the knee: a systematic review. Indian J Orthop. 2024. https:\/\/doi.org\/10.1007\/s43465-024-01172-w.","journal-title":"Indian J Orthop"},{"key":"5396_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2024.1400548","author":"A Gupta","year":"2024","unstructured":"Gupta A, Potty AG, Maffulli N, Editorial. Regenerative biologics for musculoskeletal injuries. Front Pain Res (Lausanne). 2024. https:\/\/doi.org\/10.3389\/fpain.2024.1400548.","journal-title":"Front Pain Res (Lausanne)"},{"key":"5396_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldad030","author":"A Aratikatla","year":"2024","unstructured":"Aratikatla A, Maffulli N, Gupta M, Potti IA, Potty AG, Gupta A. Wharton\u2019s jelly and osteoarthritis of the knee. Br Med Bull. 2024. https:\/\/doi.org\/10.1093\/bmb\/ldad030.","journal-title":"Br Med Bull"},{"key":"5396_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2023.1216190","author":"A Gupta","year":"2023","unstructured":"Gupta A, Potty AG, Maffulli N. Allogenic platelet-rich plasma for treatment of knee and hip osteoarthritis. Front Pain Res (Lausanne). 2023. https:\/\/doi.org\/10.3389\/fpain.2023.1216190.","journal-title":"Front Pain Res (Lausanne)"},{"key":"5396_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11051460","author":"M Jeyaraman","year":"2023","unstructured":"Jeyaraman M, Maffulli N, Gupta A. Stromal vascular fraction in Osteoarthritis of the knee. Biomedicines. 2023. https:\/\/doi.org\/10.3390\/biomedicines11051460.","journal-title":"Biomedicines"},{"key":"5396_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-03841-2","author":"A Pintore","year":"2023","unstructured":"Pintore A, Notarfrancesco D, Zara A, et al. Intra-articular injection of bone marrow aspirate concentrate (BMAC) or adipose-derived stem cells (ADSCs) for knee osteoarthritis: a prospective comparative clinical trial. J Orthop Surg Res. 2023. https:\/\/doi.org\/10.1186\/s13018-023-03841-2.","journal-title":"J Orthop Surg Res"},{"key":"5396_CR19","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0000000000000350","author":"A Gupta","year":"2022","unstructured":"Gupta A, Maffulli N. Allogenic umbilical cord tissue for treatment of knee osteoarthritis. Sports Med Arthrosc Rev. 2022. https:\/\/doi.org\/10.1097\/JSA.0000000000000350.","journal-title":"Sports Med Arthrosc Rev"},{"key":"5396_CR20","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2022.0242","author":"Y Sun","year":"2023","unstructured":"Sun Y, Xue C, Wu H, Li C, Li S, Luo J, et al. Genetically Modified Mesenchymal Stromal Cells Cartil Regeneration Stem Cells Dev. 2023. https:\/\/doi.org\/10.1089\/scd.2022.0242.","journal-title":"Genetically Modified Mesenchymal Stromal Cells Cartil Regeneration Stem Cells Dev"},{"key":"5396_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2023.02.012","author":"Z Tian","year":"2023","unstructured":"Tian Z, Yu T, Liu J, Wang T, Higuchi A. Introduction to stem cells. Prog Mol Biol Transl Sci. 2023. https:\/\/doi.org\/10.1016\/bs.pmbts.2023.02.012.","journal-title":"Prog Mol Biol Transl Sci"},{"key":"5396_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-020-05859-z","author":"EC Doyle","year":"2020","unstructured":"Doyle EC, Wragg NM, Wilson SL. Intraarticular injection of bone marrow-derived mesenchymal stem cells enhances regeneration in knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2020. https:\/\/doi.org\/10.1007\/s00167-020-05859-z.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"5396_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25724","author":"RH Xie","year":"2024","unstructured":"Xie RH, Gong SG, Song J, Wu PP, Hu WL. Effect of mesenchymal stromal cells transplantation on the outcomes of patients with knee osteoarthritis: a systematic review and meta-analysis. J Orthop Res. 2024. https:\/\/doi.org\/10.1002\/jor.25724.","journal-title":"J Orthop Res"},{"key":"5396_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01020-1","author":"G Copp","year":"2023","unstructured":"Copp G, Robb KP, Viswanathan S. Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success. Cell Mol Immunol. 2023. https:\/\/doi.org\/10.1038\/s41423-023-01020-1.","journal-title":"Cell Mol Immunol"},{"key":"5396_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118002","author":"M Maqsood","year":"2020","unstructured":"Maqsood M, Kang M, Wu X, Chen J, Teng L, Qiu L. Adult mesenchymal stem cells and their exosomes: sources, characteristics, and application in regenerative medicine. Life Sci. 2020. https:\/\/doi.org\/10.1016\/j.lfs.2020.118002.","journal-title":"Life Sci"},{"key":"5396_CR26","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-234595","author":"J Freitag","year":"2020","unstructured":"Freitag J, Wickham J, Shah K, Tenen A. Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of an osteochondral lesionof the ankle. BMJ Case Rep. 2020. https:\/\/doi.org\/10.1136\/bcr-2020-234595.","journal-title":"BMJ Case Rep"},{"key":"5396_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115543","author":"FB Dias de Oliveira","year":"2023","unstructured":"Dias de Oliveira FB, Antonioli E, Dias OFM, de Souza JG, Agarwal S, Chudzinski-Tavassi AM, et al. Comparative effects of Intra-articular versus Intravenous Mesenchymal stromal cells therapy in a rat model of Osteoarthritis by destabilization of medial Meniscus. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms242115543.","journal-title":"Int J Mol Sci"},{"key":"5396_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.626755","author":"V Planat-Benard","year":"2021","unstructured":"Planat-Benard V, Varin A, Casteilla L. MSCs and inflammatory cells crosstalk in Regenerative Medicine: concerted actions for optimized resolution driven by Energy Metabolism. Front Immunol. 2021. https:\/\/doi.org\/10.3389\/fimmu.2021.626755.","journal-title":"Front Immunol"},{"key":"5396_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031618","author":"DG Kwon","year":"2022","unstructured":"Kwon DG, Kim MK, Jeon YS, Nam YC, Park JS, Ryu DJ. State of the art: the Immunomodulatory role of MSCs for Osteoarthritis. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms23031618.","journal-title":"Int J Mol Sci"},{"key":"5396_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010059","author":"P Wei","year":"2022","unstructured":"Wei P, Bao R. Intra-articular mesenchymal stem cell injection for KneeOsteoarthritis: mechanisms and clinical evidence. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms24010059.","journal-title":"Int J Mol Sci"},{"key":"5396_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113016","author":"SS Kuppa","year":"2022","unstructured":"Kuppa SS, Kim HK, Kang JY, Lee SC, Seon JK. Role of mesenchymal stem cells and their Paracrine mediators in Macrophage polarization: an Approach to reduce inflammation in Osteoarthritis. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms232113016.","journal-title":"Int J Mol Sci"},{"key":"5396_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108765","author":"Z Si","year":"2019","unstructured":"Si Z, Wang X, Sun C, Kang Y, Xu J, Wang X, et al. Adipose-derived stem cells: sources, potency, and implications for regenerative therapies. Biomed Pharmacother. 2019. https:\/\/doi.org\/10.1016\/j.biopha.2019.108765.","journal-title":"Biomed Pharmacother"},{"key":"5396_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-02918-8","author":"JP Furia","year":"2022","unstructured":"Furia JP, Lundeen MA, Hurd JL, et al. Why and how to use the body\u2019s own stem cells for regeneration in musculoskeletal disorders: a primer. J Orthop Surg Res. 2022. https:\/\/doi.org\/10.1186\/s13018-022-02918-8.","journal-title":"J Orthop Surg Res"},{"key":"5396_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-01631-8","author":"JL Hurd","year":"2020","unstructured":"Hurd JL, Facile TR, Weiss J, et al. Safety and efficacy of treating symptomatic, partial-thickness rotator cuff tears with fresh, uncultured, unmodified, autologous adipose-derived regenerative cells (UA-ADRCs) isolated at the point of care: a prospective, randomized, controlled first-in-human pilot study. J Orthop Surg Res. 2020. https:\/\/doi.org\/10.1186\/s13018-020-01631-8.","journal-title":"J Orthop Surg Res"},{"key":"5396_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01975-2","author":"M Ortiz-Virumbrales","year":"2020","unstructured":"Ortiz-Virumbrales M, Menta R, P\u00e9rez LM, Lucchesi O, Manche\u00f1o-Corvo P, Avivar-Valderas \u00c1, et al. Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2.Stem. Cell Res Ther. 2020. https:\/\/doi.org\/10.1186\/s13287-020-01975-2.","journal-title":"Cell Res Ther"},{"key":"5396_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04701-y","author":"F Veronesi","year":"2021","unstructured":"Veronesi F, Berni M, Marchiori G, Cassiolas G, Muttini A, Barboni B, et al. Evaluation of cartilage biomechanics and knee joint microenvironment after different cell-based treatments in a sheep model of early osteoarthritis. Int Orthop. 2021. https:\/\/doi.org\/10.1007\/s00264-020-04701-y.","journal-title":"Int Orthop"},{"key":"5396_CR37","doi-asserted-by":"publisher","DOI":"10.46582\/jsrm.1601002","author":"AV Vasiliadis","year":"2020","unstructured":"Vasiliadis AV, Galanis N. Effectiveness of AD-MSCs injections for the treatment of knee osteoarthritis: analysis of the current literature. J Stem Cells Regen Med. 2020. https:\/\/doi.org\/10.46582\/jsrm.1601002.","journal-title":"J Stem Cells Regen Med"},{"key":"5396_CR38","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-022-07063-7","author":"C Perucca Orfei","year":"2023","unstructured":"Perucca Orfei C, Boffa A, Sourugeon Y, Laver L, Magalon J, S\u00e1nchez M, et al. Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies. Knee Surg Sports Traumatol Arthrosc. 2023. https:\/\/doi.org\/10.1007\/s00167-022-07063-7.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"5396_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2018.08.004","author":"I Andia","year":"2019","unstructured":"Andia I, Maffulli N. New biotechnologies for musculoskeletal injuries. Surgeon. 2019. https:\/\/doi.org\/10.1016\/j.surge.2018.08.004.","journal-title":"Surgeon"},{"key":"5396_CR40","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldx030","author":"FG Usuelli","year":"2017","unstructured":"Usuelli FG, D\u2019Ambrosi R, Maccario C, Indino C, Manzi L, Maffulli N. Adipose-derived stem cells in orthopaedic pathologies. Br Med Bull. 2017. https:\/\/doi.org\/10.1093\/bmb\/ldx030.","journal-title":"Br Med Bull"},{"key":"5396_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092134","author":"A Gupta","year":"2022","unstructured":"Gupta A, Jeyaraman M, Maffulli N. Common medications which should be stopped prior to platelet-rich plasma injection. Biomedicines. 2022. https:\/\/doi.org\/10.3390\/biomedicines10092134.","journal-title":"Biomedicines"},{"key":"5396_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184581","author":"I Andia","year":"2019","unstructured":"Andia I, Maffulli N. Blood-derived products for tissue Repair\/Regeneration. Int J Mol Sci. 2019. https:\/\/doi.org\/10.3390\/ijms20184581.","journal-title":"Int J Mol Sci"},{"key":"5396_CR43","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0000000000000349","author":"I Andia","year":"2022","unstructured":"Andia I, Atilano L, Maffulli N. Biological targets of Multimolecular therapies in Middle-Age Osteoarthritis. Sports Med Arthrosc Rev. 2022. https:\/\/doi.org\/10.1097\/JSA.0000000000000349.","journal-title":"Sports Med Arthrosc Rev"},{"key":"5396_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.10.013","author":"Z Xu","year":"2021","unstructured":"Xu Z, He Z, Shu L, Li X, Ma M, Ye C. Intra-articular platelet-rich plasma combined with hyaluronic acid injection for knee osteoarthritis is Superior to platelet-rich plasma or hyaluronic acid alone in inhibiting inflammation and improving Pain and function. Arthroscopy. 2021. https:\/\/doi.org\/10.1016\/j.arthro.2020.10.013.","journal-title":"Arthroscopy"},{"key":"5396_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00052","author":"Y Zhou","year":"2020","unstructured":"Zhou Y, Shen H, Wu Y, et al. Platelet-Rich plasma therapy enhances the beneficial effect of bone marrow stem cell transplant on endometrial regeneration. Front Cell Dev Biol. 2020. https:\/\/doi.org\/10.3389\/fcell.2020.00052.","journal-title":"Front Cell Dev Biol"},{"key":"5396_CR46","doi-asserted-by":"publisher","unstructured":"Barman A, Bandyopadhyay D, Mohakud S, Sahoo J, Maiti R, Mukherjee S et al. Comparison of clinical outcome, cartilage turnover, and inflammatory activity following either intra-articular or a combination of intra-articular with intraosseous platelet-rich plasma injections in osteoarthritis knee: a randomized, clinical trial.Injury. 2023; https:\/\/doi.org\/10.1016\/j.injury.2022.11.036","DOI":"10.1016\/j.injury.2022.11.036"},{"key":"5396_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207794","author":"P Everts","year":"2020","unstructured":"Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-Rich plasma:New Performance understandings and therapeutic considerations in 2020. Int JMol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21207794.","journal-title":"Int JMol Sci"},{"key":"5396_CR48","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19415","author":"KL Bennell","year":"2021","unstructured":"Bennell KL, Paterson KL, Metcalf BR, Duong V, Eyles J, Kasza J, et al. Effect of intra-articular platelet-rich plasma vs Placebo Injection on Pain and Medial Tibial cartilage volume in patients with knee osteoarthritis: the RESTORE Randomized Clinical Trial. JAMA. 2021. https:\/\/doi.org\/10.1001\/jama.2021.19415.","journal-title":"JAMA"},{"key":"5396_CR49","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2018-0042","author":"I Andia","year":"2018","unstructured":"Andia I, Maffulli N. A contemporary view of platelet-rich plasma therapies: moving toward refined clinical protocols and precise indications. Regen Med. 2018. https:\/\/doi.org\/10.2217\/rme-2018-0042.","journal-title":"Regen Med"},{"key":"5396_CR50","doi-asserted-by":"publisher","unstructured":"Levy O, Kuai R, Siren EMJ, Bhere D, Milton Y, Nissar N et al. Shattering barriers toward clinically meaningful MSC therapies.Sci Adv. 2020; https:\/\/doi.org\/10.1126\/sciadv.aba6884","DOI":"10.1126\/sciadv.aba6884"},{"key":"5396_CR51","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14306","author":"G Wang","year":"2022","unstructured":"Wang G, Xing D, Liu W, Zhu Y, Liu H, Yan L, et al. Preclinical studies and clinical trials on mesenchymal stem cell therapy for knee osteoarthritis: a systematic review on models and cell doses. Int J Rheum Dis. 2022. https:\/\/doi.org\/10.1111\/1756-185X.14306.","journal-title":"Int J Rheum Dis"},{"key":"5396_CR52","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520981704","author":"SHS Tan","year":"2021","unstructured":"Tan SHS, Kwan YT, Neo WJ, Chong JY, Kuek TYJ, See JZF, et al. Intra-articular injections of mesenchymal stem cells without adjuvant therapies for knee osteoarthritis: a systematic review and Meta-analysis. Am J Sports Med. 2021. https:\/\/doi.org\/10.1177\/0363546520981704.","journal-title":"Am J Sports Med"},{"key":"5396_CR53","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.104B6.BJJ-2021-1109.R2","author":"E Lewis","year":"2022","unstructured":"Lewis E, Merghani K, Robertson I, Mulford J, Prentice B, Mathew R, et al. The effectiveness of leucocyte-poor platelet-rich plasma injections on symptomatic early osteoarthritis of the knee: the PEAK randomized controlled trial.Bone. Joint J. 2022. https:\/\/doi.org\/10.1302\/0301-620X.104B6.BJJ-2021-1109.R2.","journal-title":"Joint J"},{"key":"5396_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2380879","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zhang NZ, Li M, Zhang DF, Ma X, Zhou SL, et al. SappanoneA alleviated IL-1\u03b2-Induced inflammation in OA Chondrocytes through modulating the NF-\u03baB and Nrf2\/HO-1 pathways. Dis Markers. 2022. https:\/\/doi.org\/10.1155\/2022\/2380879.","journal-title":"Dis Markers"},{"key":"5396_CR55","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14569","author":"N Kalebota","year":"2022","unstructured":"Kalebota N, Salai G, Peric P, Hrkac S, Novak R, Durmis KK, et al. ADAMTS-4 as a possible distinguishing indicator between osteoarthritis and hemohaemophilic arthropathy. HemoHaemophilia. 2022. https:\/\/doi.org\/10.1111\/hae.14569.","journal-title":"HemoHaemophilia"},{"key":"5396_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070959","author":"T Li","year":"2022","unstructured":"Li T, Peng J, Li Q, Shu Y, Zhu P, Hao L. The mechanism and role of ADAMTS protein family in Osteoarthritis. Biomolecules. 2022. https:\/\/doi.org\/10.3390\/biom12070959.","journal-title":"Biomolecules"},{"key":"5396_CR57","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-023-01040-6","author":"M Simental-Mend\u00eda","year":"2023","unstructured":"Simental-Mend\u00eda M, Ortega-Mata D, Acosta-Olivo CA. Platelet-Rich plasma for knee osteoarthritis: what does the evidence say? Drugs Aging. 2023. https:\/\/doi.org\/10.1007\/s40266-023-01040-6.","journal-title":"Drugs Aging"},{"key":"5396_CR58","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103657","author":"L Wang","year":"2020","unstructured":"Wang L, Yang M, Zhang C, Huang F. The protective effects of dehydrocostus lactone against TNF-\u03b1-induced degeneration of extracellular matrix (ECM)in SW1353 cells. Aging. 2020. https:\/\/doi.org\/10.18632\/aging.103657.","journal-title":"Aging"},{"key":"5396_CR59","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1729","author":"J Xue","year":"2013","unstructured":"Xue J, Wang J, Liu Q, Luo A. Tumor necrosis factor-\u03b1 induces ADAMTS-4 expression in human osteoarthritis chondrocytes. Mol Med Rep. 2013. https:\/\/doi.org\/10.3892\/mmr.2013.1729.","journal-title":"Mol Med Rep"},{"key":"5396_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.027","author":"BJ de Lange-Brokaar","year":"2012","unstructured":"de Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE, et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage. 2012. https:\/\/doi.org\/10.1016\/j.joca.2012.08.027.","journal-title":"Osteoarthritis Cartilage"},{"key":"5396_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00315-1","author":"X Ye","year":"2021","unstructured":"Ye X, Lu Q, Yang A, Rao J, Xie W, He C, et al. MiR-206 regulates the Th17\/Treg ratio during osteoarthritis. Mol Med. 2021. https:\/\/doi.org\/10.1186\/s10020-021-00315-1.","journal-title":"Mol Med"},{"key":"5396_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00356","author":"YS Li","year":"2017","unstructured":"Li YS, Luo W, Zhu SA, Lei GH. T cells in Osteoarthritis: alterations and Beyond. Front Immunol. 2017. https:\/\/doi.org\/10.3389\/fimmu.2017.00356.","journal-title":"Front Immunol"},{"key":"5396_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.01.003","author":"M Miyara","year":"2007","unstructured":"Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med. 2007. https:\/\/doi.org\/10.1016\/j.molmed.2007.01.003.","journal-title":"Trends Mol Med"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-05396-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-024-05396-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-024-05396-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T21:16:37Z","timestamp":1735852597000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-024-05396-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5396"],"URL":"https:\/\/doi.org\/10.1186\/s13018-024-05396-2","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]},"assertion":[{"value":"28 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of Zhuhai BesTest Biotechnology Co., Ltd., approved the study (IAC 202105052).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The manuscript does not contain any individual person data in any form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2"}}