{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:27:01Z","timestamp":1771270021375,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13019-018-0785-7","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T10:20:15Z","timestamp":1537179615000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Myocardial insufficiency is related to reduced subunit 4 content of cytochrome c oxidase"],"prefix":"10.1186","volume":"13","author":[{"given":"Sebastian","family":"Vogt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Ruppert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Pankuweit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen P. J.","family":"Paletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Rhiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Irqsusi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Cybulski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia","family":"Ramzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,17]]},"reference":[{"key":"785_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/978-1-4614-3573-0_11","volume":"748","author":"R Ramzan","year":"2012","unstructured":"Ramzan R, Weber P, Kadenbach B, Vogt S. Individual biochemical behavior versus biological robustness: spotlight on the regulation of cytochrome c oxidase. Adv Exp Med Biol. 2012;748:265\u201381.","journal-title":"Adv Exp Med Biol"},{"issue":"9","key":"785_CR2","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/j.bbabio.2010.06.005","volume":"1797","author":"R Ramzan","year":"2010","unstructured":"Ramzan R, Staniek K, Kadenbach B, Vogt S. Mitochondrial respiration and membrane potential are regulated by the allosteric ATP-inhibition of cytochrome c oxidase. Biochim Biophys Acta. 2010;1797(9):1672\u201380.","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"785_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.bbagen.2009.04.019","volume":"1800","author":"B Kadenbach","year":"2010","unstructured":"Kadenbach B, Ramzan R, Wen L, Vogt S. New extension of the Mitchell theory for oxidative phosphorylation in mitochondria of living organisms. Biochim Biophys Acta. 2010;1800(3):205\u201312.","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"785_CR4","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/bies.201600043","volume":"38","author":"S Vogt","year":"2016","unstructured":"Vogt S, Rhiel A, Weber P, Ramzan R. Revisiting Kadenbach: Electron flux rate through cytochrome c-oxidase determines the ATP-inhibitory effect and subsequent production of ROS. Bioessays. 2016;38(6):556\u201367.","journal-title":"Bioessays"},{"issue":"1","key":"785_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mito.2011.05.003","volume":"12","author":"S Arnold","year":"2012","unstructured":"Arnold S. The power of life--cytochrome c oxidase takes center stage in metabolic control, cell signalling and survival. Mitochondrion. 2012;12(1):46\u201356.","journal-title":"Mitochondrion"},{"key":"785_CR6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/S0891-5849(00)00303-8","volume":"29","author":"G Villani","year":"2000","unstructured":"Villani G, Attardi G. In vivo control of respiration by cytochrome c oxidase in human cells. Free Rad Biol Med. 2000;29:202\u201310.","journal-title":"Free Rad Biol Med"},{"issue":"48","key":"785_CR7","doi-asserted-by":"publisher","first-page":"31829","DOI":"10.1074\/jbc.273.48.31829","volume":"273","author":"G Villani","year":"1998","unstructured":"Villani G, Greco M, Papa S, Attardi G. Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J Biol Chem. 1998;273(48):31829\u201336.","journal-title":"J Biol Chem"},{"key":"785_CR8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.mito.2015.07.002","volume":"24","author":"B Kadenbach","year":"2015","unstructured":"Kadenbach B, H\u00fcttemann M. The subunit composition and function of mammalian cytochrome c oxidase. Mitochondrion. 2015;24:64\u201376.","journal-title":"Mitochondrion"},{"issue":"5\u20136","key":"785_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10863-006-9052-z","volume":"38","author":"Y Li","year":"2006","unstructured":"Li Y, Park JS, Deng JH, Bai Y. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. J Bioenerg Biomembr. 2006;38(5\u20136):283\u201391.","journal-title":"J Bioenerg Biomembr"},{"key":"785_CR10","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/oxfordjournals.eurheartj.a059743","volume":"11","author":"A Buchwald","year":"1990","unstructured":"Buchwald A, Till H, Unterberg C, Oberschmidt R, et al. Alterations of the mitochondrial respiratory chain in human dilated cardiomyopathy. Eur Heart J. 1990;11:509\u201316.","journal-title":"Eur Heart J"},{"issue":"2","key":"785_CR11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.mito.2011.11.002","volume":"12","author":"M H\u00fcttemann","year":"2012","unstructured":"H\u00fcttemann M, Klewer S, Lee I, Pecinova A, Pecina P, Liu J, Lee M, Doan JW, Larson D, Slack E, Maghsoodi B, Erickson RP, Grossman LI. Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy. Mitochondrion. 2012;12(2):294\u2013304.","journal-title":"Mitochondrion"},{"key":"785_CR12","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1006\/jmcc.1997.0501","volume":"29","author":"YY Li","year":"1997","unstructured":"Li YY, Maisch B, Rose ML, et al. Point mutations in mitochondrial DNA of patients with dilated cardiomyopathy. J Mol Cell Cardiol. 1997;29:2699\u2013709.","journal-title":"J Mol Cell Cardiol"},{"key":"785_CR13","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.bbrc.2004.04.061","volume":"28","author":"V Ruppert","year":"2004","unstructured":"Ruppert V, Nolte D, Aschenbrenner T, et al. Novel point mutations in the mitochondrial DNA detected in patients with dilated cardiomyopathy by screening the whole mitochondrial genome. Biochem Biophys Res Commun. 2004;28:535\u201343.","journal-title":"Biochem Biophys Res Commun"},{"key":"785_CR14","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/S0002-9440(10)65738-0","volume":"153","author":"E Arbustini","year":"1998","unstructured":"Arbustini E, Diegoli M, Fasani R, et al. Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy. Am J Pathol. 1998;153:1501\u201310.","journal-title":"Am J Pathol"},{"key":"785_CR15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0891-5849(00)00305-1","volume":"29","author":"B Kadenbach","year":"2000","unstructured":"Kadenbach B, Huttemann M, Arnold S, et al. Mitochondrial energy metabolism is related via nuclear-coded subunits of cytochrome c oxidase. Free Rad Biol Med. 2000;29:211\u201321.","journal-title":"Free Rad Biol Med"},{"key":"785_CR16","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.33549\/physiolres.930000.53.S213","volume":"53","author":"P Pecina","year":"2004","unstructured":"Pecina P, Houstkova H, Hansikova H, et al. Genetic defects of cytochrome c oxidase assembly. Physiol Res. 2004;53:S213\u201323.","journal-title":"Physiol Res"},{"key":"785_CR17","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1002\/j.1460-2075.1987.tb02578.x","volume":"6","author":"L Holm","year":"1987","unstructured":"Holm L, Saraste M, Wikstr\u00f6m M. Structural models of the redox centres in cytochrome oxidase. EMBO J. 1987;6:2819\u201323.","journal-title":"EMBO J"},{"key":"785_CR18","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1111\/j.1432-1033.1993.tb17865.x","volume":"213","author":"GC Steffens","year":"1993","unstructured":"Steffens GC, Soulimane T, Wolff G, Buse G. Stoichiometry and redox behaviour of metals in cytochrome-c oxidase. Eur J Biochem. 1993;213:1149\u201357.","journal-title":"Eur J Biochem"},{"key":"785_CR19","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10863-006-9052-z","volume":"38","author":"Y Li","year":"2006","unstructured":"Li Y, Park JS, Deng JH, Bai Y. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. J Bioenerg Biomembr. 2006;38:283\u201391.","journal-title":"J Bioenerg Biomembr"},{"key":"785_CR20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/978-1-4614-3573-0_11","volume":"748","author":"R Ramzan","year":"2012","unstructured":"Ramzan R, Weber P, Kadenbach B, Vogt S. Individual biochemical behaviour versus biological robustness: spotlight on the regulation of cytochrome c oxidase. Adv Exp Med Biol. 2012;748:265\u201381.","journal-title":"Adv Exp Med Biol"},{"key":"785_CR21","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","volume":"29","author":"P Elliott","year":"2008","unstructured":"Elliott P, Andersson B, Arbustini E, et al. Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases. Eur Heart J. 2008;29:270\u20136.","journal-title":"Eur Heart J"},{"key":"785_CR22","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","volume":"93","author":"P Richardson","year":"1996","unstructured":"Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation. 1996;93:841\u20132.","journal-title":"Circulation"},{"key":"785_CR23","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45.","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"785_CR24","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1515\/hsz-2016-0218","volume":"398","author":"R Ramzan","year":"2017","unstructured":"Ramzan R, Schaper AK, Weber P, Rhiel A, Siddiq MS, Vogt S. Mitochondrial cytochrome c oxidase is inhibited by ATP only at very high ATP\/ADP ratios. Biol Chem. 2017;398(7):737\u201350.","journal-title":"Biol Chem"},{"issue":"5","key":"785_CR25","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/S0735-1097(99)00428-3","volume":"34","author":"E Braunwald","year":"1999","unstructured":"Braunwald E. 50th anniversary historical article. Myocardial oxygen consumption: the quest for its determinants and some clinical fallout. J Am Coll Cardiol. 1999;34(5):1365\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"785_CR26","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJM199412083312307","volume":"331","author":"GW Dec","year":"1994","unstructured":"Dec GW, Fuster V. Idiopathic dilated cardiomyopathy. N Engl J Med. 1994;331:1564\u201375.","journal-title":"N Engl J Med"},{"key":"785_CR27","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/S0008-6363(99)00388-0","volume":"45","author":"D Jarreta","year":"2000","unstructured":"Jarreta D, Orus J, Barrientos A, et al. Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy. Cardiovasc Res. 2000;45:860\u20135.","journal-title":"Cardiovasc Res"},{"key":"785_CR28","first-page":"34","volume":"53","author":"VB Borisov","year":"2004","unstructured":"Borisov VB. Mutations in respiratory chain complexes and human diseases. Ital J Biochem. 2004;53:34\u201340.","journal-title":"Ital J Biochem"},{"key":"785_CR29","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/ajmg.1378","volume":"106","author":"EA Shoubridge","year":"2001","unstructured":"Shoubridge EA. Cytochrome c oxidase deficiency. Am J Med Genet. 2001;106:46\u201352.","journal-title":"Am J Med Genet"},{"key":"785_CR30","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1093\/hmg\/ddg284","volume":"12","author":"H Antonicka","year":"2003","unstructured":"Antonicka H, Leary SC, Guercin GH, Agar JN, Horvath R, Kennaway NG, Harding CO, Jaksch M, Shoubridge EA. Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency. Hum Molec Genet. 2003;12:2693\u2013702.","journal-title":"Hum Molec Genet"},{"key":"785_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1096-7192(03)00063-5","volume":"79","author":"A Saada","year":"2003","unstructured":"Saada A, Shaag A, Elpeleg O. mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK 2) deficiency. Mol Genetics Metabol. 2003;79:1\u20135.","journal-title":"Mol Genetics Metabol"},{"key":"785_CR32","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1242\/jeb.205.11.1625","volume":"205","author":"DS Hittel","year":"2002","unstructured":"Hittel DS, Storey KM. Differential expression of mitochondria-encoded genes in a hibernating mammal. J Exp Biol. 2002;205:1625\u201331.","journal-title":"J Exp Biol"},{"key":"785_CR33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0008-6363(02)00695-8","volume":"57","author":"D Zhang","year":"2003","unstructured":"Zhang D, Mott JL, Farrar P, et al. Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy. Cardiovasc Res. 2003;57:147\u201357.","journal-title":"Cardiovasc Res"},{"key":"785_CR34","doi-asserted-by":"publisher","first-page":"E968","DOI":"10.1152\/ajpendo.00478.2003","volume":"286","author":"TE Sheehan","year":"2004","unstructured":"Sheehan TE, Kumar PA, Hood DA. Tissue-specific regulation of cytochrome c oxidase subunit expression by thyroid hormone. Am J Physiol Endocrinol Metab. 2004;286:E968\u201374.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"785_CR35","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1177\/153537020222700901","volume":"227","author":"YH Wei","year":"2002","unstructured":"Wei YH, Lee HC. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med. 2002;227:671\u201382.","journal-title":"Exp Biol Med"},{"key":"785_CR36","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.ajhg.2011.03.002","volume":"88","author":"M Huigsloot","year":"2011","unstructured":"Huigsloot M, Nijtmans LG, Szklarczyk R, Baars MJ, van den Brand MA, Hendriksfranssen MG, van den Heuvel LP, Smeitink JA, Huynen MA, Rodenburg RJ. A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy. Am J Hum Genet. 2011;88:488\u20139.","journal-title":"Am J Hum Genet"},{"key":"785_CR37","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.mito.2011.11.002","volume":"12","author":"M H\u00fcttemann","year":"2012","unstructured":"H\u00fcttemann M, Klewer S, Lee I, Pecinova A, Pecina P, Liu J, Lee M, Doan JW, Larson D, Slack E, Maghsoodi B, Erickson RP, Grossman LI. Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy. Mitochondrion. 2012;12:294\u2013304.","journal-title":"Mitochondrion"},{"key":"785_CR38","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1515\/bchm.1997.378.9.1013","volume":"378","author":"J Napiwotzki","year":"1997","unstructured":"Napiwotzki J, Shinzawa-Itoh K, Yoshikawa S, Kadenbach B. ATP and ADP bind to cytochrome c oxidase and regulate its activity. Biol Chem. 1997;378:1013\u201321.","journal-title":"Biol Chem"},{"key":"785_CR39","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1515\/bchm.1998.379.3.335","volume":"379","author":"J Napiwotzki","year":"1998","unstructured":"Napiwotzki J, Kadenbach B. Extramitochondrial ATP\/ADP ratios regulate cytochrome c oxidase activity via binding to the cytosolic domain of subunit IV. Biol Chem. 1998;379:335\u20139.","journal-title":"Biol Chem"},{"key":"785_CR40","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1046\/j.1432-1033.2003.03447.x","volume":"270","author":"C Vijayasarathy","year":"2003","unstructured":"Vijayasarathy C, Damle S, Prabu SK, et al. Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia. Eur J Biochem. 2003;270:871\u20139.","journal-title":"Eur J Biochem"},{"issue":"5","key":"785_CR41","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1242\/jcs.161729","volume":"128","author":"S Dennerlein","year":"2015","unstructured":"Dennerlein S, Rehling P. Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance. J Cell Sci. 2015;128(5):833\u20137.","journal-title":"J Cell Sci"},{"key":"785_CR42","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbabio.2005.11.005","volume":"1757","author":"V Desquiret","year":"2006","unstructured":"Desquiret V, Loiseau D, Jacques C, et al. Dinitrophenol- induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells. Biochim Biophys Acta. 2006;1757:21\u201330.","journal-title":"Biochim Biophys Acta"},{"key":"785_CR43","doi-asserted-by":"publisher","first-page":"1534056","DOI":"10.1155\/2017\/1534056","volume":"2017","author":"CA Sinkler","year":"2017","unstructured":"Sinkler CA, Kalpage H, Shay J, Lee I, Malek MH, Grossman LI, H\u00fcttemann M. Tissue- and condition-specific isoforms of mammalian cytochrome c oxidase subunits: from function to human disease. Oxidative Med Cell Longev. 2017;2017:1534056.","journal-title":"Oxidative Med Cell Longev"},{"issue":"11","key":"785_CR44","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1097\/MNM.0b013e32833f393f","volume":"31","author":"W Fang","year":"2010","unstructured":"Fang W, Zhang J, He ZX. Myocardial ischemia in patients with dilated cardiomyopathy. Nucl Med Commun. 2010;31(11):981\u20134.","journal-title":"Nucl Med Commun"},{"issue":"6","key":"785_CR45","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/CIRCHEARTFAILURE.114.002169","volume":"8","author":"S Dass","year":"2015","unstructured":"Dass S, Holloway CJ, Cochlin LE, Rider OJ, Mahmod M, Robson M, Sever E, Clarke K, Watkins H, Ashrafian H, Karamitsos TD, Neubauer S. No evidence of myocardial oxygen deprivation in nonischemic heart failure. Circ Heart Fail. 2015;8(6):1088\u201393.","journal-title":"Circ Heart Fail"},{"issue":"6","key":"785_CR46","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1161\/CIRCHEARTFAILURE.115.002677","volume":"8","author":"J Zheng","year":"2015","unstructured":"Zheng J, Gropler RJ. Myocardial Hypoxia in Dilated Cardiomyopathy: Is it Just a Matter of Supply and Demand? Circ Heart Fail. 2015;8(6):1011\u20133.","journal-title":"Circ Heart Fail"},{"issue":"24","key":"785_CR47","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1161\/01.CIR.100.24.2425","volume":"100","author":"H Laine","year":"1999","unstructured":"Laine H, Katoh C, Luotolahti M, Yki-J\u00e4rvinen H, Kantola I, Jula A, Takala TO, Ruotsalainen U, Iida H, Haaparanta M, Nuutila P, Knuuti J. Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy. Circulation. 1999;100(24):2425\u201330.","journal-title":"Circulation"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-018-0785-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13019-018-0785-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-018-0785-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:00:39Z","timestamp":1693890039000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-018-0785-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,17]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["785"],"URL":"https:\/\/doi.org\/10.1186\/s13019-018-0785-7","relation":{},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,17]]},"assertion":[{"value":"2 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee at the University Hospital of Gie\u00dfen and Marburg (UKGM) has approved the study (AZ: 53\/18). All patients gave their informed consent to use leftover samples for scientific purposes.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"95"}}