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Patients aged under 60\u2009yr were characterized by a higher prevalence of sSIRS (OR\u2009=\u20092.93; 95% CI 2.01\u20134.28; <jats:italic>P<\/jats:italic>\u2009&lt;0.001). Higher baseline serum creatinine (OR\u2009=\u20091.61; 95% CI 1.18\u20132.20; <jats:italic>P<\/jats:italic>\u2009=\u20090.003), concomitant coronary disease (OR\u2009=\u20092.00; 95% CI 1.15\u20133.48; <jats:italic>P<\/jats:italic>\u2009=\u20090.015) and extended cardiopulmonary time (OR\u2009=\u20091.63; 95% CI 1.23\u20132.18; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) independently contributed to a greater likelihood of postoperative sSIRS onset, while the preferred administration of ulinastatin (OR\u2009=\u20090.69; 95% CI 0.51\u20130.93; <jats:italic>P<\/jats:italic>\u2009=\u20090.015) and dexmedetomidine (OR\u2009=\u20090.36; 95% CI 0.23\u20130.56; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) attenuated it. Patients with sSIRS had a greater risk of developing postoperative major adverse complications compared with the no sSIRS group [56.7%(93\/164) vs 26.8% (96\/358), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001]. sSIRS was found to be a significant risk factor for major adverse complications (OR, 4.52; 95% CI, 3.40\u20136.01; <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). A significant difference was revealed in in-hospital death following TAR between the sSIRS group and the no-sSIRS group [4.88% (8\/164) vs 1.12% (4\/358), <jats:italic>P<\/jats:italic>\u2009=\u20090.019]. The Kaplan-Meier curve indicated that the time to discharge from the intensive care unit was significantly prolonged in the sSIRS group compared with patients without it (log-rank <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>sSIRS occurs commonly in patients following TAR with DHCA. There is an inverse association between age and sSIRS onset, whereby age over 60\u2009yr can lower the risk of it. sSIRS development can increase the likelihood of major postoperative major adverse events.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13019-019-1027-3","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T17:03:17Z","timestamp":1576515797000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Severe systemic inflammatory response syndrome in patients following Total aortic arch replacement with deep hypothermic circulatory arrest"],"prefix":"10.1186","volume":"14","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"issue":"2","key":"1027_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1583\/07-2284.1","volume":"15","author":"H Eggebrecht","year":"2008","unstructured":"Eggebrecht H, Mehta RH, Metozounve H, Huptas S, Herold U, Jakob HG, et al. 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