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Trial registration: ISRCTN registry,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1186\/ISRCTN10480871\">ISRCTN10480871<\/jats:ext-link>, registered 16th of August 2017. 82 patients enrolled. Patients randomised to low dose GTN infusion (0.01 mcg\/kg\/min) or higher dose GTN infusion (0.5 mcg\/kg\/min) during rewarming on CPB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main results<\/jats:title><jats:p>There was no significant difference between the treatment arms for the total time to being rewarmed, U\u2009=\u2009759.0,<jats:italic>p<\/jats:italic>\u2009=\u20090.84. There were also no differences between the treatment arms for the time to achieve core temperature greater than 36.5 after two hours, U\u2009=\u2009714.0,<jats:italic>p<\/jats:italic>\u2009=\u20090.52, the time to achieve plateau core skin temperature, U\u2009=\u2009688.0,<jats:italic>p<\/jats:italic>\u2009=\u20090.37, and the post-intervention protamine lactate, U\u2009=\u2009721.0,<jats:italic>p<\/jats:italic>\u2009=\u20090.56.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher dose GTN infusion during rewarming on CPB does not improve peripheral-core temperature gradient post operatively and has no effect on post-operative lactate concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13019-020-01258-0","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T17:03:48Z","timestamp":1597079028000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Glyceryl trinitrate (GTN) to facilitate the rewarming process during cardiopulmonary bypass"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-9489","authenticated-orcid":false,"given":"Darren","family":"Mullane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Lenihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciara","family":"Hanley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmina","family":"Bukowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Flood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"1258_CR1","first-page":"171","volume":"37","author":"G Ja","year":"1954","unstructured":"Ja G. 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