{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:50:38Z","timestamp":1791438638451,"version":"4.3.3"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":85,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Youth Fund Project of Natural Science Foundation of Hunan Province","award":["2022JJ40742"],"award-info":[{"award-number":["2022JJ40742"]}]},{"name":"National Natural Science Foundation of China","award":["82302761"],"award-info":[{"award-number":["82302761"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orthop Surg Res"],"DOI":"10.1186\/s13018-026-07062-1","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:45:17Z","timestamp":1784087117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biologics or surgery for moderate knee osteoarthritis? a patient-centered framework for short-term relief and long-term outcomes"],"prefix":"10.1186","volume":"21","author":[{"given":"Muhammad Adil","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-7177","authenticated-orcid":false,"given":"Junjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"2","key":"7062_CR1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cger.2021.11.005","volume":"38","author":"GA Hawker","year":"2022","unstructured":"Hawker GA, King LK. The burden of osteoarthritis in older adults. Clin Geriatr Med. 2022;38(2):181\u201392.","journal-title":"Clin Geriatr Med"},{"issue":"24","key":"7062_CR2","doi-asserted-by":"publisher","first-page":"16815","DOI":"10.3390\/ijerph192416815","volume":"19","author":"A Wojcieszek","year":"2022","unstructured":"Wojcieszek A, et al. The impact of chronic pain, stiffness and difficulties in performing daily activities on the quality of life of older patients with knee osteoarthritis. Int J Environ Res Public Health. 2022;19(24):16815.","journal-title":"Int J Environ Res Public Health"},{"issue":"10258","key":"7062_CR3","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"T Vos","year":"2020","unstructured":"Vos T, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. lancet. 2020;396(10258):1204\u201322.","journal-title":"lancet"},{"issue":"6","key":"7062_CR4","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1136\/annrheumdis-2019-216515","volume":"79","author":"S Safiri","year":"2020","unstructured":"Safiri S, et al. Global, regional and national burden of osteoarthritis 1990\u20132017: a systematic analysis of the Global Burden of Disease Study 2017. Ann Rheum Dis. 2020;79(6):819\u201328.","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"7062_CR5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s12020-022-03201-w","volume":"79","author":"G Zhao","year":"2023","unstructured":"Zhao G, et al. Global Burden of osteoarthritis associated with high body mass index in 204 countries and territories, 1990\u20132019: findings from the Global Burden of Disease Study 2019. Endocrine. 2023;79(1):60\u201371.","journal-title":"Endocrine"},{"issue":"1","key":"7062_CR6","doi-asserted-by":"publisher","first-page":"2493306","DOI":"10.1080\/07853890.2025.2493306","volume":"57","author":"A Gupta","year":"2025","unstructured":"Gupta A, Maffulli N. Undenatured type II collagen for knee osteoarthritis. Ann Med. 2025;57(1):2493306.","journal-title":"Ann Med"},{"issue":"9","key":"7062_CR7","doi-asserted-by":"publisher","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","volume":"5","author":"JD Steinmetz","year":"2023","unstructured":"Steinmetz JD, et al. Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(9):e508\u201322.","journal-title":"Lancet Rheumatol"},{"issue":"2","key":"7062_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/AAP.0000000000000218","volume":"40","author":"S Narouze","year":"2015","unstructured":"Narouze S, Souzdalnitski D. Obesity and chronic pain: systematic review of prevalence and implications for pain practice. Reg Anesth Pain Med. 2015;40(2):91\u2013111.","journal-title":"Reg Anesth Pain Med"},{"issue":"4","key":"7062_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/14737167.2023.2181791","volume":"23","author":"I Atukorala","year":"2023","unstructured":"Atukorala I, Hunter DJ. A review of quality-of-life in elderly osteoarthritis. Expert Rev PharmacoEcon Outcomes Res. 2023;23(4):365\u201381.","journal-title":"Expert Rev PharmacoEcon Outcomes Res"},{"issue":"9","key":"7062_CR10","doi-asserted-by":"publisher","first-page":"e496","DOI":"10.1016\/S2665-9913(23)00207-2","volume":"5","author":"AY Wong","year":"2023","unstructured":"Wong AY, Samartzis D, Maher C. The global burden of osteoarthritis: past and future perspectives. Lancet Rheumatol. 2023;5(9):e496\u20137.","journal-title":"Lancet Rheumatol"},{"key":"7062_CR11","doi-asserted-by":"publisher","first-page":"826765","DOI":"10.3389\/fresc.2021.826765","volume":"2","author":"JP Eyles","year":"2022","unstructured":"Eyles JP, et al. Implementation of best-evidence osteoarthritis care: perspectives on challenges for, and opportunities from, low and middle-income countries. Front rehabilitation Sci. 2022;2:826765.","journal-title":"Front rehabilitation Sci"},{"key":"7062_CR12","doi-asserted-by":"publisher","unstructured":"Briggs AM et al. Health systems strengthening to arrest the global disability burden: empirical development of prioritised components for a global strategy for improving musculoskeletal health. BMJ Global Health. 2021;6(6):e006045. https:\/\/doi.org\/10.1136\/bmjgh-2021-006045","DOI":"10.1136\/bmjgh-2021-006045"},{"key":"7062_CR13","doi-asserted-by":"publisher","unstructured":"Tang X et al. Association Between Average Daily Activity Counts and Knee Osteoarthritis Progression. Am J Phys Med Rehabil. 2025;104(7):663\u201370. https:\/\/doi.org\/10.1097\/PHM.0000000000002697","DOI":"10.1097\/PHM.0000000000002697"},{"key":"7062_CR14","doi-asserted-by":"publisher","unstructured":"Lv Z et al. Molecular Classification of Knee Osteoarthritis. Front Cell Dev Biology. 2021;9:725568. https:\/\/doi.org\/10.3389\/fcell.2021.725568","DOI":"10.3389\/fcell.2021.725568"},{"issue":"3","key":"7062_CR15","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1007\/s00167-019-05614-z","volume":"28","author":"E Sasaki","year":"2020","unstructured":"Sasaki E, et al. Early knee osteoarthritis prevalence is highest among middle-aged adult females with obesity based on new set of diagnostic criteria from a large sample cohort study in the Japanese general population. Knee Surg Sports Traumatol Arthrosc. 2020;28(3):984\u201394.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"5","key":"7062_CR16","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.joca.2022.02.614","volume":"30","author":"FW Roemer","year":"2022","unstructured":"Roemer FW, et al. Heterogeneity of cartilage damage in Kellgren and Lawrence grade 2 and 3 knees: the MOST study. Osteoarthritis Cartilage. 2022;30(5):714\u201323.","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"7062_CR17","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.joca.2022.02.619","volume":"30","author":"W Wu","year":"2022","unstructured":"Wu W, et al. Walking-related knee contact forces and associations with knee pain across people with mild, moderate and severe radiographic knee osteoarthritis: a cross-sectional study. Osteoarthritis Cartilage. 2022;30(6):832\u201342.","journal-title":"Osteoarthritis Cartilage"},{"key":"7062_CR18","doi-asserted-by":"crossref","unstructured":"Husen M, Saris D. Regenerative Medicine\/Cell Therapy Approaches (BMAC, PRP, and Cellular Based Therapies), in Knee Arthroscopy and Knee Preservation Surgery, S.L. Sherman, Editors. 2024, Springer International Publishing: Cham. pp. 915\u2013931.","DOI":"10.1007\/978-3-031-29430-3_56"},{"issue":"2","key":"7062_CR19","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1177\/0363546519836090","volume":"48","author":"JD Lamplot","year":"2020","unstructured":"Lamplot JD, Rodeo SA, Brophy RH. A Practical Guide for the Current Use of Biologic Therapies in Sports Medicine. Am J Sports Med. 2020;48(2):488\u2013503.","journal-title":"Am J Sports Med"},{"key":"7062_CR20","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.knee.2024.06.003","volume":"49","author":"SJ Teo","year":"2024","unstructured":"Teo SJ, et al. High tibial osteotomy versus unicompartmental knee arthroplasty in advanced medial compartmental knee arthrosis: A comparative study with propensity score matched analysis. Knee. 2024;49:116\u201324.","journal-title":"Knee"},{"issue":"2","key":"7062_CR21","doi-asserted-by":"publisher","first-page":"232596712413109","DOI":"10.1177\/23259671241310963","volume":"13","author":"RWK Loke","year":"2025","unstructured":"Loke RWK, et al. Conversion to Total Knee Arthroplasty After High Tibial Osteotomy: A Systematic Review and Meta-analysis. Orthop J Sports Med. 2025;13(2):23259671241310963.","journal-title":"Orthop J Sports Med"},{"issue":"1","key":"7062_CR22","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1186\/s13287-024-04034-2","volume":"15","author":"H Lee","year":"2024","unstructured":"Lee H, Lim Y, Lee S-H. Rapid-acting pain relief in knee osteoarthritis: autologous-cultured adipose-derived mesenchymal stem cells outperform stromal vascular fraction: a systematic review and meta-analysis. Stem Cell Res Ther. 2024;15(1):446.","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"7062_CR23","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.mporth.2023.03.007","volume":"37","author":"K Vipulendran","year":"2023","unstructured":"Vipulendran K, Yasen S, Murray J. Osteotomy versus unicompartmental arthroplasty: an algorithm for anteromedial knee osteoarthritis. Orthop Trauma. 2023;37(3):184\u201394.","journal-title":"Orthop Trauma"},{"issue":"11","key":"7062_CR24","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1007\/s00167-023-07526-5","volume":"31","author":"A Hoorntje","year":"2023","unstructured":"Hoorntje A, et al. High tibial osteotomy versus unicompartmental knee arthroplasty for Kellgren-Lawrence grade 3\u20134 knee osteoarthritis in younger patients: comparable improvements in patient-reported outcomes, adjusted for osteoarthritis grade and sex. Knee Surg Sports Traumatol Arthrosc. 2023;31(11):4861\u201370.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"7062_CR25","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1186\/s12891-024-07845-9","volume":"25","author":"G Wei","year":"2024","unstructured":"Wei G, et al. Effects of lower-limb active resistance exercise on mobility, physical function, knee strength and pain intensity in patients with total knee arthroplasty: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2024;25(1):730.","journal-title":"BMC Musculoskelet Disord"},{"key":"7062_CR26","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.knee.2021.02.017","volume":"29","author":"S Kuriyama","year":"2021","unstructured":"Kuriyama S, et al. Differences in impact on adjacent compartments in medial unicompartmental knee arthroplasty versus high tibial osteotomy with identical valgus alignment. Knee. 2021;29:241\u201350.","journal-title":"Knee"},{"issue":"1","key":"7062_CR27","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1177\/0363546519834557","volume":"48","author":"JS Everhart","year":"2020","unstructured":"Everhart JS, et al. Cost-efficacy of Knee Cartilage Defect Treatments in the United States. Am J Sports Med. 2020;48(1):242\u201351.","journal-title":"Am J Sports Med"},{"issue":"4","key":"7062_CR28","doi-asserted-by":"publisher","first-page":"232596712311559","DOI":"10.1177\/23259671231155950","volume":"11","author":"NA Householder","year":"2023","unstructured":"Householder NA, et al. A Review of Recent Innovations in Cartilage Regeneration Strategies for the Treatment of Primary Osteoarthritis of the Knee: Intra-articular Injections. Orthop J Sports Med. 2023;11(4):23259671231155950.","journal-title":"Orthop J Sports Med"},{"key":"7062_CR29","doi-asserted-by":"publisher","first-page":"1759720X2412730","DOI":"10.1177\/1759720X241273009","volume":"16","author":"M Langworthy","year":"2024","unstructured":"Langworthy M, Dasa V, Spitzer AI. Knee osteoarthritis: disease burden, available treatments, and emerging options. Therapeutic Adv Musculoskelet Disease. 2024;16:1759720X241273009.","journal-title":"Therapeutic Adv Musculoskelet Disease"},{"key":"7062_CR30","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jor.2024.02.022","volume":"54","author":"J Harvey","year":"2024","unstructured":"Harvey J, et al. Compensatory mechanisms for proximal & distal joint alignment & gait in varus knee osteoarthritis treated with high tibial osteotomy: A systematic review. J Orthop. 2024;54:148\u201357.","journal-title":"J Orthop"},{"issue":"3","key":"7062_CR31","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1007\/s00167-021-06462-6","volume":"30","author":"C Rivi\u00e8re","year":"2022","unstructured":"Rivi\u00e8re C, et al. Kinematic alignment of medial UKA is safe: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2022;30(3):1082\u201394.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"2","key":"7062_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/NOR.0000000000000739","volume":"40","author":"CB Johnson","year":"2021","unstructured":"Johnson CB. A personalized shared decision-making tool for osteoarthritis management of the knee. Orthop Nurs. 2021;40(2):64\u201370.","journal-title":"Orthop Nurs"},{"issue":"14","key":"7062_CR33","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1055\/s-0043-56998","volume":"36","author":"K Rucinski","year":"2023","unstructured":"Rucinski K, Leary E, Royse LA. Factors important to patients when making treatment decisions for knee osteoarthritis. J Knee Surg. 2023;36(14):1413\u201321.","journal-title":"J Knee Surg"},{"issue":"9","key":"7062_CR34","doi-asserted-by":"publisher","first-page":"e721","DOI":"10.5435\/JAAOS-D-21-01233","volume":"30","author":"RH Brophy","year":"2022","unstructured":"Brophy RH, Fillingham YA. AAOS clinical practice guideline summary: management of osteoarthritis of the knee (nonarthroplasty). JAAOS-Journal Am Acad Orthop Surg. 2022;30(9):e721\u20139.","journal-title":"JAAOS-Journal Am Acad Orthop Surg"},{"issue":"7","key":"7062_CR35","doi-asserted-by":"publisher","first-page":"296","DOI":"10.5435\/JAAOS-D-23-00957","volume":"32","author":"J Dubin","year":"2024","unstructured":"Dubin J, et al. American Academy of Orthopaedic Surgeons Technology Overview Summary: Platelet-Rich Plasma (PRP) for Knee Osteoarthritis. JAAOS - J Am Acad Orthop Surg. 2024;32(7):296\u2013301.","journal-title":"JAAOS - J Am Acad Orthop Surg"},{"issue":"2","key":"7062_CR36","doi-asserted-by":"publisher","first-page":"299","DOI":"10.18203\/issn.2455-4510.IntJResOrthop20240408","volume":"10","author":"N Tripathi","year":"2024","unstructured":"Tripathi N, et al. Intra-articular autologous conditioned plasma reduces pain in early osteoarthritis and improves stiffness in advanced osteoarthritis knee: a prospective observation. Int J Res Orthop. 2024;10(2):299.","journal-title":"Int J Res Orthop"},{"issue":"8","key":"7062_CR37","first-page":"101","volume":"B","author":"L Beckers","year":"2019","unstructured":"Beckers L, et al. Reduced bone activity in the native compartments after medial mobile-bearing unicompartmental knee arthroplasty. A prospective SPECT\/CT study. Bone Joint J. 2019;B(8):101.","journal-title":"Bone Joint J"},{"issue":"1","key":"7062_CR38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/os.13111","volume":"14","author":"LP Wu","year":"2022","unstructured":"Wu LP, et al. Knee Scores of Patients with Non-Lateral Compartmental Knee Osteoarthritis Undergoing Mobile, Fixed-Bearing Unicompartmental Knee and Total Knee Arthroplasties: A Randomized Controlled Trial. Orthop Surg. 2022;14(1):73\u201387.","journal-title":"Orthop Surg"},{"key":"7062_CR39","doi-asserted-by":"crossref","unstructured":"Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. The American journal of sports medicine. 2013 Feb;41(2):356-64.","DOI":"10.1177\/0363546512471299"},{"issue":"1suppl","key":"7062_CR40","doi-asserted-by":"publisher","first-page":"S364","DOI":"10.1177\/1947603520931170","volume":"13","author":"G Filardo","year":"2021","unstructured":"Filardo G, et al. PRP injections for the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials. Cartilage. 2021;13(1suppl):S364\u201375.","journal-title":"Cartilage"},{"key":"7062_CR41","doi-asserted-by":"crossref","unstructured":"Zhang B, Qian H, Wu H, Yang X. Unicompartmental knee arthroplasty versus high tibial osteotomy for medial knee osteoarthritis: a systematic review and meta-analysis. Journal of Orthopaedic Surgery. 2023 Mar 9;31(1):10225536231162829.","DOI":"10.1177\/10225536231162829"},{"issue":"10","key":"7062_CR42","doi-asserted-by":"publisher","first-page":"807","DOI":"10.2106\/JBJS.N.00925","volume":"97","author":"MR Konopka","year":"2015","unstructured":"Konopka JF, Gomoll AH, Thornhill TS, Katz JN, Losina E. The cost-effectiveness of surgical treatment of medial unicompartmental knee osteoarthritis in younger patients: a computer model-based evaluation. Journal of Bone and Joint Surgery. 2015;97:807\u2013817. https:\/\/doi.org\/10.2106\/JBJS.N.00925","journal-title":"Journal of Bone and Joint Surgery. American Volume"},{"issue":"5","key":"7062_CR43","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s00590-019-02391-w","volume":"29","author":"P Hinarejos","year":"2019","unstructured":"Hinarejos P, et al. Pressure algometry is a suitable tool to assess anterior knee pain in osteoarthritic patients. Eur J Orthop Surg Traumatol. 2019;29(5):1089\u201393.","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"13","key":"7062_CR44","first-page":"1386","volume":"36","author":"E Hampp","year":"2022","unstructured":"Hampp E, et al. The Association of Patient and Procedural Factors on Improved Outcomes: A Cluster Analysis on 853 Total Knee Arthroplasty Patients. J Knee Surg. 2022;36(13):1386\u201390.","journal-title":"J Knee Surg"},{"key":"7062_CR45","doi-asserted-by":"crossref","unstructured":"Samuelson EM, Ebel JA, Reynolds SB, Arnold RM, Brown DE. The cost-effectiveness of platelet-rich plasma compared with hyaluronic acid injections for the treatment of knee osteoarthritis. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2020 Dec 1;36(12):3072-8.","DOI":"10.1016\/j.arthro.2020.07.027"},{"key":"7062_CR46","doi-asserted-by":"crossref","unstructured":"Regmi A, et al. Greening orthopaedic surgery: Carbon footprint, waste generation, environmental impact, and mitigation strategies. Journal of Orthopaedics; 2025.","DOI":"10.1016\/j.jor.2025.12.018"},{"issue":"4","key":"7062_CR47","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.3390\/s21041418","volume":"21","author":"Y Iwama","year":"2021","unstructured":"Iwama Y, et al. Estimation of the external knee adduction moment during gait using an inertial measurement unit in patients with knee osteoarthritis. Sensors. 2021;21(4):1418.","journal-title":"Sensors"},{"issue":"10","key":"7062_CR48","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1016\/j.apmr.2021.03.038","volume":"102","author":"GL Hatfield","year":"2021","unstructured":"Hatfield GL, et al. Association between knee joint muscle activation and knee joint moment patterns during walking in moderate medial compartment knee osteoarthritis: implications for secondary prevention. Arch Phys Med Rehabil. 2021;102(10):1910\u20137.","journal-title":"Arch Phys Med Rehabil"},{"key":"7062_CR49","doi-asserted-by":"crossref","unstructured":"Sara LK, et al. The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study. Osteoarthritis and Cartilage; 2025.","DOI":"10.1016\/j.joca.2025.04.007"},{"issue":"4","key":"7062_CR50","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3390\/medicina59040779","volume":"59","author":"S Lee","year":"2023","unstructured":"Lee S, et al. Valgus Arthritic Knee Responds Better to Conservative Treatment than the Varus Arthritic Knee. Medicina. 2023;59(4):779.","journal-title":"Medicina"},{"issue":"1","key":"7062_CR51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/bmb\/ldad030","volume":"149","author":"A Aratikatla","year":"2024","unstructured":"Aratikatla A, et al. Wharton\u2019s jelly and osteoarthritis of the knee. Br Med Bull. 2024;149(1):13\u201331.","journal-title":"Br Med Bull"},{"issue":"3","key":"7062_CR52","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/JSA.0000000000000350","volume":"30","author":"A Gupta","year":"2022","unstructured":"Gupta A, Maffulli N. Allogenic Umbilical Cord Tissue for Treatment of Knee Osteoarthritis. Sports Med Arthrosc Rev. 2022;30(3):162\u20135.","journal-title":"Sports Med Arthrosc Rev"},{"issue":"3","key":"7062_CR53","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/JSA.0000000000000349","volume":"30","author":"I Andia","year":"2022","unstructured":"Andia I, Atilano L, Maffulli N. Biological Targets of Multimolecular Therapies in Middle-Age Osteoarthritis. Sports Med Arthrosc Rev. 2022;30(3):141\u20136.","journal-title":"Sports Med Arthrosc Rev"},{"issue":"1","key":"7062_CR54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s10195-020-00551-x","volume":"21","author":"A Mittal","year":"2020","unstructured":"Mittal A, et al. Unicompartmental knee arthroplasty, an enigma, and the ten enigmas of medial UKA. J Orthop Traumatol. 2020;21(1):15.","journal-title":"J Orthop Traumatol"},{"issue":"2","key":"7062_CR55","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3390\/jcm10020368","volume":"10","author":"MP Jansen","year":"2021","unstructured":"Jansen MP, et al. Changes in cartilage thickness and denuded bone area after knee joint distraction and high tibial osteotomy\u2014post-hoc analyses of two randomized controlled trials. J Clin Med. 2021;10(2):368.","journal-title":"J Clin Med"},{"issue":"1","key":"7062_CR56","doi-asserted-by":"publisher","first-page":"232596712312199","DOI":"10.1177\/23259671231219975","volume":"12","author":"T Karasavvidis","year":"2024","unstructured":"Karasavvidis T, et al. Comparison of early complication Rates after High Tibial Osteotomy Versus Unicompartmental knee arthroplasty for knee osteoarthritis. Orthop J Sports Med. 2024;12(1):23259671231219975.","journal-title":"Orthop J Sports Med"},{"issue":"1","key":"7062_CR57","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s12891-022-05201-3","volume":"23","author":"C-M Ho-Henriksson","year":"2022","unstructured":"Ho-Henriksson C-M, et al. Physiotherapist or physician as primary assessor for patients with suspected knee osteoarthritis in primary care\u2013a cost-effectiveness analysis of a pragmatic trial. BMC Musculoskelet Disord. 2022;23(1):260.","journal-title":"BMC Musculoskelet Disord"},{"key":"7062_CR58","doi-asserted-by":"crossref","unstructured":"Kopp PT, et al. Cost-Effectiveness of Community\u2010Based Diet and Exercise for Patients with Knee Osteoarthritis and Obesity or Overweight. Volume 76. Arthritis Care & Research; 2024. pp. 1018\u201327. 7.","DOI":"10.1002\/acr.25323"},{"issue":"1","key":"7062_CR59","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2174\/1573397117666211116111738","volume":"18","author":"MA Siddiq","year":"2022","unstructured":"Siddiq MA, et al. Emerging and new treatment options for knee osteoarthritis. Curr Rheumatol reviews. 2022;18(1):20\u201332.","journal-title":"Curr Rheumatol reviews"},{"issue":"3","key":"7062_CR60","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s40674-020-00157-8","volume":"6","author":"CA Primeau","year":"2020","unstructured":"Primeau CA, et al. Cost-effectiveness of arthroplasty management in hip and knee osteoarthritis: a quality review of the literature. Curr Treat Options Rheumatol. 2020;6(3):160\u201390.","journal-title":"Curr Treat Options Rheumatol"},{"issue":"6","key":"7062_CR61","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.joca.2020.01.017","volume":"28","author":"GS Silva","year":"2020","unstructured":"Silva GS, et al. Long-term clinical and economic outcomes of a short-term physical activity program in knee osteoarthritis patients. Osteoarthr Cartil. 2020;28(6):735\u201343.","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"7062_CR62","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s12891-021-04308-3","volume":"22","author":"M McLarnon","year":"2021","unstructured":"McLarnon M, Heron N. Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis. BMC Musculoskelet Disord. 2021;22(1):550.","journal-title":"BMC Musculoskelet Disord"},{"issue":"8","key":"7062_CR63","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1007\/s00264-023-05773-2","volume":"47","author":"S-L Ding","year":"2023","unstructured":"Ding S-L, et al. Safety and efficacy of intra-articular injection of platelet-rich plasma for the treatment of ankle osteoarthritis: a systematic review and meta-analysis. Int Orthop. 2023;47(8):1963\u201374.","journal-title":"Int Orthop"},{"issue":"10","key":"7062_CR64","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1177\/03635465231213087","volume":"52","author":"Y Xu","year":"2024","unstructured":"Xu Y, et al. Platelet-rich plasma has better results for long-term functional improvement and pain relief for lateral epicondylitis: a systematic review and meta-analysis of randomized controlled trials. Am J Sports Med. 2024;52(10):2646\u201356.","journal-title":"Am J Sports Med"},{"issue":"3","key":"7062_CR65","doi-asserted-by":"publisher","first-page":"e135","DOI":"10.5435\/JAAOS-D-22-00397","volume":"31","author":"EJ Berlinberg","year":"2023","unstructured":"Berlinberg EJ, et al. The epidemiology of platelet-rich plasma injections from 2010 to 2020 in a large US commercial insurance claims database: a recent update. JAAOS-Journal Am Acad Orthop Surg. 2023;31(3):e135\u201347.","journal-title":"JAAOS-Journal Am Acad Orthop Surg"},{"issue":"3","key":"7062_CR66","first-page":"218","volume":"54","author":"F Migliorini","year":"2025","unstructured":"Migliorini F, et al. Intra-articular injections of hyaluronic acid versus plasma rich in growth factors (PRGF) for knee osteoarthritis: a meta-analysis of randomised controlled trials: A meta-analysis. Orthopadie (Heidelb). 2025;54(3):218\u201326.","journal-title":"Orthopadie (Heidelb)"},{"issue":"1","key":"7062_CR67","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s00402-024-05614-w","volume":"145","author":"F Migliorini","year":"2024","unstructured":"Migliorini F, et al. Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Arch Orthop Trauma Surg. 2024;145(1):68.","journal-title":"Arch Orthop Trauma Surg"},{"issue":"6","key":"7062_CR68","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3390\/medicina60060977","volume":"60","author":"J-H Baek","year":"2024","unstructured":"Baek J-H, et al. Effectiveness and complications of bone marrow aspirate concentrate in patients with knee osteoarthritis of Kellgren\u2013Lawrence Grades II\u2013III. Medicina. 2024;60(6):977.","journal-title":"Medicina"},{"issue":"1","key":"7062_CR69","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1038\/s41598-024-51410-2","volume":"14","author":"C Pabinger","year":"2024","unstructured":"Pabinger C, Lothaller H, Kobinia GS. Intra-articular injection of bone marrow aspirate concentrate (mesenchymal stem cells) in KL grade III and IV knee osteoarthritis: 4 year results of 37 knees. Sci Rep. 2024;14(1):2665.","journal-title":"Sci Rep"},{"issue":"2","key":"7062_CR70","doi-asserted-by":"publisher","first-page":"232596712098162","DOI":"10.1177\/2325967120981627","volume":"9","author":"S Zaffagnini","year":"2021","unstructured":"Zaffagnini S, et al. Biologic augmentation reduces the failure rate of meniscal repair: a systematic review and meta-analysis. Orthop J Sports Med. 2021;9(2):2325967120981627.","journal-title":"Orthop J Sports Med"},{"issue":"23","key":"7062_CR71","doi-asserted-by":"publisher","first-page":"11440","DOI":"10.3390\/app112311440","volume":"11","author":"A Paz","year":"2021","unstructured":"Paz A, et al. Expediting finite element analyses for subject-specific studies of knee osteoarthritis: a literature review. Appl Sci. 2021;11(23):11440.","journal-title":"Appl Sci"},{"issue":"2","key":"7062_CR72","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00264-020-04838-w","volume":"45","author":"AE Weber","year":"2021","unstructured":"Weber AE, Bolia IK, Trasolini NA. Biological strategies for osteoarthritis: from early diagnosis to treatment. Int Orthop. 2021;45(2):335\u201344.","journal-title":"Int Orthop"},{"key":"7062_CR73","doi-asserted-by":"crossref","unstructured":"Lippi L et al. Multidisciplinary rehabilitation after hyaluronic acid injections for elderly with knee, hip, shoulder, and temporomandibular joint osteoarthritis. Medicina, 2023. 59(11): p. 2047.","DOI":"10.3390\/medicina59112047"},{"issue":"1","key":"7062_CR74","doi-asserted-by":"publisher","first-page":"102255362312249","DOI":"10.1177\/10225536231224952","volume":"32","author":"L Zhu","year":"2024","unstructured":"Zhu L, et al. Platelet-rich plasma in orthopedics: bridging innovation and clinical applications for bone repair. J Orthop Surg. 2024;32(1):10225536231224952.","journal-title":"J Orthop Surg"},{"issue":"1","key":"7062_CR75","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13063-025-08828-4","volume":"26","author":"T Zhi","year":"2025","unstructured":"Zhi T, et al. Effects of opioid-free anesthesia combined with iliofascial nerve block on perioperative neurocognitive deficits in elderly patients undergoing hip fracture surgery: study protocol for a prospective, multicenter, parallel-group, randomized controlled trial. Trials. 2025;26(1):122.","journal-title":"Trials"},{"issue":"11","key":"7062_CR76","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.1007\/s00402-024-05587-w","volume":"144","author":"V M\u00e4rz","year":"2024","unstructured":"M\u00e4rz V, et al. Intraoperative cartilage analysis of the first carpometacarpal joint-comparison with conventional staging according to Eaton and Littler. Arch Orthop Trauma Surg. 2024;144(11):4947\u201354.","journal-title":"Arch Orthop Trauma Surg"},{"key":"7062_CR77","doi-asserted-by":"publisher","unstructured":"Regmi A et al. Glucagon-Like Peptide-1 Receptor Agonists in Orthopedics: A Scoping Review of Emerging Applications. Indian J Orthop, 2025: pp. 1\u201313. https:\/\/doi.org\/10.1007\/s43465-025-01614-z","DOI":"10.1007\/s43465-025-01614-z"}],"container-title":["Journal of Orthopaedic Surgery and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13018-026-07062-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-026-07062-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13018-026-07062-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:02:38Z","timestamp":1791435758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13018-026-07062-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["7062"],"URL":"https:\/\/doi.org\/10.1186\/s13018-026-07062-1","relation":{},"ISSN":["1749-799X"],"issn-type":[{"value":"1749-799X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study is a narrative literature review that did not involve any human participants, animal subjects, primary data collection, or tissue samples. As such, it relied exclusively on publicly available, previously published data. No ethical approval was required.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"584"}}