{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:26:29Z","timestamp":1791563189411,"version":"4.3.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"DOI":"10.1186\/s13018-025-06310-0","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:40:47Z","timestamp":1761039647000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["BMSC-derived exosomal lncRNA-ZFAS1 regulates the proliferation and differentiation of osteoblasts via the miR-9\/IGF-1 signaling axis"],"prefix":"10.1186","volume":"20","author":[{"given":"Hui","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"6310_CR1","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/nature02040","volume":"425","author":"LM Calvi","year":"2003","unstructured":"Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425:841\u20136.","journal-title":"Nature"},{"key":"6310_CR2","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/nature02041","volume":"425","author":"J Zhang","year":"2003","unstructured":"Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425:836\u201341.","journal-title":"Nature"},{"key":"6310_CR3","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","volume":"121","author":"MJ Kiel","year":"2005","unstructured":"Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. Slam family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005;121:1109\u201321.","journal-title":"Cell"},{"key":"6310_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00774-018-0965-5","volume":"37","author":"Y Tanaka","year":"2019","unstructured":"Tanaka Y. Clinical immunity in bone and joints. J Bone Miner Metab. 2019;37:2\u20138.","journal-title":"J Bone Miner Metab"},{"key":"6310_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.semcdb.2015.03.001","volume":"40","author":"RC Lai","year":"2015","unstructured":"Lai RC, Yeo RW, Lim SK. Mesenchymal stem cell exosomes. Semin Cell Dev Biol. 2015;40:82\u20138.","journal-title":"Semin Cell Dev Biol"},{"key":"6310_CR6","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1182\/blood.V85.4.929.bloodjournal854929","volume":"85","author":"S Gronthos","year":"1995","unstructured":"Gronthos S, Simmons PJ. The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood. 1995;85:929\u201340.","journal-title":"Blood"},{"key":"6310_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2174\/157488806776956904","volume":"1","author":"CJ Xian","year":"2006","unstructured":"Xian CJ, Foster BK. Repair of injured articular and growth plate cartilage using mesenchymal stem cells and chondrogenic gene therapy. Curr Stem Cell Res Ther. 2006;1:213\u201329.","journal-title":"Curr Stem Cell Res Ther"},{"key":"6310_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.984131","volume":"10","author":"J Zhuang","year":"2022","unstructured":"Zhuang J, Hang R, Sun R, Ding Y, Yao X, Hang R, et al. Multifunctional exosomes derived from bone marrow stem cells for fulfilled osseointegration. Front Chem. 2022;10:984131.","journal-title":"Front Chem"},{"key":"6310_CR9","doi-asserted-by":"publisher","first-page":"12203","DOI":"10.1007\/s11033-022-07807-1","volume":"49","author":"MS Gholami Farashah","year":"2022","unstructured":"Gholami Farashah MS, Javadi M, Mohammadi A, Soleimani Rad J, Shakouri SK, Roshangar L. Bone marrow mesenchymal stem cell\u2019s exosomes as key nanoparticles in osteogenesis and bone regeneration: specific capacity based on cell type. Mol Biol Rep. 2022;49:12203\u201318.","journal-title":"Mol Biol Rep"},{"key":"6310_CR10","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nri855","volume":"2","author":"C Th\u00e9ry","year":"2002","unstructured":"Th\u00e9ry C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002;2:569\u201379.","journal-title":"Nat Rev Immunol"},{"key":"6310_CR11","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00774-019-01013-z","volume":"37","author":"DE Connor","year":"2019","unstructured":"Connor DE, Paulus JA, Dabestani PJ, Thankam FK, Dilisio MF, Gross RM, et al. Therapeutic potential of exosomes in rotator cuff tendon healing. J Bone Miner Metab. 2019;37:759\u201367.","journal-title":"J Bone Miner Metab"},{"key":"6310_CR12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521230113","volume":"113","author":"J Kowal","year":"2016","unstructured":"Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, et al. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc Natl Acad Sci U S A. 2016;113:E968\u201377.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6310_CR13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/aps.2017.162","volume":"39","author":"S Samanta","year":"2018","unstructured":"Samanta S, Rajasingh S, Drosos N, Zhou Z, Dawn B, Rajasingh J. Exosomes: new molecular targets of diseases. Acta Pharmacol Sin. 2018;39:501\u201313.","journal-title":"Acta Pharmacol Sin"},{"key":"6310_CR14","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1172\/JCI81135","volume":"126","author":"R Kalluri","year":"2016","unstructured":"Kalluri R. The biology and function of exosomes in cancer. J Clin Investig. 2016;126:1208\u201315.","journal-title":"J Clin Investig"},{"key":"6310_CR15","doi-asserted-by":"publisher","first-page":"9417914","DOI":"10.1155\/2019\/9417914","volume":"2019","author":"C Masaoutis","year":"2019","unstructured":"Masaoutis C, Theocharis S. The role of exosomes in bone remodeling: implications for bone physiology and disease. Dis Markers. 2019;2019:9417914.","journal-title":"Dis Markers"},{"key":"6310_CR16","first-page":"1214","volume":"23","author":"Y Xie","year":"2019","unstructured":"Xie Y, Hu JH, Wu H, Huang ZZ, Yan HW, Shi ZY. Bone marrow stem cells derived exosomes improve osteoporosis by promoting osteoblast proliferation and inhibiting cell apoptosis. Eur Rev Med Pharmacol Sci. 2019;23:1214\u201320.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"6310_CR17","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1089\/ten.teb.2020.0246","volume":"28","author":"J Huber","year":"2022","unstructured":"Huber J, Griffin MF, Longaker MT, Quarto N. Exosomes: a tool for bone tissue engineering. Tissue Eng Part B Rev. 2022;28:101\u201313.","journal-title":"Tissue Eng Part B Rev"},{"key":"6310_CR18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00774-021-01205-6","volume":"39","author":"Y He","year":"2021","unstructured":"He Y, Chen Y. The potential role of lncRNAs in osteoporosis. J Bone Miner Metab. 2021;39:341\u201352.","journal-title":"J Bone Miner Metab"},{"key":"6310_CR19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrm.2017.104","volume":"19","author":"JD Ransohoff","year":"2018","unstructured":"Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol. 2018;19:143\u201357.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6310_CR20","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","volume":"24","author":"JS Mattick","year":"2023","unstructured":"Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen LL, et al. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol. 2023;24:430\u201347.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6310_CR21","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.14336\/AD.2019.0724","volume":"11","author":"S Chen","year":"2020","unstructured":"Chen S, Li Y, Zhi S, Ding Z, Huang Y, Wang W, et al. LncRNA Xist regulates osteoblast differentiation by sponging miR-19a-3p in aging-induced osteoporosis. Aging Dis. 2020;11:1058\u201368.","journal-title":"Aging Dis"},{"key":"6310_CR22","doi-asserted-by":"publisher","first-page":"8777","DOI":"10.18632\/aging.102264","volume":"11","author":"X Yang","year":"2019","unstructured":"Yang X, Yang J, Lei P, Wen T. LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c\/SATB2 axis. Aging. 2019;11:8777\u201391.","journal-title":"Aging"},{"key":"6310_CR23","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1007\/s12035-022-03129-2","volume":"60","author":"C Gao","year":"2023","unstructured":"Gao C, Xu YJ, Meng ZX, Gu S, Zhang L, Zheng L. BMSC-derived exosomes carrying lncRNA-ZFAS1 alleviate pulmonary ischemia\/reperfusion injury by UPF1-mediated mRNA decay of FOXD1. Mol Neurobiol. 2023;60:2379\u201396.","journal-title":"Mol Neurobiol"},{"key":"6310_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s13046-019-1208-x","volume":"38","author":"Q Liu","year":"2019","unstructured":"Liu Q, Ma H, Sun X, Liu B, Xiao Y, Pan S, et al. The regulatory ZFAS1\/miR-150\/ST6GAL1 crosstalk modulates sialylation of EGFR via PI3K\/Akt pathway in T-cell acute lymphoblastic leukemia. J Exp Clin Cancer Res. 2019;38:199.","journal-title":"J Exp Clin Cancer Res"},{"key":"6310_CR25","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/73542","volume":"24","author":"B Li","year":"2000","unstructured":"Li B, Boast S, de los Santos K, Schieren I, Quiroz M, Teitelbaum SL, et al. Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Nat Genet. 2000;24:304\u20138.","journal-title":"Nat Genet"},{"key":"6310_CR26","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1016\/j.biomaterials.2003.07.001","volume":"25","author":"JE Gough","year":"2004","unstructured":"Gough JE, Jones JR, Hench LL. Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold. Biomaterials. 2004;25:2039\u201346.","journal-title":"Biomaterials"},{"key":"6310_CR27","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.cell.2006.05.012","volume":"125","author":"G Dobreva","year":"2006","unstructured":"Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Fari\u00f1as I, et al. SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006;125:971\u201386.","journal-title":"Cell"},{"key":"6310_CR28","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/S0092-8674(00)00211-7","volume":"103","author":"Y Yoshida","year":"2000","unstructured":"Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, et al. Negative regulation of BMP\/Smad signaling by Tob in osteoblasts. Cell. 2000;103:1085\u201397.","journal-title":"Cell"},{"key":"6310_CR29","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","volume":"22","author":"C Marar","year":"2021","unstructured":"Marar C, Starich B, Wirtz D. Extracellular vesicles in immunomodulation and tumor progression. Nat Immunol. 2021;22:560\u201370.","journal-title":"Nat Immunol"},{"key":"6310_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0791-7","volume":"9","author":"S Keshtkar","year":"2018","unstructured":"Keshtkar S, Azarpira N, Ghahremani MH. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine. Stem Cell Res Ther. 2018;9:63.","journal-title":"Stem Cell Res Ther"},{"key":"6310_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403199","volume":"36","author":"Y Xia","year":"2024","unstructured":"Xia Y, Zhang J, Liu G, Wolfram J. Immunogenicity of Extracellular Vesicles. Adv Mater. 2024;36:e2403199.","journal-title":"Adv Mater"},{"issue":"12","key":"6310_CR32","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1080\/14712598.2021.1921141","volume":"21","author":"A Gupta","year":"2021","unstructured":"Gupta A, Shivaji K, Kadam S, Gupta M, Rodriguez HC, Potty AG, et al. Immunomodulatory extracellular vesicles: an alternative to cell therapy for COVID-19. Expert Opin Biol Ther. 2021;21(12):1551\u201360.","journal-title":"Expert Opin Biol Ther"},{"key":"6310_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249364","author":"A Gupta","year":"2020","unstructured":"Gupta A, Cady C, Fauser AM, Rodriguez HC, Mistovich RJ, Potty AGR, et al. Cell-free stem cell-derived extract formulation for regenerative medicine applications. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21249364.","journal-title":"Int J Mol Sci"},{"key":"6310_CR34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/bmb\/ldaa002","volume":"133","author":"L Giordano","year":"2020","unstructured":"Giordano L, Porta GD, Peretti GM, Maffulli N. Therapeutic potential of microrna in tendon injuries. Br Med Bull. 2020;133:79\u201394.","journal-title":"Br Med Bull"},{"key":"6310_CR35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1093\/bmb\/ldaa040","volume":"138","author":"G Gargano","year":"2021","unstructured":"Gargano G, Oliviero A, Oliva F, Maffulli N. Small interfering RNAs in tendon homeostasis. Br Med Bull. 2021;138:58\u201367.","journal-title":"Br Med Bull"},{"key":"6310_CR36","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1093\/bmb\/ldad023","volume":"148","author":"G Gargano","year":"2023","unstructured":"Gargano G, Asparago G, Spiezia F, Oliva F, Maffulli N. Small interfering RNAs in the management of human osteoporosis. Br Med Bull. 2023;148:58\u201369.","journal-title":"Br Med Bull"},{"key":"6310_CR37","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/bmb\/ldz015","volume":"130","author":"A Oliviero","year":"2019","unstructured":"Oliviero A, Della Porta G, Peretti GM, Maffulli N. Microrna in osteoarthritis: physiopathology, diagnosis and therapeutic challenge. Br Med Bull. 2019;130:137\u201347.","journal-title":"Br Med Bull"},{"key":"6310_CR38","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1093\/bmb\/ldac012","volume":"142","author":"G Gargano","year":"2022","unstructured":"Gargano G, Oliva F, Oliviero A, Maffulli N. Small interfering RNAs in the management of human rheumatoid arthritis. Br Med Bull. 2022;142:34\u201343.","journal-title":"Br Med Bull"},{"key":"6310_CR39","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldae024","author":"G Gargano","year":"2025","unstructured":"Gargano G, Pagano SM, Maffulli N. Circular rnas in the management of human osteoporosis. Br Med Bull. 2025. https:\/\/doi.org\/10.1093\/bmb\/ldae024.","journal-title":"Br Med Bull"},{"key":"6310_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01201-w","volume":"19","author":"H Wu","year":"2020","unstructured":"Wu H, Qin W, Lu S, Wang X, Zhang J, Sun T, et al. Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2\u2019-o-methylation via NOP58 recruitment in colorectal cancer. Mol Cancer. 2020;19:95.","journal-title":"Mol Cancer"},{"key":"6310_CR41","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1161\/CIRCRESAHA.117.312117","volume":"122","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Jiao L, Sun L, Li Y, Gao Y, Xu C, et al. LncRNA ZFAS1 as a SERCA2a inhibitor to cause intracellular Ca(2+) overload and contractile dysfunction in a mouse model of myocardial infarction. Circ Res. 2018;122:1354\u201368.","journal-title":"Circ Res"},{"key":"6310_CR42","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1159\/000535646","volume":"185","author":"J Zhan","year":"2024","unstructured":"Zhan J, Qi Y, Fu Y, Zheng J, Wu J, Wei X, et al. LncRNA ZFAS1 alleviated NLRP3 inflammasome-mediated pyroptosis through regulating miR-96-5p\/Smad7 signaling in allergic rhinitis. Int Arch Allergy Immunol. 2024;185:704\u201317.","journal-title":"Int Arch Allergy Immunol"},{"key":"6310_CR43","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ceca.2018.05.005","volume":"72","author":"T Vervliet","year":"2018","unstructured":"Vervliet T, Robinson EL, Roderick HL. Lnc\u2019ing Ca(2+), SERCA and cardiac disease. Cell Calcium. 2018;72:132\u20134.","journal-title":"Cell Calcium"},{"key":"6310_CR44","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/s41419-019-2136-6","volume":"10","author":"L Jiao","year":"2019","unstructured":"Jiao L, Li M, Shao Y, Zhang Y, Gong M, Yang X, et al. LncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca(2+) overload in myocardial infarction mice model. Cell Death Dis. 2019;10:942.","journal-title":"Cell Death Dis"},{"key":"6310_CR45","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202302704","volume":"19","author":"C Liu","year":"2023","unstructured":"Liu C, Liu W, Qi B, Fan L, Liu S, Yang Q, et al. Bone homeostasis modulating orthopedic adhesive for the closed-loop management of osteoporotic fractures. Small. 2023;19:e2302704.","journal-title":"Small"},{"key":"6310_CR46","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/s41467-019-09653-5","volume":"10","author":"J Li","year":"2019","unstructured":"Li J, Liu C, Li Y, Zheng Q, Xu Y, Liu B, et al. Tmco1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling. Nat Commun. 2019;10:1589.","journal-title":"Nat Commun"},{"key":"6310_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111490","volume":"539","author":"J Wu","year":"2022","unstructured":"Wu J, Lin T, Gao Y, Li X, Yang C, Zhang K, et al. Long noncoding RNA ZFAS1 suppresses osteogenic differentiation of bone marrow-derived mesenchymal stem cells by upregulating miR-499-EPHA5 axis. Mol Cell Endocrinol. 2022;539:111490.","journal-title":"Mol Cell Endocrinol"},{"key":"6310_CR48","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1038\/s41467-024-46057-6","volume":"15","author":"Y Deng","year":"2024","unstructured":"Deng Y, Lin Y, Chen S, Xiang Y, Chen H, Qi S, et al. Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes. Nat Commun. 2024;15:1991.","journal-title":"Nat Commun"},{"key":"6310_CR49","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1038\/s41467-021-23597-9","volume":"12","author":"M Subramanian","year":"2021","unstructured":"Subramanian M, Hyeon SJ, Das T, Suh YS, Kim YK, Lee JS, et al. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021;12:3291.","journal-title":"Nat Commun"},{"key":"6310_CR50","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.semcancer.2019.07.024","volume":"60","author":"F Orso","year":"2020","unstructured":"Orso F, Quirico L, Dettori D, Coppo R, Virga F, Ferreira LC, et al. Role of miRNAs in tumor and endothelial cell interactions during tumor progression. Semin Cancer Biol. 2020;60:214\u201324.","journal-title":"Semin Cancer Biol"},{"key":"6310_CR51","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1080\/21691401.2019.1645150","volume":"47","author":"L Yang","year":"2019","unstructured":"Yang L, Li X, Zhang S, Song J, Zhu T. Baicalein inhibits proliferation and collagen synthesis of mice fibroblast cell line NIH\/3T3 by regulation of miR-9\/insulin-like growth factor-1 axis. Artif Cells Nanomed Biotechnol. 2019;47:3202\u201311.","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"6310_CR52","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk8123","volume":"10","author":"A Potenzieri","year":"2024","unstructured":"Potenzieri A, Uccella S, Preiti D, Pisoni M, Rosati S, Lavarello C, et al. Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target. Sci Adv. 2024;10:eadk8123.","journal-title":"Sci Adv"},{"key":"6310_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102250","volume":"96","author":"FI Pinheiro","year":"2024","unstructured":"Pinheiro FI, Ara\u00fajo-Filho I, do Rego ACM, de Azevedo EP, Cobucci RN, Guzen FP. Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer\u2019s disease and vascular dementia. Ageing Res Rev. 2024;96:102250.","journal-title":"Ageing Res Rev"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-025-06310-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-025-06310-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-025-06310-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:02:35Z","timestamp":1761044555000},"score":1,"resource":{"primary":{"URL":"https:\/\/josr-online.biomedcentral.com\/articles\/10.1186\/s13018-025-06310-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["6310"],"URL":"https:\/\/doi.org\/10.1186\/s13018-025-06310-0","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"20 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"902"}}