{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:06:18Z","timestamp":1769591178452,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Foundation for Young Scientists of Gansu province","award":["1506RJYA264"],"award-info":[{"award-number":["1506RJYA264"]}]},{"name":"Scientific Research Foundation of Clinical Pharmacy Branch of Chinese Medical Association\u2014Wu Jieping Medical Foundation","award":["LCYX-Q030\/320.6750.19090-40"],"award-info":[{"award-number":["LCYX-Q030\/320.6750.19090-40"]}]},{"name":"Hospital Funds of First Hospital of Lanzhou University","award":["ldyyyn2018-03"],"award-info":[{"award-number":["ldyyyn2018-03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To assess different bridging anticoagulation therapies early after mechanical heart valve replacement (MHVR) in Chinese patients.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We performed a prospective, single-center, observational cohort study of 305 patients who underwent elective MHVR with different bridging anticoagulation regimens. Patients enrolled in the study were divided into three bridging therapy groups: the unfractionated heparin (UFH) group (<jats:italic>n<\/jats:italic>\u2009=\u2009109), the low-molecular-weight heparin (LMWH) group (<jats:italic>n<\/jats:italic>\u2009=\u200997), and the UFH with sequential LMWH (UFH-LMWH) group (<jats:italic>n<\/jats:italic>\u2009=\u200999). All patients were followed for 4 weeks.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Two patients experienced thromboembolic stroke events in the UFH group. The LMWH group was associated with an increase in the incidence of bleeding events compared with the UFH group (10.3% VS 2.8%; <jats:italic>P<\/jats:italic>\u2009=\u20090.03). With a comparison of LMWH and UFH group in secondary endpoints, the statistical test for significance indicated a trend of reduced ICU length of stay (<jats:italic>P<\/jats:italic>\u2009=\u20090.08), postoperative length of stay (P\u2009=\u20090.08) and time of achieving target INR (<jats:italic>P<\/jats:italic>\u2009=\u20090.06). The creatinine level (odds ratio\u2009=\u20091.03; 95% confidence interval\u2009=\u20091.01 to 1.05; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and hypertension (odds ratio\u2009=\u20093.72; 95% confidence interval\u2009=\u20091.35 to 10.28; <jats:italic>P<\/jats:italic>\u2009=\u20090.01) were risk factors for bleeding events.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>For Chinese patients, the LMWH bridging anticoagulation presents the increased the incidence of bleeding events, but enables patients to benefit from achieving an early anticoagulation effect. Close follow-up and personalized management are required in patients with thromboembolic and bleeding risk factors.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Trial registration<\/jats:title>\n<jats:p>Chinese Clinical Trial Registry <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/index.aspx\">ChiCTR1800019841<\/jats:ext-link>. Registered 2 December 2018 retrospectively.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13019-020-1084-7","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T13:22:45Z","timestamp":1583500965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of different bridging anticoagulation therapies used after mechanical heart valve replacement in Chinese patients - a prospective cohort study"],"prefix":"10.1186","volume":"15","author":[{"given":"Bo-Xia","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-2402","authenticated-orcid":false,"given":"Bing","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-An","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,24]]},"reference":[{"issue":"5","key":"1084_CR1","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1136\/hrt.2007.134726","volume":"95","author":"EG Butchart","year":"2009","unstructured":"Butchart EG. 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Individual patient consent for inclusion in the study was obtained.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"40"}}