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A regional myocardial infarction was created in the infarction group (18 hearts) for 120\u2009min; the control group (32 hearts) was not subjected to infarction. In each group, either Buckberg BCP or Bretschneider CCP was administered for an aortic clamping time of 90\u2009min. Functional parameters were recorded during reperfusion: coronary blood flow, left ventricular developed pressure (LVDP) and contractility (dp\/dt max). Infarct size was determined by planimetry. The results were compared between the groups using analysis of variance or parametric tests, as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cardiac function after acute myocardial infarction, 90\u2009min of cardioplegic arrest, and 90\u2009min of reperfusion was better preserved with Buckberg BCP than with Bretschneider CCP relative to baseline (BL) values (LVDP 54\u2009\u00b1\u200911% vs. 9\u2009\u00b1\u20092.9% [<jats:italic>p<\/jats:italic>\u2009=\u20090.0062]; dp\/dt max. 73\u2009\u00b1\u200911% vs. 23\u2009\u00b1\u20092.7% [<jats:italic>p<\/jats:italic>\u2009=\u20090.0001]), whereas coronary flow was similarly impaired (BCP 55\u2009\u00b1\u200915%, CCP 63\u2009\u00b1\u200917% [<jats:italic>p<\/jats:italic>\u2009=\u20090.99]). The infarct in BCP-treated hearts was smaller (25% of myocardium) and limited to the area of coronary artery ligation, whereas in CCP hearts the infarct was larger (48% of myocardium;<jats:italic>p<\/jats:italic>\u2009=\u20090.029) and myocardial necrosis was distributed unevenly to the left ventricular wall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a rat model of acute myocardial infarction followed by cardioplegic arrest, application of BCP leads to better myocardial recovery than CCP.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13019-020-1058-9","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T16:02:47Z","timestamp":1578499367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiac surgery in acute myocardial infarction: crystalloid versus blood cardioplegia \u2013 an experimental study"],"prefix":"10.1186","volume":"15","author":[{"given":"Andreas","family":"Boening","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Hinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Heep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Boengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Niemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4139-7983","authenticated-orcid":false,"given":"Philippe","family":"Grieshaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"1058_CR1","doi-asserted-by":"publisher","unstructured":"Neumann F-J, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al 2018 ESC\/EACTS Guidelines on myocardial revascularization. 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The authors declare that there are no conflicting financial or non-financial interests. All authors confirm that they had full control of the design and the methods of the study, the data analysis and the production of the written report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4"}}