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The sutureless aortic valve bioprosthesis offers an alternative to standard aortic valve replacement with a sutured valve, but limited data are available in patients who have undergone multiple valve procedures involving the new, sutureless technology. We sought to investigate outcomes in high operative risk patients with previous or concomitant valve surgery who were implanted with a sutureless valve.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>SURE-AVR is an ongoing, prospective, multinational registry of patients undergoing aortic valve replacement. In-hospital and post-discharge outcomes up to 5\u2009years were collected.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study population comprised 78 patients (mean\u2009\u00b1\u2009SD: age 73.6\u2009\u00b1\u20097.6\u2009years, logistic EuroSCORE 18.0\u2009\u00b1\u200917.5) enrolled at 13 sites who presented for concomitant or previous mitral valve repair (<jats:italic>n<\/jats:italic>\u00a0=\u200945) or replacement (<jats:italic>n<\/jats:italic>\u00a0=\u200933), with or without additional concomitant procedures, and were implanted with a sutureless valve. Mean\u2009\u00b1\u2009SD overall aortic cross-clamp time was 109\u2009\u00b1\u200941\u2009min and cardiopulmonary bypass time was 152\u2009\u00b1\u200949\u2009min. Mean\u2009\u00b1\u2009SD aortic pressure gradients decreased from 37.6\u2009\u00b1\u200917.7\u2009mmHg preoperatively to 13.0\u2009\u00b1\u20095.7\u2009mmHg at hospital discharge, and peak aortic pressure gradient from 61.5\u2009\u00b1\u200928.7 to 23.4\u2009\u00b1\u200910.6\u2009mmHg. Early events included 1 death, 1 transient ischaemic attack, and 1 bleed (all 1.3%); a permanent pacemaker implantation was required in 6 patients (7.7%), and 2 reoperations (not valve related) (2.6%) took place. Over a median follow-up of 55.5\u2009months (Q1 13.4, Q3 68.6), 12 patients died (6 cardiovascular and 6 non-cardiovascular, both 2.1% per patient-year). Five-year survival was 81.3%. Late paravalvular leak occurred in 2 patients (0.7% per patient-year) and permanent pacemaker implantation was required in 3 patients (0.1% per patient-year). There was no apparent rise in mean or peak aortic pressure gradient over the study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These results suggest that the sutureless implant is a technically feasible procedure during mitral surgery and is associated with good clinical outcomes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13019-021-01523-w","type":"journal-article","created":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T20:02:43Z","timestamp":1622404963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical outcomes after implantation of a sutureless aortic bioprosthesis with concomitant mitral valve surgery: the SURE-AVR registry"],"prefix":"10.1186","volume":"16","author":[{"name":"on behalf of the SURE-AVR investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3719-6660","authenticated-orcid":false,"given":"Max","family":"Baghai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Glauber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Cuenca","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony H.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugolino","family":"Livi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Montiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Royse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Bisleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Argano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelien","family":"Roumy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Asimakopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Solinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"issue":"4","key":"1523_CR1","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1093\/ejcts\/ezx324","volume":"52","author":"V Falk","year":"2017","unstructured":"Falk V, Baumgartner H, Bax JJ, De Bonis M, Hamm C, Holm PJ, et al. 2017 ESC\/EACTS guidelines for the management of valvular heart disease. 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Ethics committee and\/or institutional review board approval was obtained as required by local regulations. All patients gave informed consent to participate.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Max Baghai, Mattia Glauber, Gianluigi Bisleri, George Asimakopoulos, and Marco Solinas are proctors for LivaNova. The other authors declare they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"154"}}