{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:11:14Z","timestamp":1781975474297,"version":"3.54.5"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated additional pulmonary blood flow at the time of bidirectional cavopulmonary shunt and its effects on the Fontan procedure and long-term outcome of Fontan circulation and liver function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 22 patients (16 boys, 6 girls) having undergone bidirectional cavopulmonary shunt with additional pulmonary blood flow between April 2002 and January 2016. Mean age and body weight were 20\u2009\u00b1\u200913\u2009months and 7.5\u2009\u00b1\u20096.5\u2009kg, respectively. We retrospectively evaluated the patients\u2019 clinical data, including cardiac catheterization data, liver function, and liver fibrosis markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients were alive with a New York Heart Association status of I at the long-term follow-up. Changes between pre-bidirectional cavopulmonary shunt and 101\u2009months after the Fontan procedure included the following: the cardiothoracic ratio of chest X-ray decreased from 52.2\u2009\u00b1\u20093.9% to 41.8\u2009\u00b1\u20095.9% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001); systemic ventricle end-diastolic pressure decreased from 11.4\u2009\u00b1\u20093.2\u2009mmHg to 6.9\u2009\u00b1\u20093.6\u2009mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001); and the pulmonary artery index decreased from 485.1\u2009\u00b1\u2009272.3 to 269.5\u2009\u00b1\u2009100.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.02). Type IV collagen, hyaluronic acid, and procollagen levels increased over the normal range 116\u2009months after the Fontan procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The additional pulmonary blood flow at the time of bidirectional cavopulmonary shunt may contribute to pulmonary arterial growth at the Fontan procedure with low pulmonary arterial resistance and without ventricle volume overload. The Fontan circulation was well-maintained at the long-term follow-up, while liver fibrosis markers were above their normal values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-020-01335-4","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T10:04:04Z","timestamp":1601373844000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-term results of additional pulmonary blood flow with bidirectional cavopulmonary shunt"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-9822","authenticated-orcid":false,"given":"Ryosuke","family":"Kowatari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Daitoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"1335_CR1","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/0002-9149(93)90914-X","volume":"71","author":"AK Pridjian","year":"1993","unstructured":"Pridjian AK, Mendelsohn AM, Lupinetti FM, Beekman RH, Dick M, Serwer G, et al. 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