{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:22Z","timestamp":1791846382038,"version":"4.3.4"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cardiothorac Surg"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A rare cause of primary hyperparathyroidism (PHPT) is a parathyroid carcinoma. Hypercalcemia with an elevated parathyroid hormone (PTH) level seen in recurrent and metastasis disease cases is often refractory to medical therapy, thus surgical resection is recommended when possible. We performed debulking surgery for pleural dissemination of parathyroid cancer for improvement of symptoms in a patient with hypercalcemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 30-year-old male with hypercalcemia was diagnosed with parathyroid cancer. Following surgery, intact PTH level elevation and hypercalcemia progression due to recurrent disease were noted. An active status of functional left pleural dissemination was revealed in 99mTc-methoxyisobutylisonitrile and somatostatin receptor scintigraphy results, but not in the area of pulmonary metastasis, and debulking surgery was performed. Thereafter, the PTH level was decreased temporarily and activities of daily living improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aggressive resection of metastatic disease in patients with a parathyroid carcinoma is taken into consideration to control hypercalcemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13019-021-01477-z","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T07:07:49Z","timestamp":1618470469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Debulking surgery for functional pleural dissemination of parathyroid carcinoma-case report"],"prefix":"10.1186","volume":"16","author":[{"given":"Sachi","family":"Kawagishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Funaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Ose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-5288","authenticated-orcid":false,"given":"Yasushi","family":"Shintani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"issue":"5","key":"1477_CR1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00423-005-0555-6","volume":"390","author":"M Iacobone","year":"2005","unstructured":"Iacobone M, Ruffolo C, Lumachi F, Favia G. Results of iterative surgery for persistent and recurrent parathyroid carcinoma. Langenbeck's Arch Surg. 2005;390(5):385\u201390. https:\/\/doi.org\/10.1007\/s00423-005-0555-6.","journal-title":"Langenbeck's Arch Surg"},{"issue":"10","key":"1477_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrendo.2012.102","volume":"8","author":"KM Schulte","year":"2012","unstructured":"Schulte KM, Talat N. Diagnosis and management of parathyroid cancer. Nat Rev Endocrinol. 2012;8(10):612\u201322. https:\/\/doi.org\/10.1038\/nrendo.2012.102.","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"1477_CR3","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1053\/j.seminoncol.2010.10.013","volume":"37","author":"JM Sharretts","year":"2010","unstructured":"Sharretts JM, Kebebew E, Simonds WF. Parathyroid cancer. Semin Oncol. 2010;37(6):580\u201390. https:\/\/doi.org\/10.1053\/j.seminoncol.2010.10.013.","journal-title":"Semin Oncol"},{"issue":"2","key":"1477_CR4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/cncr.22790","volume":"110","author":"GG Fernandez-Ranvier","year":"2007","unstructured":"Fernandez-Ranvier GG, Khanafshar E, Jensen K, Zarnegar R, Lee J, Kebebew E, et al. Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis? Cancer. 2007;110(2):255\u201364. https:\/\/doi.org\/10.1002\/cncr.22790.","journal-title":"Cancer."},{"issue":"6","key":"1477_CR5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.4174\/jkss.2012.82.6.385","volume":"82","author":"YS Kim","year":"2012","unstructured":"Kim YS. Parathyroid carcinoma with lung metastasis in a thirteen-year-old girl. J Korean Surg Soc. 2012;82(6):385\u20138. https:\/\/doi.org\/10.4174\/jkss.2012.82.6.385.","journal-title":"J Korean Surg Soc"},{"issue":"8","key":"1477_CR6","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1530\/EC-19-0260","volume":"8","author":"S Storvall","year":"2019","unstructured":"Storvall S, Leijon H, Ryhanen E, Louhimo J, Haglund C, Schalin-Jantti C, et al. Somatostatin receptor expression in parathyroid neoplasms. Endocr Connect. 2019;8(8):1213\u201323. https:\/\/doi.org\/10.1530\/EC-19-0260.","journal-title":"Endocr Connect"}],"container-title":["Journal of Cardiothoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-021-01477-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13019-021-01477-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13019-021-01477-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T07:10:13Z","timestamp":1618470613000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiothoracicsurgery.biomedcentral.com\/articles\/10.1186\/s13019-021-01477-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1477"],"URL":"https:\/\/doi.org\/10.1186\/s13019-021-01477-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-101240\/v1","asserted-by":"object"}]},"ISSN":["1749-8090"],"issn-type":[{"value":"1749-8090","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]},"assertion":[{"value":"29 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient provided written, informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"86"}}